{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:34:08Z","timestamp":1780612448131,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":3047,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.3945\/jn.114.194829","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T07:08:18Z","timestamp":1408604898000},"page":"1658-1663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Methylmalonic Acid Quantified in Dried Blood Spots Provides a Precise, Valid, and Stable Measure of Functional Vitamin B-12 Status in Healthy Women"],"prefix":"10.1016","volume":"144","author":[{"given":"Theresa H.","family":"Schroder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teo A.W.","family":"Quay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.114.194829_bib1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1542\/peds.2008-1173","article-title":"Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification.","volume":"123","author":"Molloy","year":"2009","journal-title":"Pediatrics"},{"key":"10.3945\/jn.114.194829_bib2","first-page":"703","article-title":"Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.","volume":"86","author":"Kirke","year":"1993","journal-title":"Q J Med"},{"key":"10.3945\/jn.114.194829_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3945\/ajcn.111.032268","article-title":"Cobalamin and folate status predicts mental development scores in North Indian children 12\u201318 mo of age.","volume":"97","author":"Strand","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib4","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1373\/clinchem.2006.080382","article-title":"Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.","volume":"53","author":"Clarke","year":"2007","journal-title":"Clin Chem"},{"key":"10.3945\/jn.114.194829_bib5","doi-asserted-by":"crossref","first-page":"693S","DOI":"10.3945\/ajcn.2008.26947A","article-title":"How common is vitamin B-12 deficiency?","volume":"89","author":"Allen","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3945\/ajcn.111.015222","article-title":"Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12.","volume":"94","author":"Bailey","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcn\/82.2.442","article-title":"Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999\u20132000.","volume":"82","author":"Pfeiffer","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib8","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3945\/ajcn.111.020230","article-title":"Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey.","volume":"94","author":"MacFarlane","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MCO.0b013e328349f9a7","article-title":"Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans.","volume":"14","author":"Lamers","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.3945\/jn.114.194829_bib10","doi-asserted-by":"crossref","first-page":"348S","DOI":"10.3945\/ajcn.111.013441","article-title":"Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II.","volume":"94","author":"Carmel","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib11","doi-asserted-by":"crossref","first-page":"1981S","DOI":"10.3945\/ajcn.2009.27230C","article-title":"Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.","volume":"89","author":"Hoey","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib12","doi-asserted-by":"crossref","first-page":"313S","DOI":"10.3945\/ajcn.111.013243","article-title":"Biomarkers of vitamin B-12 status in NHANES: a roundtable summary.","volume":"94","author":"Yetley","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1542\/peds.32.3.338","article-title":"A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants.","volume":"32","author":"Guthrie","year":"1963","journal-title":"Pediatrics"},{"key":"10.3945\/jn.114.194829_bib14","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1353\/dem.2007.0038","article-title":"What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research.","volume":"44","author":"McDade","year":"2007","journal-title":"Demography"},{"key":"10.3945\/jn.114.194829_bib15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1728-4457.2001.00303.x","article-title":"Measurement of biomarkers in surveys in developing countries: opportunities and problems.","volume":"27","author":"Boerma","year":"2001","journal-title":"Popul Dev Rev"},{"key":"10.3945\/jn.114.194829_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1515\/CCLM.2007.117","article-title":"A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry.","volume":"45","author":"Blom","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"10.3945\/jn.114.194829_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00216-008-1953-8","article-title":"A fast liquid chromatographic tandem mass spectrometric method for the simultaneous determination of total homocysteine and methylmalonic acid.","volume":"391","author":"Hempen","year":"2008","journal-title":"Anal Bioanal Chem"},{"key":"10.3945\/jn.114.194829_bib18","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1373\/clinchem.2007.087775","article-title":"Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry.","volume":"53","author":"la Marca","year":"2007","journal-title":"Clin Chem"},{"key":"10.3945\/jn.114.194829_bib19","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1093\/clinchem\/46.11.1804","article-title":"Methylmalonic acid measured in plasma and urine by stable-isotope dilution and electrospray tandem mass spectrometry.","volume":"46","author":"Magera","year":"2000","journal-title":"Clin Chem"},{"key":"10.3945\/jn.114.194829_bib20","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jchromb.2011.03.039","article-title":"Methylmalonic acid quantification in low serum volumes by UPLC-MS\/MS.","volume":"879","author":"Pedersen","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.3945\/jn.114.194829_bib21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1373\/clinchem.2005.058586","article-title":"Analysis of methylmalonic acid in plasma by liquid chromatography-tandem mass spectrometry.","volume":"52","author":"Schmedes","year":"2006","journal-title":"Clin Chem"},{"key":"10.3945\/jn.114.194829_bib22","doi-asserted-by":"crossref","first-page":"S283","DOI":"10.1007\/s10545-010-9111-9","article-title":"Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria.","volume":"33","author":"Shigematsu","year":"2010","journal-title":"J Inherit Metab Dis"},{"key":"10.3945\/jn.114.194829_bib23","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1373\/clinchem.2010.148957","article-title":"Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry.","volume":"56","author":"Turgeon","year":"2010","journal-title":"Clin Chem"},{"key":"10.3945\/jn.114.194829_bib24","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1373\/clinchem.2005.053835","article-title":"Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry.","volume":"51","author":"Windelberg","year":"2005","journal-title":"Clin Chem"},{"key":"10.3945\/jn.114.194829_bib25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3945\/ajcn.113.061234","article-title":"Modeling a methylmalonic acid-derived change point for serum vitamin B-12 for adults in NHANES.","volume":"98","author":"Bailey","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.194829_bib26","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1021\/bi992535e","article-title":"Thermodynamic and kinetic characterization of Co\u2212C bond homolysis catalyzed by coenzyme B12-dependent methylmalonyl-CoA mutase.","volume":"39","author":"Chowdhury","year":"2000","journal-title":"Biochemistry"},{"key":"10.3945\/jn.114.194829_bib27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0003-9861(82)90088-1","article-title":"Purification and properties of methylmalonyl coenzyme A mutase from human liver.","volume":"214","author":"Fenton","year":"1982","journal-title":"Arch Biochem Biophys"},{"key":"10.3945\/jn.114.194829_bib28","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/clinchem\/42.6.910","article-title":"Methylmalonic acid quantification by stable isotope dilution gas chromatography-mass spectrometry from filter paper urine samples.","volume":"42","author":"McCann","year":"1996","journal-title":"Clin Chem"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622010070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622010070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/144\/10\/1658\/23977517\/1658.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T21:54:28Z","timestamp":1686693268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622010070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0022316622010070"],"URL":"https:\/\/doi.org\/10.3945\/jn.114.194829","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylmalonic Acid Quantified in Dried Blood Spots Provides a Precise, Valid, and Stable Measure of Functional Vitamin B-12 Status in Healthy Women","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.114.194829","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}