{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:46:00Z","timestamp":1778960760624,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":4506,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.3945\/jn.109.117473","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T02:25:06Z","timestamp":1282271106000},"page":"1742-1751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Salt-Induced Cardiac Hypertrophy and Interstitial Fibrosis Are Due to a Blood Pressure\u2013Independent Mechanism in Wistar Rats"],"prefix":"10.1016","volume":"140","author":[{"given":"Daniele N.","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isis A.","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivone B.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaleizu T.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzia N.S.","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michella S.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce E.","family":"Casarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel C.","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/jn.109.117473_bib1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.1996.03530430051039","article-title":"Reversal of left ventricular hypertrophy in essential hypertension. A meta-analysis of randomized double-blind studies","volume":"275","author":"Schmieder","year":"1996","journal-title":"JAMA."},{"key":"10.3945\/jn.109.117473_bib2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","article-title":"The progression from hypertension to congestive heart failure","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA."},{"key":"10.3945\/jn.109.117473_bib3","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1053\/hj.1998.v135.86973","article-title":"Hypertension, hypertrophy, hormones, and the heart","volume":"135","author":"Glasser","year":"1998","journal-title":"Am Heart J."},{"key":"10.3945\/jn.109.117473_bib4","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.HYP.34.4.782","article-title":"State of the Art Lecture. Risk mechanisms in hypertensive heart disease","volume":"34","author":"Frohlich","year":"1999","journal-title":"Hypertension."},{"key":"10.3945\/jn.109.117473_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/01.CIR.102.4.470","article-title":"Left ventricular hypertrophy: pathogenesis, detection, and prognosis","volume":"102","author":"Lorell","year":"2000","journal-title":"Circulation."},{"key":"10.3945\/jn.109.117473_bib6","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/heart.86.4.467","article-title":"Essential hypertension: the heart and hypertension","volume":"86","author":"Berkin","year":"2001","journal-title":"Heart."},{"key":"10.3945\/jn.109.117473_bib7","doi-asserted-by":"crossref","first-page":"H1495","DOI":"10.1152\/ajpheart.00025.2003","article-title":"Clinical implications of apoptosis in hypertensive heart disease","volume":"284","author":"Fortu\u00f1o","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.3945\/jn.109.117473_bib8","doi-asserted-by":"crossref","first-page":"H767","DOI":"10.1152\/ajpheart.00047.2004","article-title":"Cardiac structural and functional responses to salt loading in SHR","volume":"287","author":"Ahn","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"10.3945\/jn.109.117473_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000441-200606000-00003","article-title":"Effect of lifelong high- or low-salt intake on blood pressure, left ventricular mass and plasma insulin in Wistar rats","volume":"331","author":"Lima","year":"2006","journal-title":"Am J Med Sci."},{"key":"10.3945\/jn.109.117473_bib10","first-page":"H177","article-title":"Sodium and left ventricular mass in untreated hypertensive and normotensive subjects","volume":"263","author":"du Cailar","year":"1992","journal-title":"Am J Physiol."},{"key":"10.3945\/jn.109.117473_bib11","first-page":"R30","article-title":"Relationship between dietary sodium intake, hemodynamics, and cardiac mass in SHR and WKY rats","volume":"264","author":"Fr\u00f6hlich","year":"1993","journal-title":"Am J Physiol."},{"key":"10.3945\/jn.109.117473_bib12","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1161\/01.CIR.98.23.2621","article-title":"Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats","volume":"98","author":"Yu","year":"1998","journal-title":"Circulation."},{"key":"10.3945\/jn.109.117473_bib13","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1210\/endo.141.5.7529","article-title":"Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy","volume":"141","author":"Takeda","year":"2000","journal-title":"Endocrinology."},{"key":"10.3945\/jn.109.117473_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0895-7061(02)03268-5","article-title":"Prevention of high salt diet-induced cardiac hypertrophy and fibrosis by spironolactone","volume":"16","author":"Lal","year":"2003","journal-title":"Am J Hypertens."},{"key":"10.3945\/jn.109.117473_bib15","doi-asserted-by":"crossref","first-page":"A59","DOI":"10.1016\/0002-9149(87)90178-0","article-title":"Implications of local angiotensin production in cardiovascular physiology and pharmacology","volume":"59","author":"Dzau","year":"1987","journal-title":"Am J Cardiol."},{"key":"10.3945\/jn.109.117473_bib16","first-page":"H324","article-title":"Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats","volume":"259","author":"Baker","year":"1990","journal-title":"Am J Physiol."},{"key":"10.3945\/jn.109.117473_bib17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/01.RES.68.4.905","article-title":"The cardiac renin-angiotensin system: an appraisal of present experimental and clinical evidence","volume":"68","author":"Lindpaintner","year":"1991","journal-title":"Circ Res."},{"key":"10.3945\/jn.109.117473_bib18","first-page":"H2443","article-title":"Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin ll receptor","volume":"266","author":"Miyata","year":"1994","journal-title":"Am J Physiol."},{"key":"10.3945\/jn.109.117473_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/hrt.76.3_Suppl_3.33","article-title":"The renin-angiotensin system and cardiac hypertrophy","volume":"76","author":"Yamazaki","year":"1996","journal-title":"Heart."},{"key":"10.3945\/jn.109.117473_bib20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.RES.85.7.643","article-title":"The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function?","volume":"85","author":"Dostal","year":"1999","journal-title":"Circ Res."},{"key":"10.3945\/jn.109.117473_bib21","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.35.6.1183","article-title":"Angiotensin ll and the heart. On the intracrine renin-angiotensin system","volume":"35","author":"de Mello","year":"2000","journal-title":"Hypertension."},{"key":"10.3945\/jn.109.117473_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1291\/hypres.26.349","article-title":"Renin, sodium, and organ damage","volume":"26","author":"Morgan","year":"2003","journal-title":"Hypertens Res."},{"key":"10.3945\/jn.109.117473_bib23","unstructured":"NIH guide for care and use of laboratory animals [cited 2009 Jun 4]. Available from: http:\/\/oacu.od.nih.gov\/regs\/guide\/guide4.htm."},{"key":"10.3945\/jn.109.117473_bib24","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/00004872-199816090-00016","article-title":"Regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: effects of angiotensin converting enzyme inhibition","volume":"16","author":"Grimm","year":"1998","journal-title":"J Hypertens."},{"key":"10.3945\/jn.109.117473_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00004872-199917010-00016","article-title":"Losartan inhibits the post-transcriptional synthesis of collagen type I and reverses left ventricular fibrosis in spontaneously hypertensive rats","volume":"17","author":"Varo","year":"1999","journal-title":"J Hypertens."},{"key":"10.3945\/jn.109.117473_bib26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1046\/j.1365-2559.2001.01101.x","article-title":"Myocardial fibrosis assessment by semiquantitative, point-counting and computer-based methods in patients with heart muscle disease: a comparative study","volume":"38","author":"Vasiljevi\u0107","year":"2001","journal-title":"Histopathology."},{"key":"10.3945\/jn.109.117473_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijcard.2006.02.031","article-title":"Myocyte diameter and fractional area of collagen are not associated with survival time of outpatients with idiopathic dilated cardiomyopathy: a study based on right ventricular endomyocardial biopsies","volume":"116","author":"Benvenuti","year":"2007","journal-title":"Int J Cardiol."},{"key":"10.3945\/jn.109.117473_bib28","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1590\/S0100-879X2008000900012","article-title":"Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure","volume":"41","author":"Medeiros","year":"2008","journal-title":"Braz J Med Biol Res."},{"key":"10.3945\/jn.109.117473_bib29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0008-6363(03)00461-9","article-title":"NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system","volume":"59","author":"Franco M do","year":"2003","journal-title":"Cardiovasc Res."},{"key":"10.3945\/jn.109.117473_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.physbeh.2008.05.011","article-title":"Low birth weight in response to salt restriction during pregnancy is not due to alterations in uterine-placental blood flow or the placental and peripheral renin-angiotensin system","volume":"95","author":"Leandro","year":"2008","journal-title":"Physiol Behav."},{"key":"10.3945\/jn.109.117473_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem."},{"key":"10.3945\/jn.109.117473_bib32","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1074\/jbc.M609254200","article-title":"Conformation state-sensitive antibodies to G-protein-coupled receptors","volume":"282","author":"Gupta","year":"2007","journal-title":"J Biol Chem."},{"issue":"Suppl 1","key":"10.3945\/jn.109.117473_bib33","first-page":"I176","article-title":"High salt intake. Sensory and behavioral factors","volume":"17","author":"Beauchamp","year":"1991","journal-title":"Hypertension."},{"key":"10.3945\/jn.109.117473_bib34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/ije\/31.2.327","article-title":"Salt intake, hypertension and risk of cardiovascular disease: an important public health challenge","volume":"31","author":"He","year":"2002","journal-title":"Int J Epidemiol."},{"key":"10.3945\/jn.109.117473_bib35","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0895-7061(97)00090-3","article-title":"Chronic salt overload increases blood pressure and improves glucose metabolism without changing insulin sensitivity","volume":"10","author":"da Costa Lima","year":"1997","journal-title":"Am J Hypertens."},{"key":"10.3945\/jn.109.117473_bib36","first-page":"H1397","article-title":"Dietary sodium intake and left ventricular hypertrophy in normotensive rats","volume":"261","author":"Yuan","year":"1991","journal-title":"Am J Physiol."},{"key":"10.3945\/jn.109.117473_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/FJC.0b013e318169e948","article-title":"Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats","volume":"51","author":"Liang","year":"2008","journal-title":"J Cardiovasc Pharmacol."},{"key":"10.3945\/jn.109.117473_bib38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejphar.2008.05.003","article-title":"Hydralazine reduces leukocyte migration through different mechanisms in spontaneously hypertensive and normotensive rats","volume":"589","author":"Rodrigues","year":"2008","journal-title":"Eur J Pharmacol."},{"key":"10.3945\/jn.109.117473_bib39","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1172\/JCI107748","article-title":"Reciprocal influence of salt intake on adrenal glomerulosa and renal vascular responses to angiotensin II in normal man","volume":"54","author":"Hollenberg","year":"1974","journal-title":"J Clin Invest."},{"key":"10.3945\/jn.109.117473_bib40","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.numecd.2005.09.001","article-title":"High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats","volume":"16","author":"Coelho","year":"2006","journal-title":"Nutr Metab Cardiovasc Dis."},{"key":"10.3945\/jn.109.117473_bib41","doi-asserted-by":"crossref","first-page":"R445","DOI":"10.1152\/ajpregu.00261.2001","article-title":"Angiotensin II regulates oxygen consumption","volume":"282","author":"Cassis","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662207105X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662207105X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/140\/10\/1742\/23947771\/1742.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:12:15Z","timestamp":1686697935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002231662207105X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S002231662207105X"],"URL":"https:\/\/doi.org\/10.3945\/jn.109.117473","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salt-Induced Cardiac Hypertrophy and Interstitial Fibrosis Are Due to a Blood Pressure\u2013Independent Mechanism in Wistar Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.109.117473","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}