{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:05:07Z","timestamp":1790064307245,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":4838,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.3945\/jn.109.107359","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T01:28:47Z","timestamp":1253755727000},"page":"2119-2123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Increases in Plasma Holotranscobalamin Can Be Used to Assess Vitamin B-12 Absorption in Individuals with Low Plasma Vitamin B-12"],"prefix":"10.1016","volume":"139","author":[{"given":"Dattatray S.","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nileema V.","family":"Thuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himangi G.","family":"Lubree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charudatta V.","family":"Joglekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadanand S.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita V.","family":"Ramdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Refsum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline H.","family":"Fall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittaranjan S.","family":"Yajnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.109.107359_bib1","article-title":"Megaloblastic anaemia in a vegetarian Hindu community","volume":"2","author":"Chanarin","year":"1985","journal-title":"Lancet."},{"key":"10.3945\/jn.109.107359_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/74.2.233","article-title":"Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians","volume":"74","author":"Refsum","year":"2001","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.109.107359_bib3","article-title":"Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians","volume":"54","author":"Yajnik","year":"2006","journal-title":"J Assoc Physicians India."},{"key":"10.3945\/jn.109.107359_bib4","article-title":"Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification","volume":"28","author":"Selhub","year":"2000","journal-title":"Public Health Rev."},{"key":"10.3945\/jn.109.107359_bib5","article-title":"Adiposity, inflammation, insulin resistance and hyperglycaemia in rural and urban Indian men","volume":"51","author":"Yajnik","year":"2008","journal-title":"Diabetologia."},{"key":"10.3945\/jn.109.107359_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/156482650802900401","article-title":"Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children","volume":"29","author":"Bhate","year":"2008","journal-title":"Food Nutr Bull."},{"key":"10.3945\/jn.109.107359_bib7","article-title":"Nutro-genetic determinants of neural tube defects in India","volume":"46","author":"Godbole","year":"2009","journal-title":"Indian Pediatr."},{"key":"10.3945\/jn.109.107359_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/78.1.3","article-title":"Vegetarianism and vitamin B-12 (cobalamin) deficiency","volume":"78","author":"Antony","year":"2003","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.109.107359_bib9","article-title":"Observations on dietary practices in India","volume":"38","author":"Price","year":"1984","journal-title":"Hum Nutr Appl Nutr."},{"key":"10.3945\/jn.109.107359_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/0035-9203(88)90247-7","article-title":"Tropical sprue in southern India","volume":"82","author":"Mathan","year":"1988","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"10.3945\/jn.109.107359_bib11","article-title":"Megaloblastic anemias","volume":"52","author":"Herbert","year":"1985","journal-title":"Lab Invest."},{"issue":"Supp 2:","key":"10.3945\/jn.109.107359_bib12","first-page":"S20","article-title":"Causes of vitamin B12 and folate deficiency","volume":"29","author":"Lindsay","year":"2008","journal-title":"Food Nutr Bull."},{"key":"10.3945\/jn.109.107359_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/qjmed\/hcn138","article-title":"An update on cobalamin deficiency in adults","volume":"102","author":"Dali-Youcef","year":"2009","journal-title":"QJM."},{"key":"10.3945\/jn.109.107359_bib14","article-title":"Intrinsic factor studies II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12","volume":"42","author":"Schilling","year":"1953","journal-title":"J Lab Clin Med."},{"key":"10.3945\/jn.109.107359_bib15","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2003.027458","article-title":"Holo-transcobalamin concentration and transcobalamin saturation reflect recent vitamin B12 absorption better than does serum vitamin B12","volume":"50","author":"Bor","year":"2004","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/85.4.1057","article-title":"Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status","volume":"85","author":"von Castel-Roberts","year":"2007","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.109.107359_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/131.4.1217","article-title":"Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study","volume":"131","author":"Rao","year":"2001","journal-title":"J Nutr."},{"key":"10.3945\/jn.109.107359_bib18","unstructured":"Gopalan C, Rama Sastri BV, Balasubramanian SC. Nutritive value of Indian foods. Revised ed. Hyderabad (India): NIN, ICMR; 1989."},{"key":"10.3945\/jn.109.107359_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/33.1.52","article-title":"Microbiological assay for vitamin B12 with use of a colistin-sulfate-resistant organism","volume":"33","author":"Kelleher","year":"1987","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/jcp.44.7.592","article-title":"Microbiological assay for vitamin B12 performed in 96-well microtitre plates","volume":"44","author":"Kelleher","year":"1991","journal-title":"J Clin Pathol."},{"key":"10.3945\/jn.109.107359_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/48.3.526","article-title":"Direct assay for cobalamin bound to transcobalamin (holo-transcobalamin) in serum","volume":"48","author":"Ulleland","year":"2002","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib22","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2005.054619","article-title":"Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults","volume":"52","author":"Refsum","year":"2006","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/34.11.2357","article-title":"Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates","volume":"34","author":"Horne","year":"1988","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib24","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1093\/clinchem\/36.11.1993","article-title":"Inhibition of EDTA of growth of Lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron","volume":"36","author":"Tamura","year":"1990","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/41.7.991","article-title":"Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer","volume":"41","author":"Shipchandler","year":"1995","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib26","article-title":"Nutritional anaemias. Report of a WHO scientific group","volume":"405","year":"1968","journal-title":"World Health Organ Tech Rep Ser."},{"key":"10.3945\/jn.109.107359_bib27","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2003.021634","article-title":"Facts and recommendations about total homocysteine determinations: an expert opinion","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afg109","article-title":"Vitamin B12 and folate deficiency in later life","volume":"33","author":"Clarke","year":"2004","journal-title":"Age Ageing."},{"key":"10.3945\/jn.109.107359_bib29","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2005.061382","article-title":"Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency","volume":"52","author":"Miller","year":"2006","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib30","doi-asserted-by":"crossref","DOI":"10.1017\/S0029665107005873","article-title":"Folate and vitamin B12: friendly or enemy nutrients for the elderly","volume":"66","author":"Cuskelly","year":"2007","journal-title":"Proc Nutr Soc."},{"key":"10.3945\/jn.109.107359_bib31","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2005-03-1197","article-title":"Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo","volume":"106","author":"He","year":"2005","journal-title":"Blood."},{"key":"10.3945\/jn.109.107359_bib32","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.nutr.21.1.407","article-title":"Megalin- and cubilin-mediated endocytosis of protein- bound vitamins, lipids, and hormones in polarized epithelia","volume":"21","author":"Moestrup","year":"2001","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/jn.109.107359_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/S0950-3536(05)80224-0","article-title":"Malabsorption of food cobalamin","volume":"8","author":"Carmel","year":"1995","journal-title":"Baillieres Clin Haematol."},{"key":"10.3945\/jn.109.107359_bib34","doi-asserted-by":"crossref","DOI":"10.3109\/00365516909077650","article-title":"Plasma clearance of 57cobalt-labelled vitamin B12 bound in vitro and in vivo to transcobalamin I and II","volume":"23","author":"Hom","year":"1969","journal-title":"Scand J Clin Lab Invest."},{"key":"10.3945\/jn.109.107359_bib35","doi-asserted-by":"crossref","DOI":"10.1172\/JCI108265","article-title":"The role and fate of rabbit and human transcobalamin II in the plasma transport of vitamin B12 in the rabbit","volume":"57","author":"Schneider","year":"1976","journal-title":"J Clin Invest."},{"key":"10.3945\/jn.109.107359_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/48.3.407","article-title":"Measuring and interpreting Holo-Transcobalamin (Holo-Transcobamin II)","volume":"48","author":"Carmel","year":"2002","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/137.11.2481","article-title":"The disappearance of cobalamin absorption testing: a critical diagnostic loss","volume":"137","author":"Carmel","year":"2007","journal-title":"J Nutr."},{"key":"10.3945\/jn.109.107359_bib38","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2005.055509","article-title":"Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12","volume":"51","author":"Bor","year":"2005","journal-title":"Clin Chem."},{"key":"10.3945\/jn.109.107359_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/ajh.2830390202","article-title":"Protein-bound cobalamin absorption declines in the elderly","volume":"39","author":"Scarlett","year":"1992","journal-title":"Am J Hematol."},{"key":"10.3945\/jn.109.107359_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/66.4.750","article-title":"Cobalamin, the stomach, and aging","volume":"66","author":"Carmel","year":"1997","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.109.107359_bib41","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1177\/15648265080292S107","article-title":"Review of the magnitude of folate and vitamin B12 deficiencies worldwide","volume":"29","author":"McLean","year":"2008","journal-title":"Food Nutr Bull."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622065944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622065944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/139\/11\/2119\/23904821\/2119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:53:45Z","timestamp":1686696825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622065944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0022316622065944"],"URL":"https:\/\/doi.org\/10.3945\/jn.109.107359","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increases in Plasma Holotranscobalamin Can Be Used to Assess Vitamin B-12 Absorption in Individuals with Low Plasma Vitamin B-12","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.109.107359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}