{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:51:41Z","timestamp":1785228701655,"version":"3.55.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Abstract\n\nObjective: The aim of this study was to determine the effect of pentoxifylline (PTX) on angiogenesis and the healing of a critical-sized segmental defect of the radius diaphysis in a rat model, using radiological and histological grading systems.\nMethods: The study included 24 female Sprague-Dawley rats (weight: 300\u00b120 g) divided into 4 groups. A critical-sized segmental defect was created in the radius diaphysis in all rats. In Group 1, morcellized iliac crest autografts were used to fill the segmental bone defect. In Group 2, segmental bone defects were filled using morcellized iliac crest autografts, and 25 mg\/kg\/day PTX was applied intraperitoneally. In Group 3, the segmental bone defects were not filled, and in Group 4 the segmental bone defects were left unfilled, and an intraperitoneal (IP) dose of 25 mg\/kg\/day PTX was applied. Rats were sacrificed at postoperative Week 8, and defects were evaluated using radiographic, histological and immunohistochemical methods.\nResults: There were significant differences between Group 1 and 2 according to radiological evaluation (p=0.003) and quality of union at the defect site (p=0.01). Union quality was higher in Group 4 than Group 3 (p=0.01). Cluster of differentiation 31 (CD31) and vascular endothelial growth factor (VEGF) levels were higher in Group 2 than in Groups 3 and 4.\nConclusion: According to radiological and histological parameters, PTX appears to improve angiogenesis and healing of segmental cortical bone defects of the radius in a rat model.\n \n\nDOI: 10.3944\/AOTT.2015.15.0158\n\n \n\n\u00d6zet\n\nAma\u00e7: Bu \u00e7al\u0131\u015fman\u0131n amac\u0131; pentoksifilinin (PTX) anjiogenezis ve s\u0131\u00e7an radius diafizi \u201ccritical-sized\u201d segmenter kemik kayb\u0131 modelinde iyile\u015fme \u00fczerine etkisini radyolojik ve histolojik derecelendirme sistemleri kullan\u0131larak de\u011ferlendirilmesidir.\u00c7al\u0131\u015fma plan\u0131: Bu \u00e7al\u0131\u015fmaya 24 female Sprague Dawley s\u0131\u00e7an (a\u011f\u0131rl\u0131k: 300\u00b120 gram) kat\u0131lm\u0131\u015ft\u0131r ve 4 gruba ayr\u0131lm\u0131\u015ft\u0131r. S\u0131\u00e7anlar\u0131n radius diafizlerinde \u201ccritical-sized\u201d segmenter kemik kayb\u0131 olu\u015fturuldu. Grup 1\u2019de morselize iliak krest otogreftleri segmenter kemik defektini doldurmada kullan\u0131ld\u0131. Grup 2\u2019de segmenter kemik defekti morselize iliak krest otogreftleri ile dolduruldu ve g\u00fcnl\u00fck intraperitoneal olarak 25 mg\/kg PTX uyguland\u0131. Grup 3\u2019te kemik defekti doldurulmad\u0131. Grup 4\u2019te kemik defekti doldurulmad\u0131 ve g\u00fcnl\u00fck intraperitoneal olarak 25 mg\/kg PTX uyguland\u0131. Postoperatif sekizinci haftada s\u0131\u00e7anlar feda edildi. Defektler radiografik, histolojik ve imm\u00fcnokimyasal metodlar ile de\u011ferlendirildi.Bulgular: Group 1 ve 2 aras\u0131nda radyolojik de\u011ferlendirme sonucunda (p=0.003) ve defekt b\u00f6lgesinde kaynama kalitesi a\u00e7\u0131s\u0131ndan (p=0.01) belirgin farkl\u0131l\u0131k izlendi. Kaynama kalitesi grup 4\u2019te grup 3\u2019e g\u00f6re fazlayd\u0131 (p=0.01). CD-31 ve VEGF seviyeleri grup 2\u2019de grup 3 ve 4\u2019e g\u00f6re fazlayd\u0131.\u00c7\u0131kar\u0131mlar: Radyolojik ve histolojik parametrelere g\u00f6re; pentoksifilinin angiogenezis ve s\u0131\u00e7an radius diafizi \u201ccritical-sized\u201d segmenter kemik kayb\u0131 modelinde iyile\u015fme \u00fczerine olumlu etkisi bulunmaktad\u0131r.Bu \u00e7al\u0131\u015fman\u0131n amac\u0131; pentoksifilinin (PTX) angiogenesis ve s\u0131\u00e7an radius diafizi \u201ccritical-sized\u201d segmenter kemik kayb\u0131 modelinde iyile\u015fme \u00fczerine etkisini radyolojik ve histolojik derecelendirme sistemleri kullan\u0131larak de\u011ferlendirilmesidir.Gere\u00e7 ve y\u00f6ntemBu \u00e7al\u0131\u015fma \u00fcniversitemiz Etik kurul onay\u0131 al\u0131nd\u0131ktan sonra Hayvan Ara\u015ft\u0131rma Laboratuvarlar\u0131nda yap\u0131lm\u0131\u015ft\u0131r<\/jats:p>","DOI":"10.3944\/aott.2015.15.0158","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T04:20:34Z","timestamp":1436329234000},"page":"676-682","source":"Crossref","is-referenced-by-count":5,"title":["Effect of pentoxifylline on healing of segmental bone defects and angiogenesis"],"prefix":"10.5152","volume":"49","author":[{"given":"Gokhan","family":"Cakmak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handan","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Karadeniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,2,7]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/download\/3067\/3019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:07:50Z","timestamp":1763464070000},"score":1,"resource":{"primary":{"URL":"https:\/\/aott.org.tr\/index.php\/pub\/article\/view\/3067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,1,6]]}},"URL":"https:\/\/doi.org\/10.3944\/aott.2015.15.0158","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}