{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:28:02Z","timestamp":1765826882147,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjectives: We investigated risk factors for venous thromboembolism (VTE), prophylaxis measures employed, and incidence of symptomatic deep venous thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing major orthopaedic surgery (MOS).\\r\\nMethods: An open, multicenter, prospective, observational study was conducted in 21 medical centers, comprising 899 patients. Of these, 316 patients (35.2%) underwent total hip arthroplasty (THA), 328 patients (36.5%) underwent total knee arthroplasty (TKA), and 255 patients (28.4%) underwent surgery for hip fractures (HF). Pharmacologic prophylaxis was employed in all the patients.\\r\\nResults: Risk factors for VTE were seen in 73.2% of the patents, the most common being obesity (72%) and prolonged immobilization (36.3%). Low-molecular-weight heparin (91.1%) and fondaparinux (8.9%) were used for prophylaxis, which was short-term in 273 patients (30.4%) and long-term in 626 patients (69.6%). Mechanical prophylaxis was performed with compression stockings in 610 patients (67.9%) and by intermittent pneumatic compression in 67 patients (7.5%). During three-months of follow-up, symptomatic DVT and PE were seen in eight (0.9%) and four patients (0.4%), respectively. Mortality occurred in 10 patients (1.1%). Complications of major and minor bleeding were seen in eight (0.9%) and 40 (4.5%) patients, respectively.\\r\\nConclusion: Effective VTE prophylaxis is associated with low risk of clinically apparent DVT and PE in MOS.\n\n\u00d6zet\n\nAma\u00e7: \u00dclkemizde maj\u00f6r ortopedik cerrahi (MOC) i\u00e7in farmakolojik profilaksi uygulanan hastalarda ven\u00f6z tromboembolizm (VTE) risk fakt\u00f6rleri, kullan\u0131lan profilaksi y\u00f6ntemleri ve klinik bulgu veren derin ven trombozu (DVT) ve pulmoner emboli (PE) s\u0131kl\u0131\u011f\u0131 ara\u015ft\u0131r\u0131ld\u0131.\\r\\n\u00c7al\u0131\u015fma plan\u0131: Prospektif, \u00e7okmerkezli, a\u00e7\u0131k, m\u00fcdahalesiz bir g\u00f6zlem \u00e7al\u0131\u015fmas\u0131 planlanarak, 21 merkezden 899 hasta \u00e7al\u0131\u015fmaya al\u0131nd\u0131. Olgular\u0131n 316\u2019s\u0131nda (%35.2) total kal\u00e7a protezi (TKP), 328\u2019inde (%36.5) total diz protezi (TDP), 255\u2019inde (%28.4) kal\u00e7a k\u0131r\u0131\u011f\u0131 (KK) cerrahisi uyguland\u0131. T\u00fcm hastalarda farmakolojik DVT profilaksisine ba\u015fvuruldu. \\r\\nSonu\u00e7lar: Olgular\u0131n %73.2\u2019sinde VTE risk fakt\u00f6rleri vard\u0131. En s\u0131k g\u00f6r\u00fclen risk fakt\u00f6rleri obezite (%72) ve uzam\u0131\u015f immobilizasyon (%36.3) idi. Profilaksi i\u00e7in olgular\u0131n %91.1\u2019inde d\u00fc\u015f\u00fck molek\u00fcl a\u011f\u0131rl\u0131kl\u0131 heparin, %8.9\u2019unda fondaparinuks kullan\u0131ld\u0131. Olgular\u0131n 273\u2019\u00fcne (%30.4) k\u0131sa d\u00f6nem, 626\u2019s\u0131na (%69.6) uzun d\u00f6nem profilaksi uyguland\u0131. Mekanik profilaksi 610 olguda (%67.9) elastik \u00e7orap ile, 67 olguda (%7.5) aral\u0131kl\u0131 hava bas\u0131n\u00e7 cihaz\u0131 ile uyguland\u0131. \u00dc\u00e7 ayl\u0131k takip sonucunda sekiz olguda (%0.9) klinik bulgu veren DVT, d\u00f6rt olguda (%0.4) PE geli\u015fti. Mortalite 10 olguda (%1.1) g\u00f6r\u00fcld\u00fc. Kanama komplikasyonu sekiz olguda (%0.9) maj\u00f6r, 40 olguda (%4.5) min\u00f6r idi.\\r\\n\u00c7\u0131kar\u0131mlar: Etkin VTE profilaksi yap\u0131ld\u0131\u011f\u0131nda MOC\u2019de klinik bulgu veren DVT ve PE oranlar\u0131 d\u00fc\u015f\u00fck olmaktad\u0131r.<\/jats:p>","DOI":"10.3944\/aott.2008.322","type":"journal-article","created":{"date-parts":[[2009,1,19]],"date-time":"2009-01-19T23:01:13Z","timestamp":1232406073000},"page":"322-327","source":"Crossref","is-referenced-by-count":16,"title":["Venous thromboembolism prophylaxis in major orthopaedic surgery: A multicenter prospective observational study"],"prefix":"10.5152","volume":"42","author":[{"given":"Fatih","family":"Pestilci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Kinik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remzi","family":"Tozun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayk\u0131n","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cetin","family":"Onder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Serin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Faruk Bilgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevzat","family":"Dabak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Argun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Konal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faik","family":"Altintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Gogus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Is\u0131k","family":"Akgun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Memik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oner","family":"Savk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Ozic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Gur Ustaoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Erdemli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Gurbuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,8]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2217\/2174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:01:02Z","timestamp":1763463662000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,8]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,1,5]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2008.322","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,8]]}}}