{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:29:13Z","timestamp":1791142153300,"version":"4.1.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":4101,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.3945\/ajcn.110.000752","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T23:41:29Z","timestamp":1304552489000},"page":"S1830-S1837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"S6","title":["Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis"],"prefix":"10.1016","volume":"94","author":[{"given":"Catalina","family":"Pico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana Macek","family":"Jilkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Palou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kopecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.110.000752_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.clnu.2007.06.006","article-title":"Update on breast milk hormones: leptin, ghrelin and adiponectin","volume":"27","author":"Savino","year":"2008","journal-title":"Clin Nutr"},{"key":"10.3945\/ajcn.110.000752_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/sj.ijo.802200","article-title":"Early determinants of childhood overweight and adiposity in a birth cohort study: role of breast-feeding","volume":"27","author":"Bergmann","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.3945\/ajcn.110.000752_bib3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0022-3476(81)80579-3","article-title":"Do breast-feeding and delayed introduction of solid foods protect against subsequent obesity?","volume":"98","author":"Kramer","year":"1981","journal-title":"J Pediatr"},{"key":"10.3945\/ajcn.110.000752_bib4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/j.1550-8528.1997.tb00574.x","article-title":"Duration of breastfeeding associated with obesity during adolescence","volume":"5","author":"Elliott","year":"1997","journal-title":"Obes Res"},{"key":"10.3945\/ajcn.110.000752_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bmj.319.7203.147","article-title":"Breast feeding and obesity: cross sectional study","volume":"319","author":"von Kries","year":"1999","journal-title":"BMJ"},{"key":"10.3945\/ajcn.110.000752_bib6","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0140-6736(02)08837-2","article-title":"Breastfeeding and lowering the risk of childhood obesity","volume":"359","author":"Armstrong","year":"2002","journal-title":"Lancet"},{"key":"10.3945\/ajcn.110.000752_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tibtech.2008.06.004","article-title":"The influence of leptin on early life programming of obesity","volume":"26","author":"Stocker","year":"2008","journal-title":"Trends Biotechnol"},{"key":"10.3945\/ajcn.110.000752_bib8","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s00125-002-0918-2","article-title":"Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring","volume":"45","author":"Siemelink","year":"2002","journal-title":"Diabetologia"},{"issue":"suppl 4","key":"10.3945\/ajcn.110.000752_bib9","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1038\/sj.ijo.0803519","article-title":"Dietary fat and fat types as early determinants of childhood obesity: a reappraisal","volume":"30","author":"Mace","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/ajcn.110.000752_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.plipres.2006.01.003","article-title":"Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity","volume":"45","author":"Ailhaud","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.3945\/ajcn.110.000752_bib11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1520-7560(200005\/06)16:3<202::AID-DMRR116>3.0.CO;2-#","article-title":"Lipid metabolism in the fetus and the newborn","volume":"16","author":"Herrera","year":"2000","journal-title":"Diabetes Metab Res Rev"},{"key":"10.3945\/ajcn.110.000752_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000242171","article-title":"Hormonal and metabolic changes in the perinatal period","volume":"48","author":"Mayor","year":"1985","journal-title":"Biol Neonate"},{"key":"10.3945\/ajcn.110.000752_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0031-3955(05)70286-8","article-title":"Bioactive factors in human milk","volume":"48","author":"Hamosh","year":"2001","journal-title":"Pediatr Clin North Am"},{"key":"10.3945\/ajcn.110.000752_bib14","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1210\/jcem.82.12.4590","article-title":"Presence of leptin in colostrum and\/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake","volume":"82","author":"Casabiell","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib15","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1006\/bbrc.1997.7736","article-title":"Leptin is present in human milk and is related to maternal plasma leptin concentration and adiposity","volume":"240","author":"Houseknecht","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3945\/ajcn.110.000752_bib16","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1542\/peds.108.1.e15","article-title":"Leptin levels in preterm human breast milk and infant formula","volume":"108","author":"Resto","year":"2001","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.110.000752_bib17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/BF03345207","article-title":"Leptin is not present in infant formulas","volume":"26","author":"O\u2019Connor","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"10.3945\/ajcn.110.000752_bib18","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1210\/jcem.83.5.4952","article-title":"Leptin expression in human mammary epithelial cells and breast milk","volume":"83","author":"Smith-Kirwin","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib19","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1210\/en.2005-0112","article-title":"Leptin orally supplied to neonate rats is directly uptaken by the immature stomach and may regulate short-term feeding","volume":"146","author":"Sanchez","year":"2005","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.appet.2008.09.013","article-title":"Leptin intake during lactation prevents obesity and affects food intake and food preferences in later life","volume":"52","author":"Palou","year":"2009","journal-title":"Appetite"},{"key":"10.3945\/ajcn.110.000752_bib21","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/sj.ijo.0803585","article-title":"The intake of physiological doses of leptin during lactation in rats prevents obesity in later life","volume":"31","author":"Pico","year":"2007","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/ajcn.110.000752_bib22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1210\/en.2007-0630","article-title":"Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life","volume":"149","author":"Sanchez","year":"2008","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib23","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/oby.2006.155","article-title":"A physiological role of breast milk leptin in body weight control in developing infants","volume":"14","author":"Miralles","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"suppl 1","key":"10.3945\/ajcn.110.000752_bib24","first-page":"55","article-title":"Role of leptin during perinatal metabolic programming and obesity","volume":"59","author":"Djiane","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"10.3945\/ajcn.110.000752_bib25","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1098\/rstb.2009.0121","article-title":"Effect of the early-life nutritional environment on fecundity and fertility of mammals","volume":"364","author":"Gardner","year":"2009","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.3945\/ajcn.110.000752_bib26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/427411b","article-title":"Lifespan: catch-up growth and obesity in male mice","volume":"427","author":"Ozanne","year":"2004","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib28","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)80937-X","article-title":"Obesity and the hypothalamus: novel peptides for new pathways","volume":"92","author":"Flier","year":"1998","journal-title":"Cell"},{"key":"10.3945\/ajcn.110.000752_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1210\/rp.59.1.287","article-title":"Leptin receptor signaling and the regulation of mammalian physiology","volume":"59","author":"Myers","year":"2004","journal-title":"Recent Prog Horm Res"},{"key":"10.3945\/ajcn.110.000752_bib30","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0092-8674(95)90151-5","article-title":"Identification and expression cloning of a leptin receptor, OB-R","volume":"83","author":"Tartaglia","year":"1995","journal-title":"Cell"},{"key":"10.3945\/ajcn.110.000752_bib31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","article-title":"Effects of the obese gene product on body weight regulation in ob\/ob mice","volume":"269","author":"Pelleymounter","year":"1995","journal-title":"Science"},{"key":"10.3945\/ajcn.110.000752_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/415339a","article-title":"Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase","volume":"415","author":"Minokoshi","year":"2002","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib33","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1128\/MCB.02222-06","article-title":"Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase","volume":"27","author":"Suzuki","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.3945\/ajcn.110.000752_bib34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.molmed.2008.09.007","article-title":"AMPK: a metabolic gauge regulating whole-body energy homeostasis","volume":"14","author":"Lage","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.3945\/ajcn.110.000752_bib35","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Canto","year":"2009","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib36","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a longstanding partnership?","volume":"298","author":"Ruderman","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib37","doi-asserted-by":"crossref","first-page":"2455S","DOI":"10.1093\/jn\/134.9.2455S","article-title":"Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1)","volume":"134","author":"Cohen","year":"2004","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.110.000752_bib38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.2006.111484","article-title":"Functions of AMP-activated protein kinase in adipose tissue","volume":"574","author":"Daval","year":"2006","journal-title":"J Physiol"},{"key":"10.3945\/ajcn.110.000752_bib39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib40","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1074\/jbc.C300557200","article-title":"AMP-activated protein kinase plays a role in the control of food intake","volume":"279","author":"Andersson","year":"2004","journal-title":"J Biol Chem"},{"key":"10.3945\/ajcn.110.000752_bib41","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus","volume":"428","author":"Minokoshi","year":"2004","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib42","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1056\/NEJM199909163411204","article-title":"Effects of recombinant leptin therapy in a child with congenital leptin deficiency","volume":"341","author":"Farooqi","year":"1999","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.110.000752_bib43","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2337\/diabetes.49.7.1203","article-title":"Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice","volume":"49","author":"Surwit","year":"2000","journal-title":"Diabetes"},{"key":"10.3945\/ajcn.110.000752_bib44","doi-asserted-by":"crossref","first-page":"18933","DOI":"10.1074\/jbc.M512831200","article-title":"Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle","volume":"281","author":"Martin","year":"2006","journal-title":"J Biol Chem"},{"key":"10.3945\/ajcn.110.000752_bib45","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/75.6.993","article-title":"Early nutrition and leptin concentrations in later life","volume":"75","author":"Singhal","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.000752_bib46","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ijo.2010.18","article-title":"Leptin intake during the suckling period improves the metabolic response of adipose tissue to a high-fat diet","volume":"34","author":"Priego","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/ajcn.110.000752_bib47","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1210\/endo.138.10.5573","article-title":"Synthesis of leptin in human placenta","volume":"138","author":"Senaris","year":"1997","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib48","first-page":"1293","article-title":"The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure","volume":"82","author":"Kennedy","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/joe.0.1760313","article-title":"Developmental changes in plasma leptin and hypothalamic leptin receptor expression in the rat: peripubertal changes and the emergence of sex differences","volume":"176","author":"Smith","year":"2003","journal-title":"J Endocrinol"},{"key":"10.3945\/ajcn.110.000752_bib50","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1210\/jcem.82.2.3731","article-title":"Leptin in human reproduction: serum leptin levels in pregnant and lactating women","volume":"82","author":"Butte","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/dvdy.1233","article-title":"Perinatal expression of leptin in rat stomach","volume":"223","author":"Oliver","year":"2002","journal-title":"Dev Dyn"},{"key":"10.3945\/ajcn.110.000752_bib52","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1172\/JCI1176","article-title":"Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function","volume":"101","author":"Ahima","year":"1998","journal-title":"J Clin Invest"},{"key":"10.3945\/ajcn.110.000752_bib53","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cmet.2005.05.005","article-title":"Role of premature leptin surge in obesity resulting from intrauterine undernutrition","volume":"1","author":"Yura","year":"2005","journal-title":"Cell Metab"},{"key":"10.3945\/ajcn.110.000752_bib54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/bbrc.1997.7237","article-title":"Developmental changes in ob gene expression and circulating leptin peptide concentrations","volume":"238","author":"Devaskar","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3945\/ajcn.110.000752_bib55","first-page":"R446","article-title":"Postnatal development of the ob gene system: elevated leptin levels in suckling fa\/fa rats","volume":"273","author":"Rayner","year":"1997","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.000752_bib56","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1210\/en.2007-1263","article-title":"Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups","volume":"149","author":"Delahaye","year":"2008","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib57","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.physbeh.2005.08.063","article-title":"Development of metabolic systems","volume":"86","author":"Grove","year":"2005","journal-title":"Physiol Behav"},{"key":"10.3945\/ajcn.110.000752_bib58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2826.2006.01505.x","article-title":"Programming of the appetite-regulating neural network: a link between maternal overnutrition and the programming of obesity?","volume":"19","author":"Muhlhausler","year":"2007","journal-title":"J Neuroendocrinol"},{"key":"10.3945\/ajcn.110.000752_bib59","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.1095004","article-title":"Trophic action of leptin on hypothalamic neurons that regulate feeding","volume":"304","author":"Bouret","year":"2004","journal-title":"Science"},{"key":"10.3945\/ajcn.110.000752_bib60","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1210\/en.2007-0981","article-title":"The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy","volume":"149","author":"Vickers","year":"2008","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib61","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1210\/en.2005-0581","article-title":"Neonatal leptin treatment reverses developmental programming","volume":"146","author":"Vickers","year":"2005","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib62","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/oby.2008.57","article-title":"Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob\/ob mice","volume":"16","author":"Yura","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.3945\/ajcn.110.000752_bib63","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1463-1326.2009.01174.x","article-title":"Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and alphaMSH-neurons and impairs hypothalamic response to fed\/fasting conditions in weaned rats","volume":"12","author":"Garcia","year":"2010","journal-title":"Diabetes Obes Metab"},{"key":"10.3945\/ajcn.110.000752_bib64","doi-asserted-by":"crossref","first-page":"e7393","DOI":"10.1371\/journal.pone.0007393","article-title":"Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation","volume":"4","author":"Rhodes","year":"2009","journal-title":"PLoS ONE"},{"key":"10.3945\/ajcn.110.000752_bib65","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming","volume":"85","author":"McMillen","year":"2005","journal-title":"Physiol Rev"},{"key":"10.3945\/ajcn.110.000752_bib66","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1096\/fj.07-8972com","article-title":"Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase","volume":"22","author":"Summermatter","year":"2008","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.110.000752_bib67","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1203\/01.PDR.0000242301.64555.e2","article-title":"Expression of uncoupling protein 3 and GLUT4 Gene in skeletal muscle of preterm newborns: possible control by AMP-activated protein kinase","volume":"60","author":"Brauner","year":"2006","journal-title":"Pediatr Res"},{"key":"10.3945\/ajcn.110.000752_bib68","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.RES.80.4.482","article-title":"Upregulation of 5\u2032-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit","volume":"80","author":"Makinde","year":"1997","journal-title":"Circ Res"},{"key":"10.3945\/ajcn.110.000752_bib69","doi-asserted-by":"crossref","first-page":"R1810","DOI":"10.1152\/ajpregu.00676.2006","article-title":"Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers","volume":"292","author":"Stocker","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.3945\/ajcn.110.000752_bib70","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.regpep.2004.12.005","article-title":"Effects of maternal leptin treatment during lactation on the body weight and leptin resistance of adult offspring","volume":"127","author":"Lins","year":"2005","journal-title":"Regul Pept"},{"key":"10.3945\/ajcn.110.000752_bib71","doi-asserted-by":"crossref","first-page":"E1132","DOI":"10.1152\/ajpendo.00228.2004","article-title":"Postnatal intracerebroventricular exposure to leptin causes an altered adult female phenotype","volume":"287","author":"Varma","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib72","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1203\/00006450-200009000-00021","article-title":"Leptin reduces body weight gain in neonatal rats","volume":"48","author":"Yuan","year":"2000","journal-title":"Pediatr Res"},{"key":"10.3945\/ajcn.110.000752_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(00)00142-7","article-title":"Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation","volume":"92","author":"Ahima","year":"2000","journal-title":"Regul Pept"},{"key":"10.3945\/ajcn.110.000752_bib74","doi-asserted-by":"crossref","first-page":"E1117","DOI":"10.1152\/ajpendo.90542.2008","article-title":"Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development","volume":"295","author":"Attig","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib75","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1113\/jphysiol.2007.149237","article-title":"Role of leptin in the regulation of growth and carbohydrate metabolism in the ovine fetus during late gestation","volume":"586","author":"Forhead","year":"2008","journal-title":"J Physiol"},{"key":"10.3945\/ajcn.110.000752_bib76","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1096\/fj.02-0756fje","article-title":"Leptin alters the structural and functional characteristics of adipose tissue before birth","volume":"17","author":"Yuen","year":"2003","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.110.000752_bib77","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-2002-33473","article-title":"Leptin treatment during the neonatal period is associated with higher food intake and adult body weight in rats","volume":"34","author":"de Oliveira","year":"2002","journal-title":"Horm Metab Res"},{"key":"10.3945\/ajcn.110.000752_bib78","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1210\/en.2002-220593","article-title":"Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake","volume":"143","author":"Proulx","year":"2002","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib79","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s004240050453","article-title":"Leptin does not reduce body fat content but augments cold defense abilities in thermoneutrally reared rat pups","volume":"434","author":"Stehling","year":"1997","journal-title":"Pflugers Arch"},{"key":"10.3945\/ajcn.110.000752_bib80","first-page":"R606","article-title":"Leptin disinhibits nonshivering thermogenesis in infants after maternal separation","volume":"276","author":"Blumberg","year":"1999","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.000752_bib81","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1096\/fj.02-0839fje","article-title":"Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q2","volume":"17","author":"Moreno","year":"2003","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.110.000752_bib82","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.tem.2006.09.006","article-title":"Development of leptin antagonists and their potential use in experimental biology and medicine","volume":"17","author":"Gertler","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib83","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/ijo.2008.39","article-title":"Early postnatal leptin blockage leads to a long-term leptin resistance and susceptibility to diet-induced obesity in rats","volume":"32","author":"Attig","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/ajcn.110.000752_bib84","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1079\/BJN2003945","article-title":"Gastric leptin: a putative role in the short-term regulation of food intake","volume":"90","author":"Pico","year":"2003","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.110.000752_bib85","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.lfs.2007.02.004","article-title":"Maternal leptin treatment during lactation programs the thyroid function of adult rats","volume":"80","author":"Passos","year":"2007","journal-title":"Life Sci"},{"key":"10.3945\/ajcn.110.000752_bib86","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.276.5315.1132","article-title":"On raising energy expenditure in ob\/ob mice","volume":"276","author":"Himms-Hagen","year":"1997","journal-title":"Science"},{"key":"10.3945\/ajcn.110.000752_bib87","first-page":"E259","article-title":"Leptin induction of UCP1 gene expression is dependent on sympathetic innervation","volume":"275","author":"Scarpace","year":"1998","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.000752_bib88","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"10.3945\/ajcn.110.000752_bib89","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1152\/physrev.1995.75.2.237","article-title":"Humoral thermogenesis and its role in maintaining energy balance","volume":"75","author":"Jansk\u00fd","year":"1995","journal-title":"Physiol Rev"},{"key":"10.3945\/ajcn.110.000752_bib90","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1172\/JCI200315737","article-title":"Paradoxical resistance to diet-induced obesity in UCP1-deficient mice","volume":"111","author":"Liu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.3945\/ajcn.110.000752_bib91","first-page":"31894","article-title":"UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-\/- mice","volume":"281","author":"Ukropec","year":"2006","journal-title":"J Biol Chem"},{"key":"10.3945\/ajcn.110.000752_bib92","doi-asserted-by":"crossref","first-page":"E1230","DOI":"10.1152\/ajpendo.00197.2003","article-title":"White adipose tissue contributes to UCP1-independent thermogenesis","volume":"285","author":"Granneman","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib93","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1096\/fj.00-0536fje","article-title":"Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold.2","volume":"15","author":"Golozoubova","year":"2001","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.110.000752_bib94","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1152\/physrev.00009.2005","article-title":"Thermogenic mechanisms and their hormonal regulation","volume":"86","author":"Silva","year":"2006","journal-title":"Physiol Rev"},{"key":"10.3945\/ajcn.110.000752_bib95","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1096\/fj.06-5934fje","article-title":"A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis","volume":"20","author":"Mainieri","year":"2006","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.110.000752_bib96","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1172\/JCI114857","article-title":"Skeletal muscle metabolism is a major determinant of resting energy expenditure","volume":"86","author":"Zurlo","year":"1990","journal-title":"J Clin Invest"},{"key":"10.3945\/ajcn.110.000752_bib97","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.febslet.2004.10.066","article-title":"The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation","volume":"577","author":"Solinas","year":"2004","journal-title":"FEBS Lett"},{"key":"10.3945\/ajcn.110.000752_bib98","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.2337\/diabetes.52.5.1090","article-title":"A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth","volume":"52","author":"Crescenzo","year":"2003","journal-title":"Diabetes"},{"key":"10.3945\/ajcn.110.000752_bib99","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1210\/en.2005-1216","article-title":"Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress","volume":"147","author":"Ukropec","year":"2006","journal-title":"Endocrinology"},{"key":"10.3945\/ajcn.110.000752_bib100","doi-asserted-by":"crossref","first-page":"E356","DOI":"10.1152\/ajpendo.90256.2008","article-title":"Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance","volume":"295","author":"Kus","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/ajcn.110.000752_bib101","first-page":"R1025","article-title":"Dietary obesity in nine inbred mouse strains","volume":"262","author":"West","year":"1992","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.000752_bib102","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2337\/diab.37.9.1163","article-title":"Diet-induced type II diabetes in C57BL\/6J mice","volume":"37","author":"Surwit","year":"1988","journal-title":"Diabetes"},{"key":"10.3945\/ajcn.110.000752_bib103","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0026-0495(95)90123-X","article-title":"Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL\/6J and A\/J mice","volume":"44","author":"Surwit","year":"1995","journal-title":"Metabolism"},{"key":"10.3945\/ajcn.110.000752_bib104","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2337\/diab.46.9.1516","article-title":"Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice","volume":"46","author":"Surwit","year":"1997","journal-title":"Diabetes"},{"key":"10.3945\/ajcn.110.000752_bib105","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/oby.2007.238","article-title":"C57BL\/6J and A\/J mice fed a high-fat diet delineate components of metabolic syndrome","volume":"15","author":"Gallou-Kabani","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"10.3945\/ajcn.110.000752_bib106","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/endo.138.1.4829","article-title":"Strain-specific response to beta3-adrenergic receptor agonist treatment of diet-induced obesity in mice","volume":"138","author":"Collins","year":"1997","journal-title":"Endocrinology"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523025662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523025662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/94\/suppl_6\/1830S\/23873647\/1830s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T04:00:33Z","timestamp":1685160033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523025662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":106,"alternative-id":["S0002916523025662"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.110.000752","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.110.000752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}