{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:37:30Z","timestamp":1786243050450,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":2322,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3945\/ajcn.116.130633","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T02:18:55Z","timestamp":1473301135000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Growth of infants consuming whey-predominant term infant formulas with a protein content of 1.8 g\/100 kcal: a multicenter pooled analysis of individual participant data"],"prefix":"10.1016","volume":"104","author":[{"given":"Dominik D","family":"Alexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C","family":"Bylsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S","family":"Northington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Grathwohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Steenhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Erdmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Spivey-Krobath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Haschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.3945\/ajcn.116.130633_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1467-789X.2007.00318.x","article-title":"Breastfeeding, early growth and later obesity","volume":"8","author":"Singhal","year":"2007","journal-title":"Obes Rev"},{"key":"10.3945\/ajcn.116.130633_bib2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archpedi.158.5.449","article-title":"Identifying children at high risk for overweight at school entry by weight gain during the first 2 years","volume":"158","author":"Toschke","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.3945\/ajcn.116.130633_bib3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.ijo.0803659","article-title":"Nature and strength of epidemiological evidence for origins of childhood and adulthood obesity in the first year of life","volume":"31","author":"Stettler","year":"2007","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/ajcn.116.130633_bib4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.earlhumdev.2007.09.002","article-title":"The programming effects of early growth","volume":"83","author":"Wells","year":"2007","journal-title":"Early Hum Dev"},{"key":"10.3945\/ajcn.116.130633_bib5","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3945\/ajcn.113.064071","article-title":"Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial","volume":"99","author":"Weber","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.130633_bib6","doi-asserted-by":"crossref","first-page":"1502S","DOI":"10.3945\/ajcn.2009.27113D","article-title":"Can infant feeding choices modulate later obesity risk?","volume":"89","author":"Koletzko","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.130633_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1467-789X.2010.00735.x","article-title":"Early-life determinants of overweight and obesity: a review of systematic reviews","volume":"11","author":"Monasta","year":"2010","journal-title":"Obes Rev"},{"key":"10.3945\/ajcn.116.130633_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/MPG.0000000000000349","article-title":"Low-protein formula slows weight gain in infants of overweight mothers","volume":"59","author":"Inostroza","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.116.130633_bib9","doi-asserted-by":"crossref","first-page":"712S","DOI":"10.3945\/ajcn.113.071993","article-title":"Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas","volume":"99","author":"L\u00f6nnerdal","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.130633_bib10","series-title":"Process for treatment of a lactic raw materials. Treatment of lactic materials","author":"Erdmann","year":"2014"},{"key":"10.3945\/ajcn.116.130633_bib11","series-title":"Title 21: food and drugs","year":"2015"},{"key":"10.3945\/ajcn.116.130633_bib12","series-title":"CODEX alimentarius: standard for infant formula and formulas for special medical purposes intended for infants. Revised standard for infant formula","year":"1981"},{"key":"10.3945\/ajcn.116.130633_bib13","unstructured":"European Union. Commission Delegated Regulation (EU) 2016\/127. Official Journal of the European Union 2016;59"},{"key":"10.3945\/ajcn.116.130633_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00005176-200209000-00008","article-title":"Whey predominant, whey modified infant formula with protein\/energy ratio of 1.8 g\/100 kcal: adequate and safe for term infants from birth to four months","volume":"35","author":"R\u00e4ih\u00e4","year":"2002","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.116.130633_bib15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/MPG.0b013e3181fb9e80","article-title":"Supplementation of infant formula with probiotics and\/or prebiotics: a systematic review and comment by the ESPGHAN committee on nutrition","volume":"52","author":"Braegger","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.116.130633_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000342559","article-title":"Evaluation of growth and early infant feeding: a challenge for scientists, industry and regulatory bodies","volume":"106","author":"Haschke","year":"2013","journal-title":"World Rev Nutr Diet"},{"key":"10.3945\/ajcn.116.130633_bib17","series-title":"Postnatal high protein intake can contribute to accelerated weight gain of infants and increased obesity risk","author":"Haschke","year":"2016"},{"key":"10.3945\/ajcn.116.130633_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/28.1.1","article-title":"Traditional reviews, meta-analyses and pooled analyses in epidemiology","volume":"28","author":"Blettner","year":"1999","journal-title":"Int J Epidemiol"},{"key":"10.3945\/ajcn.116.130633_bib19","series-title":"WHO child growth standards: length\/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age, methods and development","year":"2006"},{"issue":"1","key":"10.3945\/ajcn.116.130633_bib20","doi-asserted-by":"crossref","first-page":"e003735","DOI":"10.1136\/bmjopen-2013-003735","article-title":"Worldwide variation in human growth and the World Health Organization growth standards: a systematic review","volume":"4","author":"Natale","year":"2014","journal-title":"BMJ Open"},{"key":"10.3945\/ajcn.116.130633_bib21","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.2015.3656","article-title":"Preferred reporting items for systematic review and meta-analyses of individual participant data: the PRISMA-IPD statement","volume":"313","author":"Stewart","year":"2015","journal-title":"JAMA"},{"key":"10.3945\/ajcn.116.130633_bib22","first-page":"56","article-title":"Assessment of differences in linear growth among populations in the WHO Multicentre Growth Reference Study","volume":"450","year":"2006","journal-title":"Acta Paediatr Suppl"},{"key":"10.3945\/ajcn.116.130633_bib23","first-page":"165","article-title":"An evaluation of infant growth: the use and interpretation of anthropometry in infants","volume":"73","year":"1995","journal-title":"Bull World Health Organ"},{"key":"10.3945\/ajcn.116.130633_bib24","series-title":"Clinical testing of infant formulas with respect to nutritonal suitability for term infants","year":"1988"},{"key":"10.3945\/ajcn.116.130633_bib25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ajcn\/83.2.324","article-title":"Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES)","volume":"83","author":"Ekelund","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.130633_bib26","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1080\/08035250600719754","article-title":"Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions","volume":"95","author":"Ong","year":"2006","journal-title":"Acta Paediatr"},{"key":"10.3945\/ajcn.116.130633_bib27","first-page":"388","article-title":"Growth and tolerance of a whey-based starter infant formula with enhanced protein efficiency and containing Pro-, Pre-, or synbiotics. A randomized controlled trial in term infants","volume":"37","author":"Barclay","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.116.130633_bib28","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1017\/S0007114508084080","article-title":"Safety of supplementing infant formula with long-chain polyunsaturated fatty acids and Bifidobacterium lactis in term infants: a randomised controlled trial","volume":"101","author":"Gibson","year":"2009","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.116.130633_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2006.09.007","article-title":"Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics","volume":"23","author":"Puccio","year":"2007","journal-title":"Nutrition"},{"key":"10.3945\/ajcn.116.130633_bib30","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/ajcn\/87.5.1365","article-title":"Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial","volume":"87","author":"Chouraqui","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.130633_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12519-015-0025-3","article-title":"Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants","volume":"12","author":"Wu","year":"2016","journal-title":"World J Pediatr"},{"key":"10.3945\/ajcn.116.130633_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S0007114515004456","article-title":"Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study)","volume":"115","author":"Putet","year":"2016","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.116.130633_bib33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/MPG.0b013e3182105850","article-title":"Effect of formula composition on the development of infant gut microbiota","volume":"52","author":"Hasco\u00ebt","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.116.130633_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12887-014-0306-3","article-title":"Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial","volume":"14","author":"Meli","year":"2014","journal-title":"BMC Pediatr"},{"key":"10.3945\/ajcn.116.130633_bib35","unstructured":"Cooper PA, Bolton KD, Velaphi SC, Pecquet SS, Steenhout PG. Normal growth of infants born from HIV + mothers, after normal or caesarean delivery, fed a pre and probiotics supplemented starter formula. The European Society for Paediatric Gastroenterology Hepatology and Nutrition Amsterdam, 2015."},{"key":"10.3945\/ajcn.116.130633_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4137\/CMPed.S33096","article-title":"Effect of infant formula containing a low dose of the probiotic Bifidobacterium lactis CNCM I-3446 on immune and gut functions in C-section delivered babies: a pilot study","volume":"10","author":"Baglatzi","year":"2016","journal-title":"Clin Med Insights Pediatr"},{"key":"10.3945\/ajcn.116.130633_bib37","doi-asserted-by":"crossref","first-page":"e59569","DOI":"10.1371\/journal.pone.0059569","article-title":"Construction of a new growth references for China based on urban Chinese children: comparison with the WHO growth standards","volume":"8","author":"Zong","year":"2013","journal-title":"PLoS One"},{"key":"10.3945\/ajcn.116.130633_bib38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1471-2431-13-185","article-title":"Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials","volume":"13","author":"Szajewska","year":"2013","journal-title":"BMC Pediatr"},{"issue":"Suppl 1","key":"10.3945\/ajcn.116.130633_bib39","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00005176-200007001-00002","article-title":"The Euro-Growth Study: why, who, and how","volume":"31","author":"van\u2019t Hof","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/ajcn.116.130633_bib40","first-page":"3","article-title":"Obesity prevention: is the protein intake in infants too high? The Nestle Nutrition Institute Newsletter","volume":"7","author":"Ziegler","year":"2013","journal-title":"South East Asia and Pacific Rim"},{"key":"10.3945\/ajcn.116.130633_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000363510","article-title":"Role of dietary fats in the prevention and treatment of the metabolic syndrome","volume":"64","author":"Nettleton","year":"2014","journal-title":"Ann Nutr Metab"},{"key":"10.3945\/ajcn.116.130633_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-3016.2011.01213.x","article-title":"Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis","volume":"26","author":"Druet","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.3945\/ajcn.116.130633_bib43","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jpeds.2004.06.069","article-title":"Feeding effects on growth during infancy","volume":"145","author":"Kramer","year":"2004","journal-title":"J Pediatr"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522046330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522046330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/104\/4\/1083\/24257425\/ajcn130633.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:02:57Z","timestamp":1685361777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522046330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0002916522046330"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.116.130633","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth of infants consuming whey-predominant term infant formulas with a protein content of 1.8 g\/100 kcal: a multicenter pooled analysis of individual participant data","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.116.130633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}