{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:19:47Z","timestamp":1791285587075,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":4154,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.3945\/jn.111.144717","type":"journal-article","created":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T00:27:26Z","timestamp":1314232046000},"page":"1912-1917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Low Maternal Vitamin B-12 Status Is Associated with Offspring Insulin Resistance Regardless of Antenatal Micronutrient Supplementation in Rural Nepal,"],"prefix":"10.1016","volume":"141","author":[{"given":"Christine P.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margia","family":"Arguello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"LeClerq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subarna K.","family":"Khatry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Keith P.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.111.144717_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-007-0793-y","article-title":"Vitamin B-12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study.","volume":"51","author":"Yajnik","year":"2008","journal-title":"Diabetologia."},{"issue":"Suppl 1","key":"10.3945\/jn.111.144717_bib2","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1177\/15648265100311S104","article-title":"Considering the case for vitamin B-12 fortification of flour.","volume":"31","author":"Allen","year":"2010","journal-title":"Food Nutr Bull."},{"key":"10.3945\/jn.111.144717_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00125-007-0869-8","article-title":"Metabolic programming of offspring by vitamin B-12\/folate imbalance during pregnancy.","volume":"51","author":"Rosenberg","year":"2008","journal-title":"Diabetologia."},{"issue":"Suppl 2","key":"10.3945\/jn.111.144717_bib4","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1177\/15648265080292S107","article-title":"Review of the magnitude of folate and vitamin B-12 deficiencies worldwide.","volume":"29","author":"McLean","year":"2008","journal-title":"Food Nutr Bull."},{"key":"10.3945\/jn.111.144717_bib5","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/jn\/135.5.1106","article-title":"Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural Nepali pregnant women.","volume":"135","author":"Jiang","year":"2005","journal-title":"J Nutr."},{"key":"10.3945\/jn.111.144717_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.nutr.19.1.357","article-title":"Vitamin B-12 deficiency in the elderly.","volume":"19","author":"Baik","year":"1999","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/jn.111.144717_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1542\/peds.108.3.624","article-title":"Determinants of cobalamin status in newborns.","volume":"108","author":"Bj\u00f8rke Monsen","year":"2001","journal-title":"Pediatrics."},{"issue":"Suppl 2","key":"10.3945\/jn.111.144717_bib8","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1177\/15648265080292S114","article-title":"Effects of folate and vitamin B-12 deficiencies during pregnancy on fetal, infant, and child development.","volume":"29","author":"Molloy","year":"2008","journal-title":"Food and Nutr Bull."},{"key":"10.3945\/jn.111.144717_bib9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1753-4887.2008.00031.x","article-title":"Effect of vitamin B-12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms.","volume":"66","author":"Dror","year":"2008","journal-title":"Nutr Rev."},{"key":"10.3945\/jn.111.144717_bib10","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/S0140-6736(65)91895-7","article-title":"Folic acid metabolism and human embryopathy.","volume":"285","author":"Hibbard","year":"1965","journal-title":"Lancet."},{"key":"10.3945\/jn.111.144717_bib11","series-title":"Handbook of nutrition and pregnancy.","first-page":"319","article-title":"Nutrition and maternal survival in developing countries.","author":"Christian","year":"2008"},{"key":"10.3945\/jn.111.144717_bib12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ajcn\/83.4.788","article-title":"Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal.","volume":"83","author":"Christian","year":"2006","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.111.144717_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/bmj.326.7389.571","article-title":"Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trial.","volume":"326","author":"Christian","year":"2003","journal-title":"BMJ."},{"key":"10.3945\/jn.111.144717_bib14","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3945\/jn.109.106666","article-title":"Antenatal micronutrient supplementation reduces metabolic syndrome in 6- to 8-year-old children in rural Nepal.","volume":"139","author":"Stewart","year":"2009","journal-title":"J Nutr."},{"key":"10.3945\/jn.111.144717_bib15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3945\/ajcn.2008.27368","article-title":"Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal.","volume":"90","author":"Stewart","year":"2009","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.111.144717_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0076-6879(97)81007-5","article-title":"Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method.","volume":"281","author":"Molloy","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.3945\/jn.111.144717_bib17","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/jcp.44.7.592","article-title":"Microbiological assay for vitamin B-12 in 96-well microtiter plates.","volume":"44","author":"Kelleher","year":"1991","journal-title":"J Clin Pathol."},{"key":"10.3945\/jn.111.144717_bib18","first-page":"90","article-title":"Cryo-preservation of Lactobacillus leichmannii for vitamin B-12 microbiological assay.","volume":"47","author":"Kelleher","year":"1990","journal-title":"Med Lab Sci."},{"key":"10.3945\/jn.111.144717_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia."},{"key":"10.3945\/jn.111.144717_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195171693.001.0001","article-title":"Principles of nutritional assessment.","author":"Gibson","year":"2005"},{"key":"10.3945\/jn.111.144717_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcn\/82.2.442","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999\u20132000.","volume":"82","author":"Pfeiffer","year":"2005","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.111.144717_bib22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/MCO.0b013e32833192bc","article-title":"Folic acid fortification: a double-edged sword.","volume":"12","author":"Lucock","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"10.3945\/jn.111.144717_bib23","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1073\/pnas.0707258104","article-title":"DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status.","volume":"104","author":"Sinclair","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"issue":"Suppl 8","key":"10.3945\/jn.111.144717_bib24","doi-asserted-by":"crossref","first-page":"S2393","DOI":"10.1093\/jn\/132.8.2393S","article-title":"Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring.","volume":"132","author":"Cooney","year":"2002","journal-title":"J Nutr."},{"key":"10.3945\/jn.111.144717_bib25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.nutr.27.061406.093705","article-title":"Epigenetic epidemiology of the developmental origins hypothesis.","volume":"27","author":"Waterland","year":"2007","journal-title":"Annu Rev Nutr."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622030863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622030863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/141\/10\/1912\/23949885\/1912.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:03:26Z","timestamp":1712743406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622030863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0022316622030863"],"URL":"https:\/\/doi.org\/10.3945\/jn.111.144717","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low Maternal Vitamin B-12 Status Is Associated with Offspring Insulin Resistance Regardless of Antenatal Micronutrient Supplementation in Rural Nepal,","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.111.144717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}