{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:59:07Z","timestamp":1767967147044,"version":"3.49.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjectives: We compared the electrophysiologic and histopathologic results of early primary nerve repair and grafting of transections made at different levels.\\r\\nMethods: Twenty-two male Sprague-Dawley rats were divided into three groups. In one group (distal group, n=8), the right sciatic nerve was transected near the proximal segment of, and in another (proximal group, n=7) at 15 mm proximal to, its branching. In the graft group (n=7), the nerve was resected from 5 mm to 15 mm proximal to its branching and the defect was repaired with the removed segment. All the nerves were repaired using the epiperineural technique. Electrophysiologic studies were performed before and after surgery. In the third month, bilateral biopsies were taken from the L4-5 dorsal root ganglion and from distal nerve segments for histopathologic examination and neuron and axon counts. \\r\\nResults: At two months, the distal group exhibited significantly shorter latency (p=0.001) and higher amplitude (p=0.05) values. However, at three months, all the groups had similar values of latency, amplitude, and conduction velocity. At three months, the number of the dorsal root ganglion neurons was significantly greater in the distal group compared to the graft group (p&lt;0.001), but this did not differ from the proximal group (p&gt;0.05). Axon counts per square millimeter were similar (p&gt;0.05), but axon diameter was greater in the distal group (p&lt;0.05). In correlation analyses, increases in the number of L4-5 dorsal root ganglion neurons were significantly associated with increases in the percent changes in distal latency (p&lt;0.05) and conduction velocity (p=0.018).\\r\\nConclusion: Our findings suggest that distal injuries and primary repair of the sciatic nerve result in a faster and better recovery.\n\n\n\u00d6zet\n\nAma\u00e7: Farkl\u0131 seviyelerde yap\u0131lan sinir kesilerinin erken d\u00f6nemde primer onar\u0131m\u0131 ile sinir grefti ile onar\u0131m\u0131n\u0131n sonu\u00e7lar\u0131 elektrofizyolojik ve histopatolojik olarak kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.\\r\\n\u00c7al\u0131\u015fma plan\u0131: Sprague-Dawley cinsi 22 erkek s\u0131\u00e7an \u00fc\u00e7 gruba ayr\u0131ld\u0131. Sa\u011f siyatik sinirler, distal kesi grubunda (n=8) sinirin dallanma noktas\u0131n\u0131n hemen proksimalinden, proksimal kesi grubunda (n=7) ise 15 mm proksimalinden kesildi. Son grupta (n=7) ise sinir dallanmas\u0131n\u0131n 5 mm ve 15 mm proksimalinden defekt olu\u015fturuldu ve kesilen par\u00e7a greft olarak kullan\u0131ld\u0131. T\u00fcm sinirler epiperin\u00f6ral olarak onar\u0131ld\u0131. Cerrahiden \u00f6nce ve sonra elektrofizyolojik de\u011ferlendirmeler yap\u0131ld\u0131. \u00dc\u00e7\u00fcnc\u00fc ayda, iki tarafl\u0131 L4-5 k\u00f6k gangliyonundan ve kesi distalinden al\u0131nan \u00f6rnekler histopatolojik olarak incelendi, n\u00f6ron ve akson say\u0131lar\u0131 hesapland\u0131.\\r\\nSonu\u00e7lar: \u0130kinci ayda, distal kesi grubunda latans de\u011ferleri di\u011fer iki gruba g\u00f6re anlaml\u0131 derecede d\u00fc\u015f\u00fck (p&lt;0.001), amplit\u00fcd de\u011ferleri anlaml\u0131 derecede y\u00fcksek (p&lt;0.05) bulundu. \u00dc\u00e7\u00fcnc\u00fc ayda gruplar\u0131n latans, amplit\u00fcd ve ileti h\u0131z\u0131 de\u011ferleri benzer bulundu. Distal kesi grubunda mm2\u2019deki k\u00f6k gangliyon n\u00f6ron say\u0131s\u0131 sinir grefti grubuna g\u00f6re anlaml\u0131 derecede fazla iken (p&lt;0.001), proksimal kesi grubuyla anlaml\u0131 fark g\u00f6stermedi (p&gt;0.05). Gruplar aras\u0131nda akson say\u0131s\u0131 a\u00e7\u0131s\u0131ndan anlaml\u0131 farkl\u0131l\u0131k g\u00f6r\u00fclmezken (p&gt;0.05), akson \u00e7aplar\u0131n\u0131n b\u00fcy\u00fckl\u00fc\u011f\u00fc distal kesi grubunda daha fazlayd\u0131 (p&lt;0.05). Korelasyon analizinde, kar\u015f\u0131 L4-5 k\u00f6k h\u00fccre say\u0131s\u0131 artt\u0131k\u00e7a latans de\u011fi\u015fim y\u00fczdesi (p&lt;0.05) ve ileti h\u0131z\u0131 de\u011fi\u015fim y\u00fczdesi (p=0.018) anlaml\u0131 derecede artmaktayd\u0131. \\r\\n\u00c7\u0131kar\u0131mlar: \u00c7al\u0131\u015fmam\u0131z\u0131n verileri, siyatik sinirin, distal kesilerde ve primer onar\u0131mlarda daha h\u0131zl\u0131 ve kaliteli iyile\u015fme g\u00f6sterdi\u011fini ortaya koymu\u015ftur.<\/jats:p>","DOI":"10.3944\/aott.2008.278","type":"journal-article","created":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T07:59:48Z","timestamp":1228636788000},"page":"278-283","source":"Crossref","is-referenced-by-count":7,"title":["Electrophysiologic and histopathologic evaluation of peripheral nerve regenerationat different nerve segments and with different repair techniques"],"prefix":"10.5152","volume":"42","author":[{"given":"Semra","family":"Kar\u015f\u0131da\u011f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eevki","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Kar\u015f\u0131da\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fevziye","family":"Kabuk\u00e7uo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"U\u011furlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00fctf\u00fc","family":"Ba\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,8]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2207\/2164","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:01:09Z","timestamp":1763463669000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,8]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,1,4]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2008.278","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,8]]}}}