{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:29:29Z","timestamp":1763465369419,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to evaluate the demographic characteristics of patients with bilateral bisphosphonate-related low-energy femoral shaft fractures. \\r\\nMethods: The clinical registry was reviewed for patients with bisphosphonate-related low-energy fractures localized at femoral shaft between January 2008 and January 2012. Patients with a diagnosis of postmenopausal osteoporosis, bisphosphonate usage of at least 5 years and prodromal pain prior to fracture were included the study. \\r\\nResults: Five women met the inclusion criteria. All patients had bilateral low-energy sequential femoral shaft fractures. Fracture patterns were similar and atypical (transverse-short oblique fractures with lateral cortical thickening). Mean period of bisphosphonate treatment was 8.6 years. Mean patient age was 76.2 years. Union time of three patients was between 20 and 28 weeks. The remaining two fractures were revised for delayed union or nonunion. \\r\\nConclusion: Long-term (over 5 years) use of bisphosphonates may cause insufficiency fractures due to increased fragility and brittleness which have a close relationship with depressed bone remodeling. While there is still no causal relationship between bisphosphonates and atypical, low-energy femoral shaft fractures, we have some concerns about the optimal usage time and long-term safety of bisphosphonate drugs.\n\n\u00d6zet\n\nAma\u00e7: Bu makale ile bilateral, bifosfonatla ili\u015fkili, d\u00fc\u015f\u00fck enerjili femur cisim k\u0131r\u0131\u011f\u0131 olan hastalar\u0131n demografik \u00f6zelliklerinin de\u011ferlendirilmesi ama\u00e7land\u0131. \\r\\n\u00c7al\u0131\u015fma plan\u0131: Ocak 2008 ila Ocak 2012 tarihleri aras\u0131nda d\u00fc\u015f\u00fck enerjili femur cisim k\u0131r\u0131\u011f\u0131 olan hastalar\u0131n kay\u0131tlar\u0131 incelenerek bifosfonatla ili\u015fkili olabilecek olgular saptand\u0131. Postmenopozal osteoporoz tan\u0131s\u0131 olan, en az 5 y\u0131l s\u00fcreyle bifosfonat kullanan ve k\u0131r\u0131klar\u0131 \u00f6ncesinde prodromal a\u011fr\u0131s\u0131 olan hastalar \u00e7al\u0131\u015fmaya al\u0131nd\u0131. \\r\\nBulgular: \u00c7al\u0131\u015fmaya al\u0131nma kriterlerine uyan 5 kad\u0131n hasta saptand\u0131. Hastalar\u0131n hepsinde bilateral, d\u00fc\u015f\u00fck enerjili, ard\u0131\u015f\u0131k femur cisim k\u0131r\u0131\u011f\u0131 vard\u0131. K\u0131r\u0131k yap\u0131lar\u0131 benzerdi ve atipik (lateral kortekste kal\u0131nla\u015fman\u0131n oldu\u011fu transvers-k\u0131sa oblik k\u0131r\u0131klar) idi. Ortalama bifosfonat tedavi s\u00fcresi 8.6 y\u0131l idi. Ortalama hasta ya\u015f\u0131 76.2 olarak saptand\u0131. \u00dc\u00e7 hastan\u0131n ortalama k\u0131r\u0131k kaynama s\u00fcresi 20-28 hafta idi. Di\u011fer iki hastada gecikmi\u015f kaynama veya kaynamama nedeniyle revizyon yap\u0131ld\u0131. \\r\\n\u00c7\u0131kar\u0131mlar: Uzun s\u00fcre (5 y\u0131ldan daha uzun) bifosfonat kullan\u0131lmas\u0131, kemik remodelizasyonunun bask\u0131lanmas\u0131 ile yak\u0131n ili\u015fkili olan artm\u0131\u015f k\u0131r\u0131lganl\u0131k nedeniyle yetmezlik k\u0131r\u0131klar\u0131na yol a\u00e7abilir. Bifosfonatlar ile atipik d\u00fc\u015f\u00fck enerjili femur cisim k\u0131r\u0131klar\u0131 aras\u0131nda nedensel bir ili\u015fki hen\u00fcz g\u00f6sterilememi\u015f olmakla birlikte bifosfonatlar\u0131n optimal kullan\u0131m s\u00fcresi ve uzun d\u00f6nem g\u00fcvenilirli\u011fi konusunda endi\u015felerimiz bulunmaktad\u0131r.<\/jats:p>","DOI":"10.3944\/aott.2013.2934","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T05:31:47Z","timestamp":1371015107000},"page":"162-172","source":"Crossref","is-referenced-by-count":12,"title":["Bilateral lowenergy sequential femoral shaft fractures in patients on longterm bisphosphonate therapy"],"prefix":"10.5152","volume":"47","author":[{"given":"Selami","family":"Cakmak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahir","family":"Ogullari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Keklikci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enes","family":"Sari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baran","family":"Erdik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Rodop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2712\/2667","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:25:24Z","timestamp":1763465124000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,1,3]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2013.2934","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}