{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:50:24Z","timestamp":1793375424590,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":3399,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.3945\/ajcn.113.061549","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T04:08:50Z","timestamp":1378958930000},"page":"1233-1240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study"],"prefix":"10.1016","volume":"98","author":[{"given":"Ingrid","family":"Torsvik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Magne","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond","family":"Markestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Bj\u00f8rke-Monsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.113.061549_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11065-010-9148-4","article-title":"The basics of brain development","volume":"20","author":"Stiles","year":"2010","journal-title":"Neuropsychol Rev"},{"key":"10.3945\/ajcn.113.061549_bib2","first-page":"19","article-title":"Cobalamin and folate deficiency: acquired and hereditary disorders in children","volume":"36","author":"Rosenblatt","year":"1999","journal-title":"Semin Hematol"},{"key":"10.3945\/ajcn.113.061549_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2141.2006.06133.x","article-title":"Acquired and inherited disorders of cobalamin and folate in children","volume":"134","author":"Whitehead","year":"2006","journal-title":"Br J Haematol"},{"key":"10.3945\/ajcn.113.061549_bib4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s10545-008-0839-4","article-title":"Causes of and diagnostic approach to methylmalonic acidurias","volume":"31","author":"Fowler","year":"2008","journal-title":"J Inherit Metab Dis"},{"key":"10.3945\/ajcn.113.061549_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1651-2227.2008.01059.x","article-title":"Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency","volume":"98","author":"Zengin","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.3945\/ajcn.113.061549_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/08880018909034282","article-title":"Nutritional vitamin B12 deficiency in infancy: three case reports and a review of the literature","volume":"6","author":"Doyle","year":"1989","journal-title":"Pediatr Hematol Oncol"},{"key":"10.3945\/ajcn.113.061549_bib7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/adc.63.8.921","article-title":"Vitamin B12 deficiency in a breast fed infant","volume":"63","author":"McPhee","year":"1988","journal-title":"Arch Dis Child"},{"key":"10.3945\/ajcn.113.061549_bib8","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0022-3476(05)81897-9","article-title":"Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants","volume":"121","author":"Graham","year":"1992","journal-title":"J Pediatr"},{"key":"10.3945\/ajcn.113.061549_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/08880010601001370","article-title":"Nutritional vitamin B12 deficiency in hospitalized young children","volume":"24","author":"Cetinkaya","year":"2007","journal-title":"Pediatr Hematol Oncol"},{"key":"10.3945\/ajcn.113.061549_bib10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1753-4887.2008.00031.x","article-title":"Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms","volume":"66","author":"Dror","year":"2008","journal-title":"Nutr Rev"},{"key":"10.3945\/ajcn.113.061549_bib11","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.dld.2005.01.009","article-title":"Gastrointestinal symptoms in infancy: a population-based prospective study","volume":"37","author":"Iacono","year":"2005","journal-title":"Dig Liver Dis"},{"key":"10.3945\/ajcn.113.061549_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/08830738050200010201","article-title":"Developmental screening","volume":"20","author":"Rydz","year":"2005","journal-title":"J Child Neurol"},{"key":"10.3945\/ajcn.113.061549_bib13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1542\/peds.108.1.192","article-title":"Developmental surveillance and screening of infants and young children","volume":"108","year":"2001","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.113.061549_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1542\/peds.2007-2716","article-title":"Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation","volume":"122","author":"Bj\u00f8rke-Monsen","year":"2008","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.113.061549_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/ajcn\/78.1.7","article-title":"Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence","volume":"78","author":"Bj\u00f8rke-Monsen","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.113.061549_bib16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/ajcn\/72.3.751","article-title":"Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates","volume":"72","author":"Minet","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.113.061549_bib17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1542\/peds.108.3.624","article-title":"Determinants of cobalamin status in newborns","volume":"108","author":"Bjorke Monsen","year":"2001","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.113.061549_bib18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1469-8749.1998.tb15399.x","article-title":"Assessment of gross motor skills of at-risk infants: predictive validity of the Alberta Infant Motor Scale","volume":"40","author":"Darrah","year":"1998","journal-title":"Dev Med Child Neurol"},{"key":"10.3945\/ajcn.113.061549_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1542\/peds.99.2.255","article-title":"Vitamin B12 deficiency: a cause of abnormal movements in infants","volume":"99","author":"Emery","year":"1997","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.113.061549_bib20","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/j.gastro.2005.11.065","article-title":"Childhood functional gastrointestinal disorders: neonate\/toddler","volume":"130","author":"Hyman","year":"2006","journal-title":"Gastroenterology"},{"key":"10.3945\/ajcn.113.061549_bib21","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ejpn.2009.12.003","article-title":"Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B(12) deficiency - what have we learned?","volume":"14","author":"Honzik","year":"2010","journal-title":"Eur J Paediatr Neurol"},{"key":"10.3945\/ajcn.113.061549_bib22","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s00431-011-1522-6","article-title":"Solid food refusal as the presenting sign of vitamin B(12) deficiency in a breastfed infant","volume":"170","author":"Ide","year":"2011","journal-title":"Eur J Pediatr"},{"key":"10.3945\/ajcn.113.061549_bib23","first-page":"CD008411","article-title":"Sweet-tasting solutions for needle-related procedural pain in infants one month to one year of age","volume":"12","author":"Kassab","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3945\/ajcn.113.061549_bib24","series-title":"Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline.","first-page":"306","year":"2000"},{"key":"10.3945\/ajcn.113.061549_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/DBP.0b013e318182a4ea","article-title":"Evaluation of neuromotor function in infancy-A systematic review of available methods","volume":"29","author":"Heineman","year":"2008","journal-title":"J Dev Behav Pediatr"},{"key":"10.3945\/ajcn.113.061549_bib26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/bies.950120705","article-title":"Inherited disorders of vitamin B12 utilization","volume":"12","author":"Rosenblatt","year":"1990","journal-title":"Bioessays"},{"key":"10.3945\/ajcn.113.061549_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mrdd.20052","article-title":"A comparison of developmental assessments of the newborn and young infant","volume":"11","author":"Majnemer","year":"2005","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.3945\/ajcn.113.061549_bib28","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/dev.20512","article-title":"Motor development in 9-month-old infants in relation to cultural differences and iron status","volume":"53","author":"Angulo-Barroso","year":"2011","journal-title":"Dev Psychobiol"},{"key":"10.3945\/ajcn.113.061549_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5694\/j.1326-5377.1979.tb112643.x","article-title":"Brain damage in infancy and dietary vitamin B12 deficiency","volume":"2","author":"Wighton","year":"1979","journal-title":"Med J Aust"},{"key":"10.3945\/ajcn.113.061549_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1542\/peds.2007-3569","article-title":"Prevalence and natural history of gastroesophageal reflux: pediatric prospective survey","volume":"123","author":"Campanozzi","year":"2009","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.113.061549_bib31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1182\/asheducation-2003.1.62","article-title":"Update on cobalamin, folate, and homocysteine","volume":"2003","author":"Carmel","year":"2003","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"10.3945\/ajcn.113.061549_bib32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S0029665199000580","article-title":"Folate and vitamin B12","volume":"58","author":"Scott","year":"1999","journal-title":"Proc Nutr Soc"},{"key":"10.3945\/ajcn.113.061549_bib33","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.metabol.2009.09.036","article-title":"Metabolic signs of vitamin B(12) deficiency in humans: computational model and its implications for diagnostics","volume":"59","author":"Fedosov","year":"2010","journal-title":"Metabolism"},{"key":"10.3945\/ajcn.113.061549_bib34","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1373\/clinchem.2003.019869","article-title":"Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years","volume":"49","author":"Monsen","year":"2003","journal-title":"Clin Chem"},{"key":"10.3945\/ajcn.113.061549_bib35","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1471-0528.2002.01307.x","article-title":"Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12","volume":"109","author":"Guerra-Shinohara","year":"2002","journal-title":"BJOG"},{"key":"10.3945\/ajcn.113.061549_bib36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1067\/mob.2002.121105","article-title":"Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C\u2192T variant","volume":"186","author":"Molloy","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.3945\/ajcn.113.061549_bib37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/000992288602500708","article-title":"Developmental regression as an early manifestation of vitamin B12 deficiency","volume":"25","author":"Sadowitz","year":"1986","journal-title":"Clin Pediatr (Phila)"},{"key":"10.3945\/ajcn.113.061549_bib38","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.braindev.2005.02.005","article-title":"Vitamin B12 deficiency in infancy as a cause of developmental regression","volume":"27","author":"Casella","year":"2005","journal-title":"Brain Dev"},{"key":"10.3945\/ajcn.113.061549_bib39","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1177\/08830738050200111501","article-title":"Answer to hypotonia: a simple hemogram","volume":"20","author":"Kanra","year":"2005","journal-title":"J Child Neurol"},{"key":"10.3945\/ajcn.113.061549_bib40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/01.mph.0000212958.89091.c0","article-title":"Nutritional megaloblastic anemia in young Turkish children is associated with vitamin B-12 deficiency and psychomotor retardation","volume":"28","author":"Katar","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.3945\/ajcn.113.061549_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00431-004-1613-8","article-title":"Severe nutritional vitamin deficiency in a breast-fed infant of a vegan mother","volume":"164","author":"Baatenburg de Jong","year":"2005","journal-title":"Eur J Pediatr"},{"key":"10.3945\/ajcn.113.061549_bib42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1024\/0300-9831\/a000080","article-title":"Nutritional B12 deficiency in infants of vitamin B12-deficient mothers","volume":"81","author":"Halicioglu","year":"2011","journal-title":"Int J Vitam Nutr Res"},{"key":"10.3945\/ajcn.113.061549_bib43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ajh.2830340208","article-title":"Function of vitamin B12 in the central nervous system as revealed by congenital defects","volume":"34","author":"Hall","year":"1990","journal-title":"Am J Hematol"},{"key":"10.3945\/ajcn.113.061549_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02343237","article-title":"Vitamin B12 and brain development","volume":"146","author":"Stollhoff","year":"1987","journal-title":"Eur J Pediatr"},{"key":"10.3945\/ajcn.113.061549_bib45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0361-9230(00)00434-2","article-title":"Maturation of white matter in the human brain: a review of magnetic resonance studies","volume":"54","author":"Paus","year":"2001","journal-title":"Brain Res Bull"},{"key":"10.3945\/ajcn.113.061549_bib46","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1469-8749.1991.tb14793.x","article-title":"Myelination as an expression of the functional maturity of the brain","volume":"33","author":"van der Knaap","year":"1991","journal-title":"Dev Med Child Neurol"},{"key":"10.3945\/ajcn.113.061549_bib47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-2003-43256","article-title":"Infantile cobalamin deficiency with cerebral lactate accumulation and sustained choline depletion","volume":"34","author":"Horstmann","year":"2003","journal-title":"Neuropediatrics"},{"key":"10.3945\/ajcn.113.061549_bib48","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s002470050090","article-title":"Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings","volume":"27","author":"L\u00f6vblad","year":"1997","journal-title":"Pediatr Radiol"},{"issue":"suppl","key":"10.3945\/ajcn.113.061549_bib49","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1177\/15648265080292S117","article-title":"Effects of vitamin B12 and folate deficiency on brain development in children","volume":"29","author":"Black","year":"2008","journal-title":"Food Nutr Bull"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652305298X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652305298X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/98\/5\/1233\/23829290\/1233.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:47:24Z","timestamp":1685364444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291652305298X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S000291652305298X"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.113.061549","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.113.061549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}