{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:20:37Z","timestamp":1784694037852,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":3530,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.3945\/jn.112.172593","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T03:54:57Z","timestamp":1366862097000},"page":"804-809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Partitioning of [Methyl-3H]Methionine to Methylated Products and Protein Is Altered during High Methyl Demand Conditions in Young Yucatan Miniature Pigs"],"prefix":"10.1016","volume":"143","author":[{"given":"Laura E.","family":"McBreairty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A.","family":"McGowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A.","family":"Brunton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Bertolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.112.172593_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0968-0004(03)00090-2","article-title":"Many paths to methyltransfer: a chronicle of convergence.","volume":"28","author":"Schubert","year":"2003","journal-title":"Trends Biochem Sci."},{"key":"10.3945\/jn.112.172593_bib2","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3945\/jn.109.105411","article-title":"Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance.","volume":"139","author":"Brosnan","year":"2009","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.172593_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/ajcn\/83.1.5","article-title":"Is it time to reevaluate methyl balance in humans?","volume":"83","author":"Stead","year":"2006","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.112.172593_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory.","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev."},{"key":"10.3945\/jn.112.172593_bib5","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1113\/jphysiol.2009.176156","article-title":"Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome.","volume":"587","author":"Plagemann","year":"2009","journal-title":"J Physiol."},{"key":"10.3945\/jn.112.172593_bib6","doi-asserted-by":"crossref","first-page":"1344S","DOI":"10.1093\/ajcn\/71.5.1344s","article-title":"Fetal nutrition and adult disease.","volume":"71 Suppl","author":"Godfrey","year":"2000","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.112.172593_bib7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: prediction, plasticity, and programming.","volume":"85","author":"McMillen","year":"2005","journal-title":"Physiol Rev."},{"key":"10.3945\/jn.112.172593_bib8","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1073\/pnas.0707258104","article-title":"DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status.","volume":"104","author":"Sinclair","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.112.172593_bib9","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1007\/s11033-010-0500-9","article-title":"Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets.","volume":"38","author":"Liu","year":"2011","journal-title":"Mol Biol Rep."},{"key":"10.3945\/jn.112.172593_bib10","doi-asserted-by":"crossref","first-page":"E256","DOI":"10.1152\/ajpendo.90547.2008","article-title":"Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo.","volume":"296","author":"da Silva","year":"2009","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"10.3945\/jn.112.172593_bib11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000326341","article-title":"Low birth weight is associated with reduced nephron number and increased blood pressure in adult Yucatan miniature swine.","volume":"100","author":"Myrie","year":"2011","journal-title":"Neonatology."},{"key":"10.3945\/jn.112.172593_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1139\/h11-142","article-title":"Glucose tolerance is affected by visceral adiposity and gender, but not birth weight or early nutrition, in Yucatan miniature pigs.","volume":"37","author":"McKnight","year":"2012","journal-title":"Appl Physiol Nutr Metab."},{"key":"10.3945\/jn.112.172593_bib13","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1113\/jphysiol.2001.012926","article-title":"The effects of birth weight on basal cardiovascular function in pigs at 3 months of age.","volume":"539","author":"Poore","year":"2002","journal-title":"J Physiol."},{"key":"10.3945\/jn.112.172593_bib14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1113\/jphysiol.2004.061390","article-title":"The effects of birth weight and postnatal growth patterns on fat depth and plasma leptin concentrations in juvenile and adult pigs.","volume":"558","author":"Poore","year":"2004","journal-title":"J Physiol."},{"key":"10.3945\/jn.112.172593_bib15","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.jnutbio.2011.06.005","article-title":"Intrauterine growth restriction leads to changes in sulfur amino acid metabolism, but not global DNA methylation, in Yucatan miniature piglets.","volume":"23","author":"MacKay","year":"2012","journal-title":"J Nutr Biochem."},{"key":"10.3945\/jn.112.172593_bib16","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/jssc.200401866","article-title":"Improved high-performance liquid chromatographic determination of guanidino compounds by precolumn derivatization with ninhydrin and fluorescence detection.","volume":"27","author":"Buchberger","year":"2004","journal-title":"J Sep Sci."},{"key":"10.3945\/jn.112.172593_bib17","doi-asserted-by":"crossref","first-page":"E933","DOI":"10.1152\/ajpendo.00498.2005","article-title":"Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.","volume":"290","author":"Ratnam","year":"2006","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"10.3945\/jn.112.172593_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-4347(00)85133-6","article-title":"Rapid analysis of amino acids using pre-column derivatization.","volume":"336","author":"Bidlingmeyer","year":"1984","journal-title":"J Chromatogr."},{"key":"10.3945\/jn.112.172593_bib19","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3945\/jn.110.125476","article-title":"Suckling rat pups accumulate creatine primarily via de novo synthesis rather than from dam milk.","volume":"140","author":"Lamarre","year":"2012","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.172593_bib20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues.","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.172593_bib21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography.","volume":"234","author":"Bartlett","year":"1959","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.172593_bib22","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis.","volume":"49","author":"Li","year":"2008","journal-title":"J Lipid Res."},{"key":"10.3945\/jn.112.172593_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1432-1033.1978.tb12226.x","article-title":"Effect of choline deficiency on the enzymes that synthesize phosphatidylcholine and phosphatidylethanolamine in rat liver.","volume":"85","author":"Schneider","year":"1978","journal-title":"Eur J Biochem."},{"key":"10.3945\/jn.112.172593_bib24","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1074\/jbc.271.5.2839","article-title":"Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats.","volume":"271","author":"Cui","year":"1996","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.172593_bib25","doi-asserted-by":"crossref","first-page":"47402","DOI":"10.1074\/jbc.M404027200","article-title":"Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase A in mice decreases plasma high density and very low density lipoproteins.","volume":"279","author":"Jacobs","year":"2004","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.172593_bib26","doi-asserted-by":"crossref","first-page":"28299","DOI":"10.1074\/jbc.M501971200","article-title":"Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.","volume":"280","author":"Jacobs","year":"2005","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.172593_bib27","doi-asserted-by":"crossref","first-page":"10822","DOI":"10.1016\/S0021-9258(19)70381-0","article-title":"S-Adenosylmethionine and S-adenosylhomocysteine metabolism in isolated rat liver: effects of L-methionine, L-homocysteine, and adenosine.","volume":"255","author":"Hoffman","year":"1980","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.112.172593_bib28","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1271\/bbb.70791","article-title":"Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.","volume":"72","author":"Setoue","year":"2008","journal-title":"Biosci Biotechnol Biochem."},{"key":"10.3945\/jn.112.172593_bib29","doi-asserted-by":"crossref","first-page":"E1239","DOI":"10.1152\/ajpendo.91021.2008","article-title":"Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs.","volume":"296","author":"Bauchart-Thevret","year":"2009","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"10.3945\/jn.112.172593_bib30","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1093\/jn\/133.11.3386","article-title":"Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice.","volume":"133","author":"Watkins","year":"2003","journal-title":"J Nutr."},{"key":"10.3945\/jn.112.172593_bib31","doi-asserted-by":"crossref","unstructured":"EdisonEE, BrosnanME, AzizK, BrosnanJT. Creatine and guanidinoacetate content of human milk and infant formulas: implications for creatine deficiency syndromes and amino acid metabolism. Br J Nutr. Epub 2013 Feb 7.","DOI":"10.1017\/S000711451300010X"},{"key":"10.3945\/jn.112.172593_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3382\/ps.2011-01585","article-title":"Supplementation of guanidinoacetic acid to broiler diets: effects on performance, carcass characteristics, meat quality, and energy metabolism.","volume":"91","author":"Michiels","year":"2012","journal-title":"Poult Sci."},{"key":"10.3945\/jn.112.172593_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3382\/ps.2012-02425","article-title":"Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks.","volume":"92","author":"Dilger","year":"2013","journal-title":"Poult Sci."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622012020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622012020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/143\/6\/804\/23974407\/804.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T20:13:06Z","timestamp":1738354386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622012020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0022316622012020"],"URL":"https:\/\/doi.org\/10.3945\/jn.112.172593","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Partitioning of [Methyl-3H]Methionine to Methylated Products and Protein Is Altered during High Methyl Demand Conditions in Young Yucatan Miniature Pigs","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.112.172593","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}