{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:18:51Z","timestamp":1763464731592,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to investigate Legg-Calv\u00e9-Perthes disease (PD) pathogenesis by comparing absolute circulating endothelial progenitor cell (EPC) counts, serum levels of vascular endothelial growth factor-A (VEGF-A) and immunoglobulins between PD patients and controls.\n\nMethods: The study included 28 PD cases (mean age: 8\u00b13.8) and 25 healthy age-matched control subjects. EPC, serum VEGF-A and immunoglobulin levels were measured in peripheral blood samples. Comparisons and correlation analysis were performed.\n\nResults: In the PD group, 17 subjects were in the fragmentation stage and 11 in the healing stage. Four patients had bilateral disease and 14 had hypogammaglobulinemia. Median EPC count of the PD group was 80 and was significantly higher than those of the control group (p=0.011). No significant difference was determined in serum VEGF-A levels (p=0.354). EPC count were inversely correlated with serum IgG levels of the PD group (r=0.403, p=0.03). Absolute EPC count was also significantly higher in the fragmentation stage than in the healing stage and were also greater in bilaterally affected than in unilaterally affected patients. Circulating EPC count was correlated to the serum VEGF-A levels in patients with fragmentation stage of PD (r=0.605, p=0.01) and in those with hypogammaglobulinemia (r=0.599, p=0.001).\n\nConclusion: High EPC count at the fragmentation stage of PD and relatively higher counts in bilateral disease suggest that EPC may be a valuable marker in the diagnosis and follow-up of PD. Additional studies are needed to explain the strong correlation between EPC and serum VEGF-A level in the fragmentation stage and in the presence of hypogammaglobulinemia.\n\n \n\n\u00d6zet\n\n \n\nAma\u00e7: Bu \u00e7al\u0131\u015fmada Legg-Calv\u00e9-Perthes hastal\u0131\u011f\u0131n\u0131n (PH) etiyopatogenezinin ayd\u0131nlat\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Bu amaca y\u00f6nelik olarak Perthes hastalar\u0131 ile kontrol grubu olgular\u0131nda dola\u015f\u0131mdaki endotelial progenit\u00f6r h\u00fccre (EPH) say\u0131s\u0131, serum vask\u00fcler endotelial b\u00fcy\u00fcme fakt\u00f6r\u00fc-A (VEBF-A) ve imm\u00fcnoglobulin d\u00fczeyleri kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.\n\n\u00c7al\u0131\u015fma plan\u0131: \u00c7al\u0131\u015fmaya 28 PH olgusu (ortalama ya\u015f: 8\u00b13.8) ve ya\u015flar\u0131 e\u015fle\u015fen 25 sa\u011fl\u0131kl\u0131 kontrol olgusu dahil edildi. Periferik ven\u00f6z kan \u00f6rneklerinde EPH, serum VEBF-A ve imm\u00fcnoglobulin d\u00fczeyleri \u00f6l\u00e7\u00fcld\u00fc. Kar\u015f\u0131la\u015ft\u0131rma ve korelasyon analizleri uyguland\u0131.\n\nBulgular: PH grubundaki olgular\u0131n 17\u2019si fragmantasyon, 11\u2019i ise iyile\u015fme d\u00f6neminde idi. Hastal\u0131k 4 olguda bilateral iken, 14 hastada hipogamaglobulinemi mevcuttu. PH grubundaki medyan EPH say\u0131s\u0131 80 olup kontrol grubuna g\u00f6re anlaml\u0131 derecede y\u00fcksekti (p=0.011). Serum VEBF-A d\u00fczeylerinde anlaml\u0131 farkl\u0131l\u0131k saptanmad\u0131 (p=0.354). PH grubunda EPH say\u0131s\u0131 serum IgG d\u00fczeyi ile tersine korele idi (r=-0.403, p=0.03). Mutlak EPH say\u0131s\u0131 fragmantasyon d\u00f6nemindeki hastalarda, iyile\u015fme d\u00f6nemindekilerden; bilateral hastal\u0131\u011f\u0131 olanlarda ise unilateral olanlardan anlaml\u0131 olarak y\u00fcksekti. Dola\u015f\u0131mdaki EPH say\u0131s\u0131 Perthes hastal\u0131\u011f\u0131n\u0131n fragmantasyon safhas\u0131nda (r=0.605, p=0.01) ve hipogamaglobulinemi varl\u0131\u011f\u0131nda (r=0.599, p=0.001) serum VEBF-A d\u00fczeyi ile korelasyon g\u00f6stermekteydi.\n\n\u00c7\u0131kar\u0131mlar: Fragmantasyon evresindeki hastalarda g\u00f6r\u00fclen y\u00fcksek EPH say\u0131s\u0131 ve bilateral tutulumu olan hastalarda nispeten daha y\u00fcksek bulunan EPH say\u0131s\u0131, PH\u2019nin takibinde de\u011ferli bir g\u00f6sterge olabilir. Hastal\u0131\u011f\u0131n fragmantasyon evresinde ve hipogamaglobulinemi varl\u0131\u011f\u0131nda EPH say\u0131s\u0131 ve serum VEBF-A d\u00fczeyi aras\u0131ndaki g\u00fc\u00e7l\u00fc korelasyonu a\u00e7\u0131klamak i\u00e7in daha fazla \u00e7al\u0131\u015fma yap\u0131lmas\u0131na ihtiya\u00e7 vard\u0131r.\n\n.<\/jats:p>","DOI":"10.3944\/aott.2014.13.0084","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T07:24:43Z","timestamp":1422775483000},"page":"628-634","source":"Crossref","is-referenced-by-count":4,"title":["Effects of circulating endothelial progenitor cells serum vascular endothelial growth factor and hypogammaglobulinemia in Perthes disease"],"prefix":"10.5152","volume":"48","author":[{"given":"Hicabi","family":"Sezgin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birol","family":"Gulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Cirakli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkerim","family":"Bedir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Usta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisan","family":"Yildiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2898\/2851","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:14:03Z","timestamp":1763464443000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2014.13.0084","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}