{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:15:20Z","timestamp":1781162120693,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":2743,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000135","name":"NIH","doi-asserted-by":"publisher","award":["R01 HD052069"],"award-info":[{"award-number":["R01 HD052069"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.3945\/jn.114.208678","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T11:38:27Z","timestamp":1434022707000},"page":"1916-1923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates"],"prefix":"10.1016","volume":"145","author":[{"given":"Gengli","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy M","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niko","family":"Kaciroti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K","family":"Georgieff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Twila","family":"Tardif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Lozoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.114.208678_bib1","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","article-title":"Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995\u20132011: a systematic analysis of population-representative data","volume":"1","author":"Stevens","year":"2013","journal-title":"Lancet Glob Health"},{"key":"10.3945\/jn.114.208678_bib2","series-title":"Pregnancy Nutrition Surveillance 2010 Report","author":"Dalenius","year":"2012"},{"key":"10.3945\/jn.114.208678_bib3","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3945\/ajcn.110.007195","article-title":"Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999\u20132006","volume":"93","author":"Mei","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"suppl 5","key":"10.3945\/jn.114.208678_bib4","doi-asserted-by":"crossref","first-page":"1280S","DOI":"10.1093\/ajcn\/71.5.1280s","article-title":"Anemia and iron deficiency: effects on pregnancy outcome","volume":"71","author":"Allen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.208678_bib5","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3945\/jn.112.162362","article-title":"Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy","volume":"142","author":"Shao","year":"2012","journal-title":"J Nutr"},{"key":"10.3945\/jn.114.208678_bib6","doi-asserted-by":"crossref","first-page":"S560","DOI":"10.1177\/15648265070284S409","article-title":"Iron deficiency and child development","volume":"28","author":"Lozoff","year":"2007","journal-title":"Food Nutr Bull"},{"key":"10.3945\/jn.114.208678_bib7","doi-asserted-by":"crossref","first-page":"f3443","DOI":"10.1136\/bmj.f3443","article-title":"Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis","volume":"346","author":"Haider","year":"2013","journal-title":"BMJ"},{"issue":"Suppl 1","key":"10.3945\/jn.114.208678_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1365-3016.2012.01312.x","article-title":"Routine iron\/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes","volume":"26","author":"Imdad","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.3945\/jn.114.208678_bib9","doi-asserted-by":"crossref","unstructured":"Pena-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev 2012. Issue 12. Art. No.: CD004736. DOI: 10.1002\/14651858.CD004736.pub4. 10.1002\/14651858.","DOI":"10.1002\/14651858.CD004736.pub4"},{"key":"10.3945\/jn.114.208678_bib10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1001\/jamainternmed.2013.1632","article-title":"Micronutrient supplementation and pregnancy outcomes: double-blind randomized controlled trial in China","volume":"173","author":"Liu","year":"2013","journal-title":"JAMA Intern Med"},{"key":"10.3945\/jn.114.208678_bib11","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/ije\/dyq262","article-title":"Modifying effects of wealth on the response to nutrient supplementation in pregnancy on birth weight, duration of gestation and perinatal mortality in rural western China: double-blind cluster randomized controlled trial","volume":"40","author":"Zeng","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.3945\/jn.114.208678_bib12","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3945\/jn.113.189894","article-title":"Iron-containing micronutrient supplementation of Chinese women with no or mild anemia during pregnancy improved iron status but did not affect perinatal anemia","volume":"144","author":"Mei","year":"2014","journal-title":"J Nutr"},{"key":"10.3945\/jn.114.208678_bib13","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/ajcn\/66.5.1178","article-title":"Effect of iron supplementation on the iron status of pregnant women: consequences for newborns","volume":"66","author":"Preziosi","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.208678_bib14","unstructured":"World Health Organization. Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations. Vitamin and Mineral Nutrition Information System. Geneva (Switzerland): World Health Organization; 2011. (WHO\/NMH\/NHD\/MNM\/11.2) [cited 2014 Jul 14.] Available from:.http:\/\/www.who.int\/vmnis\/indicators\/serum_ferritin.pdf."},{"key":"10.3945\/jn.114.208678_bib15","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1182\/blood-2002-10-3071","article-title":"The quantitative assessment of body iron","volume":"101","author":"Cook","year":"2003","journal-title":"Blood"},{"key":"10.3945\/jn.114.208678_bib16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1067\/mpd.2002.120688","article-title":"Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age","volume":"140","author":"Tamura","year":"2002","journal-title":"J Pediatr"},{"key":"10.3945\/jn.114.208678_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jpeds.2009.09.049","article-title":"In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response","volume":"156","author":"Amin","year":"2010","journal-title":"J Pediatr"},{"key":"10.3945\/jn.114.208678_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/sj.jp.7211178","article-title":"Iron status and neurobehavioral development of premature infants","volume":"24","author":"Armony-Sivan","year":"2004","journal-title":"J Perinatol"},{"key":"10.3945\/jn.114.208678_bib19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MPH.0b013e3182707f2e","article-title":"Impact of multiple risk factors on newborn iron status","volume":"35","author":"McLimore","year":"2013","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.3945\/jn.114.208678_bib20","first-page":"368","article-title":"The clinical measurement of serum transferrin receptor","volume":"114","author":"Flowers","year":"1989","journal-title":"J Lab Clin Med"},{"key":"10.3945\/jn.114.208678_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cca.2007.04.008","article-title":"Evaluation of an automated soluble transferrin receptor (sTfR) assay on the Roche Hitachi analyzer and its comparison to two ELISA assays","volume":"382","author":"Pfeiffer","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.3945\/jn.114.208678_bib22","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1515\/CCLM.2010.167","article-title":"A WHO reference reagent for the serum transferrin receptor (sTfR): international collaborative study to evaluate a recombinant soluble transferrin receptor preparation","volume":"48","author":"Thorpe","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"10.3945\/jn.114.208678_bib23","doi-asserted-by":"crossref","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","article-title":"Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship","volume":"131","author":"Haas","year":"2001","journal-title":"J Nutr"},{"key":"10.3945\/jn.114.208678_bib24","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ajcn\/59.4.908","article-title":"Functional consequences of iron supplementation in iron-deficient female cotton workers in Beijing, China","volume":"59","author":"Li","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.208678_bib25","first-page":"398","article-title":"Platelet parameters in women with iron deficiency anemia","volume":"98","author":"Kadikoylu","year":"2006","journal-title":"J Natl Med Assoc"},{"key":"10.3945\/jn.114.208678_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/08880011003739455","article-title":"Severe thrombocytopenia with iron deficiency anemia","volume":"27","author":"Morris","year":"2010","journal-title":"Pediatr Hematol Oncol"},{"key":"10.3945\/jn.114.208678_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/09537100903137306","article-title":"Platelet counts in adults with iron deficiency anemia","volume":"20","author":"Kuku","year":"2009","journal-title":"Platelets"},{"key":"10.3945\/jn.114.208678_bib28","first-page":"CD004736","article-title":"Effects of routine oral iron supplementation with or without folic acid for women during pregnancy","volume":"3","author":"Pena-Rosas","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3945\/jn.114.208678_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/AOG.0b013e3181cbd5f5","article-title":"Trends in birth weight and gestational length among singleton term births in the United States, 1990\u20132005","volume":"115","author":"Donahue","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"252","key":"10.3945\/jn.114.208678_bib30","article-title":"Anthropometric reference data for children and adults: United States, 2007\u20131010","volume":"11","author":"Fryar","year":"2012","journal-title":"National Center for Health Statistics. Vital Health Stat"},{"key":"10.3945\/jn.114.208678_bib31","series-title":"Weight gain during pregnancy: reexamining the guidelines","year":"2009"},{"key":"10.3945\/jn.114.208678_bib32","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/ajcn\/77.4.924","article-title":"Maternal iron status influences iron transfer to the fetus during the third trimester of pregnancy","volume":"77","author":"O'Brien","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.114.208678_bib33","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1111\/j.1753-4887.2011.00428.x","article-title":"Role of the placenta in regulation of fetal iron status","volume":"69","author":"McArdle","year":"2011","journal-title":"Nutr Rev"},{"key":"10.3945\/jn.114.208678_bib34","doi-asserted-by":"crossref","first-page":"R894","DOI":"10.1152\/ajpregu.00525.2003","article-title":"Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta","volume":"287","author":"Bradley","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.3945\/jn.114.208678_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/nyas.12314","article-title":"Issues in the timing of integrated early interventions: contributions from nutrition, neuroscience, and psychological research","volume":"1308","author":"Wachs","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"10.3945\/jn.114.208678_bib36","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1001\/jama.2010.1861","article-title":"Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal","volume":"304","author":"Christian","year":"2010","journal-title":"JAMA"},{"key":"10.3945\/jn.114.208678_bib37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/jp.2014.42","article-title":"Neonatal iron status is impaired by maternal obesity and excessive weight gain during pregnancy","volume":"34","author":"Phillips","year":"2014","journal-title":"J Perinatol"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622088393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622088393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/145\/8\/1916\/23970214\/jn208678.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:26:41Z","timestamp":1686698801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622088393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0022316622088393"],"URL":"https:\/\/doi.org\/10.3945\/jn.114.208678","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.114.208678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}