{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:14:09Z","timestamp":1763464449028,"version":"3.45.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\n\n\t\n\t\t\n\t\t\t\n\t\t\tObjective: Heterotopic ossification (HO)\u2014the formation of bone in soft tissues\u2014is a frequent problem after surgery of the hip and pelvis, but little is known about its underlying pathogenic mechanisms.It is vital to study the underlying pathogenesis in animal models to develop and evaluate new prophylactic regimens directed against HO. However, previously developed small-animal models for the study of HO imitate neither surgery nor trauma-mechanisms that potentially cause HO. Hence, the goal of this study was to develop a novel small-animal model imitating hip surgery that can reliably produce HO.\n\n\t\t\tMethods: Twenty male Wistar rats were subjected to surgery of the right hip during which the femoral canal was reamed in three steps up to 2 mm, and a muscle lesion was made. Twelve weeks after surgery, the amount of heterotopic bone was assessed using micro-computed tomography.\n\n\t\t\tResults: Eighteen of 20 animals showed HO around the hip 12 weeks after surgery. The amount of heterotopic bone varied from very small particles up to near ankylosis.\n\n\t\t\tConclusion: A rat model of hip\/pelvic surgery that does not use exogenous osteogenic stimulus and can reliably produce HO was developed.\n\t\t\t\n\t\t\n\t\n\n\n \n\n\u00d6zet\n\n \n\nAma\u00e7: Heterotopik ossifikasyon (HO)\u2013yumu\u015fak dokularda kemik olu\u015fumu\u2013pelvis ve kal\u00e7a cerrahisi sonras\u0131 s\u0131k g\u00f6r\u00fclen bir sorundur ama temelinde yatan patojenik mekanizmalar hakk\u0131nda \u00e7ok az bilinmektedir. Heterotopik ossifikasyona kar\u015f\u0131 y\u00f6neltilen yeni profilaktik tedavi rejimlerini de\u011ferlendirmek ve geli\u015ftirmek i\u00e7in hayvan modellerinde temelde yatan patojenleri irdelemek \u00f6nemlidir. Ancak, HO i\u00e7in \u00f6nceden geli\u015ftirilen k\u00fc\u00e7\u00fck hayvan modelleri potansiyel olarak HO\u2019ya sebep olan cerrahi ya da travma mekanizmalar\u0131n\u0131 \u00f6rnek almam\u0131\u015ft\u0131r. Dolay\u0131s\u0131yla, bu \u00e7al\u0131\u015fman\u0131n amac\u0131 eksiksiz bir bi\u00e7imde HO\u2019ya yol a\u00e7abilecek bir kal\u00e7a cerrahisini taklit eden yeni bir k\u00fc\u00e7\u00fck hayvan modeli geli\u015ftirmekti.\n\n\u00c7al\u0131\u015fma plan\u0131: Yirmi erkek Wistar s\u0131\u00e7an, \u00fc\u00e7 ad\u0131mda femoral kanal 2 mm\u2019ye kadar delinen ve kas lezyonu olu\u015fturulan bir sa\u011f kal\u00e7a cerrahisine tabi tutuldu. Operasyondan 12 hafta sonra mikro-bilgisayarl\u0131 tomografi kullan\u0131larak heterotopik kemik miktar\u0131 de\u011ferlendirildi.\n\nBulgular: Yirmi hayvan\u0131n 18\u2019inde, operasyondan 12 hafta sonra kal\u00e7a \u00e7evresinde HO g\u00f6r\u00fcld\u00fc. Heterotopik kemik miktar\u0131 \u00e7ok k\u00fc\u00e7\u00fck par\u00e7ac\u0131klardan neredeyse ankiloz seviyesine kadar de\u011fi\u015fkenlik g\u00f6sterdi.\n\n\u00c7\u0131kar\u0131mlar: Ekzojen osteojenik uyar\u0131c\u0131 kullanmayan ve eksiksiz bir bi\u00e7imde HO\u2019ya yol a\u00e7an kal\u00e7a\/pelvik cerrahisi bir s\u0131\u00e7an modeli \u00fczerinde geli\u015ftirildi.<\/jats:p>","DOI":"10.3944\/aott.2015.14.0271","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T11:22:57Z","timestamp":1436354577000},"page":"197-202","source":"Crossref","is-referenced-by-count":0,"title":["A new smallanimal model for the study of acquired heterotopic ossification after hip surgery"],"prefix":"10.5152","volume":"49","author":[{"given":"Joris","family":"Anthonissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ossendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Lisa Hock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pol","family":"Maria Rommens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/2964\/2917","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:09:46Z","timestamp":1763464186000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/2964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,1,2]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2015.14.0271","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"type":"electronic","value":"2589-1294"},{"type":"print","value":"1017-995X"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}