{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:41:01Z","timestamp":1791549661910,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":3767,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.3945\/ajcn.112.045708","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T23:37:57Z","timestamp":1349307477000},"page":"1064-1070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients"],"prefix":"10.1016","volume":"96","author":[{"given":"John P","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan E","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Atherton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Liptrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Larvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Rennie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.112.045708_bib1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/BF01658920","article-title":"Metabolic basis for the management of patients undergoing major surgery","volume":"17","author":"Hill","year":"1993","journal-title":"World J Surg"},{"key":"10.3945\/ajcn.112.045708_bib2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1152\/jappl.1988.65.3.1147","article-title":"Role of muscle loss in the age-associated reduction in VO2 max","volume":"65","author":"Fleg","year":"1988","journal-title":"J Appl Physiol"},{"key":"10.3945\/ajcn.112.045708_bib3","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1152\/jappl.1997.82.5.1411","article-title":"Skeletal muscle mass and the reduction of VO2max in trained older subjects","volume":"82","author":"Proctor","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.3945\/ajcn.112.045708_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/jappl.1990.68.1.329","article-title":"Strength training and determinants of VO2max in older men","volume":"68","author":"Frontera","year":"1990","journal-title":"J Appl Physiol"},{"key":"10.3945\/ajcn.112.045708_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol Rev"},{"key":"10.3945\/ajcn.112.045708_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jso.2930130205","article-title":"An investigation of the cause of death from cancer","volume":"13","author":"Houten","year":"1980","journal-title":"J Surg Oncol"},{"key":"10.3945\/ajcn.112.045708_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00000658-198808000-00013","article-title":"Risk factors for postoperative pneumonia. The importance of protein depletion","volume":"208","author":"Windsor","year":"1988","journal-title":"Ann Surg"},{"key":"10.3945\/ajcn.112.045708_bib8","doi-asserted-by":"crossref","unstructured":"Deutz NE, Safar A, Schutzler S, Memelink R, Ferrando A, Spencer H, van Helvoort A, Wolfe RR. Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food. Clin Nutr 2011;30:759\u201368.","DOI":"10.1016\/j.clnu.2011.05.008"},{"key":"10.3945\/ajcn.112.045708_bib9","first-page":"4807","article-title":"Efflux of 3-methylhistidine from the leg in cancer patients who experience weight loss","volume":"42","author":"Lundholm","year":"1982","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.112.045708_bib10","first-page":"2590","article-title":"Influence of whole body protein turnover rate on resting energy expenditure in patients with cancer","volume":"48","author":"Fearon","year":"1988","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.112.045708_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0026-0495(93)90076-Z","article-title":"Protein turnover in advanced lung cancer patients","volume":"42","author":"Richards","year":"1993","journal-title":"Metabolism"},{"key":"10.3945\/ajcn.112.045708_bib12","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(84)91929-9","article-title":"Cancer cachexia and protein metabolism","volume":"1","author":"Jeevanandam","year":"1984","journal-title":"Lancet"},{"key":"10.3945\/ajcn.112.045708_bib13","first-page":"4746","article-title":"Altered leucine metabolism in noncachectic sarcoma patients","volume":"47","author":"Inculet","year":"1987","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.112.045708_bib14","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/0026-0495(84)90231-2","article-title":"Whole-body tyrosine flux in relation to energy expenditure in weight-losing cancer patients","volume":"33","author":"Ed\u00e9n","year":"1984","journal-title":"Metabolism"},{"key":"10.3945\/ajcn.112.045708_bib15","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/bmj.289.6445.584","article-title":"Protein synthesis in muscle measured in vivo in cachectic patients with cancer","volume":"289","author":"Emery","year":"1984","journal-title":"BMJ"},{"key":"10.3945\/ajcn.112.045708_bib16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/cs0640101","article-title":"Whole-body protein turnover before and after resection of colorectal tumours","volume":"64","author":"Glass","year":"1983","journal-title":"Clin Sci (Lond)"},{"key":"10.3945\/ajcn.112.045708_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M","article-title":"Effects of cachexia due to cancer on whole body and skeletal muscle protein turnover","volume":"82","author":"Dworzak","year":"1998","journal-title":"Cancer"},{"key":"10.3945\/ajcn.112.045708_bib18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.bjc.6603031","article-title":"Mortality from all cancers and lung, colorectal, breast and prostate cancer by country of birth in England and Wales, 2001-2003","volume":"94","author":"Wild","year":"2006","journal-title":"Br J Cancer"},{"key":"10.3945\/ajcn.112.045708_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.3945\/ajcn.112.045708_bib20","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3945\/ajcn.2008.27273","article-title":"A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands","volume":"89","author":"Lieffers","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.112.045708_bib21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0899-9007(00)00385-3","article-title":"Modulation of the catabolic response to surgery","volume":"16","author":"Carli","year":"2000","journal-title":"Nutrition"},{"key":"10.3945\/ajcn.112.045708_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/CS20040192","article-title":"Impact of surgical trauma on human skeletal muscle protein synthesis","volume":"107","author":"Tj\u00e4der","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.3945\/ajcn.112.045708_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/CS20070278","article-title":"Altered protein metabolism following coronary artery bypass graft (CABG) surgery","volume":"114","author":"Caso","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"10.3945\/ajcn.112.045708_bib24","first-page":"195","article-title":"Muscle protein synthesis after operation: effects of intravenous nutrition","volume":"159","author":"Ess\u00e9n","year":"1993","journal-title":"Eur J Surg"},{"key":"10.3945\/ajcn.112.045708_bib25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/cs0880479","article-title":"Human skeletal muscle protein: effect of malnutrition, elective surgery and total parenteral nutrition","volume":"88","author":"Petersson","year":"1995","journal-title":"Clin Sci (Lond)"},{"key":"10.3945\/ajcn.112.045708_bib26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/00000542-199705000-00005","article-title":"Continuous epidural blockade arrests the postoperative decrease in muscle protein fractional synthetic rate in surgical patients","volume":"86","author":"Carli","year":"1997","journal-title":"Anesthesiology"},{"key":"10.3945\/ajcn.112.045708_bib27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10120-011-0021-9","article-title":"Nutritional recovery after open and laparoscopic gastrectomies","volume":"14","author":"Abdiev","year":"2011","journal-title":"Gastric Cancer"},{"key":"10.3945\/ajcn.112.045708_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1113\/jphysiol.2008.164483","article-title":"Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men","volume":"587","author":"Kumar","year":"2009","journal-title":"J Physiol"},{"key":"10.3945\/ajcn.112.045708_bib29","doi-asserted-by":"crossref","first-page":"E595","DOI":"10.1152\/ajpendo.90411.2008","article-title":"Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle","volume":"295","author":"Greenhaff","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/ajcn.112.045708_bib30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0950-351X(96)80651-3","article-title":"The measurement of tissue protein turnover","volume":"10","author":"Smith","year":"1996","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.112.045708_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/bms.1200190803","article-title":"Measurement of (C13)arginine incorporation into apolipoprotein B-100 in very low density lipoproteins and low density lipoproteins in normal subjects using (13C)sodium bicarbonate infusion and isotope ratio mass spectrometry","volume":"19","author":"Bennett","year":"1990","journal-title":"Biomed Environ Mass Spectrom"},{"key":"10.3945\/ajcn.112.045708_bib32","doi-asserted-by":"crossref","first-page":"e1875","DOI":"10.1371\/journal.pone.0001875","article-title":"Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women","volume":"3","author":"Smith","year":"2008","journal-title":"PloS One"},{"key":"10.3945\/ajcn.112.045708_bib33","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.exger.2011.07.010","article-title":"Young a, Mann V, Noble B, Atherton PJ. Blunting of adaptive responses to resistance exercise training in women over 75y","volume":"46","author":"Greig","year":"2011","journal-title":"Exp Gerontol"},{"key":"10.3945\/ajcn.112.045708_bib34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0277-5379(91)90051-E","article-title":"Effect on whole-body protein synthesis after institution of intravenous nutrition in cancer and non-cancer patients who lose weight","volume":"27","author":"Hyltander","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.3945\/ajcn.112.045708_bib35","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/MCO.0b013e3283455e21","article-title":"Cancer cachexia therapy: a key weapon in the fight against cancer","volume":"14","author":"Coss","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.3945\/ajcn.112.045708_bib36","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/sj.bjc.6602780","article-title":"Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia","volume":"93","author":"Khal","year":"2005","journal-title":"Br J Cancer"},{"key":"10.3945\/ajcn.112.045708_bib37","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.clnu.2007.07.004","article-title":"Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy","volume":"26","author":"Dillon","year":"2007","journal-title":"Clin Nutr"},{"key":"10.3945\/ajcn.112.045708_bib38","doi-asserted-by":"crossref","unstructured":"Winter A, Macadams J, Chevalier S. Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia. Clin Nutr (Epub ahead of print 28 May 2012).","DOI":"10.1016\/j.clnu.2012.05.003"},{"key":"10.3945\/ajcn.112.045708_bib39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2217\/fon.10.20","article-title":"Are tumoral factors responsible for host tissue wasting in cancer cachexia?","volume":"6","author":"Tisdale","year":"2010","journal-title":"Future Oncol"},{"key":"10.3945\/ajcn.112.045708_bib40","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3945\/ajcn.2010.29819","article-title":"Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling","volume":"92","author":"Atherton","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.112.045708_bib41","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1158\/1078-0432.CCR-11-2133","article-title":"Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies","volume":"18","author":"Gallagher","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"suppl 1","key":"10.3945\/ajcn.112.045708_bib42","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.ejphar.2011.07.007","article-title":"Anti-inflammatory therapies in cancer cachexia","volume":"668","author":"Argil\u00e9s","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.3945\/ajcn.112.045708_bib43","doi-asserted-by":"crossref","first-page":"R133","DOI":"10.1152\/ajpregu.2001.281.1.R133","article-title":"Higher skeletal muscle protein synthesis and lower breakdown after chemotherapy in cachectic mice","volume":"281","author":"Samuels","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523030484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523030484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/96\/5\/1064\/23817599\/1064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T08:31:36Z","timestamp":1685176296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523030484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0002916523030484"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.112.045708","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tumor burden and subsequent surgical resection on skeletal muscle mass and protein turnover in colorectal cancer patients","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.112.045708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}