{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:42:15Z","timestamp":1790772135904,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":3839,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.3945\/jn.112.162677","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T03:02:49Z","timestamp":1340852569000},"page":"1456-1462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["\u03b2-Carotene Supplementation Decreases Placental Transcription of LDL Receptor-Related Protein 1 in Wild-Type Mice and Stimulates Placental \u03b2-Carotene Uptake in Marginally Vitamin A-Deficient Mice"],"prefix":"10.1016","volume":"142","author":[{"given":"Lesley","family":"Wassef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Shete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Spiegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Quadro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.112.162677_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/nu3040385","article-title":"Vitamin A in reproduction and development.","volume":"3","author":"Clagett-Dame","year":"2011","journal-title":"Nutrients."},{"key":"10.3945\/jn.112.162677_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0074-7696(08)61566-1","article-title":"Retinoids and mammalian development.","volume":"188","author":"Morriss-Kay","year":"1999","journal-title":"Int Rev Cytol."},{"issue":"Suppl 2","key":"10.3945\/jn.112.162677_bib3","doi-asserted-by":"crossref","first-page":"S455","DOI":"10.1093\/jn\/128.2.455S","article-title":"Vitamin A and embryonic development: an overview.","volume":"128","author":"Zile","year":"1998","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.162677_bib4","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2174\/092986711795029618","article-title":"Regulation of gene expression by retinoids.","volume":"18","author":"Amann","year":"2011","journal-title":"Curr Med Chem."},{"key":"10.3945\/jn.112.162677_bib5","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/neu.20242","article-title":"Overview of retinoid metabolism and function.","volume":"66","author":"Blomhoff","year":"2006","journal-title":"J Neurobiol."},{"key":"10.3945\/jn.112.162677_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbalip.2011.04.010","article-title":"Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis.","volume":"1821","author":"Lobo","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"10.3945\/jn.112.162677_bib7","doi-asserted-by":"crossref","first-page":"e20644","DOI":"10.1371\/journal.pone.0020644","article-title":"Beta-carotene reduces body adiposity of mice via BCMO1.","volume":"6","author":"Amengual","year":"2011","journal-title":"PLoS ONE."},{"key":"10.3945\/jn.112.162677_bib8","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1096\/fj.10-175448","article-title":"beta-Carotene and its cleavage enzyme beta-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues.","volume":"25","author":"Kim","year":"2011","journal-title":"FASEB J."},{"key":"10.3945\/jn.112.162677_bib9","doi-asserted-by":"crossref","first-page":"S2268","DOI":"10.3945\/jn.109.119024","article-title":"Beta-carotene is an important vitamin A source for humans.","volume":"140","author":"Grune","year":"2010","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.162677_bib10","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1001\/jama.2011.656","article-title":"Effects of vitamin A or beta carotene supplementation on pregnancy-related mortality and infant mortality in rural Bangladesh: a cluster randomized trial.","volume":"305","author":"West","year":"2011","journal-title":"JAMA."},{"key":"10.3945\/jn.112.162677_bib11","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1074\/jbc.M009030200","article-title":"Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase.","volume":"276","author":"Redmond","year":"2001","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib12","doi-asserted-by":"crossref","first-page":"32160","DOI":"10.1074\/jbc.M010086200","article-title":"Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids.","volume":"276","author":"Paik","year":"2001","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib13","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1369\/jhc.5A6705.2005","article-title":"Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues.","volume":"53","author":"Lindqvist","year":"2005","journal-title":"J Histochem Cytochem."},{"key":"10.3945\/jn.112.162677_bib14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/002215540405200407","article-title":"Cell type-specific expression of beta-carotene 15,15'-mono-oxygenase in human tissues.","volume":"52","author":"Lindqvist","year":"2004","journal-title":"J Histochem Cytochem."},{"key":"10.3945\/jn.112.162677_bib15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbadis.2004.11.010","article-title":"Towards a better understanding of carotenoid metabolism in animals.","volume":"1740","author":"von Lintig","year":"2005","journal-title":"Biochim Biophys Acta."},{"key":"10.3945\/jn.112.162677_bib16","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/07315724.1998.10718791","article-title":"Relationship of plasma carotenoids, retinol and tocopherols in mothers and newborn infants.","volume":"17","author":"Yeum","year":"1998","journal-title":"J Am Coll Nutr."},{"key":"10.3945\/jn.112.162677_bib17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1079\/BJN20051718","article-title":"Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery.","volume":"95","author":"Scaife","year":"2006","journal-title":"Br J Nutr."},{"key":"10.3945\/jn.112.162677_bib18","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1194\/jlr.M200068-JLR200","article-title":"Carotenoid uptake and secretion by CaCo-2 cells: beta-carotene isomer selectivity and carotenoid interactions.","volume":"43","author":"During","year":"2002","journal-title":"J Lipid Res."},{"key":"10.3945\/jn.112.162677_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbalip.2011.06.002","article-title":"Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.","volume":"1821","author":"Harrison","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"10.3945\/jn.112.162677_bib20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1749-6632.1993.tb26180.x","article-title":"Distribution of beta-carotene and vitamin A in lipoprotein fractions of ferret serum. Effect of beta-carotene supplementation.","volume":"691","author":"Ribaya-Mercado","year":"1993","journal-title":"Ann N Y Acad Sci."},{"key":"10.3945\/jn.112.162677_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jn\/122.1.115","article-title":"Beta-carotene uptake and tissue distribution in ferrets (Mustela putorius furo).","volume":"122","author":"Gugger","year":"1992","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.162677_bib22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3177\/jnsv.57.108","article-title":"Altered expression of both beta-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats.","volume":"57","author":"Takitani","year":"2011","journal-title":"J Nutr Sci Vitaminol (Tokyo)."},{"key":"10.3945\/jn.112.162677_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/jn\/126.2.499","article-title":"beta-Carotene absorption and cleavage in rats is affected by the vitamin A concentration of the diet.","volume":"126","author":"van Vliet","year":"1996","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.162677_bib24","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1074\/jbc.M707928200","article-title":"Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.","volume":"283","author":"Seino","year":"2008","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib25","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1096\/fj.09-150995","article-title":"ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production.","volume":"24","author":"Lobo","year":"2010","journal-title":"FASEB J."},{"key":"10.3945\/jn.112.162677_bib26","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1074\/jbc.M708885200","article-title":"Retinyl ester formation by lecithin: retinol acyltransferase (LRAT) is a key regulator of retinoid homeostasis in mouse embryogenesis.","volume":"283","author":"Kim","year":"2008","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib27","article-title":"Guide for the care and use of laboratory animals.","year":"1996"},{"key":"10.3945\/jn.112.162677_bib28","doi-asserted-by":"crossref","first-page":"E844","DOI":"10.1152\/ajpendo.00556.2003","article-title":"Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester.","volume":"286","author":"Quadro","year":"2004","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"10.3945\/jn.112.162677_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-60327-325-1_17","article-title":"Diet in vitamin A research.","volume":"652","author":"Ross","year":"2010","journal-title":"Methods Mol Biol."},{"key":"10.3945\/jn.112.162677_bib30","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1128\/MCB.05516-11","article-title":"CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.","volume":"31","author":"Kane","year":"2011","journal-title":"Mol Cell Biol."},{"key":"10.3945\/jn.112.162677_bib31","first-page":"447","article-title":"Comparative distribution of beta-carotene and lycopene after intraperitoneal administration in mice.","volume":"12","author":"Glise","year":"1998","journal-title":"In Vivo."},{"key":"10.3945\/jn.112.162677_bib32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-60327-325-1_15","article-title":"Reverse-phase high-performance liquid chromatography (HPLC) analysis of retinol and retinyl esters in mouse serum and tissues.","volume":"652","author":"Kim","year":"2010","journal-title":"Methods Mol Biol."},{"key":"10.3945\/jn.112.162677_bib33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.abb.2008.02.010","article-title":"In vitro and in vivo characterization of retinoid synthesis from beta-carotene.","volume":"472","author":"Fierce","year":"2008","journal-title":"Arch Biochem Biophys."},{"key":"10.3945\/jn.112.162677_bib34","article-title":"Mouse development: patterning, morphogenesis and organogenesis.","author":"Rossant","year":"2002"},{"key":"10.3945\/jn.112.162677_bib35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bbalip.2011.05.003","article-title":"Maternal-fetal transfer and metabolism of vitamin A and its precursor beta-carotene in the developing tissues.","volume":"1821","author":"Spiegler","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"10.3945\/jn.112.162677_bib36","doi-asserted-by":"crossref","first-page":"32198","DOI":"10.1074\/jbc.M111.253070","article-title":"Uptake of dietary retinoids at the maternal-fetal barrier: in vivo evidence for the role of lipoprotein lipase and alternative pathways.","volume":"286","author":"Wassef","year":"2011","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib37","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1096\/fasebj.10.5.8621054","article-title":"Absorption, metabolism, and transport of carotenoids.","volume":"10","author":"Parker","year":"1996","journal-title":"FASEB J."},{"key":"10.3945\/jn.112.162677_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.abb.2010.05.010","article-title":"Hepatic stellate cells are an important cellular site for beta-carotene conversion to retinoid.","volume":"504","author":"Shmarakov","year":"2010","journal-title":"Arch Biochem Biophys."},{"key":"10.3945\/jn.112.162677_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0083-6729(06)75004-X","article-title":"Metabolism of retinol during mammalian placental and embryonic development.","volume":"75","author":"Marceau","year":"2007","journal-title":"Vitam Horm."},{"key":"10.3945\/jn.112.162677_bib40","doi-asserted-by":"crossref","first-page":"27891","DOI":"10.1074\/jbc.M110.132571","article-title":"Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner.","volume":"285","author":"Lobo","year":"2010","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib41","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/jn\/136.4.932","article-title":"Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues.","volume":"136","author":"Zaripheh","year":"2006","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.162677_bib42","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1194\/jlr.M700580-JLR200","article-title":"Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism.","volume":"49","author":"During","year":"2008","journal-title":"J Lipid Res."},{"key":"10.3945\/jn.112.162677_bib43","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1021\/bi0484320","article-title":"Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol.","volume":"44","author":"van Bennekum","year":"2005","journal-title":"Biochemistry."},{"key":"10.3945\/jn.112.162677_bib44","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/ajcn\/56.1.128","article-title":"Distribution of orally administered beta-carotene among lipoproteins in healthy men.","volume":"56","author":"Johnson","year":"1992","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.112.162677_bib45","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1152\/physrev.00033.2007","article-title":"LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.","volume":"88","author":"Lillis","year":"2008","journal-title":"Physiol Rev."},{"key":"10.3945\/jn.112.162677_bib46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/341162a0","article-title":"The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein.","volume":"341","author":"Beisiegel","year":"1989","journal-title":"Nature."},{"key":"10.3945\/jn.112.162677_bib47","doi-asserted-by":"crossref","first-page":"E416","DOI":"10.1152\/ajpendo.00619.2010","article-title":"Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta.","volume":"301","author":"Rebholz","year":"2011","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"Suppl 2","key":"10.3945\/jn.112.162677_bib48","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1016\/j.placenta.2011.01.011","article-title":"Review: transport of maternal cholesterol to the fetal circulation.","volume":"32","author":"Woollett","year":"2011","journal-title":"Placenta."},{"key":"10.3945\/jn.112.162677_bib49","doi-asserted-by":"crossref","first-page":"55271","DOI":"10.1074\/jbc.M411404200","article-title":"Human placenta secretes apolipoprotein B-100-containing lipoproteins.","volume":"279","author":"Madsen","year":"2004","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib50","doi-asserted-by":"crossref","first-page":"40226","DOI":"10.1074\/jbc.M509643200","article-title":"Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency.","volume":"280","author":"Liu","year":"2005","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.162677_bib51","first-page":"180","article-title":"Development of structures and transport functions in the mouse placenta.","volume":"20","author":"Watson","year":"2005","journal-title":"Physiology (Bethesda)."},{"key":"10.3945\/jn.112.162677_bib52","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.bcp.2008.03.012","article-title":"Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet.","volume":"75","author":"Liu","year":"2008","journal-title":"Biochem Pharmacol."},{"key":"10.3945\/jn.112.162677_bib53","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000244315","article-title":"Effect of subadequate maternal vitamin-A status on placental transfer of retinol and beta-carotene to the human fetus.","volume":"69","author":"Dimenstein","year":"1996","journal-title":"Biol Neonate."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622027250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622027250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/142\/8\/1456\/23952180\/1456.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:37:17Z","timestamp":1686695837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622027250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0022316622027250"],"URL":"https:\/\/doi.org\/10.3945\/jn.112.162677","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-Carotene Supplementation Decreases Placental Transcription of LDL Receptor-Related Protein 1 in Wild-Type Mice and Stimulates Placental \u03b2-Carotene Uptake in Marginally Vitamin A-Deficient Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.112.162677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}