{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:52:45Z","timestamp":1761519165353,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":2351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Canadian Gene Cure Foundation"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research Institute of Genetics","doi-asserted-by":"publisher","award":["703058"],"award-info":[{"award-number":["703058"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Province of Ontario Graduate Scholarship"},{"name":"Enid Walker Graduate Student Award in Women\u2019s Health Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.3945\/ajcn.116.133470","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T03:09:04Z","timestamp":1469675344000},"page":"671-677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study,"],"prefix":"10.1016","volume":"104","author":[{"given":"Shana J","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zuchniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung-Jin","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Demsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad R","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-In","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Narod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Kotsopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.116.133470_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/mnfr.200600191","article-title":"Folate and colorectal cancer: an evidence-based critical review","volume":"51","author":"Kim","year":"2007","journal-title":"Mol Nutr Food Res"},{"key":"10.3945\/ajcn.116.133470_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00043798-199808000-00003","article-title":"Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry","volume":"5","author":"Scott","year":"1998","journal-title":"J Cardiovasc Risk"},{"key":"10.3945\/ajcn.116.133470_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0027-5107(01)00070-7","article-title":"DNA damage from micronutrient deficiencies is likely to be a major cause of cancer","volume":"475","author":"Ames","year":"2001","journal-title":"Mutat Res"},{"key":"10.3945\/ajcn.116.133470_bib4","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s10552-012-0022-y","article-title":"Folate and breast cancer: what about high-risk women?","volume":"23","author":"Kotsopoulos","year":"2012","journal-title":"Cancer Causes Control"},{"key":"10.3945\/ajcn.116.133470_bib5","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1038\/bjc.2014.155","article-title":"Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis","volume":"110","author":"Chen","year":"2014","journal-title":"Br J Cancer"},{"key":"10.3945\/ajcn.116.133470_bib6","doi-asserted-by":"crossref","first-page":"e100044","DOI":"10.1371\/journal.pone.0100044","article-title":"Folate intake and the risk of breast cancer: a dose-response meta-analysis of prospective studies","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/ajcn.116.133470_bib7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.3945\/ajcn.116.133470_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nrclinonc.2010.166","article-title":"BRCA mutations in the management of breast cancer: the state of the art","volume":"7","author":"Narod","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.3945\/ajcn.116.133470_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1897-4287-2-1-37","article-title":"DNA double strand break repair and its association with inherited predispositions to breast cancer","volume":"2","author":"Scott","year":"2004","journal-title":"Hered Cancer Clin Pract"},{"key":"10.3945\/ajcn.116.133470_bib10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1158\/2159-8290.CD-12-0221","article-title":"Mechanisms of BRCA1 tumor suppression","volume":"2","author":"Silver","year":"2012","journal-title":"Cancer Discov"},{"key":"10.3945\/ajcn.116.133470_bib11","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4161\/cc.6.8.4105","article-title":"BRCA1 haploinsufficiency, but not heterozygosity for a BRCA1-truncating mutation, deregulates homologous recombination","volume":"6","author":"Cousineau","year":"2007","journal-title":"Cell Cycle"},{"key":"10.3945\/ajcn.116.133470_bib12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcn\/82.2.442","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000","volume":"82","author":"Pfeiffer","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.133470_bib13","doi-asserted-by":"crossref","first-page":"E100","DOI":"10.1503\/cmaj.100568","article-title":"Folate status of the population in the Canadian Health Measures Survey","volume":"183","author":"Colapinto","year":"2011","journal-title":"CMAJ"},{"key":"10.3945\/ajcn.116.133470_bib14","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s10552-012-9975-0","article-title":"Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study","volume":"23","author":"Kotsopoulos","year":"2012","journal-title":"Cancer Causes Control"},{"key":"10.3945\/ajcn.116.133470_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10549-013-2729-1","article-title":"The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation","volume":"142","author":"Valentini","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"10.3945\/ajcn.116.133470_bib16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10549-009-0375-4","article-title":"Accuracy of self-reported breast cancer among women undergoing mammography","volume":"118","author":"Abraham","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.3945\/ajcn.116.133470_bib17","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1093\/clinchem\/34.11.2357","article-title":"Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates","volume":"34","author":"Horne","year":"1988","journal-title":"Clin Chem"},{"key":"10.3945\/ajcn.116.133470_bib18","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/nprot.2008.181","article-title":"Nonradioactive enzymatic assay for plasma and serum vitamin B(6)","volume":"3","author":"Han","year":"2008","journal-title":"Nat Protoc"},{"key":"10.3945\/ajcn.116.133470_bib19","unstructured":"Salimetrics. Inter- and intra-assay coefficients of variability [Internet]. Version current 2015 Nov 2. Carlsbad (CA): Salimetrics. [cited 2016 Feb 23]. Available from: https:\/\/www.salimetrics.com\/assets\/documents\/Spit_Tips_-_Inter__Intra_Assay_Coefficients_of_Variability.pdf"},{"key":"10.3945\/ajcn.116.133470_bib20","unstructured":"WHO. Serum and red blood cell folate concentrations for assessing folate status in populations [Internet]. Version current 2012 Oct 15. World health Organization (WHO), Switzerland. [cited 2016 Feb 23]. Available from: http:\/\/apps.who.int\/iris\/bitstream\/10665\/75584\/1\/WHO_NMH_NHD_EPG_12.1_eng.pdf"},{"key":"10.3945\/ajcn.116.133470_bib21","first-page":"9","article-title":"Missing data imputation: focusing on single imputation","volume":"4","author":"Zhang","year":"2016","journal-title":"Ann Transl Med"},{"key":"10.3945\/ajcn.116.133470_bib22","doi-asserted-by":"crossref","first-page":"348S","DOI":"10.3945\/ajcn.111.013441","article-title":"Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II","volume":"94","author":"Carmel","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.133470_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.nu.05.070185.000555","article-title":"Vitamin B12-folate interrelationships","volume":"5","author":"Shane","year":"1985","journal-title":"Annu Rev Nutr"},{"key":"10.3945\/ajcn.116.133470_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/B:CACO.0000019471.97208.c6","article-title":"Does folate intake decrease risk of postmenopausal breast cancer among women with a family history?","volume":"15","author":"Sellers","year":"2004","journal-title":"Cancer Causes Control"},{"key":"10.3945\/ajcn.116.133470_bib25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.me.33.020182.002021","article-title":"The effects of alcohol on folate metabolism","volume":"33","author":"Hillman","year":"1982","journal-title":"Annu Rev Med"},{"key":"10.3945\/ajcn.116.133470_bib26","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/ajcn\/83.4.895","article-title":"Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial","volume":"83","author":"Stolzenberg-Solomon","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.133470_bib27","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ajcn\/87.3.734","article-title":"Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women","volume":"87","author":"Lin","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.133470_bib28","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3945\/ajcn.2009.28064","article-title":"Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele","volume":"90","author":"Ericson","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.133470_bib29","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3945\/jn.110.124313","article-title":"Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study","volume":"140","author":"Ericson","year":"2010","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.116.133470_bib30","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3945\/ajcn.2009.28553","article-title":"Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort","volume":"91","author":"Stevens","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.116.133470_bib31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/CEJ.0b013e32833ade68","article-title":"Micronutrient intake and breast cancer characteristics among postmenopausal women","volume":"19","author":"Roswall","year":"2010","journal-title":"Eur J Cancer Prev"},{"key":"10.3945\/ajcn.116.133470_bib32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1471-2407-9-122","article-title":"Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women","volume":"9","author":"Ma","year":"2009","journal-title":"BMC Cancer"},{"key":"10.3945\/ajcn.116.133470_bib33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1158\/1055-9965.511.13.4","article-title":"Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?","volume":"13","author":"Kim","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.3945\/ajcn.116.133470_bib34","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1089\/ars.2012.4554","article-title":"Folate and DNA methylation","volume":"17","author":"Ly","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.3945\/ajcn.116.133470_bib35","doi-asserted-by":"crossref","first-page":"e84635","DOI":"10.1371\/journal.pone.0084635","article-title":"Folic acid supplementation promotes mammary tumor progression in a rat model","volume":"9","author":"Deghan Manshadi","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/ajcn.116.133470_bib36","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1038\/bjc.2013.438","article-title":"Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis","volume":"109","author":"Wu","year":"2013","journal-title":"Br J Cancer"},{"key":"10.3945\/ajcn.116.133470_bib37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/nu3030370","article-title":"Folic acid food fortification-its history, effect, concerns, and future directions","volume":"3","author":"Crider","year":"2011","journal-title":"Nutrients"},{"key":"10.3945\/ajcn.116.133470_bib38","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/S0140-6736(06)68582-6","article-title":"Folic acid: a public-health challenge","volume":"367","author":"Eichholzer","year":"2006","journal-title":"Lancet"},{"key":"10.3945\/ajcn.116.133470_bib39","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3945\/jn.109.116418","article-title":"Analytical recovery of folate and its degradation products in human serum stored at -25 degrees C for up to 29 years","volume":"140","author":"Hannisdal","year":"2010","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.116.133470_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4137\/117739010700200010","article-title":"A practical approach to red blood cell folate analysis","volume":"2","author":"Piyathilake","year":"2007","journal-title":"Anal Chem Insights"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522045890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522045890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/104\/3\/671\/23773665\/ajcn133470.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:46:43Z","timestamp":1733964403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522045890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0002916522045890"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.116.133470","relation":{},"ISSN":["0002-9165"],"issn-type":[{"type":"print","value":"0002-9165"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study,","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.116.133470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}