{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:24:22Z","timestamp":1787030662999,"version":"build-2736575974"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to evaluate the effects of bone marrow-derived mesenchymal stem cell and bone marrow elements on the healing of meniscal tears. \\r\\nMethods: This study was performed on twelve, 2-year-old male Tahirova sheep. In each subject, one knee was used for experiment purposes and the other knee was used as a control. After creating a longitudinal full-thickness tear in the red-white zone of the medial meniscus, aspirated autologous bone marrow material was injected into the tear site in the experiment group. The control group received no intervention for secondary healing. \\r\\nResults: In the macroscopic evaluation of meniscus, a bridging reparation tissue and adhesion were observed between the rims of the tear in the experiment group. There was no statistical difference in collagen fibril formation between the groups (p=0.16). There was significantly more neovascularization in the experiment group than the control group (p=0.003). The cell count was also a significantly higher in the experiment group (p=0.004) and formation of cartilage plaques was more frequent in the experiment group (p=0.016). There was no evidence suggesting intrinsic repair in the meniscus of control group by light and electron microscopy. \\r\\nConclusion: An injection of bone marrow into the meniscus tear site improves healing in a meniscal tear model as demonstrated by both light and electron microscopic findings.\n\n\u00d6zet\n\nAma\u00e7: Bu \u00e7al\u0131\u015fmada kemik ili\u011fi kaynakl\u0131 mezenkimal k\u00f6k h\u00fccreleri ve kemik ili\u011fi elemanlar\u0131n\u0131n menisk\u00fcs y\u0131rt\u0131\u011f\u0131 iyile\u015fmesi \u00fczerine olan etkilerinin de\u011ferlendirilmesi ama\u00e7land\u0131. \\r\\n\u00c7al\u0131\u015fma plan\u0131: Bu \u00e7al\u0131\u015fma 12 adet 2 ya\u015f\u0131nda erkek Tahirova cinsi koyun \u00fczerinde ger\u00e7ekle\u015ftirildi. Deneklerin bir dizi deney ama\u00e7l\u0131 olarak, di\u011fer dizi kontrol grubu olarak kullan\u0131ld\u0131. \u0130\u00e7 menisk\u00fcste k\u0131rm\u0131z\u0131-beyaz b\u00f6lgede uzunlamas\u0131na tam kat bir y\u0131rt\u0131k olu\u015fturulduktan sonra deney grubunda aspire edilmi\u015f otolog kemik ili\u011fi materyali y\u0131rt\u0131k sahas\u0131na enjekte edilirken, kontrol grubunda y\u0131rt\u0131k sahas\u0131 herhangi bir i\u015flem yap\u0131lmadan ikincil iyile\u015fmeye b\u0131rak\u0131ld\u0131. \\r\\nBulgular: Makroskopik de\u011ferlendirmede deney grubunda y\u0131rt\u0131k u\u00e7lar\u0131 aras\u0131nda adezyon ve onar\u0131m dokusu olu\u015fumu tespit edildi. Gruplar aras\u0131nda kollajen fibril olu\u015fumu y\u00f6n\u00fcnden istatistiksel olarak anlaml\u0131 bir fark bulunamad\u0131 (p=0.16). Yeni damar olu\u015fumu y\u00f6n\u00fcnden deney grubu ve kontrol grubu aras\u0131nda anlaml\u0131 farkl\u0131l\u0131k mevcuttu (p=0.003). Kesitler h\u00fccre say\u0131m\u0131 y\u00f6n\u00fcnden ve k\u0131k\u0131rdak plaklar\u0131 olu\u015fumu y\u00f6n\u00fcnden deney grubunda anlaml\u0131 farkl\u0131l\u0131k bulundu (p=0.004 ve p=0.016). Kontrol grubunda \u0131\u015f\u0131k ve elektron mikroskobik d\u00fczeyde onar\u0131m\u0131 destekleyen bulgu yoktu. D\u00f6rt ay\u0131n sonunda deney grubunda menisk\u00fcs y\u0131rt\u0131k b\u00f6lgesinde k\u0131k\u0131rdak plaklar\u0131 olu\u015fumu ile giden iyile\u015fmenin a\u00e7\u0131k kan\u0131tlar\u0131 mevcuttu. \\r\\n\u00c7\u0131kar\u0131mlar: Sonu\u00e7 olarak bu \u00e7al\u0131\u015fma, \u0131\u015f\u0131k ve elektron mikroskobu bulgular\u0131n\u0131n da do\u011frultusunda, kemik ili\u011finin menisk\u00fcs y\u0131rt\u0131k b\u00f6lgesine enjeksiyonunun menisk\u00fcs y\u0131rt\u0131k modelinde iyile\u015fmeyi art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.<\/jats:p>","DOI":"10.3944\/aott.2012.2762","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T15:17:41Z","timestamp":1332861461000},"page":"61-67","source":"Crossref","is-referenced-by-count":33,"title":["Effects of intraarticular administration of autologous bone marrow aspirate on healing of fullthickness meniscal tear: an experimental study on sheep*"],"prefix":"10.5152","volume":"46","author":[{"given":"Fuat","family":"Duygulu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gultekin","family":"Atalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Figen Kaymaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Kocabey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turan","family":"Cihan Dulgeroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"Candemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2580\/2536","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:27:26Z","timestamp":1763465246000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1,1]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2012.2762","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}