{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:43:16Z","timestamp":1790995396516,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":3435,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.3945\/an.112.002220","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T05:36:42Z","timestamp":1347687402000},"page":"666-674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Copper Imbalances in Ruminants and Humans: Unexpected Common Ground"],"prefix":"10.1016","volume":"3","author":[{"given":"Neville F.","family":"Suttle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/an.112.002220_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1749-6632.1980.tb21338.x","article-title":"The role of thiomolybdates in the nutritional interactions of copper, molybdenum and sulfur: fact or fantasy","volume":"355","author":"Suttle","year":"1980","journal-title":"Ann N Y Acad Sci"},{"key":"10.3945\/an.112.002220_bib2","series-title":"Mineral nutrition of livestock","first-page":"255","article-title":"Copper","author":"Suttle","year":"2010"},{"key":"10.3945\/an.112.002220_bib3","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4065\/81.10.1371","article-title":"Copper deficiency myelopathy (human swayback)","volume":"81","author":"Kumar","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"10.3945\/an.112.002220_bib4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00415-010-5511-x","article-title":"Copper deficiency myelopathy","volume":"257","author":"Jaiser","year":"2010","journal-title":"J Neurol"},{"key":"10.3945\/an.112.002220_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.nu.08.070188.001315","article-title":"Copper deficiency in humans","volume":"8","author":"Danks","year":"1988","journal-title":"Annu Rev Nutr"},{"key":"10.3945\/an.112.002220_bib6","doi-asserted-by":"crossref","first-page":"2025S","DOI":"10.3945\/ajcn.2009.27230E","article-title":"Methods of assessment of copper status in humans: a systematic review","volume":"89","author":"Harvey","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/an.112.002220_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/vr.100716","article-title":"Residual effects of Mycobacterium avium infection on the susceptibility of sheep to copper toxicity and the efficacy of conservative treatment with tetrathiomolybdate","author":"Suttle","year":"2012","journal-title":"Vet Rec"},{"key":"10.3945\/an.112.002220_bib8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.dld.2006.12.095","article-title":"Wilson's disease - A practical approach to diagnosis, treatment and follow-up","volume":"39","author":"Medici","year":"2007","journal-title":"Dig Liver Dis"},{"key":"10.3945\/an.112.002220_bib9","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1158\/1078-0432.CCR-06-0171","article-title":"Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through inhibition of superoxide dismutase","volume":"12","author":"Juarez","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.3945\/an.112.002220_bib10","doi-asserted-by":"crossref","first-page":"H712","DOI":"10.1152\/ajpheart.01299.2010","article-title":"Copper chelation by tetrathiomolybdate inhibits lipospolysaccharide-induced inflammatory responses in vivo","volume":"301","author":"Wei","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.3945\/an.112.002220_bib11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3233\/JAD-2010-100408","article-title":"A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease","volume":"21","author":"Quinn","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3945\/an.112.002220_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3945\/an.110.000208","article-title":"Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases)","volume":"2","author":"Prohaska","year":"2011","journal-title":"Adv Nutr"},{"key":"10.3945\/an.112.002220_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1074\/jbc.R800055200","article-title":"New roles for copper metabolism in cell proliferation, signalling and disease","volume":"284","author":"Turski","year":"2009","journal-title":"J Biol Chem"},{"key":"10.3945\/an.112.002220_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1248\/jhs.57.385","article-title":"Research tools and techniques for copper metabolism in mammals","volume":"57","author":"Ogra","year":"2011","journal-title":"J Health Sci"},{"key":"10.3945\/an.112.002220_bib15","series-title":"Present knowledge in nutrition","first-page":"458","article-title":"Copper","author":"Prohaska","year":"2006"},{"key":"10.3945\/an.112.002220_bib16","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/BJ20040335","article-title":"Copper pathways in Plasmodium falciparum-infected erythrocytes indicate an efflux role for the copper P-ATPase","volume":"381","author":"Rasoloson","year":"2004","journal-title":"Biochem J"},{"key":"10.3945\/an.112.002220_bib17","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1017\/S0007114508057589","article-title":"The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle","volume":"101","author":"Hansen","year":"2009","journal-title":"Br J Nutr"},{"key":"10.3945\/an.112.002220_bib18","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.2527\/jas.2009-1978","article-title":"Technical note: copper chaperones for copper, zinc superoxide dismutase: a potential marker for copper status in cattle","volume":"87","author":"Hepburn","year":"2009","journal-title":"J Anim Sci"},{"key":"10.3945\/an.112.002220_bib19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3945\/jn.111.150755","article-title":"Erythrocyte chaperone for superoxide dismutase is increased following marginal copper deficiency in adult and post-weanling mice","volume":"142","author":"Lassi","year":"2012","journal-title":"J Nutr"},{"key":"10.3945\/an.112.002220_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1126\/science.1179907","article-title":"Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation","volume":"327","author":"Alvarez","year":"2010","journal-title":"Science"},{"key":"10.3945\/an.112.002220_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1079\/BJN2002558","article-title":"The immune system as a physiological indicator of marginal copper status?","volume":"87","author":"Bonham","year":"2002","journal-title":"Br J Nutr"},{"key":"10.3945\/an.112.002220_bib22","series-title":"Proceedings of the 21st Annual Conference on Trace Substances in Environmental Health","first-page":"514","article-title":"Copper and disease resistance","author":"Jones","year":"1987"},{"key":"10.3945\/an.112.002220_bib23","doi-asserted-by":"crossref","first-page":"13549","DOI":"10.1074\/jbc.R111.316406","article-title":"Copper homeostasis at the host-pathogen interface","volume":"287","author":"Hodgkinson","year":"2012","journal-title":"J Biol Chem"},{"key":"10.3945\/an.112.002220_bib24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jn\/138.5.849","article-title":"Copper deficiency increases the virulence of amyocarditic and myocarditic strains of coxsackievirus B3 in mice","volume":"138","author":"Smith","year":"2008","journal-title":"J Nutr"},{"key":"10.3945\/an.112.002220_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0162-0134(00)00223-3","article-title":"UV\/visible spectrophotometric studies of the interactions of thiomolybdates, copper (II) and other ligands","volume":"85","author":"Quagraine","year":"2001","journal-title":"J Inorg Biochem"},{"key":"10.3945\/an.112.002220_bib26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/vr.162.18.593","article-title":"Lack of effect of parenteral thiomolybdate on ovine caeruloplasmin activity: diagnostic implications","volume":"162","author":"Suttle","year":"2008","journal-title":"Vet Rec"},{"key":"10.3945\/an.112.002220_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0162-0134(99)00057-4","article-title":"Comparative mechanism and toxicity of tetra- and di-thiomolybdates in the removal of copper","volume":"75","author":"Ogra","year":"1999","journal-title":"J Inorg Biochem"},{"key":"10.3945\/an.112.002220_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0009-2797(99)00159-3","article-title":"Excretion of copper complexed with thiomolybdate into the bile and blood in LEC rats","volume":"124","author":"Komatsu","year":"2000","journal-title":"Chem Biol Interact"},{"key":"10.3945\/an.112.002220_bib29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0162-0134(99)00218-4","article-title":"Metabolic fate of the insoluble copper\/tetrathiomolybdate complex found in the liver of LEC rats with excess tetrathiomolybdate","volume":"78","author":"Ogra","year":"2000","journal-title":"J Inorg Biochem"},{"key":"10.3945\/an.112.002220_bib30","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jinorgbio.2010.04.001","article-title":"Effect of glutathione depletion on removal of copper from LEC rats by tetrathiomolybdate","volume":"104","author":"Ogra","year":"2010","journal-title":"J Inorg Biochem"},{"key":"10.3945\/an.112.002220_bib31","article-title":"The use of fractional change in liver copper concentration to assess the efficacy of parenteral copper supplements in cattle given a copper-deficient diet, with or without pre-treatment with tetrathiomolybdate","author":"Suttle","year":"2012","journal-title":"N Z Vet J"},{"key":"10.3945\/an.112.002220_bib32","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1096\/fj.08-127563","article-title":"Cell-surface thiols affect entry of di-sulphide-conjugated peptides","volume":"23","author":"Aubry","year":"2009","journal-title":"FASEB J"},{"key":"10.3945\/an.112.002220_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1017\/S0954422411000059","article-title":"Role of the rumen in copper and thiomolybdate absorption","volume":"24","author":"Gould","year":"2011","journal-title":"Nutr Res Rev"},{"key":"10.3945\/an.112.002220_bib34","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/rep.0.1250657","article-title":"Expression of lysyl oxidase and effect of copper chloride and ammonium tetrathiomolybdate on bovine ovarian follicle granulose cells cultured in serum-free media","volume":"125","author":"Kendall","year":"2003","journal-title":"Reproduction"},{"key":"10.3945\/an.112.002220_bib35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.1.06278","article-title":"Effect of copper and thiomolybdates on bovine theca cell differentiation in vitro","volume":"189","author":"Kendall","year":"2006","journal-title":"J Endocrinol"},{"key":"10.3945\/an.112.002220_bib36","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.bjc.6604226","article-title":"Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD 1) inhibitor tetrathiomolybdate (ATN-224)","volume":"98","author":"Do\u00f1ate","year":"2008","journal-title":"Br J Cancer"},{"key":"10.3945\/an.112.002220_bib37","series-title":"Trace element metabolism in man and animals. Proceedings of the 4th International Symposium","first-page":"557","article-title":"The effects of injecting sheep with thiomolybdate","author":"Gordon","year":"1981"},{"key":"10.3945\/an.112.002220_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0021-9975(03)00065-3","article-title":"Molybdenum-associated pituitary endocrinopathy in sheep treated with ammonium tetrathiomolybdate","volume":"130","author":"Haywood","year":"2004","journal-title":"J Comp Pathol"},{"key":"10.3945\/an.112.002220_bib39","doi-asserted-by":"crossref","DOI":"10.1136\/vr.100722","article-title":"Responsiveness of pre-hemolytic copper poisoning in sheep from a specific pathogen-free environment to recommended doses of tetrathiomolybdate","author":"Suttle","year":"2012","journal-title":"Vet Rec"},{"key":"10.3945\/an.112.002220_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.braindev.2005.08.008","article-title":"Paradigm shift in treatment of Wilson's disease: zinc therapy now the treatment of choice","volume":"28","author":"Hoogenraad","year":"2006","journal-title":"Brain Dev"},{"key":"10.3945\/an.112.002220_bib41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.anifeedsci.2012.01.013","article-title":"Control of hepatic copper retention in Texel ram lambs by dietary supplementation with copper antagonists followed by a copper depletion regimen","volume":"173","author":"Suttle","year":"2012","journal-title":"Anim Feed Sci Technol"},{"key":"10.3945\/an.112.002220_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jtemb.2008.07.002","article-title":"Evidence of decreasing mineral density in wheat grain over the last 160 years","volume":"22","author":"Fan","year":"2008","journal-title":"J Trace Elem Med Biol"},{"key":"10.3945\/an.112.002220_bib43","series-title":"Kinetics of thiomolybdate and copper-thiomolybdate interconversion processes","author":"Rhett","year":"2009"},{"key":"10.3945\/an.112.002220_bib44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1017\/S0021859600080758","article-title":"The effect of dietary molybdenum and iron on copper status, puberty, fertility and oestrus cycles in cattle","volume":"109","author":"Phillippo","year":"1987","journal-title":"J Agric Sci Camb"},{"key":"10.3945\/an.112.002220_bib45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1079\/BJN19820119","article-title":"Changes in the distribution of copper and molybdenum after Mo administration and subsequent oral or intraperitoneal Cu administration in rats","volume":"48","author":"Nederbraght","year":"1982","journal-title":"Br J Nutr"},{"key":"10.3945\/an.112.002220_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0021-9975(80)90035-3","article-title":"A sequential study of the skeletal abnormalities which develop in rats given a small dietary supplement of ammonium tetrathiomolybdate","volume":"90","author":"Spence","year":"1980","journal-title":"J Comp Pathol"},{"key":"10.3945\/an.112.002220_bib47","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/icb.1986.59","article-title":"The matrix components of the epiphyseal growth plate and articular cartilage from dogs treated with ammonium tetrathiomolybdate, a copper antagonist","volume":"64","author":"Read","year":"1986","journal-title":"Aust J Exp Biol Med Sci"},{"key":"10.3945\/an.112.002220_bib48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.trsl.2009.05.002","article-title":"Treatment of Wilson's disease with tetrathiomolybdate: V. control of free copper by tetrathiomolybdate and a comparison with trientine","volume":"154","author":"Brewer","year":"2009","journal-title":"Transl Res"},{"key":"10.3945\/an.112.002220_bib49","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1039\/b106349a","article-title":"Selective extraction of blood plasma exchangeable copper for isotope studies of copper absorption","volume":"126","author":"Beattie","year":"2001","journal-title":"Analyst"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322010481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322010481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/advances\/article-pdf\/3\/5\/666\/24278589\/666.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:10:19Z","timestamp":1761873019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831322010481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S2161831322010481"],"URL":"https:\/\/doi.org\/10.3945\/an.112.002220","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper Imbalances in Ruminants and Humans: Unexpected Common Ground","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/an.112.002220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 American Society for Nutrition","name":"copyright","label":"Copyright"}]}}