{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:36:48Z","timestamp":1791855408333,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":4283,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.3945\/ajcn.110.004671","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T00:27:51Z","timestamp":1303345671000},"page":"1365-1372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"title":["MTHFR 677C\u2192T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation"],"prefix":"10.1016","volume":"93","author":[{"given":"Krista S","family":"Crider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-He","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Gindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Maneval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin P","family":"Quinlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn B","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.110.004671_bib1","doi-asserted-by":"crossref","unstructured":"Berry RJ Li Z Erickson JD, et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999; 341: 1485 \u2013 90. [erratum to be published.].","DOI":"10.1056\/NEJM199911113412001"},{"key":"10.3945\/ajcn.110.004671_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ajmg.a.20132","article-title":"Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps","volume":"121A","author":"Botto","year":"2003","journal-title":"Am J Med Genet"},{"key":"10.3945\/ajcn.110.004671_bib3","doi-asserted-by":"crossref","unstructured":"Hobbs CASG Werler MM Mosley B. Folate status and birth defect risk: epidemiological perspective. In: Bailey L ed. Folate in health and disease. Boca Raton, FL: CRC Press, Taylor and Francis Group, 2009: 33 \u2013 53.","DOI":"10.1201\/9781420071252-c6"},{"key":"10.3945\/ajcn.110.004671_bib4","doi-asserted-by":"crossref","unstructured":"Wallis DBJ Shaw GM Lammer EJ Rinnell RH. Folate-related birth defects: embryonic consequences of abnormal folate transport and metabolism In: Bailey L ed. Folate in health and disease. Boca Raton, FL: CRC Press, Taylor and Francis Group, 2009: 155 \u2013 78.","DOI":"10.1201\/9781420071252-c7"},{"key":"10.3945\/ajcn.110.004671_bib5","first-page":"1","article-title":"Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects","volume":"41","year":"1992","journal-title":"MMWR Recomm Rep"},{"key":"10.3945\/ajcn.110.004671_bib6","first-page":"513","article-title":"Use of folic acid for prevention of spina bifida and other neural tube defects\u20131983-1991","volume":"40","year":"1991","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.3945\/ajcn.110.004671_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.3945\/ajcn.110.004671_bib8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jn\/129.5.919","article-title":"Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement","volume":"129","author":"Bailey","year":"1999","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.110.004671_bib9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/ajcn.83.3.701","article-title":"Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations","volume":"83","author":"Gueant-Rodriguez","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.004671_bib10","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/13547500701546766","article-title":"Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population","volume":"12","author":"Boccia","year":"2007","journal-title":"Biomarkers"},{"key":"10.3945\/ajcn.110.004671_bib11","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","article-title":"5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review","volume":"151","author":"Botto","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.3945\/ajcn.110.004671_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwj347","article-title":"Methylenetetrahydrofolate reductase (mthfr) genetic polymorphisms and psychiatric disorders: a HuGE review","volume":"165","author":"Gilbody","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.3945\/ajcn.110.004671_bib13","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1001\/jama.1995.03530210052030","article-title":"Folate levels and neural tube defects. Implications for prevention","volume":"274","author":"Daly","year":"1995","journal-title":"JAMA"},{"key":"10.3945\/ajcn.110.004671_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/ajcn\/76.1.180","article-title":"Methylenetetrahydrofolate reductase 677C->T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial","volume":"76","author":"Ashfield-Watt","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.004671_bib15","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/jn\/133.5.1272","article-title":"Methylenetetrahydrofolate reductase 677C\u2192T variant modulates folate status response to controlled folate intakes in young women","volume":"133","author":"Guinotte","year":"2003","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.110.004671_bib16","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/01.STR.0000199845.27512.84","article-title":"Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients","volume":"37","author":"Ho","year":"2006","journal-title":"Stroke"},{"key":"10.3945\/ajcn.110.004671_bib17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/FPC.0b013e32832af5a3","article-title":"The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability","volume":"19","author":"Lea","year":"2009","journal-title":"Pharmacogenet Genomics"},{"key":"10.3945\/ajcn.110.004671_bib18","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/ajcn\/88.2.448","article-title":"Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial","volume":"88","author":"Hao","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.004671_bib19","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/ajcn\/81.6.1436","article-title":"Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism","volume":"81","author":"von Castel-Dunwoody","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.004671_bib20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1586\/14737159.1.3.352","article-title":"Towards high-throughput genotyping of SNPs by dynamic allele-specific hybridization","volume":"1","author":"Prince","year":"2001","journal-title":"Expert Rev Mol Diagn"},{"key":"10.3945\/ajcn.110.004671_bib21","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/ajcn\/69.3.482","article-title":"Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey","volume":"69","author":"Jacques","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.004671_bib22","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl Med"},{"key":"10.3945\/ajcn.110.004671_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1079\/BJN19830026","article-title":"The effect of periconceptional supplementation on blood vitamin concentrations in women at recurrence risk for neural tube defect","volume":"49","author":"Schorah","year":"1983","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.110.004671_bib24","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1158\/0008-5472.CAN-07-5165","article-title":"Genetic variation in the one-carbon transfer pathway and ovarian cancer risk","volume":"68","author":"Kelemen","year":"2008","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.110.004671_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(95)90165-5","article-title":"Homocysteine metabolism in pregnancies complicated by neural-tube defects","volume":"345","author":"Mills","year":"1995","journal-title":"Lancet"},{"key":"10.3945\/ajcn.110.004671_bib26","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/0002-9378(95)90474-3","article-title":"Neural tube defects and elevated homocysteine levels in amniotic fluid","volume":"172","author":"Steegers-Theunissen","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.3945\/ajcn.110.004671_bib27","first-page":"509","article-title":"Single nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene are common in US Caucasian and Hispanic American populations","volume":"8","author":"Peng","year":"2001","journal-title":"Int J Mol Med"},{"key":"10.3945\/ajcn.110.004671_bib28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1542\/peds.2005-0592","article-title":"Decline in the prevalence of spina bifida and anencephaly by race\/ethnicity: 1995-2002","volume":"116","author":"Williams","year":"2005","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.110.004671_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000022929","article-title":"The 677 C\u2192T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in five Chinese ethnic groups","volume":"50","author":"Yu","year":"2000","journal-title":"Hum Hered"},{"key":"10.3945\/ajcn.110.004671_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3945\/ajcn.2010.29427","article-title":"A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy","volume":"93","author":"Tighe","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.110.004671_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/tera.10094","article-title":"Decline of neural tube defects cases after a folic acid campaign in Nuevo Leon, Mexico","volume":"66","author":"Martinez de Villarreal","year":"2002","journal-title":"Teratology"},{"key":"10.3945\/ajcn.110.004671_bib32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10995-006-0082-2","article-title":"Weekly administration of folic acid and epidemiology of neural tube defects","volume":"10","author":"Martinez de Villarreal","year":"2006","journal-title":"Matern Child Health J"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523129704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523129704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/93\/6\/1365\/23871633\/1365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T15:39:09Z","timestamp":1713973149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523129704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0002916523129704"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.110.004671","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MTHFR 677C\u2192T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.110.004671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}