{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:14:20Z","timestamp":1763464460668,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to assess the effects of locally applied simvastatin on femur nonunions in a mouse model.\n\nMethods: The study included 32 male Wistar albino mice randomly allocated to one of four groups: two control groups (control-4 week [C4w] and control-8 week (C8w)] and two treatment groups (simvastatin-4 week [S4w] and simvastatin-8 week [S8w]). The control groups received dimethylsulfoxide locally injected at a dose of 10 mg\/kg\/day after surgical intervention for 1 week. Treatment groups received a liquefied form of simvastatin locally to the osteotomy field by injection at a dose of 10 mg\/kg\/day, starting from the ?rst postoperative day for 1 week. The C4w and S4w groups were sacrificed 4 weeks and the C8w and S8w groups 8 weeks after the end of local treatment. Before sacrifice, intracardiac blood samples were retrieved for biochemical analysis and radiographies were taken. The right femurs of mice were then removed for histopathological evaluation.\n\nResults: There were significant differences between the control and treatment groups when evaluated radiologically. Significantly higher levels of bone-specific alkaline phosphatase and osteocalcin values were found in the treatment groups than in the controls (p&lt;0.05).\n\nConclusion: According to biochemical, radiological and histopathological results, local application of simvastatin appears to produce beneficial effects on the mouse femur nonunion model.\n\n \n\n\u00d6zet\n\n \n\nAma\u00e7: Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 deneysel fare femur kaynamama modelinde lokal uygulanan simvastatinin etkilerini de\u011ferlendirmekti.\n\n\u00c7al\u0131\u015fma plan\u0131: Bu \u00e7al\u0131\u015fmada 32 Wistar albino fare kullan\u0131ld\u0131. Fareler rastgele bi\u00e7imde a\u015fa\u011f\u0131daki 4 gruptan birine ayr\u0131ld\u0131: iki kontrol grubu (kontrol-4 hafta [K4h] ve kontrol-8 hafta [K8h]) ve iki tedavi grubu (simvastatin-4 hafta [S4h] ve simvastatin-8 hafta [S8h]). Kontrol gruplar\u0131nda cerrahi giri\u015fimden sonra 1 hafta s\u00fcreyle dimetils\u00fclfoksit (10 mg\/kg\/g\u00fcn) lokal olarak enjekte edildi. Tedavi gruplar\u0131nda ameliyat sonras\u0131 birinci g\u00fcnden itibaren 1 hafta boyunca simvastatinin s\u0131v\u0131la\u015ft\u0131r\u0131lm\u0131\u015f formu (10 mg\/kg\/g\u00fcn) lokal olarak osteotomi alan\u0131na enjekte edildi. K4h ve S4h gruplar\u0131ndaki hayvanlar lokal tedavinin sonlanmas\u0131ndan 4 hafta, K8h ve S8h gruplar\u0131ndaki hayvanlar ise 8 hafta sonra \u00f6ld\u00fcr\u00fcld\u00fc. \u00d6ld\u00fcr\u00fclmeden \u00f6nce biyokimyasal analiz i\u00e7in intrakardiyak kan \u00f6rnekleri al\u0131nd\u0131 ve radyografiler \u00e7ekildi. Histopatolojik inceleme i\u00e7in farelerin sa\u011f femurlar\u0131 \u00e7\u0131kar\u0131ld\u0131.\n\nBulgular: Radyolojik olarak incelendi\u011finde kontrol ve tedavi gruplar\u0131 aras\u0131nda anlaml\u0131 farkl\u0131l\u0131klar mevcuttu. Tedavi gruplar\u0131nda kontrol gruplar\u0131na k\u0131yasla anlaml\u0131 \u015fekilde daha y\u00fcksek kemi\u011fe spesifik alkalin fosfataz ve osteokalsin de\u011ferleri saptand\u0131.\n\n\u00c7\u0131kar\u0131mlar: Biyokimyasal, radyolojik ve histopatolojik sonu\u00e7lara g\u00f6re, fare femur kaynamama modelinde simvastatinin lokal uygulanmas\u0131 yararl\u0131 etkiler olu\u015fturmaktad\u0131r.<\/jats:p>","DOI":"10.3944\/aott.2014.14.0120","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T07:24:43Z","timestamp":1422775483000},"page":"679-684","source":"Crossref","is-referenced-by-count":4,"title":["The effects of locally applied simvastatin on an experimental mouse femur nonunion model"],"prefix":"10.5152","volume":"48","author":[{"given":"Atilla","family":"Ko\u00e7er","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithat","family":"Oner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Karaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Kocer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Halil Kafadar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Guney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Filiz Karaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2906\/2859","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:10:24Z","timestamp":1763464224000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2014.14.0120","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}