{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:46:05Z","timestamp":1790747165886,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":4586,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.3945\/ajcn.2010.29413","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T22:52:05Z","timestamp":1275519125000},"page":"330-335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":184,"title":["Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time"],"prefix":"10.1016","volume":"92","author":[{"given":"Kimberly A","family":"Skarupski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tangney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bichun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Clare","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.2010.29413_bib1","unstructured":"Robins LN, Regier DA, eds. Psychiatric disorders in America: the Epidemiologic Catchment Area study. New York, NY: The Free Press, 1991."},{"key":"10.3945\/ajcn.2010.29413_bib2","first-page":"419","article-title":"Depression: a neglected major illness","volume":"54","author":"Greenberg","year":"1993","journal-title":"J Clin Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1600-0447.2006.00770.x","article-title":"Prevalence and predictors of depression in populations of elderly: a review","volume":"113","author":"Djernes","year":"2006","journal-title":"Acta Psychiatr Scand"},{"key":"10.3945\/ajcn.2010.29413_bib4","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1161\/01.CIR.93.11.1976","article-title":"Symptoms of depression, acute myocardial infarction, and total mortality in a community sample","volume":"93","author":"Barefoot","year":"1996","journal-title":"Circulation"},{"key":"10.3945\/ajcn.2010.29413_bib5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1097\/01.psy.0000170334.77508.35","article-title":"Do depressive symptoms predict declines in physical performance in an elderly, biracial population?","volume":"67","author":"Everson-Rose","year":"2005","journal-title":"Psychosom Med"},{"key":"10.3945\/ajcn.2010.29413_bib6","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1001\/archinte.158.13.1422","article-title":"Depression is a risk factor for coronary artery disease in men","volume":"158","author":"Ford","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.3945\/ajcn.2010.29413_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00006842-200007000-00001","article-title":"Symptoms of depression as a prospective risk factor for stroke","volume":"62","author":"Jonas","year":"2000","journal-title":"Psychosom Med"},{"key":"10.3945\/ajcn.2010.29413_bib8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00006842-199509000-00003","article-title":"Depressive symptomatology and hypertension-associated morbidity and mortality in older adults","volume":"57","author":"Simonsick","year":"1995","journal-title":"Psychosom Med"},{"key":"10.3945\/ajcn.2010.29413_bib9","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1001\/archinte.158.19.2129","article-title":"Association between depressive symptoms and mortality in older women","volume":"158","author":"Whooley","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.3945\/ajcn.2010.29413_bib10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/archpsyc.60.9.897","article-title":"Increased medical costs of a population-based sample of depressed elderly patients","volume":"60","author":"Katon","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000080386","article-title":"Vitamin B6 level is associated with symptoms of depression","volume":"73","author":"Hvas","year":"2004","journal-title":"Psychother Psychosom"},{"key":"10.3945\/ajcn.2010.29413_bib12","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/sj.ejcn.1602804","article-title":"Dietary intake of B6-9-12 vitamins, serum homocysteine levels and their association with depressive symptoms: the Zutphen Elderly Study","volume":"62","author":"Kamphuis","year":"2008","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/07315724.2008.10719720","article-title":"Vitamin B6 is associated with depressive symptomatology in Massachusetts elders","volume":"27","author":"Merete","year":"2008","journal-title":"J Am Coll Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.nut.2007.10.013","article-title":"Dietary intake of folate, other B vitamins, and \u03c9-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults","volume":"24","author":"Murakami","year":"2008","journal-title":"Nutrition"},{"key":"10.3945\/ajcn.2010.29413_bib15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1176\/appi.ajp.157.5.715","article-title":"Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women\u2019s Health and Aging Study","volume":"157","author":"Penninx","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1017\/S0033291704003721","article-title":"Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample","volume":"35","author":"Sachdev","year":"2005","journal-title":"Psychol Med"},{"key":"10.3945\/ajcn.2010.29413_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-277X.2008.00931.x","article-title":"Association between folate, vitamin B6 and vitamin B12 intake and depression in the SUN cohort study","volume":"22","author":"S\u00e1nchez-Villegas","year":"2009","journal-title":"J Hum Nutr Diet"},{"key":"10.3945\/ajcn.2010.29413_bib18","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1176\/appi.ajp.159.12.2099","article-title":"Vitamin B12, folate, and homocysteine in depression: The Rotterdam Study","volume":"159","author":"Tiemeier","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib19","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/jn\/133.10.3233","article-title":"Dietary folate and depressive symptoms are associated in middle-aged Finnish men","volume":"133","author":"Tolmunen","year":"2003","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0950-3536(05)80225-2","article-title":"Neurological complications of acquired cobalamin deficiency: clinical aspects","volume":"8","author":"Savage","year":"1995","journal-title":"Baillieres Clin Haematol"},{"key":"10.3945\/ajcn.2010.29413_bib21","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1056\/NEJM198806303182604","article-title":"Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis","volume":"318","author":"Lindenbaum","year":"1998","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.2010.29413_bib22","doi-asserted-by":"crossref","first-page":"693S","DOI":"10.3945\/ajcn.2008.26947A","article-title":"How common is vitamin B-12 deficiency?","volume":"89","author":"Allen","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1532-5415.1991.tb01646.x","article-title":"B complex vitamin patterns in geriatric and young adult inpatients with major depression","volume":"39","author":"Bell","year":"1991","journal-title":"J Am Geriatr Soc"},{"key":"10.3945\/ajcn.2010.29413_bib24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3945\/jn.109.113878","article-title":"The sex-specific role of plasma folate in mediating the association of dietary quality with depression symptoms","volume":"140","author":"Beydoun","year":"2009","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib25","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pnpbp.2005.06.021","article-title":"Homocysteine and folate metabolism in depression","volume":"29","author":"Bottiglieri","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/jnnp.69.2.228","article-title":"Homocysteine, folate, methylation, and monoamine metabolism in depression","volume":"69","author":"Bottiglieri","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00075197-200411000-00011","article-title":"Folate and brain function in the elderly","volume":"7","author":"D\u2019Anci","year":"2004","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.3945\/ajcn.2010.29413_bib28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000080385","article-title":"Dietary folate and the risk of depression in Finnish middle-aged men","volume":"73","author":"Tolmunen","year":"2004","journal-title":"Psychother Psychosom"},{"key":"10.3945\/ajcn.2010.29413_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1192\/bjp.bp.107.039511","article-title":"Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression","volume":"192","author":"Kim","year":"2008","journal-title":"Br J Psychiatry"},{"key":"10.3945\/ajcn.2010.29413_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3233\/JAD-2003-5501","article-title":"Design of the Chicago Health and Aging Project (CHAP)","volume":"5","author":"Bienias","year":"2003","journal-title":"J Alzheimers Dis"},{"key":"10.3945\/ajcn.2010.29413_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1001\/archneur.60.2.185","article-title":"Incidence of Alzheimer\u2019s disease in a biracial urban community: relation to apolipoprotein E allele status","volume":"60","author":"Evans","year":"2003","journal-title":"Arch Neurol"},{"key":"10.3945\/ajcn.2010.29413_bib32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1047-2797(97)00236-6","article-title":"Response to a mail nutritional survey in an older bi-racial community population","volume":"8","author":"Morris","year":"1998","journal-title":"Ann Epidemiol"},{"key":"10.3945\/ajcn.2010.29413_bib33","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/aje\/kwg290","article-title":"Validity and reproducibility of a food frequency questionnaire by cognition in an older biracial sample","volume":"158","author":"Morris","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.3945\/ajcn.2010.29413_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.aje.a114366","article-title":"Total energy intake: implications for epidemiologic analysis","volume":"124","author":"Willett","year":"1986","journal-title":"Am J Epidemiol"},{"key":"10.3945\/ajcn.2010.29413_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/089826439300500202","article-title":"Two shorter forms of the CES-D depression symptoms index","volume":"5","author":"Kohout","year":"1993","journal-title":"J Aging Health"},{"key":"10.3945\/ajcn.2010.29413_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"key":"10.3945\/ajcn.2010.29413_bib37","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/archinte.159.15.1701","article-title":"Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D)","volume":"159","author":"Irwin","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.3945\/ajcn.2010.29413_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/00207459109150691","article-title":"Use of brief cognitive tests to identify individuals in the community with clinically diagnosed Alzheimer\u2019s disease","volume":"57","author":"Albert","year":"1991","journal-title":"Int J Neurosci"},{"key":"10.3945\/ajcn.2010.29413_bib39","unstructured":"Smith A. Symbol digit modalities test manual\u2014revised. Los Angeles, CA: Western Psychological Services, 1984."},{"key":"10.3945\/ajcn.2010.29413_bib40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3945\/ajcn.2010.29413_bib41","doi-asserted-by":"crossref","first-page":"P155","DOI":"10.1093\/geronb\/54B.3.P155","article-title":"Cognitive activity in older persons from a geographically defined population","volume":"54","author":"Wilson","year":"1999","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10.3945\/ajcn.2010.29413_bib42","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2105\/AJPH.74.3.266","article-title":"A prospective study of functional status among community elders","volume":"74","author":"Branch","year":"1984","journal-title":"Am J Public Health"},{"key":"10.3945\/ajcn.2010.29413_bib43","doi-asserted-by":"crossref","unstructured":"Diggle PJ, Heagerty P, Liang KY, Zeger SL. Analysis of longitudinal data. 2nd ed. New York, NY: Oxford University Press, 2002.","DOI":"10.1093\/oso\/9780198524847.001.0001"},{"key":"10.3945\/ajcn.2010.29413_bib44","unstructured":"SAS Institute Inc. SAS\/STAT user\u2019s guide (version 9.2). Cary, NC: SAS Institute Inc, 2008. [Computer software]."},{"key":"10.3945\/ajcn.2010.29413_bib45","unstructured":"Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. Washington, DC: National Academy Press, 1998:196\u2013305."},{"key":"10.3945\/ajcn.2010.29413_bib46","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ajcn\/71.2.514","article-title":"Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study","volume":"71","author":"Tucker","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib47","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/ajcn\/79.5.805","article-title":"Breakfast cereal fortification with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: A randomized trial","volume":"79","author":"Tucker","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib48","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1212\/01.wnl.0000341272.48617.b0","article-title":"Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline","volume":"72","author":"Tangney","year":"2009","journal-title":"Neurology"},{"key":"10.3945\/ajcn.2010.29413_bib49","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archneur.62.4.641","article-title":"Dietary folate and vitamin B-12 and cognitive decline among community dwelling older persons","volume":"62","author":"Morris","year":"2005","journal-title":"Arch Neurol"},{"key":"10.3945\/ajcn.2010.29413_bib50","unstructured":"Shils ME, Olson JA, Shike M, eds. Modern nutrition in health and disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994."},{"key":"10.3945\/ajcn.2010.29413_bib51","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.2010.29413_bib52","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.2105\/AJPH.2005.067371","article-title":"Population-level changes in folate intake by age, gender, and race\/ethnicity after folic acid fortification","volume":"96","author":"Bentley","year":"2006","journal-title":"Am J Public Health"},{"key":"10.3945\/ajcn.2010.29413_bib53","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/ajcn\/86.3.718","article-title":"Trends in blood folate and vitamin B-12 concentrations in the United States, 1988\u20132004","volume":"86","author":"Pfeiffer","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcn\/82.2.442","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000","volume":"82","author":"Pfeiffer","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29413_bib55","doi-asserted-by":"crossref","first-page":"P136","DOI":"10.1093\/geronb\/60.3.P136","article-title":"Black-white differences in depressive symptoms among older adults over time","volume":"60","author":"Skarupski","year":"2005","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10.3945\/ajcn.2010.29413_bib56","doi-asserted-by":"crossref","unstructured":"Roberts SH, Bedson E, Hughes D, et al. Folate augmentation of treatment\u2013evaluation for depression (FolATED): protocol of a randomized controlled trial. BMC Psychiatry 2007;7:65. Available from: http:\/\/www.biomedcentral.com\/1471-244X\/7\/65 (cited April 2010).","DOI":"10.1186\/1471-244X-7-65"},{"key":"10.3945\/ajcn.2010.29413_bib57","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/fampra\/cmi040","article-title":"The role for vitamin B-6 as treatment for depression: a systematic review","volume":"22","author":"Williams","year":"2005","journal-title":"Fam Pract"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523019159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523019159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/92\/2\/330\/23865634\/330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T03:51:21Z","timestamp":1711511481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523019159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0002916523019159"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.2010.29413","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.2010.29413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}