{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:01:54Z","timestamp":1790060514719,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":3839,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.3945\/jn.112.159020","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T03:02:49Z","timestamp":1340852569000},"page":"1410-1416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Prolonged Dietary Selenium Deficiency or Excess Does Not Globally Affect Selenoprotein Gene Expression and\/or Protein Production in Various Tissues of Pigs"],"prefix":"10.1016","volume":"142","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Jie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Gen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.112.159020_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/jn\/65.4.601","article-title":"Studies of the nutritive effects of selenium for chicks.","volume":"65","author":"Nesheim","year":"1958","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/184645b0","article-title":"Curative effect of selenium upon the incisor teeth of rats deficient in vitamin E.","volume":"184","author":"Irving","year":"1959","journal-title":"Nature."},{"key":"10.3945\/jn.112.159020_bib3","first-page":"20","article-title":"Selenium and ewe fertility.","volume":"23","author":"Hartley","year":"1963","journal-title":"Proc New Zealand Soc Anim Prod."},{"key":"10.3945\/jn.112.159020_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00480169.1968.33738","article-title":"Selenium responsive diseases of animals in New Zealand.","volume":"16","author":"Andrews","year":"1968","journal-title":"N Z Vet J."},{"key":"10.3945\/jn.112.159020_bib5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3181\/00379727-128-33170","article-title":"Selenium deficiency and impaired reproduction in Japanese quail.","volume":"128","author":"Jensen","year":"1968","journal-title":"Proc Soc Exp Biol Med."},{"key":"10.3945\/jn.112.159020_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/jn\/98.4.383","article-title":"Some selenium response in the rat not related to vitamin E.","volume":"98","author":"McCoy","year":"1969","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/jn\/97.3.335","article-title":"Role of selenium in the nutrition of the chick.","volume":"97","author":"Thompson","year":"1969","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib8","first-page":"85","article-title":"Effect of selenium in reproduction.","volume":"20","author":"Wu","year":"1969","journal-title":"Proc West Sec Am Soc An Sci."},{"key":"10.3945\/jn.112.159020_bib9","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/jnci\/85.18.1483","article-title":"Nutrition intervention trials in Linxian, China: supplementation with specific vitamin\/mineral combinations, cancer incidence, and disease-specific mortality in the general population.","volume":"85","author":"Blot","year":"1993","journal-title":"J Natl Cancer Inst."},{"key":"10.3945\/jn.112.159020_bib10","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.1996.03540240035027","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin.","volume":"276","author":"Clark","year":"1996","journal-title":"JAMA."},{"key":"10.3945\/jn.112.159020_bib11","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1464-410x.1998.00630.x","article-title":"Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.","volume":"81","author":"Clark","year":"1998","journal-title":"Br J Urol."},{"key":"10.3945\/jn.112.159020_bib12","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/jn\/128.11.1845","article-title":"Lessons from basic research in selenium and cancer prevention.","volume":"128","author":"Ip","year":"1998","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1098-2744(199912)26:4<213::AID-MC1>3.0.CO;2-Z","article-title":"Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake.","volume":"26","author":"Jiang","year":"1999","journal-title":"Mol Carcinog."},{"key":"10.3945\/jn.112.159020_bib14","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1083516","article-title":"Characterization of mammalian selenoproteomes.","volume":"300","author":"Kryukov","year":"2003","journal-title":"Science."},{"key":"10.3945\/jn.112.159020_bib15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3945\/jn.109.104901","article-title":"Selenoprotein gene expression in thyroid and pituitary of young pigs is not affected by dietary selenium deficiency or excess.","volume":"139","author":"Zhou","year":"2009","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib16","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3945\/jn.111.145722","article-title":"The selenium deficiency disease exudative diathesis in chicks is associated with downregulation of seven common selenoprotein genes in liver and muscle.","volume":"141","author":"Huang","year":"2011","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/BSR20080146","article-title":"Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome.","volume":"29","author":"Sunde","year":"2009","journal-title":"Biosci Rep."},{"key":"10.3945\/jn.112.159020_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1258\/ebm.2009.009262","article-title":"Phospholipid hydroperoxide glutathione peroxidase (Gpx4) is highly regulated in male turkey poults and can be used to determine dietary selenium requirements.","volume":"235","author":"Sunde","year":"2010","journal-title":"Exp Biol Med (Maywood)."},{"key":"10.3945\/jn.112.159020_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3945\/jn.108.098624","article-title":"Transcript analysis of the selenoproteome indicates that dietary selenium requirements of rats based on selenium-regulated selenoprotein mRNA levels are uniformly less than those based on glutathione peroxidase activity.","volume":"139","author":"Barnes","year":"2009","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3945\/an.110.000240","article-title":"Selenium regulation of the selenoprotein and nonselenoprotein transcriptomes in rodents.","volume":"2","author":"Sunde","year":"2011","journal-title":"Adv Nutr."},{"key":"10.3945\/jn.112.159020_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.nu.07.070187.002045","article-title":"The pig as a model for human nutrition.","volume":"7","author":"Miller","year":"1987","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/jn.112.159020_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1079\/BJN19940108","article-title":"Comparison of the ileal and faecal digestibility of dietary amino acids in adult humans and evaluation of the pig as a model animal for digestion studies in man.","volume":"71","author":"Rowan","year":"1994","journal-title":"Br J Nutr."},{"key":"10.3945\/jn.112.159020_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1046\/j.1524-475x.2001.00066.x","article-title":"Wound repair and regeneration: the pig as a model for human wound healing.","volume":"9","author":"Tory","year":"2001","journal-title":"Wound Repair Regen."},{"key":"10.3945\/jn.112.159020_bib24","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1210\/en.2004-0356","article-title":"Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs.","volume":"145","author":"Wassen","year":"2004","journal-title":"Endocrinology."},{"key":"10.3945\/jn.112.159020_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.7326\/0003-4819-147-4-200708210-00175","article-title":"Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial.","volume":"147","author":"Stranges","year":"2007","journal-title":"Ann Intern Med."},{"key":"10.3945\/jn.112.159020_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.2008.864","article-title":"Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT).","volume":"301","author":"Lippman","year":"2009","journal-title":"JAMA."},{"key":"10.3945\/jn.112.159020_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3945\/jn.109.111252","article-title":"Higher selenium status is associated with adverse blood lipid profile in British adults.","volume":"140","author":"Stranges","year":"2010","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2337\/dc06-1726","article-title":"Serum selenium and diabetes in U.S. adults.","volume":"30","author":"Bleys","year":"2007","journal-title":"Diabetes Care."},{"key":"10.3945\/jn.112.159020_bib29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jnutbio.2005.10.006","article-title":"Compendium of the antidiabetic effects of supranutritional selenate doses. In vivo and in vitro investigations with type II diabetic db\/db mice.","volume":"17","author":"Mueller","year":"2006","journal-title":"J Nutr Biochem."},{"key":"10.3945\/jn.112.159020_bib30","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1089\/ars.2010.3526","article-title":"Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.","volume":"14","author":"Labunskyy","year":"2011","journal-title":"Antioxid Redox Signal."},{"key":"10.3945\/jn.112.159020_bib31","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.freeradbiomed.2012.01.017","article-title":"A high-selenium diet induced insulin resistance in gestating rats and their offspring.","volume":"52","author":"Zeng","year":"2012","journal-title":"Free Radic Biol Med."},{"key":"10.3945\/jn.112.159020_bib32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1042\/BSR20090089","article-title":"Impact of selenite and selenate on differentially expressed genes in rat liver examined by microarray analysis.","volume":"30","author":"Bosse","year":"2010","journal-title":"Biosci Rep."},{"key":"10.3945\/jn.112.159020_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jnutbio.2008.02.007","article-title":"Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats.","volume":"20","author":"Mueller","year":"2009","journal-title":"J Nutr Biochem."},{"key":"10.3945\/jn.112.159020_bib34","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/jn\/135.10.2295","article-title":"New roles for an old selenoenzyme: evidence from glutathione peroxidase-1 null and overexpressing mice.","volume":"135","author":"Lei","year":"2005","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev.nutr.24.012003.132120","article-title":"Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis.","volume":"25","author":"Burk","year":"2005","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/jn.112.159020_bib36","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1073\/pnas.0308096101","article-title":"Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase.","volume":"101","author":"McClung","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.112.159020_bib37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cmet.2010.09.015","article-title":"A liver-derived secretory protein, selenoprotein P, causes insulin resistance.","volume":"12","author":"Misu","year":"2010","journal-title":"Cell Metab."},{"key":"10.3945\/jn.112.159020_bib38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbrc.2007.10.171","article-title":"Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor.","volume":"365","author":"Walter","year":"2008","journal-title":"Biochem Biophys Res Commun."},{"key":"10.3945\/jn.112.159020_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0014-5793(04)00296-0","article-title":"Kantham L, Collier GR. Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress: SelS is a novel glucose-regulated protein.","volume":"563","author":"Gao","year":"2004","journal-title":"FEBS Lett."},{"key":"10.3945\/jn.112.159020_bib40","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1074\/jbc.M701605200","article-title":"Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.","volume":"282","author":"Novoselov","year":"2007","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.159020_bib41","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1073\/pnas.1332633100","article-title":"Insulin signaling through Akt\/protein kinase B analyzed by small interfering RNA-mediated gene silencing.","volume":"100","author":"Jiang","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.112.159020_bib42","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/bib\/1.1.76","article-title":"Searching the expressed sequence tag (EST) databases: panning for genes.","volume":"1","author":"Jongeneel","year":"2000","journal-title":"Brief Bioinform."},{"key":"10.3945\/jn.112.159020_bib43","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1039\/A909590J","article-title":"Speciation of inorganic selenium in environmental matrices by flow injection analysis-hydride generation-atomic fluorescence spectrometry. Comparison of off-line, pseudo on-line and on-line extraction and reduction methods.","volume":"15","author":"Moreno","year":"2000","journal-title":"J Anal At Spectrom."},{"key":"10.3945\/jn.112.159020_bib44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0014-4835(74)90062-1","article-title":"Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake.","volume":"18","author":"Lawrence","year":"1974","journal-title":"Exp Eye Res."},{"key":"10.3945\/jn.112.159020_bib45","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding.","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem."},{"key":"10.3945\/jn.112.159020_bib46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0304-4165(88)90123-7","article-title":"Evidence for specific selenium target tissues and new biologically important selenoproteins.","volume":"966","author":"Behne","year":"1988","journal-title":"Biochim Biophys Acta."},{"key":"10.3945\/jn.112.159020_bib47","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00125-008-1055-3","article-title":"Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice.","volume":"51","author":"Wang","year":"2008","journal-title":"Diabetologia."},{"key":"10.3945\/jn.112.159020_bib48","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/ars.2010.3302","article-title":"Knockouts of SOD1 and GPX1 exert different impacts on murine islet function and pancreatic integrity.","volume":"14","author":"Wang","year":"2011","journal-title":"Antioxid Redox Signal."},{"key":"10.3945\/jn.112.159020_bib49","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.3945\/jn.108.089482","article-title":"Redox regulation of protein tyrosine phosphatase 1B by manipulation of dietary selenium affects the triglyceride concentration in rat liver.","volume":"138","author":"Mueller","year":"2008","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.159020_bib50","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmet.2009.08.009","article-title":"Reactive oxygen species enhance insulin sensitivity.","volume":"10","author":"Loh","year":"2009","journal-title":"Cell Metab."},{"key":"10.3945\/jn.112.159020_bib51","doi-asserted-by":"crossref","first-page":"23759","DOI":"10.1074\/jbc.M702267200","article-title":"Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification.","volume":"282","author":"Panee","year":"2007","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.159020_bib52","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1399-0039.2007.00888.x","article-title":"The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation.","volume":"70","author":"Seiderer","year":"2007","journal-title":"Tissue Antigens."},{"key":"10.3945\/jn.112.159020_bib53","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2337\/diabetes.52.4.929","article-title":"Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells.","volume":"52","author":"Gao","year":"2003","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.159020_bib54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3164\/jcbn.11-002FR","article-title":"High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism.","volume":"48","author":"Steinbrenner","year":"2011","journal-title":"J Clin Biochem Nutr."},{"key":"10.3945\/jn.112.159020_bib55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.1.05971","article-title":"Selenium and endocrine systems.","volume":"184","author":"Beckett","year":"2005","journal-title":"J Endocrinol."},{"key":"10.3945\/jn.112.159020_bib56","first-page":"176","article-title":"Nutritional interactions: credentialing of molecular targets for cancer prevention.","volume":"232","author":"Davis","year":"2007","journal-title":"Exp Biol Med (Maywood)."},{"key":"10.3945\/jn.112.159020_bib57","unstructured":"NCBI BLAST. Internet web site [cited 2009]. Available from: http:\/\/blast.ncbi.nlm.nih.gov\/Blast.cgi."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622027109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622027109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/142\/8\/1410\/23951935\/1410.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:36:49Z","timestamp":1686695809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622027109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0022316622027109"],"URL":"https:\/\/doi.org\/10.3945\/jn.112.159020","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged Dietary Selenium Deficiency or Excess Does Not Globally Affect Selenoprotein Gene Expression and\/or Protein Production in Various Tissues of Pigs","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.112.159020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}