{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:56:19Z","timestamp":1781902579357,"version":"3.54.5"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nThe effect of genetic factors on hip dislocation, acetabular dysplasia, and developmental dysplasia of the hip (DDH) has long been recognized. In this report, we presented a large family that showed single gene inheritance for DDH. Pedigree analysis of a pregnant woman revealed a history of DDH in 16 members of the family. Although the pedigree showed autosomal dominant inheritance with reduced penetrance, the prevalence of DDH was considerably high, almost accounting for one-third of the family members, and skipping only one generation. Of 16 cases, three patients were diagnosed at our center. The remaining 13 patients were diagnosed at other centers. Dislocation was diagnosed very late in most of the family members, while four cases were diagnosed at birth. All family members were informed by a detailed clinical letter and recommended evaluation for DDH at every birth.\n\n\u00d6zet\n\nGenetik fakt\u00f6rlerin kal\u00e7a \u00e7\u0131k\u0131\u011f\u0131, asetab\u00fcler displazi ve geli\u015fimsel kal\u00e7a displazisi (GKD) \u00fczerine etkileri uzun zamand\u0131r bilinmektedir. Bu yaz\u0131da, olduk\u00e7a nadir bir durum olan tek gen kal\u0131t\u0131m\u0131 g\u00f6steren GKD\u2019li bir aile sunuldu. Hamile bir kad\u0131n\u0131n pedigri analizi s\u0131ras\u0131nda 16 aile ferdinde GKD \u00f6yk\u00fcs\u00fc oldu\u011fu \u00f6\u011frenildi. Pedigri analizi d\u00fc\u015f\u00fck penetransl\u0131 otozomal dominant kal\u0131t\u0131m g\u00f6stermesine kar\u015f\u0131n, GKD\u2019li olgu say\u0131s\u0131n\u0131n y\u00fcksek oldu\u011fu (aile bireylerinin neredeyse \u00fc\u00e7te biri) ve sadece bir ku\u015fak atlad\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc. Olgular\u0131n \u00fc\u00e7\u00fc klini\u011fimizde de\u011ferlendirildi ve bu hastalara GKD tan\u0131s\u0131 kondu. Di\u011fer 13 hastaya daha \u00f6nce ba\u015fka kliniklerde tan\u0131 konmu\u015ftu. Kal\u00e7a \u00e7\u0131k\u0131\u011f\u0131 genellikle \u00e7ok ge\u00e7 tespit edilmekle beraber, d\u00f6rt olguda tan\u0131 do\u011fum s\u0131ras\u0131nda konmu\u015ftu. Aile bireyleri ayr\u0131nt\u0131l\u0131 bir klinik mektup ile bilgilendirildi ve aileye her do\u011fumu takiben de\u011ferlendirme \u00f6nerildi.<\/jats:p>","DOI":"10.3944\/aott.2008.289","type":"journal-article","created":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T07:59:48Z","timestamp":1228636788000},"page":"289-291","source":"Crossref","is-referenced-by-count":21,"title":["Autosomal dominant inheritance of congenital dislocation of the hip in 16 members of a family"],"prefix":"10.5152","volume":"42","author":[{"given":"G\u00fclay","family":"Ceylaner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Ceylaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulya","family":"\u00dcst\u00fcnkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muharrem","family":"\u0130nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,8]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2209\/2166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:01:07Z","timestamp":1763463667000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,8]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,1,4]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2008.289","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,8]]}}}