{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:01:02Z","timestamp":1775613662393,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: Diabetes mellitus and chemotherapy use are well-known factors that can affect success after microvascular repair. Although many studies have investigated each factor individually, no study exists on their combined effect. The aim of our study was to investigate the effects of preoperative vinblastine, a vinca alkaloid, on the healing of microvascular anastomosis in diabetic and non-diabetic rats. \\r\\nMethods: In this study, 144 Sprague Dawley rats were assigned randomly and equally into experimental or control groups. The experimental group consisted of 72 rats which were made diabetic by alloxan injections. Diabetes was confirmed by glycosuria (&gt;2%) and elevated plasma glucose (&gt;300 mg\/100 ml) after three days of alloxan injections. The experimental group then received a single dose of intraperitoneal vinblastine. After applying the medication, the two main groups were divided into three subgroups. For each group, we performed end-to-end femoral artery anastomosis on Day 7, 14, and 21, respectively. We further divided each subgroup equally into three smaller groups to test patency and took biopsies at Day 7, 14 and 21, respectively. Histopathologic evaluation was carried out. \\r\\nResults: The comparison of patency tests and pathologic examination indicated that there was no statistically significant difference between the two groups. \\r\\nConclusion: The negative effects of diabetes and the administration of vinblastine did not significantly influence anastomosis healing.\n\n\u00d6zet\n\nAma\u00e7: Diabetes mellitus ve kemoterapi mikrovask\u00fcler cerrahinin ba\u015far\u0131s\u0131n\u0131 etkileyen fakt\u00f6rlerin ba\u015f\u0131nda gelir. Bu iki fakt\u00f6r\u00fcn tek ba\u015f\u0131na etkilerini inceleyen bir\u00e7ok \u00e7al\u0131\u015fma olmas\u0131na ra\u011fmen, ikisinin birlikte oldu\u011fu durumlardaki etkilerini ara\u015ft\u0131ran \u00e7al\u0131\u015fmaya rastlamad\u0131k. \u00c7al\u0131\u015fmam\u0131zda vinka alkaloidi olan vinblastinin diyabetik ve diyabetik olmayan s\u0131\u00e7anlarda mikrovask\u00fcler anastomoz iyile\u015fmesi \u00fczerine etkilerini ara\u015ft\u0131rd\u0131k. \\r\\n\u00c7al\u0131\u015fma plan\u0131: Bu \u00e7al\u0131\u015fmada 144 Sprague Dawley cinsi s\u0131\u00e7an kullan\u0131ld\u0131. Deney ve kontrol gruplar\u0131 rastgele ve e\u015fit say\u0131da olu\u015fturuldu. Deney grubuna (72 s\u0131\u00e7an) alloksan verilerek diyabet olu\u015fumu sa\u011fland\u0131. Alloksan enjeksiyonundan 3 g\u00fcn sonra s\u0131\u00e7anlarda glukoz\u00fcri (&gt;%2) ve artm\u0131\u015f plazma glukoz seviyeleri (&gt;300 mg\/100 ml) sa\u011fland\u0131. Tek doz vinblastin intraperitoneal olarak uyguland\u0131. Medikasyonlar\u0131n tamamlanmas\u0131ndan sonra iki ana grup \u00fc\u00e7 alt guba ayr\u0131ld\u0131. Her bir grupta femoral artere, s\u0131ras\u0131yla 7., 14. ve 21. g\u00fcnlerde u\u00e7-uca anastomoz uyguland\u0131. Daha sonra, her alt grup ge\u00e7irgenlik testi amac\u0131yla \u00fc\u00e7 k\u00fc\u00e7\u00fck gruba ayr\u0131ld\u0131 ve s\u0131ras\u0131yla 7., 14. ve 21. g\u00fcnlerde biyopsileri al\u0131nd\u0131. Histopatolojik incelemeler yap\u0131ld\u0131. \\r\\nBulgular: Anostomozun ge\u00e7irgenlik testlerinde ve patolojik incelemede guplar aras\u0131nda istatistiksel olarak anlaml\u0131 bir fark saptanmad\u0131. \\r\\n\u00c7\u0131kar\u0131mlar: Diyabetin negatif etkileri ve birlikte vinblastin verilmesi mikrovask\u00fcler anastomoz iyile\u015fmesini belirgin olarak etkilememektedir.<\/jats:p>","DOI":"10.3944\/aott.2011.2430","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T06:02:26Z","timestamp":1327384946000},"page":"446-452","source":"Crossref","is-referenced-by-count":3,"title":["Effects of vinblastine on microvascular anastomosis healing in diabetic rats"],"prefix":"10.5152","volume":"45","author":[{"given":"Semra","family":"Karsidag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soner","family":"Tatlidede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Tosun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemalettin","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fevziye","family":"Kabukcuoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Akcal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2540\/2496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:27:41Z","timestamp":1763465261000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2011.2430","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}