{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:44Z","timestamp":1790659724205,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":1895,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3945\/ajcn.117.155960","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T13:32:03Z","timestamp":1508938323000},"page":"1634S-1639S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":220,"special_numbering":"S6","title":["Serum ferritin as an indicator of iron status: what do we need to know?"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-2609","authenticated-orcid":false,"given":"Jahnavi","family":"Daru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Colman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J","family":"Stanworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"De La Salle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica M","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sant-Rayn","family":"Pasricha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.117.155960_bib1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5694\/j.1326-5377.2010.tb04038.x","article-title":"Diagnosis and management of iron deficiency anaemia: a clinical update","volume":"193","author":"Pasricha","year":"2010","journal-title":"Med J Aust."},{"key":"10.3945\/ajcn.117.155960_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2141.2011.09012.x","article-title":"UK guidelines on the management of iron deficiency in pregnancy","volume":"156","author":"Pavord","year":"2012","journal-title":"Br J Haematol."},{"key":"10.3945\/ajcn.117.155960_bib3","doi-asserted-by":"crossref","first-page":"1606S","DOI":"10.3945\/ajcn.117.155887","article-title":"Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges","volume":"106","author":"Pfeiffer","year":"2017","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/ajcn.117.155960_bib4","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/ejh.12645","article-title":"Non-anaemic iron deficiency - a disease looking for recognition of diagnosis: a systematic review","volume":"96","author":"Pratt","year":"2016","journal-title":"Eur J Haematol."},{"key":"10.3945\/ajcn.117.155960_bib5","article-title":"Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review to update the U.S. Preventive Services Task Force recommendation.","author":"McDonagh","year":"2015","journal-title":"Routine iron supplementation and screening for iron deficiency anemia in children ages 6 to 24 months: a systematic review to update the U.S. Preventive Services Task Force recommendation."},{"key":"10.3945\/ajcn.117.155960_bib6","article-title":"Routine iron supplementation and screening for iron deficiency anemia in pregnant women: a systematic review to update the U.S. Preventive Services Task Force recommendation.","author":"McDonagh","year":"2015","journal-title":"Routine iron supplementation and screening for iron deficiency anemia in pregnant women: a systematic review to update the U.S. Preventive Services Task Force recommendation."},{"key":"10.3945\/ajcn.117.155960_bib7","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/jn\/135.8.1974","article-title":"Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials","volume":"135","author":"Mei","year":"2005","journal-title":"J Nutr."},{"key":"10.3945\/ajcn.117.155960_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.nutr.28.061807.155521","article-title":"Systemic iron homeostasis and the iron-responsive element\/iron-regulatory protein (IRE\/IRP) regulatory network","volume":"28","author":"Muckenthaler","year":"2008","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/ajcn.117.155960_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1182\/blood.V49.1.147.147","article-title":"Effect of induced fever on serum iron and ferritin concentrations in man","volume":"49","author":"Elin","year":"1977","journal-title":"Blood."},{"key":"10.3945\/ajcn.117.155960_bib10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2009-11-253815","article-title":"Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway","volume":"116","author":"Cohen","year":"2010","journal-title":"Blood."},{"key":"10.3945\/ajcn.117.155960_bib11","first-page":"CD011817","article-title":"Serum or plasma ferritin concentration as an index of iron deficiency and overload (Protocol)","volume":"7","author":"Garcia-Casal","year":"2015","journal-title":"Cochrane Database Syst Rev."},{"key":"10.3945\/ajcn.117.155960_bib12","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1136\/bmj.283.6300.1147","article-title":"Assessment of iron stores in inflammation by assay of serum ferritin concentrations","volume":"283","author":"Blake","year":"1981","journal-title":"Br Med J (Clin Res Ed)."},{"key":"10.3945\/ajcn.117.155960_bib13","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1309\/2YT4-CMP3-KYW7-9RK1","article-title":"Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels","volume":"117","author":"Dale","year":"2002","journal-title":"Am J Clin Pathol."},{"key":"10.3945\/ajcn.117.155960_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1365-2141.1993.tb03225.x","article-title":"Screening for iron deficiency: an analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women","volume":"85","author":"Hallberg","year":"1993","journal-title":"Br J Haematol."},{"key":"10.3945\/ajcn.117.155960_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/jclinpath-2014-202291","article-title":"Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian children","volume":"67","author":"Jonker","year":"2014","journal-title":"J Clin Pathol."},{"key":"10.3945\/ajcn.117.155960_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0609.1983.tb01502.x","article-title":"Serum ferritin in non-dialysis patients with chronic renal failure: relation to bone marrow iron stores","volume":"30","author":"Milman","year":"1983","journal-title":"Scand J Haematol."},{"key":"10.3945\/ajcn.117.155960_bib17","first-page":"1173","article-title":"Serum ferritin, cobalt excretion and body iron status","volume":"112","author":"Sorbie","year":"1975","journal-title":"Can Med Assoc J."},{"key":"10.3945\/ajcn.117.155960_bib18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1365-2141.1998.01035.x","article-title":"Iron status in pregnant women: which measurements are valid?","volume":"103","author":"van den Broek","year":"1998","journal-title":"Br J Haematol."},{"key":"10.3945\/ajcn.117.155960_bib19","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.4269\/ajtmh.2009.09-0162","article-title":"Baseline iron indices as predictors of hemoglobin improvement in anemic Vietnamese women receiving weekly iron-folic acid supplementation and deworming","volume":"81","author":"Pasricha","year":"2009","journal-title":"Am J Trop Med Hyg."},{"key":"10.3945\/ajcn.117.155960_bib20","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/S2214-109X(13)70046-9","article-title":"Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-analysis of randomised controlled trials","volume":"1","author":"Pasricha","year":"2013","journal-title":"Lancet Glob Health."},{"key":"10.3945\/ajcn.117.155960_bib21","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/S2352-3026(14)00025-8","article-title":"Rethinking ferritin cutoffs for iron deficiency and overload","volume":"1","author":"Garcia-Casal","year":"2014","journal-title":"Lancet Haematol."},{"key":"10.3945\/ajcn.117.155960_bib22","article-title":"Assessing methodological quality","author":"Reitsma","year":"2009","journal-title":"Cochrane handbook for systematic reviews of diagnostic test accuracy version 100: the Cochrane collaboration."},{"key":"10.3945\/ajcn.117.155960_bib23","article-title":"Essential medical statistics.","author":"Kirkwood","year":"2003","journal-title":"Essential medical statistics."},{"key":"10.3945\/ajcn.117.155960_bib24","doi-asserted-by":"crossref","first-page":"e3999","DOI":"10.1136\/bmj.e3999","article-title":"Interpreting diagnostic accuracy studies for patient care","volume":"345","author":"Mallett","year":"2012","journal-title":"BMJ."},{"key":"10.3945\/ajcn.117.155960_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology."},{"key":"10.3945\/ajcn.117.155960_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/bimj.200410135","article-title":"Estimation of the Youden index and its associated cutoff point","volume":"47","author":"Fluss","year":"2005","journal-title":"Biom J."},{"key":"10.3945\/ajcn.117.155960_bib27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/bmj.329.7458.168","article-title":"Diagnostic tests 4: likelihood ratios","volume":"329","author":"Deeks","year":"2004","journal-title":"BMJ."},{"key":"10.3945\/ajcn.117.155960_bib28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/0272989X0002000403","article-title":"Patient preference-based treatment thresholds and recommendations: a comparison of decision-analytic modeling with the probability-tradeoff technique","volume":"20","author":"Man-Son-Hing","year":"2000","journal-title":"Med Decis Making."},{"key":"10.3945\/ajcn.117.155960_bib29","article-title":"Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations.","year":"2011","journal-title":"Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations."},{"key":"10.3945\/ajcn.117.155960_bib30","year":"2007"},{"key":"10.3945\/ajcn.117.155960_bib31","first-page":"1","article-title":"Recommendations to prevent and control iron deficiency in the United States","volume":"47","year":"1998","journal-title":"MMWR Recomm Rep."},{"key":"10.3945\/ajcn.117.155960_bib32","article-title":"Iron studies standardised reporting protocol","year":"2013","journal-title":"Surry Hills (New South Wales): Royal College of Pathologists of Australasia"},{"key":"10.3945\/ajcn.117.155960_bib33","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/OGX.0000000000000172","article-title":"Iron deficiency anemia in women: a practical guide to detection, diagnosis, and treatment","volume":"70","author":"Friedman","year":"2015","journal-title":"Obstet Gynecol Surv."},{"key":"10.3945\/ajcn.117.155960_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1440-1754.2007.01128.x","article-title":"Policy statement on iron deficiency in pre-school-aged children","volume":"43","author":"Grant","year":"2007","journal-title":"J Paediatr Child Health."},{"key":"10.3945\/ajcn.117.155960_bib35","unstructured":"AABB. Management of risk for iron deficiency in female blood donors with HB levels of 12.0-<12.5 g\/dL using ferritin testing [Internet].. [cited 2016 Oct 4]. Available from: http:\/\/www.aabb.org\/advocacy\/regulatorygovernment\/donoreligibility\/hsim\/Pages\/Management-of-Risk-for-Iron-Deficiency-in%20Female-Blood-Donors-with-HB-Levels-12.0-12.5.aspx."},{"key":"10.3945\/ajcn.117.155960_bib36","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/01.MIB.0000199223.27595.e3","article-title":"Ferritin as a simple indicator of iron deficiency in anemic IBD patients","volume":"12","author":"Guagnozzi","year":"2006","journal-title":"Inflamm Bowel Dis."},{"key":"10.3945\/ajcn.117.155960_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.47102\/annals-acadmedsg.V34N7p437","article-title":"Accuracy of various iron parameters in the prediction of iron deficiency in an acute care hospital","volume":"34","author":"Ong","year":"2005","journal-title":"Ann Acad Med Singapore."},{"key":"10.3945\/ajcn.117.155960_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/ajcp\/90.1.85","article-title":"Predicting bone marrow iron stores in anemic patients in a community hospital using ferritin and erythrocyte sedimentation rate","volume":"90","author":"Witte","year":"1988","journal-title":"Am J Clin Pathol."},{"key":"10.3945\/ajcn.117.155960_bib39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/00365518409083610","article-title":"A comparison between serum ferritin concentration and the amount of bone marrow stainable iron","volume":"44","author":"Harju","year":"1984","journal-title":"Scand J Clin Lab Invest."},{"key":"10.3945\/ajcn.117.155960_bib40","doi-asserted-by":"crossref","first-page":"443S","DOI":"10.1093\/jn\/130.2.443S","article-title":"Anemia, iron and pregnancy outcome","volume":"130","author":"Scholl","year":"2000","journal-title":"J Nutr."},{"key":"10.3945\/ajcn.117.155960_bib41","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1182\/blood-2011-11-391219","article-title":"Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children","volume":"119","author":"Prentice","year":"2012","journal-title":"Blood."},{"key":"10.3945\/ajcn.117.155960_bib42","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/jn\/136.9.2435","article-title":"Iron deficiency, but not anemia, upregulates iron absorption in breast-fed peruvian infants","volume":"136","author":"Hicks","year":"2006","journal-title":"J Nutr."},{"key":"10.3945\/ajcn.117.155960_bib43","doi-asserted-by":"crossref","first-page":"235re3","DOI":"10.1126\/scitranslmed.3008249","article-title":"Expression of the iron hormone hepcidin distinguishes different types of anemia in African children","volume":"6","author":"Pasricha","year":"2014","journal-title":"Sci Transl Med."},{"key":"10.3945\/ajcn.117.155960_bib44","article-title":"Treatment of iron deficiency anemia in adults","author":"Schrier","year":"2016","journal-title":"UpToDate."},{"key":"10.3945\/ajcn.117.155960_bib45","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.24330","article-title":"American Association for the Study of Liver D. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases","volume":"54","author":"Bacon","year":"2011","journal-title":"Hepatology."},{"key":"10.3945\/ajcn.117.155960_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1079\/BJN19910104","article-title":"Iron absorption during normal human pregnancy: a study using stable isotopes","volume":"65","author":"Whittaker","year":"1991","journal-title":"Br J Nutr."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522027356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522027356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3945\/ajcn.117.155960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:51:54Z","timestamp":1750949514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522027356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":46,"alternative-id":["S0002916522027356"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.117.155960","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum ferritin as an indicator of iron status: what do we need to know?","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.117.155960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}