{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:58:06Z","timestamp":1787237886935,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":3839,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.3945\/jn.112.159467","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:02:49Z","timestamp":1340838169000},"page":"1596-1602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dietary Supplementation with Lacto-Wolfberry Enhances the Immune Response and Reduces Pathogenesis to Influenza Infection in Mice,"],"prefix":"10.1016","volume":"142","author":[{"given":"Zhihong","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Rozati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin Nikbin","family":"Meydani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.112.159467_bib1","unstructured":"WHO. Influenza. WHO fact sheet No 211. WHO Media Center,Geneva, 2003. Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/2003\/fs211\/en\/."},{"key":"10.3945\/jn.112.159467_bib2","doi-asserted-by":"crossref","first-page":"478S","DOI":"10.1093\/ajcn\/66.2.478S","article-title":"Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments.","volume":"66","author":"Lesourd","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.112.159467_bib3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0899-9007(99)00093-3","article-title":"Aging and the immune system: the role of micronutrient nutrition.","volume":"15","author":"Bogden","year":"1999","journal-title":"Nutrition"},{"key":"10.3945\/jn.112.159467_bib4","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1086\/324509","article-title":"Nutritional strategies to boost immunity and prevent infection in elderly individuals.","volume":"33","author":"High","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.3945\/jn.112.159467_bib5","first-page":"2","article-title":"Aging nutrition and immune function.","volume":"8","author":"Ahluwalia","year":"2004","journal-title":"J Nutr Health Aging"},{"key":"10.3945\/jn.112.159467_bib6","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/jama.1997.03540410058031","article-title":"Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial.","volume":"277","author":"Meydani","year":"1997","journal-title":"JAMA"},{"key":"10.3945\/jn.112.159467_bib7","series-title":"Herbal medicine: biomolecular and clinical aspects","article-title":"Biomolecular and clinical aspects of Chinese wolfberry.","author":"Bucheli","year":"2011"},{"key":"10.3945\/jn.112.159467_bib8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/jmf.2008.1232","article-title":"Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer.","volume":"12","author":"Luo","year":"2009","journal-title":"J Med Food"},{"key":"10.3945\/jn.112.159467_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(03)01827-2","article-title":"A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells.","volume":"471","author":"Gan","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.3945\/jn.112.159467_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0029-1186218","article-title":"Goji (Lycium barbarum and L. chinense): phytochemistry pharmacology and safety in the perspective of traditional uses and recent popularity.","volume":"76","author":"Potterat","year":"2010","journal-title":"Planta Med"},{"key":"10.3945\/jn.112.159467_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jep.2006.12.024","article-title":"Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice.","volume":"111","author":"Li","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.3945\/jn.112.159467_bib12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10571-007-9181-x","article-title":"Use of anti-aging herbal medicine Lycium barbarum against aging-associated diseases: what do we know so far?","volume":"28","author":"Chang","year":"2008","journal-title":"Cell Mol Neurobiol"},{"key":"10.3945\/jn.112.159467_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/jop.1999.15.557","article-title":"The identification of dipalmityl zeaxanthin as the major carotenoid in Gou Qi Zi by high pressure liquid chromatography and mass spectrometry.","volume":"15","author":"Zhou","year":"1999","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.3945\/jn.112.159467_bib14","doi-asserted-by":"crossref","first-page":"e16380","DOI":"10.1371\/journal.pone.0016380","article-title":"Lycium barbarum polysaccharides reduce neuronal damage blood-retinal barrier disruption and oxidative stress in retinal ischemia\/reperfusion injury.","volume":"6","author":"Li","year":"2011","journal-title":"PLoS ONE"},{"key":"10.3945\/jn.112.159467_bib15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0165-2427(00)00152-5","article-title":"Modulation of humoral and cell-mediated immune responses by dietary lutein in cats.","volume":"73","author":"Kim","year":"2000","journal-title":"Vet Immunol Immunopathol"},{"key":"10.3945\/jn.112.159467_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clindermatol.2008.01.011","article-title":"Lutein and zeaxanthin in eye and skin health.","volume":"27","author":"Roberts","year":"2009","journal-title":"Clin Dermatol"},{"key":"10.3945\/jn.112.159467_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/02713680902745408","article-title":"Zeaxanthin a retinal carotenoid protects retinal cells against oxidative stress.","volume":"34","author":"Nakajima","year":"2009","journal-title":"Curr Eye Res"},{"key":"10.3945\/jn.112.159467_bib18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1079\/BJN20061796","article-title":"Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.).","volume":"96","author":"Benzie","year":"2006","journal-title":"Br J Nutr"},{"key":"10.3945\/jn.112.159467_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/rej.2009.0895","article-title":"Intake of a milk-based wolfberry formulation enhances the immune response of young-adult and aged mice.","volume":"13","author":"Vidal","year":"2010","journal-title":"Rejuvenation Res"},{"key":"10.3945\/jn.112.159467_bib20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1089\/jmf.2008.0300","article-title":"Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects.","volume":"12","author":"Amagase","year":"2009","journal-title":"J Med Food"},{"key":"10.3945\/jn.112.159467_bib21","doi-asserted-by":"crossref","DOI":"10.1089\/rej.2011.1241","article-title":"Effect of dietary supplementation with a milk-based wolfberry preparation on the immune response to influenza vaccine in elderly.","author":"Vidal","year":"2012","journal-title":"Rejuvenation Res"},{"key":"10.3945\/jn.112.159467_bib22","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.3945\/jn.112.159467_bib23","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1096\/fj.00-0721fje","article-title":"Selenium deficiency increases the pathology of an influenza virus infection.","volume":"15","author":"Beck","year":"2001","journal-title":"FASEB J"},{"key":"10.3945\/jn.112.159467_bib24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3945\/jn.110.121434","article-title":"Dietary supplementation with tocotrienols enhances immune function in C57BL\/6 mice.","volume":"140","author":"Ren","year":"2010","journal-title":"J Nutr"},{"key":"10.3945\/jn.112.159467_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2567.2000.00070.x","article-title":"Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus.","volume":"100","author":"Han","year":"2000","journal-title":"Immunology"},{"key":"10.3945\/jn.112.159467_bib26","first-page":"4","article-title":"A simple method of estimating fifty percent endpoints.","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Hyg"},{"key":"10.3945\/jn.112.159467_bib27","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/jn\/137.6.1472","article-title":"Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL\/6 mice.","volume":"137","author":"Wu","year":"2007","journal-title":"J Nutr"},{"key":"10.3945\/jn.112.159467_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0009-8981(89)90001-6","article-title":"The simultaneous determination of oxidized and reduced glutathiones in liver tissue by ion pairing reverse phase high performance liquid chromatography with a coulometric electrochemical detector.","volume":"180","author":"Harvey","year":"1989","journal-title":"Clin Chim Acta"},{"key":"10.3945\/jn.112.159467_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1089\/acm.2008.0004","article-title":"A randomized double-blind placebo-controlled clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice GoChi.","volume":"14","author":"Amagase","year":"2008","journal-title":"J Altern Complement Med"},{"key":"10.3945\/jn.112.159467_bib30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cellbi.2006.12.002","article-title":"Lycium barbarum polysaccharides regulate phenotypic and functional maturation of murine dendritic cells.","volume":"31","author":"Zhu","year":"2007","journal-title":"Cell Biol Int"},{"key":"10.3945\/jn.112.159467_bib31","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.4049\/jimmunol.0802567","article-title":"Polysaccharide-protein complex from Lycium barbarum L. is a novel stimulus of dendritic cell immunogenicity.","volume":"182","author":"Chen","year":"2009","journal-title":"J Immunol"},{"key":"10.3945\/jn.112.159467_bib32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1465-9921-10-112","article-title":"Impaired immune responses in the lungs of aged mice following influenza infection.","volume":"10","author":"Toapanta","year":"2009","journal-title":"Respir Res"},{"key":"10.3945\/jn.112.159467_bib33","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.4049\/jimmunol.158.5.2363","article-title":"Regulation of IFN-alpha\/beta MxA 2\u20195\u2019-oligoadenylate synthetase and HLA gene expression in influenza A-infected human lung epithelial cells.","volume":"158","author":"Ronni","year":"1997","journal-title":"J Immunol"},{"key":"10.3945\/jn.112.159467_bib34","doi-asserted-by":"crossref","first-page":"8550","DOI":"10.1128\/JVI.72.11.8550-8558.1998","article-title":"The role of interferon in influenza virus tissue tropism.","volume":"72","author":"Garc\u00eda-Sastre","year":"1998","journal-title":"J Virol"},{"key":"10.3945\/jn.112.159467_bib35","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.femsre.2004.12.003","article-title":"Role of apoptosis and cytokines in influenza virus morbidity.","volume":"29","author":"Brydon","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"10.3945\/jn.112.159467_bib36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1286-4579(02)01583-6","article-title":"Mechanisms of inhibition of the host interferon alpha\/beta-mediated antiviral responses by viruses.","volume":"4","author":"Garc\u00eda-Sastre","year":"2002","journal-title":"Microbes Infect"},{"key":"10.3945\/jn.112.159467_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1359-6101(98)00024-0","article-title":"Cytokine regulation of cellular adhesion molecule expression in inflammation.","volume":"10","author":"Meager","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.3945\/jn.112.159467_bib38","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1128\/JVI.79.10.6441-6448.2005","article-title":"Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection.","volume":"79","author":"Schmitz","year":"2005","journal-title":"J Virol"},{"key":"10.3945\/jn.112.159467_bib39","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1084\/jem.184.3.1191","article-title":"Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection.","volume":"184","author":"Sprenger","year":"1996","journal-title":"J Exp Med"},{"key":"10.3945\/jn.112.159467_bib40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<277::AID-IMMU277>3.0.CO;2-8","article-title":"Augmentation of naive Th1 and Th2 effector CD4 responses by IL-6 IL-1 and TNF.","volume":"28","author":"Joseph","year":"1998","journal-title":"Eur J Immunol"},{"issue":"Suppl 1","key":"10.3945\/jn.112.159467_bib41","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/S0264-410X(00)00275-9","article-title":"Inflammatory responses in influenza A virus infection.","volume":"19","author":"Julkunen","year":"2000","journal-title":"Vaccine"},{"key":"10.3945\/jn.112.159467_bib42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu Rev Biochem"},{"key":"10.3945\/jn.112.159467_bib43","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L","article-title":"Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology.","volume":"31","author":"Hussell","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.3945\/jn.112.159467_bib44","first-page":"R78","article-title":"Cytokines and the acute phase response to influenza virus in mice.","volume":"268","author":"Conn","year":"1995","journal-title":"Am J Physiol"},{"key":"10.3945\/jn.112.159467_bib45","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4049\/jimmunol.149.3.932","article-title":"A kinetic study of immune mediators in the lungs of mice infected with influenza A virus.","volume":"149","author":"Hennet","year":"1992","journal-title":"J Immunol"},{"key":"10.3945\/jn.112.159467_bib46","doi-asserted-by":"crossref","first-page":"B496","DOI":"10.1093\/gerona\/55.10.B496","article-title":"Effect of long-term dietary antioxidant supplementation on influenza virus infection.","volume":"55","author":"Han","year":"2000","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3945\/jn.112.159467_bib47","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4049\/jimmunol.148.1.212","article-title":"Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.","volume":"148","author":"Scherle","year":"1992","journal-title":"J Immunol"},{"key":"10.3945\/jn.112.159467_bib48","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.4049\/jimmunol.156.10.3892","article-title":"Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein.","volume":"156","author":"Tamura","year":"1996","journal-title":"J Immunol"},{"key":"10.3945\/jn.112.159467_bib49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1099\/0022-1317-73-1-39","article-title":"Alterations in antioxidant defences in lung and liver of mice infected with influenza A virus.","volume":"73","author":"Hennet","year":"1992","journal-title":"J Gen Virol"},{"key":"10.3945\/jn.112.159467_bib50","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/OPX.0b013e318205a18f","article-title":"Goji berry effects on macular characteristics and plasma antioxidant levels.","volume":"88","author":"Bucheli","year":"2011","journal-title":"Optom Vis Sci"},{"key":"10.3945\/jn.112.159467_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1124\/dmd.104.003434","article-title":"Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues.","volume":"34","author":"Lambert","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.3945\/jn.112.159467_bib52","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.yrtph.2004.03.001","article-title":"Allometric principles for interspecies extrapolation in toxicological risk assessment\u2014empirical investigations.","volume":"39","author":"Schneider","year":"2004","journal-title":"Regul Toxicol Pharmacol"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622027134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622027134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/142\/8\/1596\/23952976\/1596.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T18:36:57Z","timestamp":1686681417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622027134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0022316622027134"],"URL":"https:\/\/doi.org\/10.3945\/jn.112.159467","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Supplementation with Lacto-Wolfberry Enhances the Immune Response and Reduces Pathogenesis to Influenza Infection in Mice,","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.112.159467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}