{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:00:29Z","timestamp":1790330429590,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":2453,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3945\/ajcn.115.126714","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T02:22:27Z","timestamp":1459390947000},"page":"1489-1496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial"],"prefix":"10.1016","volume":"103","author":[{"given":"Beverly S","family":"Muhlhausler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa N","family":"Yelland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Tapsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McPhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Makrides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.115.126714_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming","volume":"85","author":"McMillen","year":"2005","journal-title":"Physiol Rev"},{"key":"10.3945\/ajcn.115.126714_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tem.2008.10.006","article-title":"Early-life origins of metabolic dysfunction: role of the adipocyte","volume":"20","author":"Muhlhausler","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"10.3945\/ajcn.115.126714_bib3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1139\/cjpp-2012-0353","article-title":"Nutritional approaches to breaking the intergenerational cycle of obesity","volume":"91","author":"Muhlhausler","year":"2013","journal-title":"Can J Physiol Pharmacol"},{"key":"10.3945\/ajcn.115.126714_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000209267","article-title":"The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development. Rationale and design of the INFAT study","volume":"54","author":"Hauner","year":"2009","journal-title":"Ann Nutr Metab"},{"key":"10.3945\/ajcn.115.126714_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1203\/01.PDR.0000169978.92437.58","article-title":"Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life","volume":"58","author":"Lauritzen","year":"2005","journal-title":"Pediatr Res"},{"key":"10.3945\/ajcn.115.126714_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20070456","article-title":"Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism","volume":"116","author":"Flachs","year":"2009","journal-title":"Clin Sci"},{"key":"10.3945\/ajcn.115.126714_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.plipres.2006.01.003","article-title":"Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity","volume":"45","author":"Ailhaud","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.3945\/ajcn.115.126714_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.beem.2005.07.005","article-title":"Nutrition-\/diet-induced changes in gene expression in white adipose tissue","volume":"19","author":"Al-Hasani","year":"2005","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.115.126714_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbadis.2005.03.001","article-title":"Regulation of adipocyte differentiation and function by polyunsaturated fatty acids","volume":"1740","author":"Masden","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.3945\/ajcn.115.126714_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1172\/JCI28003","article-title":"PPAR{gamma} and human metabolic disease","volume":"116","author":"Semple","year":"2006","journal-title":"J Clin Invest"},{"key":"10.3945\/ajcn.115.126714_bib11","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ejcn.2013.197","article-title":"Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management","volume":"67","author":"Gray","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/ajcn.115.126714_bib12","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3945\/ajcn.2010.29495","article-title":"Effect of long-chain polyunsaturated fatty acid supplementation during pregnancy or lactation on infant and child body composition: a systematic review","volume":"92","author":"Muhlhausler","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126714_bib13","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1001\/jama.2010.1507","article-title":"Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial","volume":"304","author":"Makrides","year":"2010","journal-title":"JAMA"},{"key":"10.3945\/ajcn.115.126714_bib14","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/oby.20150","article-title":"Pro12Ala variant of the PPARG2 gene increases body mass index: an updated meta-analysis encompassing 49,092 subjects","volume":"21","author":"Galbete","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.3945\/ajcn.115.126714_bib15","series-title":"WHO Child Growth Standards: length\/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development","year":"2006"},{"key":"10.3945\/ajcn.115.126714_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents","volume":"85","author":"de Onis","year":"2007","journal-title":"Bull World Health Organ"},{"key":"10.3945\/ajcn.115.126714_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/ajcn\/70.5.847","article-title":"Measurement of body water by multifrequency bioelectrical impedance spectroscopy in a multiethnic pediatric population","volume":"70","author":"Ellis","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126714_bib18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/ajcn\/56.5.835","article-title":"Is the impedance index (ht2\/R) significant in predicting total body water?","volume":"56","author":"Kushner","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.115.126714_bib19","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1152\/jappl.1993.75.4.1776","article-title":"Estimating body composition of young children by using bioelectrical resistance","volume":"75","author":"Goran","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.3945\/ajcn.115.126714_bib20","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/sj.ejcn.1600446","article-title":"Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants","volume":"51","author":"Gibson","year":"1997","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/ajcn.115.126714_bib21","series-title":"Multiple imputation for nonresponse in surveys","author":"Rubin","year":"1987"},{"key":"10.3945\/ajcn.115.126714_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.5694\/mja11.11080","article-title":"Nutrient intakes and status of preschool children in Adelaide, South Australia","volume":"196","author":"Zhou","year":"2012","journal-title":"Med J Aust"},{"key":"10.3945\/ajcn.115.126714_bib23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1034-4810.2004.00401.x","article-title":"Increasing prevelence of obesity in South Australian 4-year olds: 1995-2002","volume":"40","author":"Vaska","year":"2004","journal-title":"J Paediatr Child Health"},{"key":"10.3945\/ajcn.115.126714_bib24","doi-asserted-by":"crossref","first-page":"e15186","DOI":"10.1371\/journal.pone.0015186","article-title":"Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15","volume":"5","author":"Howe","year":"2010","journal-title":"PLoS One"},{"key":"10.3945\/ajcn.115.126714_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1139\/H10-076","article-title":"Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARgamma mRNA, in 3T3-L1 adipocytes","volume":"35","author":"Oster","year":"2010","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.3945\/ajcn.115.126714_bib26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1677\/jme.1.01909","article-title":"Defining high-fat-diet rat models: metabolic and molecular effects of different fat types","volume":"36","author":"Buettner","year":"2006","journal-title":"J Mol Endocrinol"},{"key":"10.3945\/ajcn.115.126714_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/aje\/kwp450","article-title":"The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis","volume":"171","author":"Gouda","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.3945\/ajcn.115.126714_bib28","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1001\/jama.2014.2194","article-title":"Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation","volume":"311","author":"Makrides","year":"2014","journal-title":"JAMA"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523041771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523041771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/103\/6\/1489\/23768190\/ajcn126714.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T07:25:49Z","timestamp":1685431549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523041771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0002916523041771"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.115.126714","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.115.126714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}