{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:33:37Z","timestamp":1759530817331},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":3223,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.3945\/jn.113.186007","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T20:54:49Z","timestamp":1396385689000},"page":"419-424","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Azoxymethane-Induced Colon Carcinogenesis in Mice Occurs Independently of De Novo Thymidylate Synthesis Capacity"],"prefix":"10.1016","volume":"144","author":[{"given":"Amanda J.","family":"MacFarlane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"McEntee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Stover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/jn.113.186007_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/jnci\/85.11.875","article-title":"Folate, methionine, and alcohol intake and risk of colorectal adenoma","volume":"85","author":"Giovannucci","year":"1993","journal-title":"J Natl Cancer Inst."},{"key":"10.3945\/jn.113.186007_bib2","first-page":"1098","article-title":"Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer","volume":"57","author":"Ma","year":"1997","journal-title":"Cancer Res."},{"key":"10.3945\/jn.113.186007_bib3","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ejcn.2009.37","article-title":"Folate intake and the risk of colorectal cancer in a Korean population","volume":"63","author":"Kim","year":"2009","journal-title":"Eur J Clin Nutr."},{"key":"10.3945\/jn.113.186007_bib4","series-title":"Folate in health and disease","first-page":"1","article-title":"Folate chemistry and metabolism","author":"Shane","year":"1995"},{"key":"10.3945\/jn.113.186007_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/oxfordjournals.jbchem.a022730","article-title":"The rate of cell growth is regulated by purine biosynthesis via ATP production and G(1) to S phase transition","volume":"128","author":"Kondo","year":"2000","journal-title":"J Biochem."},{"key":"10.3945\/jn.113.186007_bib6","first-page":"145","article-title":"Aberrant DNA repair and enhanced mutagenesis following mutagen treatment of Chinese hamster Ade-C cells in a state of purine deprivation","volume":"193","author":"Collins","year":"1988","journal-title":"Mutat Res."},{"key":"10.3945\/jn.113.186007_bib7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/carcin\/10.7.1209","article-title":"Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats","volume":"10","author":"James","year":"1989","journal-title":"Carcinogenesis."},{"key":"10.3945\/jn.113.186007_bib8","first-page":"5401","article-title":"Folate deficiency increases genetic damage caused by alkylating agents and gamma-irradiation in Chinese hamster ovary cells","volume":"53","author":"Branda","year":"1993","journal-title":"Cancer Res."},{"key":"10.3945\/jn.113.186007_bib9","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1096\/fasebj.12.14.1491","article-title":"DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro","volume":"12","author":"Duthie","year":"1998","journal-title":"FASEB J."},{"key":"10.3945\/jn.113.186007_bib10","first-page":"2071s","article-title":"Methyl groups in carcinogenesis: effects on DNA methylation and gene expression","volume":"52","author":"Wainfan","year":"1992","journal-title":"Cancer Res."},{"key":"10.3945\/jn.113.186007_bib11","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.062066299","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status","volume":"99","author":"Friso","year":"2002","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.3945\/jn.113.186007_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.1083558","article-title":"Induction of tumors in mice by genomic hypomethylation","volume":"300","author":"Gaudet","year":"2003","journal-title":"Science."},{"key":"10.3945\/jn.113.186007_bib13","doi-asserted-by":"crossref","first-page":"38381","DOI":"10.1074\/jbc.M205000200","article-title":"Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses","volume":"277","author":"Herbig","year":"2002","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib14","doi-asserted-by":"crossref","first-page":"25846","DOI":"10.1074\/jbc.M802671200","article-title":"Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice","volume":"283","author":"MacFarlane","year":"2008","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib15","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1074\/jbc.M111.302174","article-title":"Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus","volume":"287","author":"Anderson","year":"2012","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib16","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1074\/jbc.M111.333120","article-title":"Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis","volume":"287","author":"Anderson","year":"2012","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib17","doi-asserted-by":"crossref","first-page":"e5839","DOI":"10.1371\/journal.pone.0005839","article-title":"SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis","volume":"4","author":"Anderson","year":"2009","journal-title":"PLoS ONE."},{"key":"10.3945\/jn.113.186007_bib18","doi-asserted-by":"crossref","first-page":"17623","DOI":"10.1074\/jbc.M702526200","article-title":"Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway","volume":"282","author":"Woeller","year":"2007","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib19","doi-asserted-by":"crossref","first-page":"44015","DOI":"10.1074\/jbc.M111.307629","article-title":"Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA","volume":"286","author":"MacFarlane","year":"2011","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib20","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1515\/CCLM.2007.355","article-title":"Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase","volume":"45","author":"Anderson","year":"2007","journal-title":"Clin Chem Lab Med."},{"key":"10.3945\/jn.113.186007_bib21","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0021-9258(18)52328-0","article-title":"5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase","volume":"266","author":"Stover","year":"1991","journal-title":"J Biol Chem."},{"key":"10.3945\/jn.113.186007_bib22","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1158\/0008-5472.CAN-10-1886","article-title":"Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apcmin-mediated intestinal cancer risk","volume":"71","author":"MacFarlane","year":"2011","journal-title":"Cancer Res."},{"key":"10.3945\/jn.113.186007_bib23","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr."},{"key":"10.3945\/jn.113.186007_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0003-2697(76)80064-4","article-title":"Assay of proteins in the presence of interfering materials","volume":"70","author":"Bensadoun","year":"1976","journal-title":"Anal Biochem."},{"key":"10.3945\/jn.113.186007_bib25","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1021\/bi002598t","article-title":"Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism","volume":"40","author":"Liu","year":"2001","journal-title":"Biochemistry."},{"key":"10.3945\/jn.113.186007_bib26","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1093\/carcin\/21.12.2261","article-title":"Folate deficiency reduces the development of colorectal cancer in rats","volume":"21","author":"Le Leu","year":"2000","journal-title":"Carcinogenesis."},{"key":"10.3945\/jn.113.186007_bib27","first-page":"5434","article-title":"Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse","volume":"60","author":"Song","year":"2000","journal-title":"Cancer Res."},{"key":"10.3945\/jn.113.186007_bib28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/gut.39.5.732","article-title":"Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats","volume":"39","author":"Kim","year":"1996","journal-title":"Gut."},{"key":"10.3945\/jn.113.186007_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1207\/s15327914nc5402_6","article-title":"Methionine restriction inhibits colon carcinogenesis","volume":"54","author":"Komninou","year":"2006","journal-title":"Nutr Cancer."},{"key":"10.3945\/jn.113.186007_bib30","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1046\/j.1440-1746.2000.02327.x","article-title":"Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status","volume":"15","author":"Le Leu","year":"2000","journal-title":"J Gastroenterol Hepatol."},{"key":"10.3945\/jn.113.186007_bib31","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1093\/jn\/137.12.2701","article-title":"Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon","volume":"137","author":"Liu","year":"2007","journal-title":"J Nutr."},{"key":"10.3945\/jn.113.186007_bib32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1053\/gast.2000.8518","article-title":"Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon","volume":"119","author":"Kim","year":"2000","journal-title":"Gastroenterology."},{"key":"10.3945\/jn.113.186007_bib33","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1038\/bjc.1998.359","article-title":"Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats","volume":"77","author":"De Filippo","year":"1998","journal-title":"Br J Cancer."},{"key":"10.3945\/jn.113.186007_bib34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1349-7006.2004.tb03235.x","article-title":"Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents","volume":"95","author":"Takahashi","year":"2004","journal-title":"Cancer Sci."},{"key":"10.3945\/jn.113.186007_bib35","first-page":"5002","article-title":"Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats","volume":"52","author":"Cravo","year":"1992","journal-title":"Cancer Res."},{"key":"10.3945\/jn.113.186007_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mrrev.2012.05.001","article-title":"The influence of folate and methionine on intestinal tumour development in the Apc(Min\/+) mouse model","volume":"751","author":"Teh","year":"2012","journal-title":"Mutat Res."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622008392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622008392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/144\/4\/419\/23976608\/419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T21:48:30Z","timestamp":1686692910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622008392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0022316622008392"],"URL":"https:\/\/doi.org\/10.3945\/jn.113.186007","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Azoxymethane-Induced Colon Carcinogenesis in Mice Occurs Independently of De Novo Thymidylate Synthesis Capacity","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.113.186007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}