{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:45:28Z","timestamp":1785199528892,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":3257,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.3945\/jn.113.184820","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T20:58:20Z","timestamp":1395867500000},"page":"352-358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Higher Urinary Lignan Concentrations in Women but Not Men Are Positively Associated with Shorter Time to Pregnancy"],"prefix":"10.1016","volume":"144","author":[{"given":"Sunni L.","family":"Mumford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique F.","family":"Schisterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Boyd","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Rybak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Maisog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine M. Buck","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.113.184820_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jsbmb.2006.06.020","article-title":"Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration","volume":"101","author":"Hwang","year":"2006","journal-title":"J Steroid Biochem Mol Biol."},{"key":"10.3945\/jn.113.184820_bib2","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology."},{"key":"10.3945\/jn.113.184820_bib3","first-page":"348","article-title":"A specific breeding problem of sheep on subterranean clover pastures in Western Australia","volume":"102","author":"Bennetts","year":"1946","journal-title":"Br Vet J."},{"key":"10.3945\/jn.113.184820_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0016-5085(87)91006-7","article-title":"Dietary estrogens\u2014a probable cause of infertility and liver disease in captive cheetahs","volume":"93","author":"Setchell","year":"1987","journal-title":"Gastroenterology."},{"key":"10.3945\/jn.113.184820_bib5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/humupd\/dmp010","article-title":"Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis","volume":"15","author":"Hooper","year":"2009","journal-title":"Hum Reprod Update."},{"key":"10.3945\/jn.113.184820_bib6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1089\/jmf.2005.8.550","article-title":"The effect of soybeans on the anovulatory cycle","volume":"8","author":"Kohama","year":"2005","journal-title":"J Med Food."},{"key":"10.3945\/jn.113.184820_bib7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S1472-6483(10)60465-8","article-title":"Adding phytoestrogens to clomiphene induction in unexplained infertility patients\u2014a randomized trial","volume":"16","author":"Shahin","year":"2008","journal-title":"Reprod Biomed Online."},{"key":"10.3945\/jn.113.184820_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jsgi.2003.12.007","article-title":"High dose of phytoestrogens can reverse the antiestrogenic effects of clomiphene citrate on the endometrium in patients undergoing intrauterine insemination: a randomized trial","volume":"11","author":"Unfer","year":"2004","journal-title":"J Soc Gynecol Investig."},{"key":"10.3945\/jn.113.184820_bib9","doi-asserted-by":"crossref","first-page":"210.e1","DOI":"10.1016\/j.ajog.2007.06.057","article-title":"Protein intake and ovulatory infertility","volume":"198","author":"Chavarro","year":"2008","journal-title":"Am J Obstet Gynecol."},{"key":"10.3945\/jn.113.184820_bib10","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1093\/humrep\/den243","article-title":"Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic","volume":"23","author":"Chavarro","year":"2008","journal-title":"Hum Reprod."},{"key":"10.3945\/jn.113.184820_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.envint.2013.06.009","article-title":"Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men","volume":"59","author":"Xia","year":"2013","journal-title":"Environ Int."},{"key":"10.3945\/jn.113.184820_bib12","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.fertnstert.2009.08.055","article-title":"Soy protein isolates of varying isoflavone content do not adversely affect semen quality in healthy young men","volume":"94","author":"Beaton","year":"2010","journal-title":"Fertil Steril."},{"key":"10.3945\/jn.113.184820_bib13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/cs1000613","article-title":"Effect of a phytoestrogen food supplement on reproductive health in normal males","volume":"100","author":"Mitchell","year":"2001","journal-title":"Clin Sci."},{"key":"10.3945\/jn.113.184820_bib14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-3016.2011.01205.x","article-title":"Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development\u2014the LIFE Study","volume":"25","author":"Buck Louis","year":"2011","journal-title":"Paediatr Perinat Epidemiol."},{"key":"10.3945\/jn.113.184820_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1289\/ehp.6262","article-title":"Prospective pregnancy study designs for assessing reproductive and developmental toxicants","volume":"112","author":"Buck","year":"2004","journal-title":"Environ Health Perspect."},{"key":"10.3945\/jn.113.184820_bib16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/01.ede.0000221781.15114.88","article-title":"Feasibility of the current-duration approach to studying human fecundity","volume":"17","author":"Slama","year":"2006","journal-title":"Epidemiology."},{"key":"10.3945\/jn.113.184820_bib17","series-title":"Anthropometric Standardization Reference Manual","author":"Lohman","year":"1988"},{"key":"10.3945\/jn.113.184820_bib18","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1093\/humrep\/15.12.2478","article-title":"Prediction of ovulation by urinary hormone measurements with the home use ClearPlan Fertility Monitor: comparison with transvaginal ultrasound scans and serum hormone measurements","volume":"15","author":"Behre","year":"2000","journal-title":"Hum Reprod."},{"key":"10.3945\/jn.113.184820_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jchromb.2007.11.013","article-title":"Determination of urinary phytoestrogens by HPLC-MS\/MS: a comparison of atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI)","volume":"861","author":"Rybak","year":"2008","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci."},{"key":"10.3945\/jn.113.184820_bib20","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/EDE.0b013e3181d60e56","article-title":"How well quantified is the limit of quantification?","volume":"21","author":"Guo","year":"2010","journal-title":"Epidemiology."},{"key":"10.3945\/jn.113.184820_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/aje\/kwf217","article-title":"Effects of exposure measurement error when an exposure variable is constrained by a lower limit","volume":"157","author":"Richardson","year":"2003","journal-title":"Am J Epidemiol."},{"key":"10.3945\/jn.113.184820_bib22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/aje\/kwj039","article-title":"The limitations due to exposure detection limits for regression models","volume":"163","author":"Schisterman","year":"2006","journal-title":"Am J Epidemiol."},{"key":"10.3945\/jn.113.184820_bib23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables (with discussion)","volume":"20","author":"Cox","year":"1972","journal-title":"J R Stat Soc Series B (Methodological)."},{"key":"10.3945\/jn.113.184820_bib24","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1158\/1055-9965.698.13.5","article-title":"Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk","volume":"13","author":"Grace","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"Suppl 3","key":"10.3945\/jn.113.184820_bib25","doi-asserted-by":"crossref","first-page":"956S","DOI":"10.1093\/jn\/133.3.956S","article-title":"Isoflavonoid and lignan phytoestrogens as dietary biomarkers","volume":"133","author":"Lampe","year":"2003","journal-title":"J Nutr."},{"key":"10.3945\/jn.113.184820_bib26","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3945\/ajcn.2009.27990","article-title":"Effect of daily fiber intake on reproductive function: the BioCycle Study","volume":"90","author":"Gaskins","year":"2009","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.113.184820_bib27","first-page":"699","article-title":"Urinary isoflavonoid and lignan excretion on a western diet: relation to soy, vegetable, and fruit intake","volume":"8","author":"Lampe","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"10.3945\/jn.113.184820_bib28","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/sim.4780131603","article-title":"Statistical analysis of proliferative index data in clinical trials","volume":"13","author":"Grambsch","year":"1994","journal-title":"Stat Med."},{"key":"10.3945\/jn.113.184820_bib29","series-title":"Statistics for biology and health","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3294-8","article-title":"Modeling survival data: extending the Cox model","author":"Therneau","year":"2000"},{"key":"10.3945\/jn.113.184820_bib30","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0140-6736(91)92867-2","article-title":"Dietary effects on breast-cancer risk in Singapore","volume":"337","author":"Lee","year":"1991","journal-title":"Lancet."},{"key":"10.3945\/jn.113.184820_bib31","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/bjc.1995.263","article-title":"Diet and breast cancer in Shanghai and Tianjin, China","volume":"71","author":"Yuan","year":"1995","journal-title":"Br J Cancer."},{"key":"10.3945\/jn.113.184820_bib32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/10408360701612942","article-title":"Lignans and human health","volume":"44","author":"Adlercreutz","year":"2007","journal-title":"Crit Rev Clin Lab Sci."},{"key":"10.3945\/jn.113.184820_bib33","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1289\/ehp.10538","article-title":"Phytoestrogens and breast cancer prevention: possible mechanisms of action","volume":"116","author":"Mense","year":"2008","journal-title":"Environ Health Perspect."},{"key":"10.3945\/jn.113.184820_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2188\/jea.10.127","article-title":"Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake","volume":"10","author":"Arai","year":"2000","journal-title":"J Epidemiol."},{"key":"10.3945\/jn.113.184820_bib35","unstructured":"Centers for Disease Control and Prevention. Second National Report on Biochemical Indicators of Diet and Nutrition in the U.S. Population. 2012 [cited 2013 Nov 1]. Available from: http:\/\/www.cdc.gov\/nutritionreport\/."},{"key":"10.3945\/jn.113.184820_bib36","unstructured":"Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals. Updated tables. 2013. Available from: http:\/\/www.cdc.gov\/exposurereport\/."},{"issue":"Suppl 1","key":"10.3945\/jn.113.184820_bib37","first-page":"I11","article-title":"Relationship of prebiotics and food to intestinal microflora","volume":"41","author":"Blaut","year":"2002","journal-title":"Eur J Nutr."},{"key":"10.3945\/jn.113.184820_bib38","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/ajcn\/73.6.1094","article-title":"Determinants of serum enterolactone concentration","volume":"73","author":"Kilkkinen","year":"2001","journal-title":"Am J Clin Nutr."},{"key":"10.3945\/jn.113.184820_bib39","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/aje\/155.5.472","article-title":"Use of oral antimicrobials decreases serum enterolactone concentration","volume":"155","author":"Kilkkinen","year":"2002","journal-title":"Am J Epidemiol."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662200829X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002231662200829X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/144\/3\/352\/23973998\/352.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T11:26:14Z","timestamp":1716636374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002231662200829X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S002231662200829X"],"URL":"https:\/\/doi.org\/10.3945\/jn.113.184820","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher Urinary Lignan Concentrations in Women but Not Men Are Positively Associated with Shorter Time to Pregnancy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.113.184820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}