{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:29:30Z","timestamp":1772065770706,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to evaluate the treatment results of the application of nitric oxide (NO) in the form of topical glyceryl trinitrate (GTN) for the treatment of lateral epicondylitis (LE).\n\nMethods: The study included 40 patients with LE randomized into 2 equal groups. Selection criteria included the presence of pain, tenderness, and positive pain stimulating maneuvers. Glyceryl trinitrate patches were applied to the area of maximal tenderness once a day in the treatment group and placebo patches in the control group. Outcomes in terms of pain relief was assessed using the visual analog scale (VAS) and were evaluated according to the criteria of Verhaar et al. Excellent or good results were considered successful. Differences in VAS scores between the two groups were calculated using the Mann-Whitney U-test and the chi-square test was used to investigate distributions of categorical variables (sex, affected side) and good and excellent results among groups.\n\nResults: There were no significant differences in any of the baseline clinical parameters between groups. At the 3rd week follow-up, there were statistically significant differences in the pain measured using VAS between groups (mean VAS score of the control and treatment groups were 6.45 and 3.15, respectively) (p=0.001). Patients in the GTN group and control group had lower VAS pain scores and reduced elbow pain at 3 weeks (3.15 vs 8.05 in the GTN and 6.45 vs 8.80 in the control group). In the control group, no patient had excellent or good results while 18 (90%) patients in treatment group reported successful treatment. There was statistically significant difference in the VAS measured at 6 months between groups (mean VAS score of the control and treatment groups were 4.85 and 0.70, respectively) (p=0.001).\n\nConclusion: The administration of NO directly over an area of tendinopathy through a GTN patch reduces pain and other symptoms in chronic LE.\n\n \n\n\u00d6zet\n\n \n\n\u00c7al\u0131\u015fma plan\u0131: Lateral epikondiliti olan 40 hasta rastgele 2 e\u015fit gruba b\u00f6l\u00fcnd\u00fc. Se\u00e7im kriterleri a\u011fr\u0131, hassasiyet ve a\u011fr\u0131 uyar\u0131c\u0131 manevralar\u0131n pozitifli\u011fi olarak kabul edildi. Teadvi grubunda GTN yamalar\u0131, kontrol grubunda ise plasebo yamalar g\u00fcnde bir kez olmak \u00fczere en \u00e7ok hassasiyet olan b\u00f6lgeye uyguland\u0131. Hastalar\u0131n g\u00f6rsel analog skala (GAS) ile a\u011fr\u0131n\u0131n ne derece giderildi\u011fi baz\u0131nda de\u011ferlendirildi ve sonu\u00e7lar Verhaar ve ark.\u2019n\u0131n kriterlerine g\u00f6re s\u0131n\u0131fland\u0131r\u0131ld\u0131. M\u00fckemmel ve iyi sonu\u00e7lar ba\u015far\u0131l\u0131 tedavi olarak kabul edildi. Gruplar aras\u0131 GAS skorundaki farkl\u0131l\u0131k Mann-Whitney U-testi ile hesapland\u0131. Kategorik de\u011fi\u015fkenlerin da\u011f\u0131l\u0131mlar\u0131 (cinsiyet, etkilenen taraf) ve gruplar aras\u0131 iyi ve m\u00fckemmel sonu\u00e7lar\u0131n kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131 i\u00e7in ki-kare testi kullan\u0131ld\u0131.\n\n\u00c7\u0131kar\u0131mlar: Gliseril trinitrat yamas\u0131 kullan\u0131larak tendinopatili b\u00f6lge \u00fczerine uygulanan NO, kronik LE\u2019deki a\u011fr\u0131 ve di\u011fer semptomlar\u0131 azaltmaktad\u0131r.<\/jats:p>","DOI":"10.3944\/aott.2014.3123","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T16:30:50Z","timestamp":1398443450000},"page":"175-180","source":"Crossref","is-referenced-by-count":13,"title":["Management of tennis elbow with topical glyceryl trinitrate"],"prefix":"10.5152","volume":"48","author":[{"given":"Raif","family":"Ozden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedat","family":"Uruc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunus","family":"Dogramaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aydiner","family":"Kalaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Yengil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2808\/2762","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:20:31Z","timestamp":1763464831000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,1,2]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2014.3123","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}