{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:29:42Z","timestamp":1763465382026,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to examine the changes in the lumbar intervertebral area after extracorporeal shockwave therapy (ESWT) at different energy levels in a rabbit model using magnetic resonance imaging (MRI) and histopathological evaluation.\\r\\nMethods: The study included 30 male New Zealand white rabbits divided randomly into five groups: Groups A and C received 1,000 shockwave impulses at an intensity of 14 kV, Groups B and D received 1,000 impulses at 21 kV, and Group E was a sham group. Side effects such as subcutaneous and paravertebral soft-tissue injuries were evaluated using MRI one day after ESWT administration. Neovascularization, edema and fibroblast activity in the intervertebral area were evaluated histopathologically.\\r\\nResults: No change was observed in any group on MRI. Histopathologically, Groups A and C showed no change, whereas Groups B and D showed edema, fibroblast activity and significant neovascularization at the intervertebral end-plate (p&lt;0.05).\\r\\nConclusion: Our findings indicate that ESWT caused dose-dependent changes in the intervertebral end-plate. This study constitutes a preliminary evaluation of shockwave therapy to the intervertebral area in an animal model. High-dose ESWT may stimulate angiogenesis at cartilage end-plates in rabbits.\n\n\n\u00d6zet\n\nAma\u00e7: Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 manyetik rezonans g\u00f6r\u00fcnt\u00fcleme (MRG) ve histopatolojik de\u011ferlendirme ile farkl\u0131 enerji seviyelerinde uygulanan ekstrakorporeal \u015fok dalga tedavisi (extracorporeal shockwave therapy, ESWT) ile bel b\u00f6lgesindeki omurlar aras\u0131 alanda olu\u015fan de\u011fi\u015fimleri incelemekti.\\r\\n\u00c7al\u0131\u015fma plan\u0131: Otuz adet, erkek Yeni Zelanda beyaz tav\u015fan\u0131 rastgele be\u015f gruba ayr\u0131ld\u0131: Grup A ve C\u2019ye 14 kV ve 1000 vurulu \u015fok dalgas\u0131, Grup B ve D\u2019ye ise 21 kV ve 1000 vurulu \u015fok dalgas\u0131 uyguland\u0131. Grup E ise kontrol grubu olarak ayr\u0131ld\u0131. ESWT uygulamas\u0131ndan bir g\u00fcn sonra, MRG ile, ESWT\u2019nin cilt alt\u0131 ve paravertebral yumu\u015fak dokularda yaralanma benzeri yan etkileri incelendi. Histopatolojik inceleme ile omurlar aras\u0131 alanda yeni damar olu\u015fumu, \u00f6dem ve fibroblast etkinli\u011fi ara\u015ft\u0131r\u0131ld\u0131.\\r\\nBulgular: MRG\u2019de deneklerin hi\u00e7birinde herhangi bir de\u011fi\u015fiklik saptanmad\u0131. Histopatolojik olarak, Grup A ve C\u2019de de\u011fi\u015fiklik g\u00f6zlenmezken; Grup B ve D\u2019de omurlar aras\u0131 u\u00e7 plaklarda anlaml\u0131 derecede yeni damar olu\u015fumu, \u00f6dem ve fibroblast etkinli\u011fi saptand\u0131 (p&lt;0.05).\\r\\n\u00c7\u0131kar\u0131mlar: Bulgular\u0131m\u0131z ESWT\u2019nin omurlar aras\u0131 u\u00e7 plaklarda doza ba\u011f\u0131ml\u0131 etkiler g\u00f6sterdi\u011fini desteklemektedir. Bu \u00e7al\u0131\u015fma hayvan modelinde, omurlar aras\u0131 alanda \u015fok dalga tedavisinde bir \u00f6nc\u00fcl de\u011ferlendirmeden olu\u015fmaktad\u0131r. Y\u00fcksek doz ESWT tav\u015fan k\u0131k\u0131rdak u\u00e7 plaklar\u0131nda anjiyogenezi uyarabilir.<\/jats:p>","DOI":"10.3944\/aott.2012.2931","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T03:50:13Z","timestamp":1361764213000},"page":"449-454","source":"Crossref","is-referenced-by-count":3,"title":["The effect of extracorporeal shockwaves on cartilage endplates in rabbits: a preliminary MRI and histopathological study"],"prefix":"10.5152","volume":"46","author":[{"given":"Cemil","family":"Erturk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Akif Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilyas","family":"Ozardali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Cece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Erdem Isikan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2665\/2620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:25:56Z","timestamp":1763465156000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2012.2931","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}