{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:05:37Z","timestamp":1792479937936,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":2543,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["127000-MRSG-14-157-01-CCE"],"award-info":[{"award-number":["127000-MRSG-14-157-01-CCE"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.3945\/ajcn.115.124586","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T20:32:20Z","timestamp":1455222740000},"page":"808-817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":152,"title":["Association of body mass index and survival in pediatric leukemia: a meta-analysis"],"prefix":"10.1016","volume":"103","author":[{"given":"Etan","family":"Orgel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine M","family":"Genkinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena J","family":"Ladas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.115.124586_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"10.3945\/ajcn.115.124586_bib2","series-title":"Advance data from vital and health statistics","article-title":"CDC growth charts: United States","author":"Kuczmarski","year":"2000"},{"key":"10.3945\/ajcn.115.124586_bib3","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.115.124586_bib4","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/ijc.23176","article-title":"Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies","volume":"122","author":"Larsson","year":"2008","journal-title":"Int J Cancer"},{"key":"10.3945\/ajcn.115.124586_bib5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.leukres.2011.12.020","article-title":"Obesity but not overweight increases the incidence and mortality of leukemia in adults: a meta-analysis of prospective cohort studies","volume":"36","author":"Castillo","year":"2012","journal-title":"Leuk Res"},{"key":"10.3945\/ajcn.115.124586_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/jama.293.2.203","article-title":"Mortality in overweight and underweight children with acute myeloid leukemia","volume":"293","author":"Lange","year":"2005","journal-title":"JAMA"},{"key":"10.3945\/ajcn.115.124586_bib7","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1200\/JCO.2006.07.7792","article-title":"Obesity and outcome in pediatric acute lymphoblastic leukemia","volume":"25","author":"Butturini","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.3945\/ajcn.115.124586_bib8","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/oby.2011.195","article-title":"Overweight as a prognostic factor in children with acute lymphoblastic leukemia","volume":"19","author":"Gelelete","year":"2011","journal-title":"Obesity"},{"key":"10.3945\/ajcn.115.124586_bib9","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2006-05-024414","article-title":"Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia","volume":"108","author":"Hijiya","year":"2006","journal-title":"Blood"},{"key":"10.3945\/ajcn.115.124586_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/MPH.0000000000000056","article-title":"Prognostic significance of being overweight and obese at diagnosis in children with acute lymphoblastic leukemia","volume":"36","author":"Aldhafiri","year":"2014","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.3945\/ajcn.115.124586_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.mph.0000212985.33941.d8","article-title":"Obesity and survival in a cohort of predominantly Hispanic children with acute lymphoblastic leukemia","volume":"28","author":"Baillargeon","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.3945\/ajcn.115.124586_bib12","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3109\/10428194.2012.664843","article-title":"Association between obesity at diagnosis and weight change during induction and survival in pediatric acute lymphoblastic leukemia","volume":"53","author":"Ethier","year":"2012","journal-title":"Leuk Lymphoma"},{"key":"10.3945\/ajcn.115.124586_bib13","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1200\/JCO.2013.52.6962","article-title":"Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: a report from the Children\u2019s Oncology Group","volume":"32","author":"Orgel","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.3945\/ajcn.115.124586_bib14","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1182\/blood-2014-08-595389","article-title":"Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia","volume":"124","author":"Orgel","year":"2014","journal-title":"Blood"},{"key":"10.3945\/ajcn.115.124586_bib15","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1200\/JCO.2006.06.2539","article-title":"High body mass index increases the risk for osteonecrosis in children with acute lymphoblastic leukemia","volume":"25","author":"Niinim\u00e4ki","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.3945\/ajcn.115.124586_bib16","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1002\/cncr.28342","article-title":"Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent\/young adult and younger patients: a report from the Children\u2019s Oncology Group","volume":"119","author":"Canner","year":"2013","journal-title":"Cancer"},{"key":"10.3945\/ajcn.115.124586_bib17","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1002\/cncr.27640","article-title":"Effect of body mass index on the outcome of children with acute myeloid leukemia","volume":"118","author":"Inaba","year":"2012","journal-title":"Cancer"},{"key":"10.3945\/ajcn.115.124586_bib18","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1182\/blood-2007-04-084293","article-title":"Outcomes in CCG-2961, a children\u2019s oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children\u2019s oncology group","volume":"111","author":"Lange","year":"2008","journal-title":"Blood"},{"key":"10.3945\/ajcn.115.124586_bib19","article-title":"Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis","author":"Amankwah","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"10.3945\/ajcn.115.124586_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/pbc.21889","article-title":"Treatment strategies and regimens of graduated intensity for childhood acute lymphoblastic leukemia in low-income countries: a proposal","volume":"52","author":"Hunger","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.3945\/ajcn.115.124586_bib21","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ejcn.2014.122","article-title":"An international survey of nutritional practices in low- and middle-income countries: a report from the International Society of Pediatric Oncology (SIOP) PODC Nutrition Working Group","volume":"68","author":"Murphy","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/ajcn.115.124586_bib22","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"10.3945\/ajcn.115.124586_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1200\/JCO.1996.14.1.18","article-title":"Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia","volume":"14","author":"Smith","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.3945\/ajcn.115.124586_bib24","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"Global patterns of cancer incidence and mortality rates and trends","volume":"19","author":"Jemal","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.3945\/ajcn.115.124586_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Group P-P. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.3945\/ajcn.115.124586_bib26","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1200\/JCO.2014.57.1034","article-title":"The leukemias: a half-century of discovery","volume":"32","author":"Freireich","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.3945\/ajcn.115.124586_bib27","year":"2015","journal-title":"The World Bank report on high income countries [Internet]"},{"key":"10.3945\/ajcn.115.124586_bib28","series-title":"Cochrane handbook for systematic reviews of interventions Version 5.1.0 [updated March 2011] The Cochrane Collaboration","year":"2011"},{"key":"10.3945\/ajcn.115.124586_bib29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.3945\/ajcn.115.124586_bib30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2307\/2532893","article-title":"Meta-analysis of published data using a linear mixed-effects model","volume":"52","author":"Stram","year":"1996","journal-title":"Biometrics"},{"key":"10.3945\/ajcn.115.124586_bib31","year":"2015","journal-title":"Quality assessment tool for observational cohort and cross-sectional studies [Internet]"},{"key":"10.3945\/ajcn.115.124586_bib32","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis","volume":"54","author":"Sterne","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"10.3945\/ajcn.115.124586_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/jrsm.1095","article-title":"Meta-regression approximations to reduce publication selection bias","volume":"5","author":"Stanley","year":"2014","journal-title":"Res Synth Methods"},{"key":"10.3945\/ajcn.115.124586_bib34","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/pbc.24420","article-title":"Children\u2019s Oncology Group\u2019s 2013 blueprint for research: acute lymphoblastic leukemia","volume":"60","author":"Hunger","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.3945\/ajcn.115.124586_bib35","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1182\/blood-2012-02-408336","article-title":"Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children\u2019s Oncology Group","volume":"120","author":"Loken","year":"2012","journal-title":"Blood"},{"key":"10.3945\/ajcn.115.124586_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.phrs.2010.01.007","article-title":"Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice","volume":"61","author":"Behan","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.3945\/ajcn.115.124586_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00280-008-0854-z","article-title":"Impact of body composition on pharmacokinetics of doxorubicin in children: a Glaser Pediatric Research Network study","volume":"64","author":"Thompson","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.3945\/ajcn.115.124586_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00007691-199101000-00004","article-title":"Fat body mass and pharmacokinetics of oral 6-mercaptopurine in children with acute lymphoblastic leukemia","volume":"13","author":"Zuccaro","year":"1991","journal-title":"Ther Drug Monit"},{"key":"10.3945\/ajcn.115.124586_bib39","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3109\/10428194.2012.717278","article-title":"Influence of obesity on efficacy and toxicity of induction chemotherapy in patients with newly diagnosed acute myeloid leukemia","volume":"54","author":"Lin","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"10.3945\/ajcn.115.124586_bib40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/ajh.23530","article-title":"Outcomes in obese and overweight acute myeloid leukemia patients receiving chemotherapy dosed according to actual body weight","volume":"88","author":"Wenzell","year":"2013","journal-title":"Am J Hematol"},{"key":"10.3945\/ajcn.115.124586_bib41","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3324\/haematol.2011.056390","article-title":"Impact of body-mass index on the outcome of adult patients with acute myeloid leukemia","volume":"97","author":"Medeiros","year":"2012","journal-title":"Haematologica"},{"key":"10.3945\/ajcn.115.124586_bib42","doi-asserted-by":"crossref","first-page":"632461","DOI":"10.1155\/2013\/632461","article-title":"A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors","volume":"2013","author":"Westley","year":"2013","journal-title":"Int J Endocrinol"},{"key":"10.3945\/ajcn.115.124586_bib43","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1158\/0008-5472.CAN-06-4237","article-title":"The obesity-cancer link: lessons learned from a fatless mouse","volume":"67","author":"Hursting","year":"2007","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.115.124586_bib44","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1182\/blood-2011-06-362830","article-title":"Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies","volume":"119","author":"Castillo","year":"2012","journal-title":"Blood"},{"key":"10.3945\/ajcn.115.124586_bib45","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1002\/ijc.24225","article-title":"Birth weight and childhood leukemia: a meta-analysis and review of the current evidence","volume":"124","author":"Caughey","year":"2009","journal-title":"Int J Cancer"},{"key":"10.3945\/ajcn.115.124586_bib46","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.1158\/0008-5472.CAN-09-0800","article-title":"Adipocytes impair leukemia treatment in mice","volume":"69","author":"Behan","year":"2009","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.115.124586_bib47","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1158\/0008-5472.CAN-12-4402","article-title":"Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine","volume":"73","author":"Ehsanipour","year":"2013","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.115.124586_bib48","first-page":"584","article-title":"Leptin in human acute myelogenous leukemia: studies of in vivo levels and in vitro effects on native functional leukemia blasts","volume":"87","author":"Bruserud","year":"2002","journal-title":"Haematologica"},{"key":"10.3945\/ajcn.115.124586_bib49","doi-asserted-by":"crossref","first-page":"139239","DOI":"10.1155\/2013\/139239","article-title":"Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines","volume":"2013","author":"Makki","year":"2013","journal-title":"ISRN inflamm"},{"key":"10.3945\/ajcn.115.124586_bib50","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/jama.2011.163","article-title":"Index event bias as an explanation for the paradoxes of recurrence risk research","volume":"305","author":"Dahabreh","year":"2011","journal-title":"JAMA"},{"key":"10.3945\/ajcn.115.124586_bib51","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jclinepi.2012.06.023","article-title":"Index event bias-a numerical example","volume":"66","author":"Smits","year":"2013","journal-title":"J Clin Epidemiol"},{"key":"10.3945\/ajcn.115.124586_bib52","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1200\/JCO.2014.58.4680","article-title":"American society of clinical oncology position statement on obesity and cancer","volume":"32","author":"Ligibel","year":"2014","journal-title":"J Clin Oncol"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522065674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522065674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/103\/3\/808\/28753020\/ajcn124586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T02:32:04Z","timestamp":1685759524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522065674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0002916522065674"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.115.124586","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of body mass index and survival in pediatric leukemia: a meta-analysis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.115.124586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}