{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:36:03Z","timestamp":1790674563977,"version":"4.1.0"},"reference-count":157,"publisher":"American Institute of Mathematical Sciences (AIMS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIMSN"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p xml:lang=\"fr\">&lt;abstract&gt;\n&lt;p&gt;Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in adults involving non-demyelinating motor disorders. About 90% of ALS cases are sporadic, while 10\u201312% of cases are due to some genetic reasons. Mutations in superoxide dismutase 1 (&lt;italic&gt;SOD1&lt;\/italic&gt;), &lt;italic&gt;TAR&lt;\/italic&gt;, &lt;italic&gt;c9orf72&lt;\/italic&gt; (chromosome 9 open reading frame 72) and &lt;italic&gt;VAPB&lt;\/italic&gt; genes are commonly found in ALS patients. Therefore, the mechanism of ALS development involves oxidative stress, endoplasmic reticulum stress, glutamate excitotoxicity and aggregation of proteins, neuro-inflammation and defective RNA function. Cholesterol and LDL\/HDL levels are also associated with ALS development. As a result, sterols could be a suitable biomarker for this ailment. The main mechanisms of ALS development are reticulum stress, neuroinflammation and RNA metabolism. The multi-nature development of ALS makes it more challenging to pinpoint a treatment.&lt;\/p&gt;\n&lt;\/abstract&gt;<\/jats:p>","DOI":"10.3934\/neuroscience.2022023","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T05:46:16Z","timestamp":1668145576000},"page":"423-443","source":"Crossref","is-referenced-by-count":11,"title":["Biomarkers and molecular mechanisms of Amyotrophic Lateral 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