{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:26:58Z","timestamp":1766467618891,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to investigate the effects of demineralized bone matrix (DBM) on tendon-bone healing.\\r\\nMethods: The extensor digitorum longus tendon was fixed with pegged suture technique in a tunnel at the proximal tibia in both legs of 12 New Zealand rabbits. Rabbit DBM was applied in the tunnel on the right limbs before fixation (study group), while the fixation was performed without DBM in the left legs (control group). Randomly, four rabbits were sacrificed at the 3rd, four rabbits at the 6th and the remaining four rabbits at the 9th week with an intravenous high dose (200 mg\/kg) pentothal and both legs were collected for histological analysis. Each specimen was blindly and independently examined to assess fibrocartilage formation, new bone formation, tendon graft bonding to adjacent tissue and Sharpey\u2019s fiber formation. A scoring system was used for quantification of histopathological analysis.\\r\\nResults: The DBM group showed higher number of Sharpey\u2019s fibers, slightly increased fibrocartilage formation and new bone formation scores than the control group in the 3rd week. All histological scores were similar in both groups in the 6th and 9th weeks (p&gt;0.05).\\r\\nConclusion: DBM increased new bone formation and the number of Sharpey\u2019s fibers in a bone tunnel animal model within the first three weeks of tendon-bone healing process.\n\n\u00d6zet\n\nAma\u00e7: Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 demineralize kemik matriksinin (DKM) tendon-kemik iyile\u015fmesi \u00fczerindeki etkilerini ara\u015ft\u0131rmak idi.\\r\\n\u00c7al\u0131\u015fma plan\u0131: On iki Yeni Zelanda tav\u015fan\u0131n\u0131n her iki baca\u011f\u0131nda uzun dijital ekstans\u00f6r tendon tibia proksimalinde a\u00e7\u0131lan t\u00fcnelin i\u00e7ine ask\u0131 diki\u015f y\u00f6ntemi ile tespit edildi. Sa\u011f tibialarda tendon t\u00fcnele yerle\u015ftirilmeden \u00f6nce t\u00fcnel i\u00e7ine tav\u015fan kaynakl\u0131 DKM enjekte edildi. Sol tibialar ise kontrol grubu olarak al\u0131nd\u0131 ve sadece uzun dijital ekstans\u00f6r tendonlar\u0131 t\u00fcnel i\u00e7erisinde tespit edildi. \u00dc\u00e7\u00fcnc\u00fc, 6. ve 9. haftalarda 4\u2019er adet tav\u015fan rastgele \u015fekilde intraven\u00f6z y\u00fcksek doz (200 mg\/kg) pentotal ile sakrifiye edildi ve tav\u015fanlar\u0131n her iki baca\u011f\u0131 histolojik inceleme i\u00e7in al\u0131nd\u0131. \u00d6rnekler histopatolojik a\u00e7\u0131dan fibrokartilaj olu\u015fumu, yeni kemik olu\u015fumu, tendonun kemik t\u00fcnel i\u00e7erisindeki tutunmas\u0131 ve Sharpey lifleri olu\u015fumu a\u00e7\u0131s\u0131ndan bir skorlama sistemi ile k\u00f6r ve ba\u011f\u0131ms\u0131z bir \u015fekilde de\u011ferlendirildi. \\r\\nBulgular: \u00dc\u00e7\u00fcnc\u00fc haftada DKM grubunda Sharpey lifleri, fibrokartilaj ve yeni kemik olu\u015fumu skorlar\u0131n\u0131n kontrol grubuna g\u00f6re daha fazla oldu\u011fu g\u00f6zlendi. Alt\u0131nc\u0131 ve 9. haftalarda ise histolojik de\u011ferlendirme parametreleri a\u00e7\u0131s\u0131ndan gruplar aras\u0131nda istatiksel anlaml\u0131 farkl\u0131l\u0131k saptanmad\u0131 (p&gt;0.05). \\r\\n\u00c7\u0131kar\u0131mlar: Demineralize kemik matriksinin kemik t\u00fcnel hayvan modelinde tendon-kemik iyile\u015fmesi s\u00fcrecinin ilk 3 haftas\u0131nda yeni kemik olu\u015fumunu ve Sharpey liflerinin say\u0131s\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/jats:p>","DOI":"10.3944\/aott.2012.2748","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T03:50:13Z","timestamp":1361764213000},"page":"443-448","source":"Crossref","is-referenced-by-count":8,"title":["Effects of demineralized bone matrix on tendonbone healing: an in vivo experimental study on rabbits"],"prefix":"10.5152","volume":"46","author":[{"given":"Onder","family":"Ismet Kilicoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goksel","family":"Dikmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Koyuncu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilge","family":"Bilgic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Kaya Alturfan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2664\/2619","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:25:56Z","timestamp":1763465156000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2012.2748","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}