{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:04:07Z","timestamp":1792659847681,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":4679,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.3945\/ajcn.2009.29094","type":"journal-article","created":{"date-parts":[[2010,3,10]],"date-time":"2010-03-10T22:51:00Z","timestamp":1268261460000},"page":"1255-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":727,"title":["Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren"],"prefix":"10.1016","volume":"91","author":[{"given":"Mitsuyoshi","family":"Urashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Segawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.2009.29094_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1743-422X-5-29","article-title":"On the epidemiology of influenza.","volume":"5","author":"Cannell","year":"2008","journal-title":"Virol J"},{"key":"10.3945\/ajcn.2009.29094_bib2","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1001\/archinte.165.14.1618","article-title":"A randomized controlled trial of vitamin D3 supplementation in African American women.","volume":"165","author":"Aloia","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.3945\/ajcn.2009.29094_bib3","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1017\/S0950268807008308","article-title":"Re: epidemic influenza and vitamin D.","volume":"135","author":"Aloia","year":"2007","journal-title":"Epidemiol Infect"},{"key":"10.3945\/ajcn.2009.29094_bib4","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1017\/S0950268809002404","article-title":"A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections.","volume":"137","author":"Li-Ng","year":"2009","journal-title":"Epidemiol Infect"},{"key":"10.3945\/ajcn.2009.29094_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/archinternmed.2008.560","article-title":"Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey.","volume":"169","author":"Ginde","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.3945\/ajcn.2009.29094_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4158\/EP09101.ORR","article-title":"Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials.","volume":"15","author":"Yamshchikov","year":"2009","journal-title":"Endocr Pract"},{"key":"10.3945\/ajcn.2009.29094_bib7","doi-asserted-by":"crossref","first-page":"b3620","DOI":"10.1136\/bmj.b3172","article-title":"Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials.","volume":"339","author":"Shun-Shin","year":"2009","journal-title":"BMJ"},{"key":"10.3945\/ajcn.2009.29094_bib8","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1542\/peds.2008-2666","article-title":"Probiotic effects on cold and influenza-like symptom incidence and duration in children.","volume":"124","author":"Leyer","year":"2009","journal-title":"Pediatrics"},{"key":"10.3945\/ajcn.2009.29094_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/archpedi.158.3.217","article-title":"Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study.","volume":"158","author":"Cohen","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.3945\/ajcn.2009.29094_bib10","doi-asserted-by":"crossref","unstructured":"Wang TT, Dabbas B, Laperriere D, et al. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2\/CARD15-beta defensin 2 innate immune pathway defective in Crohn\u2019s disease. J Biol Chem (Epub ahead of print 30 November 2009).","DOI":"10.1074\/jbc.C109.071225"},{"key":"10.3945\/ajcn.2009.29094_bib11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ni1248","article-title":"Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins.","volume":"6","author":"Leikina","year":"2005","journal-title":"Nat Immunol"},{"key":"10.3945\/ajcn.2009.29094_bib12","doi-asserted-by":"crossref","first-page":"7878","DOI":"10.4049\/jimmunol.0804049","article-title":"Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.","volume":"182","author":"Doss","year":"2009","journal-title":"J Immunol"},{"key":"10.3945\/ajcn.2009.29094_bib13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.virol.2008.07.024","article-title":"Enhanced expression of murine beta-defensins (MBD-1, -2,- 3, and -4) in upper and lower airway mucosa of influenza virus infected mice.","volume":"380","author":"Chong","year":"2008","journal-title":"Virology"},{"key":"10.3945\/ajcn.2009.29094_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/jcp.22004","article-title":"Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D.","volume":"222","author":"Bahar-Shany","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.3945\/ajcn.2009.29094_bib15","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4049\/jimmunol.0902840","article-title":"Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state.","volume":"184","author":"Hansdottir","year":"2010","journal-title":"J Immunol"},{"key":"10.3945\/ajcn.2009.29094_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1681\/ASN.2009040451","article-title":"Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD.","volume":"21","author":"Stubbs","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.3945\/ajcn.2009.29094_bib17","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.4049\/jimmunol.0803217","article-title":"1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.","volume":"183","author":"Jeffery","year":"2009","journal-title":"J Immunol"},{"key":"10.3945\/ajcn.2009.29094_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2009.05.003","article-title":"Differences in serum cytokine levels between influenza virus A and B infections in children.","volume":"47","author":"Sato","year":"2009","journal-title":"Cytokine"},{"key":"10.3945\/ajcn.2009.29094_bib19","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1210\/jc.2007-2530","article-title":"Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children.","volume":"93","author":"Maalouf","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/ajcn.2009.29094_bib20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/ajcn\/73.2.288","article-title":"Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level.","volume":"73","author":"Vieth","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2009.29094_bib21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3201\/eid1503.080238","article-title":"Prevalence and seasonality of influenza-like illness in children, Nicaragua, 2005-2007.","volume":"15","author":"Gordon","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"10.3945\/ajcn.2009.29094_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0091-6749(99)70177-6","article-title":"Diminished IL-10 production in subjects with allergy after infection with influenza A virus.","volume":"103","author":"Gentile","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.3945\/ajcn.2009.29094_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1465-9921-10-98","article-title":"Asthma and genes encoding components of the vitamin D pathway.","volume":"10","author":"Boss\u00e9","year":"2009","journal-title":"Respir Res"},{"key":"10.3945\/ajcn.2009.29094_bib24","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1378\/chest.128.6.3792","article-title":"Relationship between serum 25-hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey.","volume":"128","author":"Black","year":"2005","journal-title":"Chest"},{"key":"10.3945\/ajcn.2009.29094_bib25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ajcn\/85.3.788","article-title":"Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age.","volume":"85","author":"Camargo","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2009.29094_bib26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1164\/rccm.200808-1361OC","article-title":"Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.","volume":"179","author":"Brehm","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.3945\/ajcn.2009.29094_bib27","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/j.1476-5381.2009.00428.x","article-title":"Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1.","volume":"158","author":"Damera","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.3945\/ajcn.2009.29094_bib28","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1164\/rccm.200901-0145ED","article-title":"Vitamin D and asthma: time for intervention?","volume":"179","author":"Devereux","year":"2009","journal-title":"Am J Respir Crit Care Med"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523018324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523018324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/91\/5\/1255\/23864600\/1255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T21:26:04Z","timestamp":1711315564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523018324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0002916523018324"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.2009.29094","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.2009.29094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}