{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:03:20Z","timestamp":1773291800115,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":4808,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.3945\/jn.109.105130","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T01:51:10Z","timestamp":1255571470000},"page":"2272-2278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dietary Sulfur Amino Acid Supplementation Reduces Small Bowel Thiol\/Disulfide Redox State and Stimulates Ileal Mucosal Growth after Massive Small Bowel Resection in Rats"],"prefix":"10.1016","volume":"139","author":[{"given":"Yvonne","family":"Shyntum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita S.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqiang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanci O.","family":"Mannery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/jn.109.105130_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.nutr.23.011702.073036","article-title":"Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair and barrier function","volume":"23","author":"Ziegler","year":"2003","journal-title":"Annu Rev Nutr."},{"issue":"2 Suppl 1","key":"10.3945\/jn.109.105130_bib2","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1053\/j.gastro.2005.09.063","article-title":"Parenteral nutrition: transient or permanent therapy in intestinal failure?","volume":"130","author":"Ziegler","year":"2006","journal-title":"Gastroenterology."},{"key":"10.3945\/jn.109.105130_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0148607188012003299","article-title":"Nutrition, operations, and intestinal adaptation","volume":"12","author":"Bristol","year":"1988","journal-title":"JPEN J Parenter Enteral Nutr."},{"key":"10.3945\/jn.109.105130_bib4","doi-asserted-by":"crossref","first-page":"R1421","DOI":"10.1152\/ajpregu.00702.2002","article-title":"Glutamine and KGF each regulate extracellular thiol\/disulfide redox and enhance proliferation in Caco-2 cells","volume":"285","author":"Jonas","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.3945\/jn.109.105130_bib5","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0891-5849(02)01081-X","article-title":"Extracellular thiol\/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line","volume":"33","author":"Jonas","year":"2002","journal-title":"Free Radic Biol Med."},{"key":"10.3945\/jn.109.105130_bib6","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic Biol Med."},{"key":"10.3945\/jn.109.105130_bib7","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1089\/ars.2006.8.1865","article-title":"Redefining oxidative stress","volume":"8","author":"Jones","year":"2006","journal-title":"Antioxid Redox Signal."},{"key":"10.3945\/jn.109.105130_bib8","doi-asserted-by":"crossref","first-page":"G1352","DOI":"10.1152\/ajpgi.00183.2002","article-title":"Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells","volume":"283","author":"Nkabyo","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"10.3945\/jn.109.105130_bib9","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0891-5849(99)00145-8","article-title":"Glutathione redox potential in response to differentiation and enzyme inducers","volume":"27","author":"Kirlin","year":"1999","journal-title":"Free Radic Biol Med."},{"key":"10.3945\/jn.109.105130_bib10","doi-asserted-by":"crossref","first-page":"R1081","DOI":"10.1152\/ajpregu.00050.2006","article-title":"Stimulation of colonic mucosal growth associated with oxidized redox status in rats","volume":"292","author":"Tian","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.3945\/jn.109.105130_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0300-483X(94)90119-8","article-title":"Exogenous glutathione attenuates the antiproliferative effect of buthionine sulfoximine","volume":"88","author":"Kang","year":"1994","journal-title":"Toxicology."},{"key":"10.3945\/jn.109.105130_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/bmmb.1994.1062","article-title":"Glutathione metabolism in Crohn\u2019s disease","volume":"53","author":"Iantomasi","year":"1994","journal-title":"Biochem Med Metab Biol."},{"key":"10.3945\/jn.109.105130_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0261-5614(98)80030-7","article-title":"Low levels of glutathione in endoscopic biopsies of patients with Crohn\u2019s colitis: the role of malnutrition","volume":"18","author":"Miralles-Barrachina","year":"1999","journal-title":"Clin Nutr."},{"key":"10.3945\/jn.109.105130_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/gut.42.4.485","article-title":"Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease","volume":"42","author":"Sido","year":"1998","journal-title":"Gut."},{"key":"10.3945\/jn.109.105130_bib15","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/labinvest.3780077","article-title":"Replenishment of glutathione levels improves mucosal function in experimental acute colitis","volume":"80","author":"Ardite","year":"2000","journal-title":"Lab Invest."},{"key":"10.3945\/jn.109.105130_bib16","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/jn\/136.5.1242","article-title":"Thiol\/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake","volume":"136","author":"Nkabyo","year":"2006","journal-title":"J Nutr."},{"key":"10.3945\/jn.109.105130_bib17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0148607104028006399","article-title":"Comparative effects of glucagon-like peptide-2 (GLP-2), growth hormone (GH) and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats","volume":"28","author":"Washizawa","year":"2004","journal-title":"J Parent Enteral Nutr."},{"key":"10.3945\/jn.109.105130_bib18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1165\/rcmb.2007-0447OC","article-title":"Oxidation of plasma cysteine\/cystine redox state in endotoxin-induced lung injury","volume":"40","author":"Iyer","year":"2009","journal-title":"Am J Respir Cell Mol Biol."},{"key":"10.3945\/jn.109.105130_bib19","doi-asserted-by":"crossref","first-page":"L37","DOI":"10.1152\/ajplung.90401.2008","article-title":"Oxidation of extracellular cysteine\/cystine redox state in bleomycin-induced lung fibrosis","volume":"296","author":"Iyer","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"10.3945\/jn.109.105130_bib20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0003-2697(80)90165-7","article-title":"A simple, rapid, and sensitive DNA assay procedure","volume":"102","author":"Labarca","year":"1980","journal-title":"Anal Biochem."},{"key":"10.3945\/jn.109.105130_bib21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem."},{"key":"10.3945\/jn.109.105130_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(02)48630-2","article-title":"Redox potential of GSH\/GSSG couple: assay and biological significance","volume":"348","author":"Jones","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.3945\/jn.109.105130_bib23","first-page":"81","article-title":"Intramucosal pH and oxygen extraction in the gastrointestinal tract after major liver resection in rats","volume":"159","author":"Wang","year":"1993","journal-title":"Eur J Surg."},{"key":"10.3945\/jn.109.105130_bib24","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/jn\/129.7.1278","article-title":"Keratinocyte growth factor enhances glutathione redox state in rat intestinal mucosa during nutritional repletion","volume":"129","author":"Jonas","year":"1999","journal-title":"J Nutr."},{"key":"10.3945\/jn.109.105130_bib25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/ajcn\/76.3.646","article-title":"Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition","volume":"76","author":"Badaloo","year":"2002","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.109.105130_bib26","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.exger.2004.06.001","article-title":"Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats","volume":"39","author":"Grattagliano","year":"2004","journal-title":"Exp Gerontol."},{"key":"10.3945\/jn.109.105130_bib27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0891-5849(99)00275-0","article-title":"Redox state of glutathione in human plasma","volume":"28","author":"Jones","year":"2000","journal-title":"Free Radic Biol Med."},{"key":"10.3945\/jn.109.105130_bib28","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1167\/iovs.04-0949","article-title":"Oxidant-induced apoptosis in human retinal pigment epithelial cells: dependence on extracellular redox state","volume":"46","author":"Jiang","year":"2005","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"10.3945\/jn.109.105130_bib29","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/ajcn\/86.4.1016","article-title":"Diurnal variation in glutathione and cysteine redox states in human plasma","volume":"86","author":"Blanco","year":"2007","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.109.105130_bib30","doi-asserted-by":"crossref","first-page":"G70","DOI":"10.1152\/ajpgi.00280.2004","article-title":"Extracellular cysteine\/cystine redox regulates the p44\/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling","volume":"289","author":"Nkabyo","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"issue":"Suppl 1:","key":"10.3945\/jn.109.105130_bib31","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1097\/01.mpg.0000226393.87106.da","article-title":"Critical roles for EGF receptor signaling during resection-induced intestinal adaptation","volume":"43","author":"Warner","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.3945\/jn.109.105130_bib32","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1210\/endo.139.7.6097","article-title":"Intestinal adaptation after extensive small bowel resection: differential changes in growth and IGF-I system messenger ribonucleic acids in jejunum and ileum","volume":"139","author":"Ziegler","year":"1998","journal-title":"Endocrinology."},{"key":"10.3945\/jn.109.105130_bib33","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1073\/pnas.87.5.1715","article-title":"Glutathione is required for intestinal function","volume":"87","author":"Martensson","year":"1990","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.109.105130_bib34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1023\/A:1021775524062","article-title":"Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and reversal by glutathione","volume":"48","author":"Tsunada","year":"2003","journal-title":"Dig Dis Sci."},{"key":"10.3945\/jn.109.105130_bib35","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/jn\/137.2.320","article-title":"Local glutathione redox status does not regulate ileal mucosal growth after massive small bowel resection in rats","volume":"137","author":"Tian","year":"2007","journal-title":"J Nutr."},{"key":"10.3945\/jn.109.105130_bib36","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1096\/fj.03-0971fje","article-title":"Cysteine\/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control","volume":"18","author":"Jones","year":"2004","journal-title":"FASEB J."},{"key":"10.3945\/jn.109.105130_bib37","doi-asserted-by":"crossref","first-page":"C849","DOI":"10.1152\/ajpcell.00283.2008","article-title":"Radical-free biology of oxidative stress","volume":"295","author":"Jones","year":"2008","journal-title":"Am J Physiol Cell Physiol."},{"key":"10.3945\/jn.109.105130_bib38","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0955-2863(02)00218-8","article-title":"Dietary supplementation with cysteine prodrugs selectively restores tissue glutathione levels and redox status in protein-malnourished mice","volume":"13","author":"Li","year":"2002","journal-title":"J Nutr Biochem."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622066093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622066093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/139\/12\/2272\/23904450\/2272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:54:18Z","timestamp":1686696858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622066093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0022316622066093"],"URL":"https:\/\/doi.org\/10.3945\/jn.109.105130","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Sulfur Amino Acid Supplementation Reduces Small Bowel Thiol\/Disulfide Redox State and Stimulates Ileal Mucosal Growth after Massive Small Bowel Resection in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.109.105130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}