{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:56Z","timestamp":1792084136097,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":3369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.3945\/ajcn.112.054478","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T04:08:50Z","timestamp":1378958930000},"page":"1468-1474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country"],"prefix":"10.1016","volume":"98","author":[{"given":"Gianluca","family":"Terrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Berni Canani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Passariello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giulia","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Caoci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Smaldore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bertino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"De Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.112.054478_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0095-5108(18)30310-5","article-title":"Trace elements in nutrition for premature infants","volume":"22","author":"Zlotkin","year":"1995","journal-title":"Clin Perinatol"},{"key":"10.3945\/ajcn.112.054478_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000241580","article-title":"Zinc balances in preterm infants","volume":"42","author":"Voyer","year":"1982","journal-title":"Biol Neonate"},{"key":"10.3945\/ajcn.112.054478_bib3","first-page":"165","article-title":"Zinc in extremely low-birth weight or very preterm infants","volume":"8","author":"Giles","year":"2007","journal-title":"Neo Rev"},{"key":"10.3945\/ajcn.112.054478_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3945\/an.110.000174","article-title":"Zinc and neurogenesis: making new neurons from development to adulthood","volume":"2","author":"Levenson","year":"2011","journal-title":"Adv Nutr"},{"key":"10.3945\/ajcn.112.054478_bib5","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.2741\/222","article-title":"Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability","volume":"3","author":"Gu","year":"2011","journal-title":"Front Biosci Schol Ed"},{"key":"10.3945\/ajcn.112.054478_bib6","first-page":"33","article-title":"The effect of intracisternal Zn (II) protoporphyrin IX on vasospasm process in the experimental subarachnoid hemorrhage model","volume":"110","author":"Isikay","year":"2011","journal-title":"Acta Neurochir Suppl"},{"key":"10.3945\/ajcn.112.054478_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2165\/00148581-200406050-00004","article-title":"Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategies","volume":"6","author":"D\u2019Angio","year":"2004","journal-title":"Paediatr Drugs"},{"key":"10.3945\/ajcn.112.054478_bib8","first-page":"666","article-title":"Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia","volume":"116","author":"Strange","year":"1990","journal-title":"J Lab Clin Med"},{"issue":"suppl 1","key":"10.3945\/ajcn.112.054478_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.earlhumdev.2010.01.008","article-title":"The functional effects of nutrients on enterocyte proliferation and intestinal ion transport in early infancy","volume":"86","author":"Buccigrossi","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.3945\/ajcn.112.054478_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.mpg.0000214159.60445.9a","article-title":"The dawning of the zinc era in the treatment of pediatric acute gastroenteritis worldwide?","volume":"42","author":"Canani","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.112.054478_bib11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3945\/jn.111.138180","article-title":"Marginal zinc deficiency exacerbates experimental colitis induced by dextran sulfate sodium in rats","volume":"141","author":"Iwaya","year":"2011","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.112.054478_bib12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.pcl.2009.08.001","article-title":"Nutrient deficiencies in the premature infant","volume":"56","author":"Shah","year":"2009","journal-title":"Pediatr Clin North Am"},{"key":"10.3945\/ajcn.112.054478_bib13","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1542\/peds.111.5.1002","article-title":"The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants","volume":"111","author":"D\u00edaz-G\u00f3mez","year":"2003","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.112.054478_bib14","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1203\/00006450-198809000-00010","article-title":"Hepatic metallothionein as a source of zinc and cysteine during the first year of life","volume":"24","author":"Zlotkin","year":"1988","journal-title":"Pediatr Res"},{"key":"10.3945\/ajcn.112.054478_bib15","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1542\/peds.108.6.1280","article-title":"Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial","volume":"108","author":"Sazawal","year":"2001","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.112.054478_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13312-011-0043-8","article-title":"Neonatal zinc supplementation for prevention of mortality and morbidity in breastfed low birth weight infants: systematic review of randomized controlled trials","volume":"48","author":"Gulani","year":"2011","journal-title":"Indian Pediatr"},{"issue":"suppl 3","key":"10.3945\/ajcn.112.054478_bib17","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1186\/1471-2458-11-S3-S23","article-title":"Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria","volume":"11","author":"Yakoob","year":"2011","journal-title":"BMC Public Health"},{"key":"10.3945\/ajcn.112.054478_bib18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1542\/peds.2010-3091","article-title":"A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children","volume":"129","author":"Basnet","year":"2012","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.112.054478_bib19","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0140-6736(12)60477-2","article-title":"Zinc as adjunct treatment in infants aged between 7 and 120 days with probable serious bacterial infection: a randomized, double-blind, placebo-controlled trial","volume":"379","author":"Bhatnagar","year":"2012","journal-title":"Lancet"},{"key":"10.3945\/ajcn.112.054478_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0140-6736(93)92296-6","article-title":"International Neonatal Network. The CRIB (clinical risk index for babies) score: a tool for assessing inicial neonatal risk and comparing the performance of neonatal intensive care units","volume":"342","year":"1993","journal-title":"Lancet"},{"key":"10.3945\/ajcn.112.054478_bib21","doi-asserted-by":"crossref","first-page":"291085","DOI":"10.1155\/2011\/291085","article-title":"Serum calprotectin: an antimicrobial peptide as a new marker for the diagnosis of sepsis in very low birth weight newborns","volume":"2011","author":"Terrin","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.3945\/ajcn.112.054478_bib22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"Neu","year":"2011","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.112.054478_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2001-12940","article-title":"Changes in the pathogenesis and prevention of chronic lung disease of prematurity","volume":"18","author":"Bancalari","year":"2001","journal-title":"Am J Perinatol"},{"key":"10.3945\/ajcn.112.054478_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/siny.2001.0047","article-title":"Intraventricular haemorrhage and posthaemorrhagic hydrocephalus: pathogenesis, prevention and future interventions","volume":"6","author":"Whitelaw","year":"2001","journal-title":"Semin Neonatol"},{"key":"10.3945\/ajcn.112.054478_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/08820530802506045","article-title":"Retinopathy of prematurity","volume":"23","author":"Sylvester","year":"2008","journal-title":"Semin Ophthalmol"},{"key":"10.3945\/ajcn.112.054478_bib26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1542\/peds.2008-2174","article-title":"Hospital discharge of the high-risk neonate","volume":"122","year":"2008","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.112.054478_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1651-2227.2008.00987.x","article-title":"Minimal enteral feeding reduces the risk of sepsis in feed-intolerant very low birth weight newborns","volume":"98","author":"Terrin","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.3945\/ajcn.112.054478_bib28","series-title":"Handbook of growth and growth monitoring in health and disease.","first-page":"387","article-title":"Artificial nutrition in very low birth weight newborns and impact on growth: practical methods to avoid and treat malnutrition in stable and unstable neonates","author":"Terrin","year":"2012"},{"key":"10.3945\/ajcn.112.054478_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/MPG.0b013e3181adaee0","article-title":"Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition","volume":"50","author":"Agostoni","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.112.054478_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clp.2008.09.013","article-title":"Iron therapy for preterm infants","volume":"36","author":"Rao","year":"2009","journal-title":"Clin Perinatol"},{"key":"10.3945\/ajcn.112.054478_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00005176-199307000-00015","article-title":"Zinc supplementation in very-low-birth-weight infants","volume":"17","author":"Friel","year":"1993","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.112.054478_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0022-3476(95)70296-2","article-title":"Zinc supplementation and growth of infants born small for gestational age","volume":"127","author":"Castillo-Dur\u00e1n","year":"1995","journal-title":"J Pediatr"},{"key":"10.3945\/ajcn.112.054478_bib33","doi-asserted-by":"crossref","first-page":"418S","DOI":"10.1093\/ajcn\/68.2.418S","article-title":"Effect of zinc supplementation on the morbidity, immune function, and growth of low-birth-weight, full-term infants in northeast Brazil","volume":"68","author":"Lira","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.112.054478_bib34","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1542\/peds.112.6.1327","article-title":"Impact of zinc supplementation on diarrheal morbidity and growth pattern of low birth weight infants in kolkata, India: a randomized, double-blind, placebo-controlled, community-based study","volume":"112","author":"Sur","year":"2003","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.112.054478_bib35","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1542\/peds.113.5.1297","article-title":"Cognitive and motor development among small-for-gestational-age infants: impact of zinc supplementation, birth weight, and caregiving practices","volume":"113","author":"Black","year":"2004","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.112.054478_bib36","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00005176-200410000-00009","article-title":"Nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized controlled trial","volume":"39","author":"Loui","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.112.054478_bib37","first-page":"212","article-title":"Zinc supplementation in infants with asymmetric intra uterine growth retardation; effect on growth, nutritional status and leptin secretion","volume":"23","author":"Bueno","year":"2008","journal-title":"Nutr Hosp"},{"key":"10.3945\/ajcn.112.054478_bib38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3945\/ajcn.2009.27707","article-title":"Effect of zinc supplementation on morbidity and growth in hospital-born, low-birth-weight infants","volume":"90","author":"Taneja","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.112.054478_bib39","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s13312-010-0145-8","article-title":"Effect of oral zinc supplementation on the growth of preterm infants","volume":"47","author":"Islam","year":"2010","journal-title":"Indian Pediatr"},{"key":"10.3945\/ajcn.112.054478_bib40","first-page":"CD005436","article-title":"Oral zinc for treating diarrhoea in children","volume":"1","author":"Lazzerini","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3945\/ajcn.112.054478_bib41","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1542\/peds.2012-2980","article-title":"Short-course prophylactic zinc supplementation for diarrhea morbidity in infants of 6 to 11 months","volume":"132","author":"Malik","year":"2013","journal-title":"Pediatrics"},{"issue":"suppl 1","key":"10.3945\/ajcn.112.054478_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000348261","article-title":"Update on zinc deficiency and excess in clinical pediatric practice","volume":"62","author":"Krebs","year":"2013","journal-title":"Ann Nutr Metab"},{"key":"10.3945\/ajcn.112.054478_bib43","doi-asserted-by":"crossref","first-page":"1500S","DOI":"10.1093\/jn\/130.5.1500S","article-title":"The role of zinc in growth and cell proliferation","volume":"130","author":"MacDonald","year":"2000","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.112.054478_bib44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1203\/01.PDR.0000139428.77791.3D","article-title":"Zinc homeostasis in premature infants does not differ between those fed preterm formula or fortified human milk","volume":"56","author":"Jalla","year":"2004","journal-title":"Pediatr Res"},{"key":"10.3945\/ajcn.112.054478_bib45","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/0140-6736(90)93304-8","article-title":"total enteral nutrition at and neonatal necrotizing enterocolitis","volume":"336","author":"Lucas","year":"1990","journal-title":"Lancet"},{"key":"10.3945\/ajcn.112.054478_bib46","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.blre.2010.08.001","article-title":"Anaemia of prematurity: pathophysiology and treatment","volume":"24","author":"Strauss","year":"2010","journal-title":"Blood Rev"},{"key":"10.3945\/ajcn.112.054478_bib47","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.earlhumdev.2007.03.008","article-title":"Individualized developmental care for high risk newborns in the NICU: a practice guideline","volume":"83","author":"Vandenberg","year":"2007","journal-title":"Early Hum Dev"},{"key":"10.3945\/ajcn.112.054478_bib48","first-page":"CD000501","article-title":"Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants","volume":"10","author":"Darlow","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3945\/ajcn.112.054478_bib49","doi-asserted-by":"crossref","first-page":"F9","DOI":"10.1136\/fn.84.1.F9","article-title":"Randomised controlled trial of oral vitamin A supplementation in preterm infants to prevent chronic lung disease","volume":"84","author":"Wardle","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523053340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523053340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/98\/6\/1468\/23829656\/1468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:50:06Z","timestamp":1685364606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523053340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0002916523053340"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.112.054478","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.112.054478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}