{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:35:56Z","timestamp":1791016556141,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":5056,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.3945\/ajcn.2009.27113b","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T01:57:01Z","timestamp":1236218221000},"page":"1488S-1493S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":167,"title":["Epigenetic mechanisms for nutrition determinants of later health outcomes"],"prefix":"10.1016","volume":"89","author":[{"given":"Steven H","family":"Zeisel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.2009.27113B_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0168-9525(97)01180-3","article-title":"DNA methylation and imprinting: why bother?","volume":"13","author":"Jaenisch","year":"1997","journal-title":"Trends Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib2","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1073\/pnas.94.6.2103","article-title":"Altered DNA methylation and genome instability: a new pathway to cancer?","volume":"94","author":"Jones","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.3945\/ajcn.2009.27113B_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35049533","article-title":"DNA methylation in health and disease.","volume":"1","author":"Robertson","year":"2000","journal-title":"Nat Rev Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1097-2765(00)80249-X","article-title":"M6P\/IGF2R imprinting evolution in mammals.","volume":"5","author":"Killian","year":"2000","journal-title":"Mol Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib5","first-page":"1232","article-title":"Maternal and grandmaternal smoking patterns are associated with early childhood asthma.","volume":"127","author":"Li","year":"2005","journal-title":"Chest"},{"key":"10.3945\/ajcn.2009.27113B_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.ejhg.5200901","article-title":"Time to take epigenetic inheritance seriously.","volume":"10","author":"Pembrey","year":"2002","journal-title":"Eur J Hum Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0027-5107(93)90052-H","article-title":"DNA methylation and mutation.","volume":"285","author":"Holliday","year":"1993","journal-title":"Mutat Res"},{"key":"10.3945\/ajcn.2009.27113B_bib8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrg2341","article-title":"DNA methylation landscapes: provocative insights from epigenomics.","volume":"9","author":"Suzuki","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S","article-title":"Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases.","volume":"3","author":"Jeltsch","year":"2002","journal-title":"ChemBioChem"},{"key":"10.3945\/ajcn.2009.27113B_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","article-title":"CpG-rich islands and the function of DNA methylation.","volume":"321","author":"Bird","year":"1986","journal-title":"Nature"},{"key":"10.3945\/ajcn.2009.27113B_bib11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.str.2008.01.004","article-title":"Mammalian DNA methyltransferases: a structural perspective.","volume":"16","author":"Cheng","year":"2008","journal-title":"Structure"},{"key":"10.3945\/ajcn.2009.27113B_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.tig.2007.08.010","article-title":"The potential role of epigenomic dysregulation in complex human disease.","volume":"23","author":"Hatchwell","year":"2007","journal-title":"Trends Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib13","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib14","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00018-008-7324-y","article-title":"Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?","volume":"65","author":"Clouaire","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.3945\/ajcn.2009.27113B_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01411","article-title":"Controlling the double helix.","volume":"421","author":"Felsenfeld","year":"2003","journal-title":"Nature"},{"key":"10.3945\/ajcn.2009.27113B_bib16","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1101\/gad.1463706","article-title":"Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication.","volume":"20","author":"Esteve","year":"2006","journal-title":"Genes Dev"},{"key":"10.3945\/ajcn.2009.27113B_bib17","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.bcp.2006.06.016","article-title":"Chromatin structure and epigenetics.","volume":"72","author":"Quina","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.3945\/ajcn.2009.27113B_bib18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.molcel.2004.05.026","article-title":"Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes.","volume":"14","author":"Roopra","year":"2004","journal-title":"Mol Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib19","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S1097-2765(03)00477-5","article-title":"Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.","volume":"12","author":"Peters","year":"2003","journal-title":"Mol Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib20","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S1097-2765(03)00479-9","article-title":"Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.","volume":"12","author":"Rice","year":"2003","journal-title":"Mol Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib21","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1101\/gad.988502","article-title":"The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation.","volume":"16","author":"Mutskov","year":"2002","journal-title":"Genes Dev"},{"key":"10.3945\/ajcn.2009.27113B_bib22","doi-asserted-by":"crossref","first-page":"25309","DOI":"10.1074\/jbc.M101914200","article-title":"Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.","volume":"276","author":"Tachibana","year":"2001","journal-title":"J Biol Chem"},{"key":"10.3945\/ajcn.2009.27113B_bib23","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1101\/gad.989402","article-title":"G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.","volume":"16","author":"Tachibana","year":"2002","journal-title":"Genes Dev"},{"key":"10.3945\/ajcn.2009.27113B_bib24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1101\/gad.1284005","article-title":"Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.","volume":"19","author":"Tachibana","year":"2005","journal-title":"Genes Dev"},{"key":"10.3945\/ajcn.2009.27113B_bib25","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature01378","article-title":"Structure and catalytic mechanism of the human histone methyltransferase SET7\/9.","volume":"421","author":"Xiao","year":"2003","journal-title":"Nature"},{"key":"10.3945\/ajcn.2009.27113B_bib26","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0092-8674(95)90298-8","article-title":"REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.","volume":"80","author":"Chong","year":"1995","journal-title":"Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2005.03.013","article-title":"REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.","volume":"121","author":"Ballas","year":"2005","journal-title":"Cell"},{"key":"10.3945\/ajcn.2009.27113B_bib28","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.conb.2005.08.015","article-title":"The many faces of REST oversee epigenetic programming of neuronal genes.","volume":"15","author":"Ballas","year":"2005","journal-title":"Curr Opin Neurobiol"},{"key":"10.3945\/ajcn.2009.27113B_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1055\/s-2000-8466","article-title":"Pathways and regulation of homocysteine metabolism in mammals.","volume":"26","author":"Finkelstein","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"10.3945\/ajcn.2009.27113B_bib30","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1093\/jn\/133.12.4135","article-title":"Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women.","volume":"133","author":"Olthof","year":"2003","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0021-9150(00)00671-7","article-title":"The 1298A\u2192C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.","volume":"156","author":"Weisberg","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.3945\/ajcn.2009.27113B_bib32","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1093\/jn\/133.12.4107","article-title":"Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C\u2192T polymorphism in young women.","volume":"133","author":"Shelnutt","year":"2003","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/ajcn\/73.3.613","article-title":"Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort.","volume":"73","author":"Jacques","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1086\/341354","article-title":"Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L.","volume":"71","author":"Watkins","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0026-0495(80)90192-4","article-title":"Labile methyl group balances in the human: the role of sarcosine.","volume":"29","author":"Mudd","year":"1980","journal-title":"Metabolism"},{"key":"10.3945\/ajcn.2009.27113B_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abbi.1997.0246","article-title":"Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene.","volume":"345","author":"Sunden","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"10.3945\/ajcn.2009.27113B_bib37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.ATV.0000114569.54976.31","article-title":"Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation.","volume":"24","author":"Holm","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.3945\/ajcn.2009.27113B_bib38","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/jn\/133.5.1291","article-title":"Betaine supplementation lowers plasma homocysteine in healthy men and women.","volume":"133","author":"Steenge","year":"2003","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00445602","article-title":"Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency.","volume":"142","author":"Wendel","year":"1984","journal-title":"Eur J Pediatr"},{"key":"10.3945\/ajcn.2009.27113B_bib40","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/jn\/124.11.2197","article-title":"Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver.","volume":"124","author":"Kim","year":"1994","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib41","first-page":"16","article-title":"Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution.","volume":"51","author":"Selhub","year":"1991","journal-title":"Cancer Res"},{"key":"10.3945\/ajcn.2009.27113B_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0955-2863(92)90073-R","article-title":"Effect of chronic choline deficiency in rats on liver folate content and distribution.","volume":"3","author":"Varela-Moreiras","year":"1992","journal-title":"J Nutr Biochem"},{"key":"10.3945\/ajcn.2009.27113B_bib43","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0955-2863(90)90039-N","article-title":"Effects of choline deficiency and methotrexate treatment upon rat liver.","volume":"1","author":"Pomfret","year":"1990","journal-title":"J Nutr Biochem"},{"key":"10.3945\/ajcn.2009.27113B_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1042\/bj2590725","article-title":"Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver.","volume":"259","author":"Zeisel","year":"1989","journal-title":"Biochem J"},{"key":"10.3945\/ajcn.2009.27113B_bib45","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/07315724.1995.10718539","article-title":"Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats.","volume":"14","author":"Varela-Moreiras","year":"1995","journal-title":"J Am Coll Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib46","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ajcn.81.2.440","article-title":"Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.","volume":"81","author":"da Costa","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1096\/fj.05-4707com","article-title":"Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains.","volume":"20","author":"Niculescu","year":"2006","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.2009.27113B_bib48","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1152\/jn.1998.79.4.1790","article-title":"Prenatal choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats.","volume":"79","author":"Pyapali","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.3945\/ajcn.2009.27113B_bib49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-3806(00)00075-4","article-title":"Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood.","volume":"123","author":"Montoya","year":"2000","journal-title":"Brain Res Dev Brain Res"},{"key":"10.3945\/ajcn.2009.27113B_bib50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-3806(99)00103-0","article-title":"Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation.","volume":"118","author":"Jones","year":"1999","journal-title":"Brain Res Dev Brain Res"},{"key":"10.3945\/ajcn.2009.27113B_bib51","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1097\/00001756-199709290-00010","article-title":"Perinatal choline supplementation increases the threshold for chunking in spatial memory.","volume":"8","author":"Meck","year":"1997","journal-title":"Neuroreport"},{"key":"10.3945\/ajcn.2009.27113B_bib52","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1097\/00001756-199709080-00005","article-title":"Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory.","volume":"8","author":"Meck","year":"1997","journal-title":"Neuroreport"},{"key":"10.3945\/ajcn.2009.27113B_bib53","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1097\/00001756-199709290-00009","article-title":"Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats.","volume":"8","author":"Meck","year":"1997","journal-title":"Neuroreport"},{"key":"10.3945\/ajcn.2009.27113B_bib54","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1037\/0735-7044.103.6.1234","article-title":"Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both.","volume":"103","author":"Meck","year":"1989","journal-title":"Behav Neurosci"},{"key":"10.3945\/ajcn.2009.27113B_bib55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/dev.420210405","article-title":"Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory.","volume":"21","author":"Meck","year":"1988","journal-title":"Dev Psychobiol"},{"key":"10.3945\/ajcn.2009.27113B_bib56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0165-3806(99)00105-4","article-title":"Choline supplementation during prenatal development reduces proactive interference in spatial memory.","volume":"118","author":"Meck","year":"1999","journal-title":"Brain Res Dev Brain Res"},{"key":"10.3945\/ajcn.2009.27113B_bib57","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1471-4159.2004.02414.x","article-title":"Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene.","volume":"89","author":"Niculescu","year":"2004","journal-title":"J Neurochem"},{"key":"10.3945\/ajcn.2009.27113B_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0165-3806(98)00183-7","article-title":"Choline availability alters embryonic development of the hippocampus and septum in the rat.","volume":"113","author":"Albright","year":"1999","journal-title":"Brain Res Dev Brain Res"},{"key":"10.3945\/ajcn.2009.27113B_bib59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0165-3806(99)00057-7","article-title":"Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum.","volume":"115","author":"Albright","year":"1999","journal-title":"Brain Res Dev Brain Res"},{"key":"10.3945\/ajcn.2009.27113B_bib60","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0149-7634(03)00069-1","article-title":"Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan.","volume":"27","author":"Meck","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3945\/ajcn.2009.27113B_bib61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0006-8993(98)00229-7","article-title":"Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats.","volume":"794","author":"Williams","year":"1998","journal-title":"Brain Res"},{"key":"10.3945\/ajcn.2009.27113B_bib62","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1096\/fasebj.12.11.949","article-title":"Maternal epigenetics and methyl supplements affect agouti gene expression in Avy\/a mice.","volume":"12","author":"Wolff","year":"1998","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.2009.27113B_bib63","doi-asserted-by":"crossref","first-page":"2393S","DOI":"10.1093\/jn\/132.8.2393S","article-title":"Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring.","volume":"132","author":"Cooney","year":"2002","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib64","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/jn\/135.5.1040","article-title":"The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.","volume":"135","author":"Davis","year":"2005","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib65","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1073\/pnas.0504285102","article-title":"Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.","volume":"102","author":"Kohlmeier","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.3945\/ajcn.2009.27113B_bib66","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1096\/fj.07-8227com","article-title":"Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.","volume":"21","author":"Resseguie","year":"2007","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.2009.27113B_bib67","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ajcn\/85.5.1275","article-title":"Sex and menopausal status influence human dietary requirements for the nutrient choline.","volume":"85","author":"Fischer","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib68","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/jn\/133.2.476","article-title":"Neither methionine nor nitrous oxide inactivation of methionine synthase affect the concentration of 5,10-methylenetetrahydrofolate in rat liver.","volume":"133","author":"Horne","year":"2003","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2009.27113B_bib69","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/344213","volume":"71","author":"Brody","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.3945\/ajcn.2009.27113B_bib70","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1096\/fj.06-5734com","article-title":"Common genetic polymorphisms affect the human requirement for the nutrient choline.","volume":"20","author":"da Costa","year":"2006","journal-title":"FASEB J"},{"key":"10.3945\/ajcn.2009.27113B_bib71","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior.","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.3945\/ajcn.2009.27113B_bib72","doi-asserted-by":"crossref","first-page":"e2085","DOI":"10.1371\/journal.pone.0002085","article-title":"Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.","volume":"3","author":"McGowan","year":"2008","journal-title":"PLoS One"},{"key":"10.3945\/ajcn.2009.27113B_bib73","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ajhg.2008.01.008","article-title":"Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.","volume":"82","author":"Mill","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib74","doi-asserted-by":"crossref","first-page":"1485S","DOI":"10.3945\/ajcn.2009.27113A","article-title":"Introduction to the workshop.","volume":"89","author":"Atkinson","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib75","doi-asserted-by":"crossref","first-page":"1494S","DOI":"10.3945\/ajcn.2009.27113C","article-title":"Childhood obesity: are genetic differences involved?","volume":"89","author":"Bouchard","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib76","doi-asserted-by":"crossref","first-page":"1502S","DOI":"10.3945\/ajcn.2009.27113D","article-title":"Can infant feeding choices modulate later obesity risk?","volume":"89","author":"Koletzko","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib77","doi-asserted-by":"crossref","first-page":"1509S","DOI":"10.3945\/ajcn.2009.27113E","article-title":"Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention.","volume":"89","author":"Ordovas","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib78","doi-asserted-by":"crossref","first-page":"1518S","DOI":"10.3945\/ajcn.2009.27113F","article-title":"Early determinants of cardiovascular disease: the role of early diet in later blood pressure control.","volume":"89","author":"Symonds","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib79","doi-asserted-by":"crossref","first-page":"1523S","DOI":"10.3945\/ajcn.2009.27113G","article-title":"Early determinants of development: a lipid perspective.","volume":"89","author":"Carlson","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib80","doi-asserted-by":"crossref","first-page":"1533S","DOI":"10.3945\/ajcn.2009.27113H","article-title":"Summary of the workshop.","volume":"89","author":"Field","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.3945\/ajcn.2009.27113B_bib81","doi-asserted-by":"crossref","first-page":"1530S","DOI":"10.3945\/ajcn.2009.27113I","article-title":"Driving research in infant and children\u2019s nutrition: a perspective on industry.","volume":"89","author":"Rai","year":"2009","journal-title":"Am J Clin Nutr"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523238149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523238149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/89\/5\/1488S\/23851366\/1488s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T12:55:01Z","timestamp":1685451301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523238149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0002916523238149"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.2009.27113b","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic mechanisms for nutrition determinants of later health outcomes","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.2009.27113B","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}