{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:42:30Z","timestamp":1790412150305,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":4466,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.3945\/ajcn.2010.29955","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T03:11:37Z","timestamp":1288235497000},"page":"1452-1460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"title":["Fatty acid consumption and risk of fracture in the Women's Health Initiative"],"prefix":"10.1016","volume":"92","author":[{"given":"Tonya S","family":"Orchard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A","family":"Cauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail C","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian L","family":"Neuhouser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Snetselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Tylavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Wactawski-Wende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia M","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/ajcn.2010.29955_bib1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1359\/jbmr.2005.20.5.886","article-title":"How many women have osteoporosis? JBMR Anniversary Classic. JBMR, Volume 7, Number 9, 1992","volume":"20","author":"Melton","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.3945\/ajcn.2010.29955_bib2","unstructured":"Bone health and osteoporosis: a report of the Surgeon General. Rockville, MD: US Department of Health and Human Services, Office of the Surgeon General, 2004."},{"key":"10.3945\/ajcn.2010.29955_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/jbmr.5650070902","article-title":"Perspective. How many women have osteoporosis?","volume":"7","author":"Melton","year":"1992","journal-title":"J Bone Miner Res"},{"key":"10.3945\/ajcn.2010.29955_bib4","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.3945\/ajcn.2008.26956","article-title":"Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial","volume":"89","author":"McTiernan","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJMoa055218","article-title":"Calcium plus vitamin D supplementation and the risk of fractures","volume":"354","author":"Jackson","year":"2006","journal-title":"N Engl J Med"},{"key":"10.3945\/ajcn.2010.29955_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3945\/ajcn.2008.26451","article-title":"Vitamin A and retinol intakes and the risk of fractures among participants of the Women's Health Initiative Observational Study","volume":"89","author":"Caire-Juvera","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib7","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s00198-009-0897-y","article-title":"Protective effect of total and supplemental vitamin C intake on the risk of hip fracture\u2014a 17-year follow-up from the Framingham Osteoporosis Study","volume":"20","author":"Sahni","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.3945\/ajcn.2010.29955_bib8","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1017\/S0007114509311721","article-title":"Gu?guen Lo, Palacios C, Shearer MJ, Weaver CM. Minerals and vitamins in bone health: the potential value of dietary enhancement","volume":"101","author":"Bonjour","year":"2009","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clnu.2009.07.003","article-title":"Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture","volume":"29","author":"Chevalley","year":"2010","journal-title":"Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/jn\/136.1.159","article-title":"Dietary saturated fat intake is inversely associated with bone density in humans: analysis of NHANES III","volume":"136","author":"Corwin","year":"2006","journal-title":"J Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib11","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/sj.ejcn.1602624","article-title":"Dietary fat intake and the risk of osteoporotic fractures in the elderly","volume":"61","author":"Martinez-Ramirez","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2891-6-2","article-title":"An increase in dietary n\u22123 fatty acids decreases a marker of bone resorption in humans","volume":"6","author":"Griel","year":"2007","journal-title":"Nutr J"},{"key":"10.3945\/ajcn.2010.29955_bib13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/ajcn\/85.3.803","article-title":"n\u22123 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study","volume":"85","author":"Hogstrom","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/ajcn\/81.4.934","article-title":"Ratio of n\u22126 to n\u22123 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study","volume":"81","author":"Weiss","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib15","first-page":"385","article-title":"Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis","volume":"10","author":"Kruger","year":"1998","journal-title":"Aging (Milano)"},{"key":"10.3945\/ajcn.2010.29955_bib16","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1271\/bbb.68.2613","article-title":"Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat","volume":"68","author":"Sun","year":"2004","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.3945\/ajcn.2010.29955_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jnutbio.2005.01.019","article-title":"Protective actions of soy isoflavones and n\u22123 PUFAs on bone mass in ovariectomized rats","volume":"16","author":"Watkins","year":"2005","journal-title":"J Nutr Biochem"},{"key":"10.3945\/ajcn.2010.29955_bib18","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jnutbio.2005.05.012","article-title":"Dietary ratio of n\u22126\/n\u22123 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats","volume":"17","author":"Watkins","year":"2006","journal-title":"J Nutr Biochem"},{"key":"10.3945\/ajcn.2010.29955_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0952-3278(03)00063-2","article-title":"Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism","volume":"68","author":"Watkins","year":"2003","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.3945\/ajcn.2010.29955_bib20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1079\/BJN20051664","article-title":"Protective effect of dietary long-chain n\u22123 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats","volume":"95","author":"Shen","year":"2006","journal-title":"Br J Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00774-007-0815-3","article-title":"Dietary fish oil results in a greater bone mass and bone formation indices in aged ovariectomized rats","volume":"26","author":"Matsushita","year":"2008","journal-title":"J Bone Miner Metab"},{"key":"10.3945\/ajcn.2010.29955_bib22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jnutbio.2006.03.002","article-title":"Effects of arachidonic acid, docosahexaenoic acid, prostaglandin E(2) and parathyroid hormone on osteoprotegerin and RANKL secretion by MC3T3-E1 osteoblast-like cells","volume":"18","author":"Coetzee","year":"2007","journal-title":"J Nutr Biochem"},{"key":"10.3945\/ajcn.2010.29955_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jcp.21188","article-title":"Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid","volume":"214","author":"Rahman","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.3945\/ajcn.2010.29955_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1161\/01.CIR.0000079224.46084.C2","article-title":"Habitual dietary intake of n\u22123 and n\u22126 fatty acids in relation to inflammatory markers among US men and women","volume":"108","author":"Pischon","year":"2003","journal-title":"Circulation"},{"key":"10.3945\/ajcn.2010.29955_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/ajcn\/78.3.376","article-title":"Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation","volume":"78","author":"Trebble","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0197-2456(97)00078-0","article-title":"Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group","volume":"19","year":"1998","journal-title":"Control Clin Trials"},{"key":"10.3945\/ajcn.2010.29955_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1047-2797(98)00055-6","article-title":"Measurement characteristics of the Women's Health Initiative food frequency questionnaire","volume":"9","author":"Patterson","year":"1999","journal-title":"Ann Epidemiol"},{"key":"10.3945\/ajcn.2010.29955_bib28","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0002-8223(21)07997-9","article-title":"Sources of data for developing and maintaining a nutrient database","volume":"88","author":"Schakel","year":"1988","journal-title":"J Am Diet Assoc"},{"key":"10.3945\/ajcn.2010.29955_bib29","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1016\/S1047-2797(03)00048-6","article-title":"Outcomes ascertainment and adjudication methods in the Women's Health Initiative","volume":"13","author":"Curb","year":"2003","journal-title":"Ann Epidemiol"},{"key":"10.3945\/ajcn.2010.29955_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.GME.0000094210.15096.FD","article-title":"Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women's Health Initiative observational study and clinical trials","volume":"11","author":"Chen","year":"2004","journal-title":"Menopause"},{"key":"10.3945\/ajcn.2010.29955_bib31","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1359\/jbmr.070713","article-title":"Clinical Risk Factors for Fractures in Multi-Ethnic Women: The Women s Health Initiative","volume":"22","author":"Cauley","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.3945\/ajcn.2010.29955_bib32","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1001\/jama.298.20.2389","article-title":"Factors associated with 5-year risk of hip fracture in postmenopausal women","volume":"298","author":"Robbins","year":"2007","journal-title":"JAMA"},{"key":"10.3945\/ajcn.2010.29955_bib33","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.3945\/ajcn.2010.29955_bib34","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/jbmr.87","article-title":"Fish consumption, bone mineral density, and risk of hip fracture among older adults: the cardiovascular health study","volume":"25","author":"Virtanen","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.3945\/ajcn.2010.29955_bib35","doi-asserted-by":"crossref","first-page":"1526S","DOI":"10.1093\/ajcn\/83.6.1526S","article-title":"n\u22123 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits","volume":"83","author":"Gebauer","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0163-7827(00)00016-3","article-title":"Bioactive fatty acids: role in bone biology and bone cell function","volume":"40","author":"Watkins","year":"2001","journal-title":"Prog Lipid Res"},{"key":"10.3945\/ajcn.2010.29955_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5122(02)00022-1","article-title":"Polyunsaturated fatty acids. Is there a role in postmenopausal osteoporosis prevention?","volume":"42","author":"Albertazzi","year":"2002","journal-title":"Maturitas"},{"key":"10.3945\/ajcn.2010.29955_bib38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/ajcn\/63.1.116","article-title":"The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n\u22123 fatty acids from vegetable oil or fish oil","volume":"63","author":"Caughey","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/ajcn.2010.29955_bib39","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jama.292.4.490","article-title":"Clinical implications of the osteoprotegerin\/rankl\/rank system for bone and vascular diseases","volume":"292","author":"Hofbauer","year":"2004","journal-title":"JAMA"},{"key":"10.3945\/ajcn.2010.29955_bib40","unstructured":"US Department of Health and Human Services. Dietary guidelines for Americans. Washington, DC: US Government Printing Office, 2005."},{"key":"10.3945\/ajcn.2010.29955_bib41","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.jada.2006.09.002","article-title":"Dietary supplements in a national survey: prevalence of use and reports of adverse events","volume":"106","author":"Timbo","year":"2006","journal-title":"J Am Diet Assoc"},{"key":"10.3945\/ajcn.2010.29955_bib42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ajcn\/86.1.74","article-title":"Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women","volume":"86","author":"Sun","year":"2007","journal-title":"Am J Clin Nutr"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523021536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523021536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/92\/6\/1452\/23866618\/1452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T16:28:55Z","timestamp":1685377735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523021536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0002916523021536"],"URL":"https:\/\/doi.org\/10.3945\/ajcn.2010.29955","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatty acid consumption and risk of fracture in the Women's Health Initiative","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/ajcn.2010.29955","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}