{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:33:06Z","timestamp":1790688786036,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":2640,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy and Competitiveness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","award":["AGL2009-13906-C02-01"],"award-info":[{"award-number":["AGL2009-13906-C02-01"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ISCII-Subdirecci\u00f3n General de Evaluaci\u00f3n y Fomento de la Investigaci\u00f3n"},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Italian Ministry of Health"},{"name":"United States National Institute on Aging"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.3945\/ajcn.115.118976","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T02:44:11Z","timestamp":1445481851000},"page":"1534-1542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study"],"prefix":"10.1016","volume":"102","author":[{"given":"Montserrat","family":"Rabassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Zamora-Ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Urpi-Sarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bandinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Andres-Lacueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cherubini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.115.118976_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/03610730802545051","article-title":"Change in frailty and risk of death in older persons","volume":"35","author":"Buchman","year":"2009","journal-title":"Exp Aging Res"},{"key":"10.3945\/ajcn.115.118976_bib2","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.amjmed.2005.01.062","article-title":"Frailty, hospitalization, and progression of disability in a cohort of disabled older women","volume":"118","author":"Boyd","year":"2005","journal-title":"Am J Med"},{"key":"10.3945\/ajcn.115.118976_bib3","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/j.1532-5415.2008.01840.x","article-title":"Frailty predicts some but not all adverse outcomes in older adults discharged from the emergency department","volume":"56","author":"Hastings","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.3945\/ajcn.115.118976_bib4","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3945\/ajcn.115.118976_bib5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s12603-011-0130-5","article-title":"Oxidative stress, frailty and cognitive decline","volume":"15","author":"Mulero","year":"2011","journal-title":"J Nutr Health Aging"},{"key":"10.3945\/ajcn.115.118976_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/21551197.2011.623931","article-title":"The frailty syndrome: a comprehensive review","volume":"30","author":"Heuberger","year":"2011","journal-title":"J Nutr Gerontol Geriatr"},{"key":"10.3945\/ajcn.115.118976_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1017\/S0007114507882997","article-title":"Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort","volume":"100","author":"Zamora-Ros","year":"2008","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.115.118976_bib8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.chroma.2010.12.012","article-title":"Determination of resveratrol and piceid in beer matrices by solid-phase extraction and liquid chromatography-tandem mass spectrometry","volume":"1218","author":"Chiva-Blanch","year":"2011","journal-title":"J Chromatogr A"},{"key":"10.3945\/ajcn.115.118976_bib9","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1021\/jf801297w","article-title":"Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products","volume":"56","author":"Hurst","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.3945\/ajcn.115.118976_bib10","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/jf0609633","article-title":"Detection and quantitation of resveratrol in tomato fruit (Lycopersicon esculentum Mill.)","volume":"54","author":"Ragab","year":"2006","journal-title":"J Agric Food Chem"},{"key":"10.3945\/ajcn.115.118976_bib11","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1021\/acs.jafc.5b00291","article-title":"Is there room for improving the nutraceutical composition of apple?","volume":"63","author":"Farneti","year":"2015","journal-title":"J Agric Food Chem"},{"key":"10.3945\/ajcn.115.118976_bib12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule SIRT1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.3945\/ajcn.115.118976_bib13","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.2174\/13816128113199990407","article-title":"Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence","volume":"19","author":"Tom\u00e9-Carneiro","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.3945\/ajcn.115.118976_bib14","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/jc.2010-0482","article-title":"An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol","volume":"95","author":"Ghanim","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.115.118976_bib15","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2174\/0929867311320100009","article-title":"Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial","volume":"20","author":"Bo","year":"2013","journal-title":"Curr Med Chem"},{"key":"10.3945\/ajcn.115.118976_bib16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.phrs.2012.08.001","article-title":"Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets","volume":"66","author":"Rotches-Ribalta","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.3945\/ajcn.115.118976_bib17","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.freeradbiomed.2008.12.023","article-title":"Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: the PREDIMED Study","volume":"46","author":"Zamora-Ros","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.3945\/ajcn.115.118976_bib18","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1373\/clinchem.2005.065870","article-title":"Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption","volume":"52","author":"Zamora-Ros","year":"2006","journal-title":"Clin Chem"},{"key":"10.3945\/ajcn.115.118976_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-5573-7-2","article-title":"Can we use biomarkers in combination with self-reports to strengthen the analysis of nutritional epidemiologic studies?","volume":"7","author":"Freedman","year":"2010","journal-title":"Epidemiol Perspect Innov"},{"key":"10.3945\/ajcn.115.118976_bib20","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/j.1532-5415.2000.tb03873.x","article-title":"Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study","volume":"48","author":"Ferrucci","year":"2000","journal-title":"J Am Geriatr Soc"},{"key":"10.3945\/ajcn.115.118976_bib21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1373\/clinchem.2006.071936","article-title":"HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans","volume":"53","author":"Urpi-Sarda","year":"2007","journal-title":"Clin Chem"},{"key":"10.3945\/ajcn.115.118976_bib22","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3945\/ajcn.111.027847","article-title":"Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers","volume":"95","author":"Queipo-Ortu\u00f1o","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 1","key":"10.3945\/ajcn.115.118976_bib23","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1093\/ije\/26.suppl_1.S152","article-title":"Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres","volume":"26","author":"Pisani","year":"1997","journal-title":"Int J Epidemiol"},{"key":"10.3945\/ajcn.115.118976_bib24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1532-5415.2011.03830.x","article-title":"Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti Study","volume":"60","author":"Shardell","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.3945\/ajcn.115.118976_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/gerona\/61.3.262","article-title":"Phenotype of frailty: characterization in the women\u2019s health and aging studies","volume":"61","author":"Bandeen-Roche","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3945\/ajcn.115.118976_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0304-3835(97)04686-7","article-title":"A food composition database for epidemiological studies in Italy","volume":"114","author":"Salvini","year":"1997","journal-title":"Cancer Lett"},{"key":"10.3945\/ajcn.115.118976_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3945\/ajcn.115.118976_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"key":"10.3945\/ajcn.115.118976_bib29","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function","volume":"185","author":"Katz","year":"1963","journal-title":"JAMA"},{"key":"10.3945\/ajcn.115.118976_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.3945\/ajcn.115.118976_bib31","series-title":"The women\u2019s health and aging study. In: Health and social characteristics of older women with disability.","year":"1995"},{"key":"10.3945\/ajcn.115.118976_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/gerona\/glt023","article-title":"Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults","volume":"69","author":"Varadhan","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3945\/ajcn.115.118976_bib33","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0140-6736(13)61836-X","article-title":"Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants","volume":"383","author":"Lu","year":"2014","journal-title":"Lancet"},{"key":"10.3945\/ajcn.115.118976_bib34","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1001\/jamainternmed.2014.1582","article-title":"Resveratrol levels and all-cause mortality in older community-dwelling adults","volume":"174","author":"Semba","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.3945\/ajcn.115.118976_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.freeradbiomed.2011.10.484","article-title":"The role of sirtuins in modulating redox stressors","volume":"52","author":"Webster","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.3945\/ajcn.115.118976_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2008.06.011","article-title":"Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span","volume":"8","author":"Pearson","year":"2008","journal-title":"Cell Metab"},{"key":"10.3945\/ajcn.115.118976_bib37","doi-asserted-by":"crossref","first-page":"e2264","DOI":"10.1371\/journal.pone.0002264","article-title":"A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice","volume":"3","author":"Barger","year":"2008","journal-title":"PLoS One"},{"key":"10.3945\/ajcn.115.118976_bib38","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cmet.2011.10.002","article-title":"Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans","volume":"14","author":"Timmers","year":"2011","journal-title":"Cell Metab"},{"key":"10.3945\/ajcn.115.118976_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRT1 in cellular functions: role of polyphenols","volume":"501","author":"Chung","year":"2010","journal-title":"Arch Biochem Biophys"},{"key":"10.3945\/ajcn.115.118976_bib40","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.phrs.2012.03.009","article-title":"High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients","volume":"65","author":"Zamora-Ros","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.3945\/ajcn.115.118976_bib41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.nutres.2012.06.003","article-title":"Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus","volume":"32","author":"Bhatt","year":"2012","journal-title":"Nutr Res"},{"key":"10.3945\/ajcn.115.118976_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S0007114511000316","article-title":"Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients","volume":"106","author":"Brasny\u00f3","year":"2011","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.115.118976_bib43","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/gerona\/glr235","article-title":"Pilot study of resveratrol in older adults with impaired glucose tolerance","volume":"67","author":"Crandall","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3945\/ajcn.115.118976_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/neuro.24.004.2009","article-title":"Resveratrol preserves cerebrovascular density and cognitive function in aging mice","volume":"1","author":"Oomen","year":"2009","journal-title":"Front Aging Neurosci"},{"key":"10.3945\/ajcn.115.118976_bib45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.euroneuro.2010.02.013","article-title":"Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system","volume":"20","author":"Xu","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.3945\/ajcn.115.118976_bib46","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.0385-14.2014","article-title":"Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults","volume":"34","author":"Witte","year":"2014","journal-title":"J Neurosci"},{"key":"10.3945\/ajcn.115.118976_bib47","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1001\/archinte.161.15.1844","article-title":"Better psychological functioning and higher social status may largely explain the apparent health benefits of wine: a study of wine and beer drinking in young Danish adults","volume":"161","author":"Mortensen","year":"2001","journal-title":"Arch Intern Med"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523272287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523272287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/102\/6\/1534\/23758015\/ajcn118976.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:56:43Z","timestamp":1685361403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523272287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0002916523272287"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.115.118976","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.115.118976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}