{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:29:07Z","timestamp":1763465347535,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to assess the apoptotic effects of systemic corticosteroid application on the articular cartilage chondrocytes in vivo and to investigate the potential effects of zoledronic acid on corticosteroid-induced apoptosis. \\r\\nMethods: Twenty-four Wistar rats were randomly divided into 3 groups. In the control group, intramuscular isotonic salt solution was injected weekly. In the second group, a dose of 10 mg\/kg intramuscular corticosteroid (methylprednisolone) injection was applied weekly for 8 weeks. In the third group, a dose of 10 mg\/kg intramuscular corticosteroid (methylprednisolone) injection was applied weekly for 8 weeks and 0.1 mg\/kg zoledronic acid was injected subcutaneously on days 0, 21 and 42. Femoral head specimens from each group were obtained at the end of the treatment and the TUNEL method was applied to detect apoptotic chondrocytes. Comparison analyses were performed using the ANOVA method and Tukey\u2019s test. \\r\\nResults: There was a significant difference between the corticosteroid group and two other groups (control group: p=0.005; corticosteroid + zoledronic acid group: p=0.047). Zoledronic acid treatment significantly decreased the number of corticosteroid-induced apoptotic chondrocytes in the joint cartilage (p&lt;0.05). \\r\\nConclusion: Zoledronic acid may have the potential to prevent joint cartilage deterioration due to the corticosteroid-induced apoptosis of the chondrocytes.\n\n\n\u00d6zet\n\nAma\u00e7: Bu \u00e7al\u0131\u015fmam\u0131zda sistemik kortikosteroid uygulamas\u0131n\u0131n in vivo eklem k\u0131k\u0131rda\u011f\u0131 kondrositleri \u00fczerindeki apoptotik etkilerini ve zoledronik asidin kortikosteroide ba\u011fl\u0131 apoptoz \u00fczerindeki olas\u0131 etkileri olup olmad\u0131\u011f\u0131n\u0131 de\u011ferlendirmeyi ama\u00e7lad\u0131k.\\r\\n\u00c7al\u0131\u015fma plan\u0131: Yirmi d\u00f6rt adet Wistar s\u0131\u00e7an\u0131 rastgele 3 gruba ayr\u0131ld\u0131. Kontrol grubunda, intramusk\u00fcler izotonik tuz \u00e7\u00f6zeltisi haftal\u0131k olarak enjekte edildi. \u0130kinci grupta ise, kas i\u00e7ine 10 mg\/kg dozunda kortikosteroid (metilprednizolon) enjeksiyonu 8 hafta boyunca haftada bir uyguland\u0131. \u00dc\u00e7\u00fcnc\u00fc grupta, 10 mg\/kg intramusk\u00fcler kortikosteroid (metilprednizolon) enjeksiyonu 8 hafta boyunca haftada bir doz uygulan\u0131rken, ek olarak 0.1 mg\/kg zoledronik asit 0, 21 ve 42. g\u00fcnde deri alt\u0131na enjekte edildi. Tedavinin sonunda her gruptan femur ba\u015f\u0131 \u00f6rnekleri al\u0131nd\u0131 ve apoptotik kondrositleri saptamak i\u00e7in TUNEL y\u00f6ntemi kullan\u0131ld\u0131. Kar\u015f\u0131la\u015ft\u0131rmal\u0131 analizler i\u00e7in ANOVA y\u00f6ntemi ve Tukey testinden yararlan\u0131ld\u0131.\\r\\nBulgular: Kortikosteroid grupla di\u011fer iki grup (kontrol grubu i\u00e7in p=0.005 ve kortikosteroid + zoledronik asit grubu i\u00e7in p=0.047) aras\u0131nda anlaml\u0131 bir fark vard\u0131. Zoledronik asit tedavisi eklem k\u0131k\u0131rda\u011f\u0131nda kortikosteroide ba\u011fl\u0131 geli\u015fen apoptotik kondrosit say\u0131s\u0131n\u0131 anlaml\u0131 olarak azaltt\u0131 (p&lt;0.05).\\r\\n\u00c7\u0131kar\u0131mlar: Zoledronik asit, kondrositlerde kortikosteroide ba\u011fl\u0131 geli\u015fen apoptoz nedeniyle olu\u015fabilecek eklem k\u0131k\u0131rda\u011f\u0131 bozulmas\u0131n\u0131 \u00f6nleyici bir potansiyele sahip olabilir.<\/jats:p>","DOI":"10.3944\/aott.2013.3136","type":"journal-article","created":{"date-parts":[[2014,3,16]],"date-time":"2014-03-16T08:55:18Z","timestamp":1394960118000},"page":"430-435","source":"Crossref","is-referenced-by-count":4,"title":["Protective effect of zoledronic acid on corticosteroidinduced chondrocyte apoptosis"],"prefix":"10.5152","volume":"47","author":[{"given":"Alpay","family":"Merter Ozenci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tevfik","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeliha","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Ozbey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuray","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Ustunel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2766\/2720","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:24:41Z","timestamp":1763465081000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2013.3136","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}