{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:23:02Z","timestamp":1761823382342},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":4283,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.3945\/ajcn.110.009043","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T01:57:38Z","timestamp":1302746258000},"page":"1248-1254","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phenylbutyrate improves nitrogen disposal via an alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylase\u2013deficient patients"],"prefix":"10.1016","volume":"93","author":[{"given":"Juan C","family":"Marini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan C","family":"Lanpher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Scaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Garlick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farook","family":"Jahoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.110.009043_bib1","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1067\/mpd.2001.111836","article-title":"Alternative pathway therapy for urea cycle disorders: twenty years later","volume":"138","author":"Batshaw","year":"2001","journal-title":"J Pediatr"},{"key":"10.3945\/ajcn.110.009043_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1203\/00006450-199102000-00009","article-title":"Phenylacetylglutamine may replace urea as a vehicle for waste nitrogen excretion","volume":"29","author":"Brusilow","year":"1991","journal-title":"Pediatr Res"},{"key":"10.3945\/ajcn.110.009043_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/mgme.2001.3156","article-title":"Long-term treatment with sodium phenylbutyrate in ornithine transcarbamylase-deficient patients","volume":"72","author":"Burlina","year":"2001","journal-title":"Mol Genet Metab"},{"key":"10.3945\/ajcn.110.009043_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1098\/rspb.1972.0064","article-title":"The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species","volume":"182","author":"James","year":"1972","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"10.3945\/ajcn.110.009043_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0021-9258(18)70632-7","article-title":"Synthesis of phenylacetylglutamine by human tissue","volume":"229","author":"Moldave","year":"1957","journal-title":"J Biol Chem"},{"key":"10.3945\/ajcn.110.009043_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1124\/dmd.32.1.10","article-title":"New secondary metabolites of phenylbutyrate in humans and rats","volume":"32","author":"Kasumov","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.3945\/ajcn.110.009043_bib7","first-page":"1755","article-title":"Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells","volume":"3","author":"Gore","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.3945\/ajcn.110.009043_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ijc.1399","article-title":"Inhibition of estrogen-dependent breast cell responses with phenylacetate","volume":"93","author":"Sawatsri","year":"2001","journal-title":"Int J Cancer"},{"key":"10.3945\/ajcn.110.009043_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/bj1810143","article-title":"Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds","volume":"181","author":"Shama Bhat","year":"1979","journal-title":"Biochem J"},{"key":"10.3945\/ajcn.110.009043_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ymgme.2006.07.002","article-title":"Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines","volume":"90","author":"Kern","year":"2007","journal-title":"Mol Genet Metab"},{"key":"10.3945\/ajcn.110.009043_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1023\/A:1005661631281","article-title":"Three cases of intravenous sodium benzoate and sodium phenylacetate toxicity occurring in the treatment of acute hyperammonaemia","volume":"23","author":"Praphanphoj","year":"2000","journal-title":"J Inherit Metab Dis"},{"key":"10.3945\/ajcn.110.009043_bib12","first-page":"E801","article-title":"Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism","volume":"274","author":"Darmaun","year":"1998","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.009043_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.clnu.2006.09.010","article-title":"Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans","volume":"26","author":"Le Bacquer","year":"2007","journal-title":"Clin Nutr"},{"issue":"suppl 1","key":"10.3945\/ajcn.110.009043_bib14","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.ymgme.2003.11.017","article-title":"Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients","volume":"81","author":"Scaglia","year":"2004","journal-title":"Mol Genet Metab"},{"key":"10.3945\/ajcn.110.009043_bib15","first-page":"201","article-title":"Effect of cellular hydration on protein metabolism","volume":"23","author":"Waldegger","year":"1997","journal-title":"Miner Electrolyte Metab"},{"key":"10.3945\/ajcn.110.009043_bib16","doi-asserted-by":"crossref","first-page":"1580S","DOI":"10.1093\/jn\/135.6.1580S","article-title":"Observations of branched-chain amino acid administration in humans","volume":"135","author":"Matthews","year":"2005","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.110.009043_bib17","doi-asserted-by":"crossref","first-page":"1553S","DOI":"10.1093\/jn\/135.6.1553S","article-title":"The role of leucine in the regulation of protein metabolism","volume":"135","author":"Garlick","year":"2005","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.110.009043_bib18","first-page":"E631","article-title":"Rapid measurement of whole body and forearm protein turnover using a [2H5]phenylalanine model","volume":"256","author":"Thompson","year":"1989","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.009043_bib19","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/j.1552-4604.1995.tb04075.x","article-title":"Disposition of phenylbutyrate and its metabolites, phenylacetate and phenylacetylglutamine","volume":"35","author":"Piscitelli","year":"1995","journal-title":"J Clin Pharmacol"},{"key":"10.3945\/ajcn.110.009043_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1152\/jappl.1974.36.6.693","article-title":"Intracellular free amino acid concentration in human muscle tissue","volume":"36","author":"Bergstrom","year":"1974","journal-title":"J Appl Physiol"},{"key":"10.3945\/ajcn.110.009043_bib21","first-page":"G1061","article-title":"Manipulation of citrulline availability in humans","volume":"293","author":"Rouge","year":"2007","journal-title":"Am J Physiol"},{"key":"10.3945\/ajcn.110.009043_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ymgme.2008.05.004","article-title":"Cross-sectional multicenter study of patients with urea cycle disorders in the United States","volume":"94","author":"Tuchman","year":"2008","journal-title":"Mol Genet Metab"},{"key":"10.3945\/ajcn.110.009043_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1753-4887.2007.tb00289.x","article-title":"Leucine and protein synthesis: mTOR and beyond","volume":"65","author":"Stipanuk","year":"2007","journal-title":"Nutr Rev"},{"key":"10.3945\/ajcn.110.009043_bib24","doi-asserted-by":"crossref","unstructured":"Lee B Singh RH Rhead WJ King LS Smith W Summar ML. Considerations in the difficult-to-manage urea cycle disorder patient. Crit Care Clin 2005; 21 (4 suppl): S19 \u2013 25.","DOI":"10.1016\/j.ccc.2005.05.001"},{"key":"10.3945\/ajcn.110.009043_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/hmg\/ddq507","article-title":"Phenylbutyrate therapy for maple syrup urine disease","volume":"20","author":"Brunetti-Pierri","year":"2011","journal-title":"Hum Mol Genet"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523129558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523129558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/93\/6\/1248\/23871199\/1248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T15:38:31Z","timestamp":1713973111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523129558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0002916523129558"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.110.009043","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenylbutyrate improves nitrogen disposal via an alternative pathway without eliciting an increase in protein breakdown and catabolism in control and ornithine transcarbamylase\u2013deficient patients","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.110.009043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}