{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:52:56Z","timestamp":1792115576184,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":3715,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.3945\/jn.112.167031","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T01:00:42Z","timestamp":1351126842000},"page":"2119-2127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dietary Zinc Reduction, Pyruvate Supplementation, or Zinc Transporter 5 Knockout Attenuates \u03b2-Cell Death in Nonobese Diabetic Mice, Islets, and Insulinoma Cells3"],"prefix":"10.1016","volume":"142","author":[{"given":"Christian T.","family":"Sheline","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Joshua","family":"Sheline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Li","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.112.167031_bib1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0092-8674(00)81106-X","article-title":"Insulin-dependent diabetes mellitus.","volume":"85","author":"Tisch","year":"1996","journal-title":"Cell."},{"key":"10.3945\/jn.112.167031_bib2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ecl.2010.05.011","article-title":"Epidemiology of type 1 diabetes.","volume":"39","author":"Maahs","year":"2010","journal-title":"Endocrinol Metab Clin North Am."},{"key":"10.3945\/jn.112.167031_bib3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2337\/diabetes.49.3.367","article-title":"Kim KW, Lee MS. Zinc as a paracrine effector in pancreatic islet cell death.","volume":"49","author":"Kim","year":"2000","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib4","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1007\/s00125-003-1171-z","article-title":"Koh JY, Lee MS. Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.","volume":"46","author":"Chang","year":"2003","journal-title":"Diabetologia."},{"key":"10.3945\/jn.112.167031_bib5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejphar.2007.02.064","article-title":"Aricha-Tamir B, Sekler I. Clioquinol attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice.","volume":"565","author":"Priel","year":"2007","journal-title":"Eur J Pharmacol."},{"key":"10.3945\/jn.112.167031_bib6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/414792a","article-title":"Vence L, Benoist C. beta-Cell death during progression to diabetes.","volume":"414","author":"Mathis","year":"2001","journal-title":"Nature."},{"key":"10.3945\/jn.112.167031_bib7","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1046\/j.1432-1033.2003.03470.x","article-title":"2-Oxo acid dehydrogenase complexes in redox regulation.","volume":"270","author":"Bunik","year":"2003","journal-title":"Eur J Biochem."},{"key":"10.3945\/jn.112.167031_bib8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/diabetes.51.5.1470","article-title":"Garchon HJ, Levi-Strauss M. Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.","volume":"51","author":"Gonzalez","year":"2002","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib9","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1523\/JNEUROSCI.20-09-03139.2000","article-title":"Behrens MM, Choi DW. Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis.","volume":"20","author":"Sheline","year":"2000","journal-title":"J Neurosci."},{"key":"10.3945\/jn.112.167031_bib10","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1111\/j.1460-9568.2006.05110.x","article-title":"Zipfel GJ, Sheline CT. Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway.","volume":"24","author":"Cai","year":"2006","journal-title":"Eur J Neurosci."},{"key":"10.3945\/jn.112.167031_bib11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1460-9568.2010.07372.x","article-title":"Zhu J, Shi C. Serum or target deprivation-induced neuronal death causes oxidative neuronal accumulation of Zn2+ and loss of NAD+.","volume":"32","author":"Sheline","year":"2010","journal-title":"Eur J Neurosci."},{"key":"10.3945\/jn.112.167031_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0303-7207(88)90198-0","article-title":"Korsgren O, Sandler S. Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations.","volume":"59","author":"Strandell","year":"1988","journal-title":"Mol Cell Endocrinol."},{"key":"10.3945\/jn.112.167031_bib13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/294284a0","article-title":"Uchigata Y, Okamoto H. Streptozotocin and alloxan induce DNA strand breaks and poly(ADP- ribose) synthetase in pancreatic islets.","volume":"294","author":"Yamamoto","year":"1981","journal-title":"Nature."},{"key":"10.3945\/jn.112.167031_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1677\/joe.0.1730457","article-title":"Salzman AL, Szabo C. NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes.","volume":"173","author":"Mabley","year":"2002","journal-title":"J Endocrinol."},{"key":"10.3945\/jn.112.167031_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2337\/diab.38.3.379","article-title":"Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis.","volume":"38","author":"Mendola","year":"1989","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2337\/diab.33.3.229","article-title":"Schmid-Formby F, Grodsky GM. Relationship between insulin release and 65zinc efflux from rat pancreatic islets maintained in tissue culture.","volume":"33","author":"Formby","year":"1984","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib17","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1177\/153537020422901113","article-title":"Friesen N, Gleichmann H. Prevention of spontaneous and experimentally induced diabetes in mice with zinc sulfate-enriched drinking water is associated with activation and reduction of NF-kappa B and AP-1 in islets, respectively.","volume":"229","author":"Schott-Ohly","year":"2004","journal-title":"Exp Biol Med (Maywood)."},{"key":"10.3945\/jn.112.167031_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10534-005-3686-x","article-title":"Zinc, the pancreas, and diabetes: insights from rodent studies and future directions.","volume":"18","author":"Taylor","year":"2005","journal-title":"Biometals."},{"key":"10.3945\/jn.112.167031_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/exnr.1998.6931","article-title":"Hong SH, Koh JY. Depletion of intracellular zinc induces protein synthesis-dependent neuronal apoptosis in mouse cortical culture.","volume":"154","author":"Ahn","year":"1998","journal-title":"Exp Neurol."},{"key":"10.3945\/jn.112.167031_bib20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.272.5264.1013","article-title":"Hsu CY, Choi DW. The role of zinc in selective neuronal death after transient global cerebral ischemia.","volume":"272","author":"Koh","year":"1996","journal-title":"Science."},{"key":"10.3945\/jn.112.167031_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-nutr-033009-083312","article-title":"Mammalian zinc transporters: nutritional and physiologic regulation.","volume":"29","author":"Lichten","year":"2009","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/jn.112.167031_bib22","doi-asserted-by":"crossref","first-page":"14355","DOI":"10.1073\/pnas.0406216101","article-title":"Samuelson DA, Cousins RJ. Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis.","volume":"101","author":"Liuzzi","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.112.167031_bib23","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1074\/jbc.M508542200","article-title":"Dai F, Wheeler MB. The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel.","volume":"281","author":"Gyulkhandanyan","year":"2006","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.167031_bib24","doi-asserted-by":"crossref","first-page":"19049","DOI":"10.1074\/jbc.M200910200","article-title":"Iwanaga T, Nagao M. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.","volume":"277","author":"Kambe","year":"2002","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.167031_bib25","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.2337\/diabetes.53.9.2330","article-title":"Favier A, Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.","volume":"53","author":"Chimienti","year":"2004","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib26","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1073\/pnas.0705894104","article-title":"The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.","volume":"104","author":"Wenzlau","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.112.167031_bib27","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05616","article-title":"A genome-wide association study identifies novel risk loci for type 2 diabetes.","volume":"445","author":"Sladek","year":"2007","journal-title":"Nature."},{"key":"10.3945\/jn.112.167031_bib28","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.2337\/db09-0551","article-title":"Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.","volume":"58","author":"Nicolson","year":"2009","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib29","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1007\/s00125-010-1733-9","article-title":"Rutter GA, Wheeler MB. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.","volume":"53","author":"Wijesekara","year":"2010","journal-title":"Diabetologia."},{"key":"10.3945\/jn.112.167031_bib30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/glia.10313","article-title":"Yu SP, Choi DW. Potassium attenuates zinc-induced death of cultured cortical astrocytes.","volume":"46","author":"Sheline","year":"2004","journal-title":"Glia."},{"key":"10.3945\/jn.112.167031_bib31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0076-6879(83)98149-1","article-title":"Kotagal N, Lacy PE. A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans.","volume":"98","author":"McDaniel","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.3945\/jn.112.167031_bib32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1074\/jbc.M307907200","article-title":"Chen H, Epstein PN. Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species.","volume":"279","author":"Li","year":"2004","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.167031_bib33","series-title":"Handbook of fluorescent probes and research chemicals.","author":"Haugland","year":"2005"},{"key":"10.3945\/jn.112.167031_bib34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jn\/126.4.825","article-title":"Palmiter RD, Andrews GK. Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency.","volume":"126","author":"Dalton","year":"1996","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.167031_bib35","series-title":"Survival analysis: techniques for censored and truncated data.","author":"Klein","year":"1997"},{"key":"10.3945\/jn.112.167031_bib36","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jn\/128.5.825","article-title":"McMahon RJ, Cousins RJ. Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression.","volume":"128","author":"Davis","year":"1998","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.167031_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jinf.2004.05.001","article-title":"Tezeren D, Ciftci U. Serum copper and zinc concentrations in patients with brucellosis.","volume":"50","author":"Cesur","year":"2005","journal-title":"J Infect."},{"key":"10.3945\/jn.112.167031_bib38","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/jn\/112.4.652","article-title":"Murray EJ, Goebel NK. Removal of trace metals from culture media and sera for in vitro deficiency studies.","volume":"112","author":"Messer","year":"1982","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.167031_bib39","doi-asserted-by":"crossref","first-page":"RC171","DOI":"10.1523\/JNEUROSCI.21-20-j0002.2001","article-title":"Kim YH, Koh JY. Protection by pyruvate against transient forebrain ischemia in rats.","volume":"21","author":"Lee","year":"2001","journal-title":"J Neurosci."},{"key":"10.3945\/jn.112.167031_bib40","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.nbd.2004.04.017","article-title":"Chen Y, Swanson RA. Zinc release contributes to hypoglycemia-induced neuronal death.","volume":"16","author":"Suh","year":"2004","journal-title":"Neurobiol Dis."},{"key":"10.3945\/jn.112.167031_bib41","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.2337\/diabetes.54.5.1452","article-title":"Liu J, Swanson RA. Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment.","volume":"54","author":"Suh","year":"2005","journal-title":"Diabetes."},{"key":"10.3945\/jn.112.167031_bib42","doi-asserted-by":"crossref","first-page":"30914","DOI":"10.1074\/jbc.M202314200","article-title":"Powers AC, Piston DW. Pancreatic islet beta-cells transiently metabolize pyruvate.","volume":"277","author":"Rocheleau","year":"2002","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.167031_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1432-1033.1986.tb09733.x","article-title":"Synaptosomal bioenergetics. The role of glycolysis, pyruvate oxidation and responses to hypoglycaemia.","volume":"158","author":"Kauppinen","year":"1986","journal-title":"Eur J Biochem."},{"key":"10.3945\/jn.112.167031_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The sir2 family of protein deacetylases.","volume":"73","author":"Blander","year":"2004","journal-title":"Annu Rev Biochem."},{"key":"10.3945\/jn.112.167031_bib45","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ncb951","article-title":"Herrera PL, Wollheim CB. Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.","volume":"5","author":"Ishihara","year":"2003","journal-title":"Nat Cell Biol."},{"key":"10.3945\/jn.112.167031_bib46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1096-9896(200005)191:1<86::AID-PATH573>3.0.CO;2-0","article-title":"Cameron DP, Allan DJ. Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing beta-cell apoptosis.","volume":"191","author":"O'Brien","year":"2000","journal-title":"J Pathol."},{"key":"10.3945\/jn.112.167031_bib47","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.2337\/diacare.19.12.1357","article-title":"Browne PD, Kolb H. Meta-analysis of nicotinamide treatment in patients with recent-onset IDDM. The nicotinamide trialists.","volume":"19","author":"Pozzilli","year":"1996","journal-title":"Diabetes Care."},{"key":"10.3945\/jn.112.167031_bib48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmet.2007.09.003","article-title":"Nampt\/PBEF\/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.","volume":"6","author":"Revollo","year":"2007","journal-title":"Cell Metab."},{"key":"10.3945\/jn.112.167031_bib49","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab."},{"key":"10.3945\/jn.112.167031_bib50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2005.07.001","article-title":"Permutt MA, Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.","volume":"2","author":"Moynihan","year":"2005","journal-title":"Cell Metab."},{"key":"10.3945\/jn.112.167031_bib51","first-page":"193","article-title":"Involvement of SIRT1 in Zn2+, steptozotocin, non-obese diabetic, and cytokine-mediated toxicities of beta-cells.","volume":"3","author":"Sheline","year":"2012","journal-title":"J Diab Metab."},{"key":"10.3945\/jn.112.167031_bib52","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1046\/j.1471-4159.2003.01803.x","article-title":"Susceptibility to kainate-induced seizures under dietary zinc deficiency.","volume":"85","author":"Takeda","year":"2003","journal-title":"J Neurochem."},{"key":"10.3945\/jn.112.167031_bib53","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/jcbfm.2009.80","article-title":"Takeda A, Liu J. Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats.","volume":"29","author":"Suh","year":"2009","journal-title":"J Cereb Blood Flow Metab."},{"key":"10.3945\/jn.112.167031_bib54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-nutr-080508-141119","article-title":"Functional significance of zinc-related signaling pathways in immune cells.","volume":"29","author":"Haase","year":"2009","journal-title":"Annu Rev Nutr."},{"key":"10.3945\/jn.112.167031_bib55","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0006-291X(02)00636-8","article-title":"Gurwitz D, Eldar-Finkelman H. Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc.","volume":"295","author":"Ilouz","year":"2002","journal-title":"Biochem Biophys Res Commun."},{"key":"10.3945\/jn.112.167031_bib56","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8227(00)00249-7","article-title":"Tirth S, Parab P. Beneficial effect of supplementation with copper sulfate on STZ- diabetic mice (IDDM).","volume":"52","author":"Sitasawad","year":"2001","journal-title":"Diabetes Res Clin Pract."},{"key":"10.3945\/jn.112.167031_bib57","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3945\/jn.108.091504","article-title":"Development of a compartmental model of zinc kinetics in mice.","volume":"138","author":"Wastney","year":"2008","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.167031_bib58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.neuro.21.1.347","article-title":"Zinc and brain injury.","volume":"21","author":"Choi","year":"1998","journal-title":"Annu Rev Neurosci."},{"key":"10.3945\/jn.112.167031_bib59","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1093\/jn\/132.11.3422","article-title":"Mineral intakes of elderly adult supplement and non-supplement users in the third national health and nutrition examination survey.","volume":"132","author":"Ervin","year":"2002","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.167031_bib60","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/jcbfm.2008.61","article-title":"Chan PH, Swanson RA. Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.","volume":"28","author":"Suh","year":"2008","journal-title":"J Cereb Blood Flow Metab."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622026244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622026244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/142\/12\/2119\/23948127\/2119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T22:34:10Z","timestamp":1686695650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622026244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0022316622026244"],"URL":"https:\/\/doi.org\/10.3945\/jn.112.167031","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Zinc Reduction, Pyruvate Supplementation, or Zinc Transporter 5 Knockout Attenuates \u03b2-Cell Death in Nonobese Diabetic Mice, Islets, and Insulinoma Cells3","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.112.167031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}