{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:26:50Z","timestamp":1791232010061,"version":"4.1.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":2583,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.3945\/an.114.007500","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T12:47:45Z","timestamp":1421326065000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":243,"title":["Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases"],"prefix":"10.1016","volume":"6","author":[{"given":"Isha","family":"Solanki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Parihar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Lukman","family":"Mansuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordhwaj S","family":"Parihar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/an.114.007500_bib1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in neurodegenerative diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"10.3945\/an.114.007500_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1582-4934.2001.tb00134.x","article-title":"Cell death mechanisms in neurodegeneration","volume":"5","author":"Jellinger","year":"2001","journal-title":"J Cell Mol Med"},{"key":"10.3945\/an.114.007500_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12263-007-0056-z","article-title":"The interactions of flavonoids within neuronal signalling pathways","volume":"2","author":"Spencer","year":"2007","journal-title":"Genes Nutr"},{"key":"10.3945\/an.114.007500_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/an.114.007500_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1471-4159.2003.01652.x","article-title":"Interaction between flavonoids and the blood-brain barrier: in vitro studies","volume":"85","author":"Youdim","year":"2003","journal-title":"J Neurochem"},{"key":"10.3945\/an.114.007500_bib6","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.freeradbiomed.2003.11.023","article-title":"Flavonoid permeability across an in situ model of the blood-brain barrier","volume":"36","author":"Youdim","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.3945\/an.114.007500_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0378-4347(98)00204-7","article-title":"Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography","volume":"714","author":"Peng","year":"1998","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.3945\/an.114.007500_bib8","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0891-5849(02)01137-1","article-title":"Uptake and metabolism of epicatechin and its access to the brain after oral ingestion","volume":"33","author":"Abd El Mohsen","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.3945\/an.114.007500_bib9","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/jf050145v","article-title":"Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain","volume":"53","author":"Talav\u00e9ra","year":"2005","journal-title":"J Agric Food Chem"},{"key":"10.3945\/an.114.007500_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2007.12.015","article-title":"Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro","volume":"1198","author":"Zhang","year":"2008","journal-title":"Brain Res"},{"key":"10.3945\/an.114.007500_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12263-008-0091-4","article-title":"The neuroprotective potential of flavonoids: a multiplicity of effects","volume":"3","author":"Vauzour","year":"2008","journal-title":"Genes Nutr"},{"key":"10.3945\/an.114.007500_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmed.2007.12.002","article-title":"Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease","volume":"14","author":"Reddy","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.3945\/an.114.007500_bib13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.disamonth.2010.06.001","article-title":"Alzheimer disease","volume":"56","author":"Castellani","year":"2010","journal-title":"Dis Mon"},{"key":"10.3945\/an.114.007500_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1471-4159.2003.01976.x","article-title":"Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease","volume":"87","author":"Ono","year":"2003","journal-title":"J Neurochem"},{"key":"10.3945\/an.114.007500_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.lfs.2011.09.023","article-title":"Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells","volume":"89","author":"Jim\u00e9nez-Aliaga","year":"2011","journal-title":"Life Sci"},{"key":"10.3945\/an.114.007500_bib16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/acel.12185","article-title":"Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice","volume":"13","author":"Currais","year":"2014","journal-title":"Aging Cell"},{"key":"10.3945\/an.114.007500_bib17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/jn\/136.4.1043","article-title":"Long-term administration of green tea catechins improves spatial cognition learning ability in rats","volume":"136","author":"Haque","year":"2006","journal-title":"J Nutr"},{"key":"10.3945\/an.114.007500_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2012.02.029","article-title":"Potential protection of green tea polyphenols against intracellular amyloid beta-induced toxicity on primary cultured prefrontal cortical neurons of rats","volume":"513","author":"Qin","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.3945\/an.114.007500_bib19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1039\/c2fo10174b","article-title":"Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites","volume":"3","author":"Okello","year":"2012","journal-title":"Food Funct"},{"key":"10.3945\/an.114.007500_bib20","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1046\/j.1460-9568.2000.00069.x","article-title":"The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid","volume":"12","author":"Bastianetto","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.3945\/an.114.007500_bib21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0024-3205(01)01438-2","article-title":"The green tea polyphenol (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons","volume":"70","author":"Choi","year":"2001","journal-title":"Life Sci"},{"key":"10.3945\/an.114.007500_bib22","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.freeradbiomed.2003.10.018","article-title":"Genistein ameliorates beta-amyloid peptide (25\u201335)-induced hippocampal neuronal apoptosis","volume":"36","author":"Zeng","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.3945\/an.114.007500_bib23","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1074\/jbc.M006406200","article-title":"The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons","volume":"276","author":"Wang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.3945\/an.114.007500_bib24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3724\/SP.J.1206.2009.00773","article-title":"Protective effect of anthocyanin against the oxidative stress in neuroblastoma N2a cells","volume":"37","author":"Liu","year":"2010","journal-title":"Prog Biochem Biophys"},{"key":"10.3945\/an.114.007500_bib25","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuro.2012.03.003","article-title":"Rutin inhibits \u03b2-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines","volume":"33","author":"Wang","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.3945\/an.114.007500_bib26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2202-6-54","article-title":"Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans","volume":"6","author":"Gutierrez-Zepeda","year":"2005","journal-title":"BMC Neurosci"},{"key":"10.3945\/an.114.007500_bib27","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.3390\/molecules18089949","article-title":"Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer's disease mouse model","volume":"18","author":"Zhao","year":"2013","journal-title":"Molecules"},{"key":"10.3945\/an.114.007500_bib28","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.neurobiolaging.2010.11.006","article-title":"Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols","volume":"33","author":"Ksiezak-Reding","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.3945\/an.114.007500_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nbd.2011.07.005","article-title":"Morin attenuates tau hyperphosphorylation by inhibiting GSK3\u03b2","volume":"44","author":"Gong","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.3945\/an.114.007500_bib30","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J"},{"key":"10.3945\/an.114.007500_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(01)01677-9","article-title":"Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1\u201342) insult","volume":"303","author":"Kim","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.3945\/an.114.007500_bib32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbr.2007.03.001","article-title":"A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25\u201335)","volume":"180","author":"Alkam","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.3945\/an.114.007500_bib33","first-page":"39","article-title":"Neuroprotective effects of carnosic Acid in an experimental model of Alzheimer's disease in rats","volume":"13","author":"Azad","year":"2011","journal-title":"Cell J."},{"key":"10.3945\/an.114.007500_bib34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/10284150290032012","article-title":"Effect of aged garlic extract on caspase-3 activity, in vitro","volume":"5","author":"Jackson","year":"2002","journal-title":"Nutr Neurosci"},{"key":"10.3945\/an.114.007500_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.3945\/an.114.007500_bib36","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s00018-008-7589-1","article-title":"Mitochondrial association of alpha-synuclein causes oxidative stress","volume":"65","author":"Parihar","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.3945\/an.114.007500_bib37","first-page":"1","article-title":"Effect of quercetin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease","volume":"2012","author":"Lv","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.3945\/an.114.007500_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/921941","article-title":"Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system","volume":"2012","author":"Bournival","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"10.3945\/an.114.007500_bib39","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/aje\/155.8.732","article-title":"Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake","volume":"155","author":"Checkoway","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.3945\/an.114.007500_bib40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1471-4159.2001.00490.x","article-title":"Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration","volume":"78","author":"Levites","year":"2001","journal-title":"J Neurochem"},{"key":"10.3945\/an.114.007500_bib41","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1248\/bpb.b12-00127","article-title":"Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo","volume":"35","author":"Kim","year":"2012","journal-title":"Biol Pharm Bull"},{"key":"10.3945\/an.114.007500_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1179\/135100002125000424","article-title":"Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells","volume":"7","author":"Nie","year":"2002","journal-title":"Redox Rep"},{"key":"10.3945\/an.114.007500_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12640-011-9295-2","article-title":"Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease","volume":"22","author":"Khan","year":"2012","journal-title":"Neurotox Res"},{"key":"10.3945\/an.114.007500_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ptr.2564","article-title":"Neuroprotective effect of genistein in 6-hydroxydopamine hemi-parkinsonian rat model","volume":"23","author":"Baluchnejadmojarad","year":"2009","journal-title":"Phytother Res"},{"key":"10.3945\/an.114.007500_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4236\/pp.2013.44053","article-title":"Additive protective effects of luteolin and pyruvate against 6-hydroxydopamine and 3-hydroxykynurenine induced neurotoxicity in SH-SY5Y cells","volume":"4","author":"Wszelaki","year":"2013","journal-title":"Pharmacol & Pharm"},{"key":"10.3945\/an.114.007500_bib46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bcp.2004.09.018","article-title":"Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures","volume":"69","author":"Mercer","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.3945\/an.114.007500_bib47","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.nut.2012.03.007","article-title":"Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: therapeutic perspectives","volume":"28","author":"Rojas","year":"2012","journal-title":"Nutrition"},{"key":"10.3945\/an.114.007500_bib48","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1097\/00001756-200112040-00053","article-title":"Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinsonaposs disease","volume":"12","author":"Datla","year":"2001","journal-title":"Neuroreport"},{"key":"10.3945\/an.114.007500_bib49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2010.02.031","article-title":"Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease","volume":"1328","author":"Khan","year":"2010","journal-title":"Brain Res"},{"key":"10.3945\/an.114.007500_bib50","first-page":"157","article-title":"Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"10","author":"Rajeswari","year":"2006","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.3945\/an.114.007500_bib51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tox.2008.06.010","article-title":"Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis","volume":"250","author":"Lee","year":"2008","journal-title":"Toxicology"},{"key":"10.3945\/an.114.007500_bib52","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1124\/jpet.106.110866","article-title":"Protective effect of sulforaphane against dopaminergic cell death","volume":"321","author":"Han","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.3945\/an.114.007500_bib53","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/mp.54.6.409","article-title":"Huntington's disease","volume":"54","author":"Davies","year":"2001","journal-title":"Mol Pathol"},{"key":"10.3945\/an.114.007500_bib54","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/hmg\/ddl210","article-title":"Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models","volume":"15","author":"Ehrnhoefer","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.3945\/an.114.007500_bib55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2012.07.060","article-title":"Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway","volume":"227","author":"Gopinath","year":"2012","journal-title":"Neuroscience"},{"key":"10.3945\/an.114.007500_bib56","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.neuro.2012.07.007","article-title":"Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats","volume":"33","author":"Menze","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.3945\/an.114.007500_bib57","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbadis.2012.11.018","article-title":"Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: implications in Huntingtonaposs disease","volume":"1832","author":"Sandhir","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.3945\/an.114.007500_bib58","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1016\/j.fct.2009.07.011","article-title":"Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism","volume":"47","author":"Kumar","year":"2009","journal-title":"Food Chem Toxicol"},{"key":"10.3945\/an.114.007500_bib59","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1167\/iovs.08-2088","article-title":"The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression","volume":"50","author":"Johnson","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.3945\/an.114.007500_bib60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutation in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.3945\/an.114.007500_bib61","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neulet.2005.10.056","article-title":"The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice","volume":"395","author":"Koh","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.3945\/an.114.007500_bib62","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s11064-006-9166-z","article-title":"Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"31","author":"Xu","year":"2006","journal-title":"Neurochem Res"},{"key":"10.3945\/an.114.007500_bib63","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1006\/bbrc.1999.0577","article-title":"Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke","volume":"258","author":"Trieu","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3945\/an.114.007500_bib64","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.iy.10.040192.001101","article-title":"Immunological aspects of demyelinating diseases","volume":"10","author":"Martin","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"10.3945\/an.114.007500_bib65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00415-005-5002-7","article-title":"The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage","volume":"252","author":"Br\u00fcck","year":"2005","journal-title":"J Neurol"},{"key":"10.3945\/an.114.007500_bib66","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1084\/jem.20040819","article-title":"Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis","volume":"200","author":"Hendriks","year":"2004","journal-title":"J Exp Med"},{"key":"10.3945\/an.114.007500_bib67","doi-asserted-by":"crossref","first-page":"e25456","DOI":"10.1371\/journal.pone.0025456","article-title":"Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation","volume":"6","author":"Herges","year":"2011","journal-title":"PLoS ONE"},{"key":"10.3945\/an.114.007500_bib68","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0006-2952(02)01609-X","article-title":"Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study","volume":"65","author":"Hendriks","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.3945\/an.114.007500_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-5728(91)90073-G","article-title":"Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis","volume":"32","author":"Maimone","year":"1991","journal-title":"J Neuroimmunol"},{"key":"10.3945\/an.114.007500_bib70","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jneuroim.2008.09.008","article-title":"Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients","volume":"205","author":"Sternberg","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.3945\/an.114.007500_bib71","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s12263-014-0400-z","article-title":"Flavonoids in modulation of cell survival signalling pathways","volume":"9","author":"Mansuri","year":"2014","journal-title":"Genes Nutr."},{"key":"10.3945\/an.114.007500_bib72","doi-asserted-by":"crossref","first-page":"30574","DOI":"10.1074\/jbc.M202832200","article-title":"Involvement of protein kinase C activation and cell survival\/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action","volume":"277","author":"Levites","year":"2002","journal-title":"J Biol Chem"},{"key":"10.3945\/an.114.007500_bib73","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1471-4159.2007.04841.x","article-title":"Activation of pro-survival Akt and ERK1\/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons","volume":"103","author":"Vauzour","year":"2007","journal-title":"J Neurochem"},{"key":"10.3945\/an.114.007500_bib74","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2008.04.008","article-title":"Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels","volume":"45","author":"Williams","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.3945\/an.114.007500_bib75","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1021\/jf301511m","article-title":"Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1\/Nrf2\/HO-1 and involving PKC\u03b1 and PI3K\/AKT signalling pathways","volume":"60","author":"Zhang","year":"2012","journal-title":"J Agric Food Chem"},{"key":"10.3945\/an.114.007500_bib76","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-0082(99)00042-8","article-title":"JNK and p38 stresskinases\u2014degenerative effectors of signal-transduction-cascades in the nervous system","volume":"61","author":"Mielke","year":"2000","journal-title":"Prog Neurobiol"},{"key":"10.3945\/an.114.007500_bib77","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/6854","article-title":"Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation","volume":"21","author":"Behrens","year":"1999","journal-title":"Nat Genet"},{"key":"10.3945\/an.114.007500_bib78","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1046\/j.1523-1755.2000.00265.x","article-title":"Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways","volume":"58","author":"Ishikawa","year":"2000","journal-title":"Kidney Int"},{"key":"10.3945\/an.114.007500_bib79","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/bj3580547","article-title":"Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3","volume":"358","author":"Schroeter","year":"2001","journal-title":"Biochem J"},{"key":"10.3945\/an.114.007500_bib80","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1021\/jf8033607","article-title":"Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide","volume":"57","author":"Hwang","year":"2009","journal-title":"J Agric Food Chem"},{"key":"10.3945\/an.114.007500_bib81","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1474-9726.2007.00356.x","article-title":"Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38","volume":"7","author":"Vall\u00e9s","year":"2008","journal-title":"Aging Cell"},{"key":"10.3945\/an.114.007500_bib82","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00394-008-0761-4","article-title":"Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress","volume":"48","author":"Ramiro-Puig","year":"2009","journal-title":"Eur J Nutr"},{"key":"10.3945\/an.114.007500_bib83","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0278-5846(03)00124-6","article-title":"Inflammatory processes in Alzheimer's disease","volume":"27","author":"McGeer","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.3945\/an.114.007500_bib84","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jnr.20671","article-title":"Lipopolysaccharide and proinflammatory cytokines require different astrocyte states to induce nitric oxide production","volume":"82","author":"Kozuka","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.3945\/an.114.007500_bib85","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/jnr.21205","article-title":"Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia","volume":"85","author":"Lau","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.3945\/an.114.007500_bib86","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1179\/1743132811Y.0000000023","article-title":"Luteolin reduces primary hippocampal neurons death induced by neuroinflammation","volume":"33","author":"Zhu","year":"2011","journal-title":"Neurol Res"},{"key":"10.3945\/an.114.007500_bib87","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1476-5381.2011.01389.x","article-title":"Kaempferol acts through mitogen-activated protein kinases and protein kinase B\/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells","volume":"164","author":"Park","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.3945\/an.114.007500_bib88","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1096\/fj.03-0057fje","article-title":"Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia","volume":"17","author":"Lee","year":"2003","journal-title":"FASEB J"},{"key":"10.3945\/an.114.007500_bib89","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jnr.20315","article-title":"(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury","volume":"78","author":"Li","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.3945\/an.114.007500_bib90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2005.08.005","article-title":"Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia","volume":"521","author":"Chen","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.3945\/an.114.007500_bib91","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.lfs.2009.12.014","article-title":"Inhibition of nitric oxide production by quercetin in endotoxin\/cytokine-stimulated microglia","volume":"86","author":"Kao","year":"2010","journal-title":"Life Sci"},{"key":"10.3945\/an.114.007500_bib92","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1523\/JNEUROSCI.18-05-01633.1998","article-title":"Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures","volume":"18","author":"Bhat","year":"1998","journal-title":"J Neurosci"},{"key":"10.3945\/an.114.007500_bib93","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.intimp.2007.12.012","article-title":"Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity","volume":"8","author":"Zheng","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.3945\/an.114.007500_bib94","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1073\/pnas.0802865105","article-title":"Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1","volume":"105","author":"Jang","year":"2008","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322006238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831322006238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/advances\/article-pdf\/6\/1\/64\/23880599\/64.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:05:26Z","timestamp":1761872726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831322006238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S2161831322006238"],"URL":"https:\/\/doi.org\/10.3945\/an.114.007500","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/an.114.007500","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 American Society for Nutrition","name":"copyright","label":"Copyright"}]}}