{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:48:08Z","timestamp":1777571288719,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":2453,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3945\/ajcn.115.126342","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T04:18:49Z","timestamp":1463026729000},"page":"1417-1425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease"],"prefix":"10.1016","volume":"103","author":[{"given":"Arve","family":"Ulvik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva R","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gard FT","family":"Svingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"McCann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ivind","family":"Midttun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottar","family":"Nyg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per M","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.115.126342_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/1471-2105-10-273","article-title":"The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families","volume":"10","author":"Percudani","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.3945\/ajcn.115.126342_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MCO.0b013e328349f9a7","article-title":"Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans","volume":"14","author":"Lamers","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"Suppl 11","key":"10.3945\/ajcn.115.126342_bib3","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/jn\/120.suppl_11.1503","article-title":"Vitamin B-6: a status report","volume":"120","author":"Leklem","year":"1990","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.115.126342_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-nutr-071714-034330","article-title":"Direct and functional biomarkers of vitamin B6 status","volume":"35","author":"Ueland","year":"2015","journal-title":"Annu Rev Nutr"},{"key":"10.3945\/ajcn.115.126342_bib5","first-page":"208","article-title":"Prevention of myocardial infarction by vitamin B6","volume":"89","author":"Ellis","year":"1995","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"10.3945\/ajcn.115.126342_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/jama.279.5.359","article-title":"Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women","volume":"279","author":"Rimm","year":"1998","journal-title":"JAMA"},{"key":"10.3945\/ajcn.115.126342_bib7","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/sj.ejcn.1601960","article-title":"Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy","volume":"58","author":"Tavani","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/01.CIR.98.3.204","article-title":"Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study","volume":"98","author":"Folsom","year":"1998","journal-title":"Circulation"},{"key":"10.3945\/ajcn.115.126342_bib9","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/ajcn\/79.6.992","article-title":"Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk","volume":"79","author":"Friso","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/01.STR.0000106481.59944.2F","article-title":"Inflammation, homocysteine, and vitamin B6 status after ischemic stroke","volume":"35","author":"Kelly","year":"2004","journal-title":"Stroke"},{"key":"10.3945\/ajcn.115.126342_bib11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.CIR.97.5.437","article-title":"Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group","volume":"97","author":"Robinson","year":"1998","journal-title":"Circulation"},{"key":"10.3945\/ajcn.115.126342_bib12","doi-asserted-by":"crossref","first-page":"R1254","DOI":"10.1186\/ar1821","article-title":"Inflammation causes tissue-specific depletion of vitamin B6","volume":"7","author":"Chiang","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.3945\/ajcn.115.126342_bib13","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1161\/01.CIR.103.23.2788","article-title":"Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels","volume":"103","author":"Friso","year":"2001","journal-title":"Circulation"},{"key":"10.3945\/ajcn.115.126342_bib14","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3945\/jn.111.153056","article-title":"Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults","volume":"142","author":"Sakakeeny","year":"2012","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.115.126342_bib15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/ajcn\/81.3.725","article-title":"Low plasma pyridoxal-5\u2032phosphate and cardiovascular disease risk in women: results from the Coronary Risk Factors for Atherosclerosis in Women Study","volume":"81","author":"Dierkes","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/ajcn\/86.1.214","article-title":"Plasma pyridoxal-5-phosphate and future risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition Potsdam cohort","volume":"86","author":"Dierkes","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib17","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1161\/CIRCULATIONAHA.108.809038","article-title":"Plasma vitamin B(6) and risk of myocardial infarction in women","volume":"120","author":"Page","year":"2009","journal-title":"Circulation"},{"key":"10.3945\/ajcn.115.126342_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/nure.12014","article-title":"Mechanistic perspective on the relationship between pyridoxal 5\u2032-phosphate and inflammation","volume":"71","author":"Paul","year":"2013","journal-title":"Nutr Rev"},{"key":"10.3945\/ajcn.115.126342_bib19","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3945\/ajcn.111.029751","article-title":"Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris","volume":"95","author":"Ulvik","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3945\/ajcn.114.083196","article-title":"Evidence for increased catabolism of vitamin B-6 during systemic inflammation","volume":"100","author":"Ulvik","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib21","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1161\/ATVBAHA.108.179713","article-title":"The discovery of cellular immunity in the atherosclerotic plaque","volume":"29","author":"Hansson","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3945\/ajcn.115.126342_bib22","doi-asserted-by":"crossref","first-page":"456S","DOI":"10.1093\/ajcn\/83.2.456S","article-title":"Inflammation and cardiovascular disease mechanisms","volume":"83","author":"Libby","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126342_bib23","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1161\/ATVBAHA.110.219329","article-title":"Systemic markers of interferon-\u03b3-mediated immune activation and long-term prognosis in patients with stable coronary artery disease","volume":"31","author":"Pedersen","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3945\/ajcn.115.126342_bib24","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1038\/srep03426","article-title":"Network analysis reveals functional cross-links between disease and inflammation genes","volume":"3","author":"Zhang","year":"2013","journal-title":"Sci Rep"},{"key":"10.3945\/ajcn.115.126342_bib25","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/ijc.29345","article-title":"Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study","volume":"136","author":"Zuo","year":"2015","journal-title":"Int J Cancer"},{"key":"10.3945\/ajcn.115.126342_bib26","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"B\u00f8naa","year":"2006","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.115.126342_bib27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.300.7.795","article-title":"Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial","volume":"300","author":"Ebbing","year":"2008","journal-title":"JAMA"},{"key":"10.3945\/ajcn.115.126342_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2796.2010.02259.x","article-title":"Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials","volume":"268","author":"Ebbing","year":"2010","journal-title":"J Intern Med"},{"key":"10.3945\/ajcn.115.126342_bib29","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2105\/AJPH.77.11.1435","article-title":"Comparison of tests used to distinguish smokers from nonsmokers","volume":"77","author":"Jarvis","year":"1987","journal-title":"Am J Public Health"},{"key":"10.3945\/ajcn.115.126342_bib30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.3945\/ajcn.115.126342_bib31","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/ATVBAHA.113.301714","article-title":"Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris","volume":"33","author":"Svingen","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3945\/ajcn.115.126342_bib32","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/rcm.4013","article-title":"Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography\/tandem mass spectrometry","volume":"23","author":"Midttun","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.3945\/ajcn.115.126342_bib33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1177\/2047487314529351","article-title":"Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease","volume":"22","author":"Svingen","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"10.3945\/ajcn.115.126342_bib34","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1002\/sim.5762","article-title":"Model selection in competing risks regression","volume":"32","author":"Kuk","year":"2013","journal-title":"Stat Med"},{"key":"10.3945\/ajcn.115.126342_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1179\/135100007X162167","article-title":"Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2\/ARE transcription pathway","volume":"12","author":"Siow","year":"2007","journal-title":"Redox Rep"},{"key":"10.3945\/ajcn.115.126342_bib36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.gene.2012.06.010","article-title":"Aldehyde oxidase 1 gene is regulated by Nrf2 pathway","volume":"505","author":"Maeda","year":"2012","journal-title":"Gene"},{"key":"10.3945\/ajcn.115.126342_bib37","doi-asserted-by":"crossref","first-page":"878030","DOI":"10.1155\/2012\/878030","article-title":"Nrf2\/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS","volume":"2012","author":"Petri","year":"2012","journal-title":"Neurol Res Int"},{"key":"10.3945\/ajcn.115.126342_bib38","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/bj0480333","article-title":"The enzymic oxidation of pyridoxal by liver aldehyde oxidase","volume":"48","author":"Schwartz","year":"1951","journal-title":"Biochem J"},{"key":"10.3945\/ajcn.115.126342_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1479-7364-4-2-119","article-title":"The mammalian aldehyde oxidase gene family","volume":"4","author":"Garattini","year":"2009","journal-title":"Hum Genomics"},{"key":"10.3945\/ajcn.115.126342_bib40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/cvr\/cvq192","article-title":"Mitochondrial aldehyde dehydrogenase and cardiac diseases","volume":"88","author":"Chen","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.3945\/ajcn.115.126342_bib41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/1479-7364-5-4-283","article-title":"Update on the aldehyde dehydrogenase gene (ALDH) superfamily","volume":"5","author":"Jackson","year":"2011","journal-title":"Hum Genomics"},{"key":"10.3945\/ajcn.115.126342_bib42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1179\/1351000213Y.0000000044","article-title":"Redox regulation of the immune response","volume":"18","author":"Gostner","year":"2013","journal-title":"Redox Rep"},{"key":"10.3945\/ajcn.115.126342_bib43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/CS20140392","article-title":"Role of indoleamine 2,3-dioxygenase in health and disease","volume":"129","author":"Yeung","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"10.3945\/ajcn.115.126342_bib44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0014-5793(93)80627-7","article-title":"Neopterin modulates toxicity mediated by reactive oxygen and chloride species","volume":"321","author":"Weiss","year":"1993","journal-title":"FEBS Lett"},{"key":"10.3945\/ajcn.115.126342_bib45","first-page":"559","article-title":"Role of prostaglandins in the stimulation of the hypothalamic-pituitary-adrenal axis by adrenergic and neurohormone systems","volume":"47","author":"Bugajski","year":"1996","journal-title":"J Physiol Pharmacol"},{"key":"10.3945\/ajcn.115.126342_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF03349862","article-title":"Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1 beta, TNF alpha and IL-6: a dose response study","volume":"19","author":"van der Meer","year":"1996","journal-title":"J Endocrinol Invest"},{"key":"10.3945\/ajcn.115.126342_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1096\/fasebj.8.3.8143940","article-title":"Modulation of steroid receptor-mediated gene expression by vitamin B6","volume":"8","author":"Tully","year":"1994","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.115.126342_bib48","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/1523-1747.ep12337529","article-title":"Endothelial cell surface alkaline phosphatase activity is induced by IL-6 released during wound repair","volume":"109","author":"Gallo","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.3945\/ajcn.115.126342_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2613.2003.00345.x","article-title":"Induction of glomerular alkaline phosphatase after challenge with lipopolysaccharide","volume":"84","author":"Kapojos","year":"2003","journal-title":"Int J Exp Pathol"},{"key":"10.3945\/ajcn.115.126342_bib50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0021-9150(87)90126-2","article-title":"Vitamin B6 and coronary artery disease. Epidemiological observations and case studies","volume":"63","author":"Vermaak","year":"1987","journal-title":"Atherosclerosis"},{"key":"10.3945\/ajcn.115.126342_bib51","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1373\/clinchem.2009.137513","article-title":"Long- and short-term effects of tobacco smoking on circulating concentrations of B vitamins","volume":"56","author":"Ulvik","year":"2010","journal-title":"Clin Chem"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523041680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523041680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/103\/6\/1417\/23768170\/ajcn126342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T09:57:27Z","timestamp":1718531847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523041680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0002916523041680"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.115.126342","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.115.126342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}