{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T04:13:35Z","timestamp":1698984815751},"reference-count":43,"publisher":"American Institute of Mathematical Sciences (AIMS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIMSN"],"published-print":{"date-parts":[[2023]]},"abstract":"<abstract>\n<p>Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy, through the neuronal mechanisms of this syndrome remain elusive. In addition to the temporal lobe structures, it was found that the basal forebrain cholinergic cells are also involved in epileptogenesis. However, little is known about the involvement of the basal forebrain GABAergic neurons in epilepsy; despite this, they largely project to the temporal lobe and are crucial for the regulation of the hippocampal circuitry. In this study, we assessed epilepsy-induced changes in parvalbumin (PARV) immunoreactive neurons of the medial septum (MS) and of the magnocellular preoptic nucleus (MCPO) using the kainic acid (KA) model in rats. In addition, we estimated the respective changes in the cholinergic varicosities in the MS, where we observed a significant reduction in the PARV cell number (12849 \u00b1 2715 vs. 9372 \u00b1 1336, <italic>p<\/italic> = .029) and density (16.2 \u00b1 2.62 vs. 10.5 \u00b1 1.00 per .001 mm<sup>3<\/sup>, <italic>p<\/italic> =.001), and an increase in the density of cholinergic varicosities (47.9 \u00b1 11.1 vs. 69.4 \u00b1 17.8 per 30,000 \u00b5m<sup>2<\/sup>, <italic>p<\/italic> =.036) in KA-treated animals. In the MCPO, these animals showed a significant increase in somatic volume (827.9 \u00b1 235.2 \u00b5m<sup>3<\/sup> vs. 469.9 \u00b1 79.6 \u00b5m<sup>3<\/sup>, <italic>p<\/italic> = .012) and total cell number (2268.6 \u00b1 707.1 vs. 1362.4 \u00b1 262.0, <italic>p<\/italic> =.028). These results show that the basal forebrain GABAergic cell populations undergo numerical and morphological changes in epileptic animals, which may contribute to an increased vulnerability of brain circuits to epilepsy and epilepsy-related functional impairments.<\/p>\n<\/abstract><\/jats:p>","DOI":"10.3934\/neuroscience.2023023","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T01:19:46Z","timestamp":1698974386000},"page":"300-314","source":"Crossref","is-referenced-by-count":0,"title":["Plastic rearrangement of basal forebrain parvalbumin-immunoreactive neurons in the kainite model of epilepsy"],"prefix":"10.3934","volume":"10","author":[{"given":"Ruben","family":"Carvalho","sequence":"first","affiliation":[{"name":"Master in Neurobiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Neuronal Networks Group, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"},{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Alisa N.","family":"Lukoyanova","sequence":"additional","affiliation":[{"name":"Neuronal Networks Group, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Casalta-Lopes","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Coimbra, Portugal"},{"name":"Life and Health Sciences Research Institute \/ School of Medicine - University of Minho, Braga, Portugal"},{"name":"Department of Radiotherapy, University Hospital Center of S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Nikolay V.","family":"Lukoyanov","sequence":"additional","affiliation":[{"name":"Neuronal Networks Group, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"},{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Joana Isabel","family":"Soares","sequence":"additional","affiliation":[{"name":"Neuronal Networks Group, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"},{"name":"Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Basic Sciences, Polytechnic Institute of Coimbra, Coimbra Health School, Coimbra, Portugal"}]}],"member":"2321","reference":[{"key":"key-10.3934\/Neuroscience.2023023-1"},{"key":"key-10.3934\/Neuroscience.2023023-2"},{"key":"key-10.3934\/Neuroscience.2023023-3"},{"key":"key-10.3934\/Neuroscience.2023023-4"},{"key":"key-10.3934\/Neuroscience.2023023-5"},{"key":"key-10.3934\/Neuroscience.2023023-6"},{"key":"key-10.3934\/Neuroscience.2023023-7"},{"key":"key-10.3934\/Neuroscience.2023023-8"},{"key":"key-10.3934\/Neuroscience.2023023-9"},{"key":"key-10.3934\/Neuroscience.2023023-10"},{"key":"key-10.3934\/Neuroscience.2023023-11"},{"key":"key-10.3934\/Neuroscience.2023023-12"},{"key":"key-10.3934\/Neuroscience.2023023-13"},{"key":"key-10.3934\/Neuroscience.2023023-14"},{"key":"key-10.3934\/Neuroscience.2023023-15"},{"key":"key-10.3934\/Neuroscience.2023023-16"},{"key":"key-10.3934\/Neuroscience.2023023-17"},{"key":"key-10.3934\/Neuroscience.2023023-18"},{"key":"key-10.3934\/Neuroscience.2023023-19"},{"key":"key-10.3934\/Neuroscience.2023023-20"},{"key":"key-10.3934\/Neuroscience.2023023-21"},{"key":"key-10.3934\/Neuroscience.2023023-22"},{"key":"key-10.3934\/Neuroscience.2023023-23"},{"key":"key-10.3934\/Neuroscience.2023023-24"},{"key":"key-10.3934\/Neuroscience.2023023-25"},{"key":"key-10.3934\/Neuroscience.2023023-26"},{"key":"key-10.3934\/Neuroscience.2023023-27"},{"key":"key-10.3934\/Neuroscience.2023023-28"},{"key":"key-10.3934\/Neuroscience.2023023-29"},{"key":"key-10.3934\/Neuroscience.2023023-30"},{"key":"key-10.3934\/Neuroscience.2023023-31"},{"key":"key-10.3934\/Neuroscience.2023023-32"},{"key":"key-10.3934\/Neuroscience.2023023-33"},{"key":"key-10.3934\/Neuroscience.2023023-34"},{"key":"key-10.3934\/Neuroscience.2023023-35"},{"key":"key-10.3934\/Neuroscience.2023023-36"},{"key":"key-10.3934\/Neuroscience.2023023-37"},{"key":"key-10.3934\/Neuroscience.2023023-38"},{"key":"key-10.3934\/Neuroscience.2023023-39"},{"key":"key-10.3934\/Neuroscience.2023023-40"},{"key":"key-10.3934\/Neuroscience.2023023-41"},{"key":"key-10.3934\/Neuroscience.2023023-42"},{"key":"key-10.3934\/Neuroscience.2023023-43"}],"container-title":["AIMS Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/www.aimspress.com\/article\/doi\/10.3934\/Neuroscience.2023023?viewType=html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T01:19:46Z","timestamp":1698974386000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aimspress.com\/article\/doi\/10.3934\/Neuroscience.2023023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3934\/neuroscience.2023023","relation":{},"ISSN":["2373-7972"],"issn-type":[{"value":"2373-7972","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}