{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:24:49Z","timestamp":1763465089672,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to investigate the influence of the antiproliferative agent 5-Fluorouracil (5FU) over inhibition of spinal bone formation in an experimental rat model.\\r\\nMethods: The study included 30 6-month-old Sprague-Dawley rats divided into 3 groups. Aggressive periosteal denuding was performed by scalpel to induce punctuate bleeding in the posterior elements of the L4-L5 vertebrae in the spontaneous fusion model. Spinous processes were fixated by wires and no graft substitute was applied. Adcon-L was applied in Group 1, single-touch technique 5FU in Group 2. Group 3 was the control group. Rats were sacrificed at 4 weeks and specimens acquired for histological examination.\\r\\nResults: 5FU substantially inhibited fibroblast and inflammatory cell densities as well as bone formation compared to the control group. 5FU was considerably superior to Adcon-L with regard to inhibition of bone formation and inflammatory cells (p=0.0001).\\r\\nConclusion: 5FU can inhibit fusion, fibrosis and unwanted scar tissue in spinal surgery. We believe that after further studies on its local delivery dose, it can be used in humans for inhibition of unintended fusion.\n\n\u00d6zet\n\nAma\u00e7: Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, antiproliferatif bir ajan olan 5-florourasilin (5FU) deneysel s\u0131\u00e7an modelinde spinal kemik olu\u015fumunun inhibisyonuna etkisinin ara\u015ft\u0131r\u0131lmas\u0131 idi.\\r\\n\u00c7al\u0131\u015fma plan\u0131: Alt\u0131 ayl\u0131k 30 adet Sprague-Dawley s\u0131\u00e7an \u00e7al\u0131\u015fmaya al\u0131nd\u0131 ve 3 grup olu\u015fturuldu. Spontan f\u00fczyon modelinde L4-L5 omurlar\u0131n\u0131n posterior elemanlar\u0131nda noktasal kanama olu\u015fturmak i\u00e7in bisturi ile agresif periostal soyma i\u015flemi ger\u00e7ekle\u015ftirildi. Spin\u00f6z \u00e7\u0131k\u0131nt\u0131lar tellerle tespit edildi ve herhangi bir greft materyali uygulanmad\u0131. Grup 1\u2019e Adcon-L, Grup 2\u2019ye tek dokunu\u015f tekni\u011fi ile 5FU uygulan\u0131rken, Grup 3 kontrol grubunu olu\u015fturdu. D\u00f6rt hafta sonra s\u0131\u00e7anlar sakrifiye edildi ve histolojik inceleme i\u00e7in \u00f6rnekler al\u0131nd\u0131.\\r\\nBulgular: Bu \u00e7al\u0131\u015fmada 5FU\u2019nun, kontrol grubuna k\u0131yasla, fibroblast ve enflamatuvar h\u00fccre yo\u011funlu\u011fu ve kemik formasyonunu \u00f6nemli \u00f6l\u00e7\u00fcde inhibe etti\u011fi g\u00f6zlendi. Ayr\u0131ca, 5FU\u2019nun kemik formasyonu ve enflamatuvar h\u00fccrelerin inhibisyonu a\u00e7\u0131s\u0131ndan Adcon-L\u2019ye g\u00f6re belirgin \u015fekilde \u00fcst\u00fcn oldu\u011fu saptand\u0131 (p=0.0001).\\r\\n\u00c7\u0131kar\u0131mlar: \u00c7al\u0131\u015fmam\u0131z 5FU\u2019nun spinal cerrahide f\u00fczyon, fibrozis ve istenmeyen skar doku olu\u015fumunu inhibe edebildi\u011fini g\u00f6stermi\u015ftir. 5FU\u2019nun lokal uygulama dozuyla ilgili gelecekteki \u00e7al\u0131\u015fmalar sonras\u0131 insanlarda istenmeyen f\u00fczyonun inhibisyonu i\u00e7in kullan\u0131labilece\u011fi d\u00fc\u015f\u00fcncesindeyiz.<\/jats:p>","DOI":"10.3944\/aott.2014.3161","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T08:46:59Z","timestamp":1395305219000},"page":"86-91","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of 5Fluorouracil in inhibition of unintended bone formation in spinal surgery: a histological evaluation on a rat model of spontaneous spinal fusion"],"prefix":"10.5152","volume":"48","author":[{"given":"Esat","family":"Kiter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertan","family":"Er","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilay","family":"Sen Turk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Oto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semih","family":"Akkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2790\/2744","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:20:45Z","timestamp":1763464845000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2014.3161","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}