{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:44:54Z","timestamp":1790685894860,"version":"4.1.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":3746,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.3945\/jn.112.166835","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T11:41:24Z","timestamp":1348746084000},"page":"1964-1967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Homocysteinemia in Mice with Genetic Betaine HomocysteineS -Methyltransferase Deficiency Is Independent of Dietary Folate Intake"],"prefix":"10.1016","volume":"142","author":[{"given":"Ya-Wen","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Cerdena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Zeisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.112.166835_bib1","first-page":"473","article-title":"Plasma homocysteine a risk factor for vascular disease: plasma levels in health disease and drug therapy.","volume":"114","author":"Ueland","year":"1989","journal-title":"J Lab Clin Med."},{"key":"10.3945\/jn.112.166835_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3132\/dvdr.2007.033","article-title":"Homocysteine and cardiovascular disease: a review of the evidence.","volume":"4","author":"Wierzbicki","year":"2007","journal-title":"Diab Vasc Dis Res."},{"key":"10.3945\/jn.112.166835_bib3","doi-asserted-by":"crossref","first-page":"36258","DOI":"10.1074\/jbc.M111.265348","article-title":"Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism resulting in fatty liver and hepatocellular carcinomas.","volume":"286","author":"Teng","year":"2011","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.166835_bib4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/jn\/134.1.162","article-title":"Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain.","volume":"134","author":"Craciunescu","year":"2004","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.166835_bib5","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1093\/clinchem\/34.11.2357","article-title":"Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates.","volume":"34","author":"Horne","year":"1988","journal-title":"Clin Chem."},{"key":"10.3945\/jn.112.166835_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0378-4347(91)80407-4","article-title":"Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum.","volume":"565","author":"Ubbink","year":"1991","journal-title":"J Chromatogr."},{"key":"10.3945\/jn.112.166835_bib7","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/carcin\/4.8.1051","article-title":"Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient amino acid-defined diets for one to five weeks.","volume":"4","author":"Shivapurkar","year":"1983","journal-title":"Carcinogenesis."},{"key":"10.3945\/jn.112.166835_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/bmc.1130040611","article-title":"A new high performance liquid chromatographic method for the simultaneous measurement of S-adenosylmethionine and S-adenosylhomocysteine.","volume":"4","author":"Molloy","year":"1990","journal-title":"Biomed Chromatogr."},{"key":"10.3945\/jn.112.166835_bib9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ajcn.81.2.440","article-title":"Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.","volume":"81","author":"da Costa","year":"2005","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.112.166835_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-006-0106-5","article-title":"Homocysteine metabolism hyperhomocysteinaemia and vascular disease: an overview.","volume":"29","author":"Castro","year":"2006","journal-title":"J Inherit Metab Dis."},{"key":"10.3945\/jn.112.166835_bib11","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/ATVBAHA.108.166421","article-title":"Murine models of hyperhomocysteinemia and their vascular phenotypes.","volume":"28","author":"Dayal","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.3945\/jn.112.166835_bib12","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.nutres.2010.06.017","article-title":"Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.","volume":"30","author":"Strakova","year":"2010","journal-title":"Nutr Res."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622026499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622026499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/142\/11\/1964\/23953318\/1964.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T15:32:05Z","timestamp":1686670325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622026499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0022316622026499"],"URL":"https:\/\/doi.org\/10.3945\/jn.112.166835","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteinemia in Mice with Genetic Betaine HomocysteineS -Methyltransferase Deficiency Is Independent of Dietary Folate Intake","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.112.166835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}